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The product of this gene is a member of the saposin-like protein (SAPLIP) family and is located in the cytotoxic granules of T cells, which are released upon antigen stimulation. This protein is present in cytotoxic granules of cytotoxic T lymphocytes and natural killer cells, and it has antimicrobial activity against M. tuberculosis and other organisms. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
GNLY (Granulysin) is a Protein Coding gene. Diseases associated with GNLY include Erythema Multiforme and Kyphoscoliotic Heart Disease. Among its related pathways are Allograft rejection and Innate Immune System.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | TAS | -- |
GO:0005615 | extracellular space | TAS | 2212946 |
GO:0044194 | colocalizes_with cytolytic granule | IBA,IDA | 9756476 |
GO:0097013 | phagocytic vesicle lumen | TAS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Innate Immune System |
.61
|
|
2 | Defensins | ||
3 | Allograft rejection |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006968 | cellular defense response | IBA,IDA | 9756476 |
GO:0019730 | antimicrobial humoral response | TAS | -- |
GO:0031640 | killing of cells of other organism | IBA,IDA | 9756476 |
GO:0042742 | defense response to bacterium | IEA,IDA | 9756476 |
GO:0050832 | defense response to fungus | IEA | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
3-(N-morpholino)propanesulfonic acid | Experimental | Pharma | Target | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | · | 1f | · | 1g | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | · | 6d | · | 6e | · | 6f | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
SP3: | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
SP4: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
SP5: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
SP6: | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
SP7: | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
SP8: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
SP9: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
SP10: | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP11: | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP12: | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
SP13: |
This gene was present in the common ancestor of mammals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | GNLY 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
Dog (Canis familiaris) |
Mammalia | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 02 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
728937 | Benign: not provided | 85,694,426(+) | C/T | MISSENSE_VARIANT,FIVE_PRIME_UTR_VARIANT | |
780828 | Benign: not provided | 85,694,429(+) | G/A | NONSENSE,FIVE_PRIME_UTR_VARIANT | |
786859 | Benign: not provided | 85,695,345(+) | T/C | SYNONYMOUS_VARIANT | |
rs11127 | - | p.Thr119Ile |
Disorder | Aliases | PubMed IDs |
---|---|---|
erythema multiforme |
|
|
kyphoscoliotic heart disease |
|
|
erythematosquamous dermatosis |
|
|
folliculitis |
|
|
mycobacterium tuberculosis 1 |
|