Aliases for GNPDA1 Gene
External Ids for GNPDA1 Gene
Previous HGNC Symbols for GNPDA1 Gene
Previous GeneCards Identifiers for GNPDA1 Gene
Glucosamine-6-phosphate deaminase (EC 18.104.22.168) is an allosteric enzyme that catalyzes the reversible conversion of D-glucosamine-6-phosphate into D-fructose-6-phosphate and ammonium (Arreola et al., 2003 [PubMed 12965206]).[supplied by OMIM, Jan 2010]
GeneCards Summary for GNPDA1 Gene
GNPDA1 (Glucosamine-6-Phosphate Deaminase 1) is a Protein Coding gene. Diseases associated with GNPDA1 include Griscelli Syndrome, Type 3. Among its related pathways are Amino sugar and nucleotide sugar metabolism and Glycosaminoglycan metabolism. Gene Ontology (GO) annotations related to this gene include hydrolase activity and glucosamine-6-phosphate deaminase activity. An important paralog of this gene is GNPDA2.
UniProtKB/Swiss-Prot Summary for GNPDA1 Gene
Seems to trigger calcium oscillations in mammalian eggs. These oscillations serve as the essential trigger for egg activation and early development of the embryo (By similarity).