The protein encoded by this gene appears to be a nucleolar GTPase that is essential for ribosomal pre-rRNA processing and cell proliferation. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, May 2010] See more...

Aliases for GNL3L Gene

Aliases for GNL3L Gene

  • G Protein Nucleolar 3 Like 2 3 5
  • Guanine Nucleotide Binding Protein-Like 3 (Nucleolar)-Like 2 3
  • Guanine Nucleotide-Binding Protein-Like 3-Like Protein 3 4
  • G Protein Nucleolar 3B 2 3
  • Novel GTPase 3
  • EC 3.6.1 52
  • GNL3B 3

External Ids for GNL3L Gene

Previous GeneCards Identifiers for GNL3L Gene

  • GC0XP054440
  • GC0XP054573
  • GC0XP051606

Summaries for GNL3L Gene

Entrez Gene Summary for GNL3L Gene

  • The protein encoded by this gene appears to be a nucleolar GTPase that is essential for ribosomal pre-rRNA processing and cell proliferation. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, May 2010]

GeneCards Summary for GNL3L Gene

GNL3L (G Protein Nucleolar 3 Like) is a Protein Coding gene. Among its related pathways are Ribosome biogenesis in eukaryotes. Gene Ontology (GO) annotations related to this gene include GTPase activity. An important paralog of this gene is GNL3.

UniProtKB/Swiss-Prot Summary for GNL3L Gene

  • Stabilizes TERF1 telomeric association by preventing TERF1 recruitment by PML. Stabilizes TERF1 protein by preventing its ubiquitination and hence proteasomal degradation. Does so by interfering with TERF1-binding to FBXO4 E3 ubiquitin-protein ligase. Required for cell proliferation. By stabilizing TRF1 protein during mitosis, promotes metaphase-to-anaphase transition. Stabilizes MDM2 protein by preventing its ubiquitination, and hence proteasomal degradation. By acting on MDM2, may affect TP53 activity. Required for normal processing of ribosomal pre-rRNA. Binds GTP.

Additional gene information for GNL3L Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GNL3L Gene

Genomics for GNL3L Gene

GeneHancer (GH) Regulatory Elements for GNL3L Gene

Promoters and enhancers for GNL3L Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ054528 Promoter/Enhancer 1.6 Ensembl ENCODE CraniofacialAtlas 506.3 +0.3 304 3.4 ZBTB40 EP300 SIN3A TCF12 NRF1 MYC POLR2G USF1 PHF8 ZIC2 GNL3L lnc-GNL3L-1 lnc-FGD1-1 PHF8 piR-38637
GH0XJ054042 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas 19.3 -486.1 -486062 4.3 FOXK2 ZBTB40 ZNF217 ZSCAN5C SIN3A TCF12 POLR2G NCOR1 GTF2E2 PHF8 PHF8 lnc-FAM120C-3 KDM5C SMC1A ACTG1P10 APEX2 KANTR GNL3L ENSG00000233250 TSPYL2
GH0XJ054439 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 16.6 -89.2 -89210 3.2 ZNF217 EP300 NRF1 TCF12 POLR2G USF1 ZFX ZNF639 REST POLR2A TSR2 WNK3 GNL3L PHF8 piR-46643
GH0XJ054481 Enhancer 0.9 ENCODE CraniofacialAtlas 19.7 -46.7 -46654 3.6 NRF1 USF1 TEAD4 ZNF263 MXI1 CTCF SP2 ZFHX2 SMAD4 ZNF189 GNL3L TSR2 FGD1 piR-46643
GH0XJ054638 Promoter/Enhancer 1.7 FANTOM5 ENCODE CraniofacialAtlas 6.1 +110.4 110367 3.9 ZNF217 CTCF NRF1 POLR2G SP1 PHF8 JUND REST POLR2A CLOCK GNL3L PHF8 HSALNG0138079 piR-36971
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GNL3L on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GNL3L

Top Transcription factor binding sites by QIAGEN in the GNL3L gene promoter:
  • CREB
  • deltaCREB
  • FOXJ2
  • FOXJ2 (long isoform)
  • HTF
  • PPAR-gamma1
  • PPAR-gamma2
  • USF-1
  • USF-1:USF-2
  • USF1

Genomic Locations for GNL3L Gene

Genomic Locations for GNL3L Gene
chrX:54,530,211-54,621,565
(GRCh38/hg38)
Size:
91,355 bases
Orientation:
Plus strand
chrX:54,556,644-54,593,720
(GRCh37/hg19)
Size:
37,077 bases
Orientation:
Plus strand

Genomic View for GNL3L Gene

Genes around GNL3L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GNL3L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GNL3L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GNL3L Gene

Proteins for GNL3L Gene

  • Protein details for GNL3L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NVN8-GNL3L_HUMAN
    Recommended name:
    Guanine nucleotide-binding protein-like 3-like protein
    Protein Accession:
    Q9NVN8

    Protein attributes for GNL3L Gene

    Size:
    582 amino acids
    Molecular mass:
    65573 Da
    Quaternary structure:
    • Interacts with MDM2; this interaction, which occurs in the nucleoplasm, stabilizes MDM2. Indirectly interacts with TP53, via MDM2-binding. Interacts with TERF1; this interaction probably occurs in the nucleoplasm and is increased during mitosis, when the nucleolus is disassembled. This binding may promote TERF1 homodimerization. Interacts with TERT.

neXtProt entry for GNL3L Gene

Selected DME Specific Peptides for GNL3L Gene

Q9NVN8:
  • PNVGKSS
  • VLNKIDL

Post-translational modifications for GNL3L Gene

  • Ubiquitination at Lys200, Lys208, Lys226, Lys228, Lys297, Lys327, Lys477, and Lys482
  • Modification sites at PhosphoSitePlus

Other Protein References for GNL3L Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for GNL3L Gene

Gene Families for GNL3L Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for GNL3L Gene

Blocks:
  • GTP-binding protein, HSR1-related
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GNL3L Gene

GenScript: Design optimal peptide antigens:
  • Guanine nucleotide-binding protein-like 3-like protein (GNL3L_HUMAN)
  • GNL3L protein (Q05DU1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9NVN8

UniProtKB/Swiss-Prot:

GNL3L_HUMAN :
  • In contrast to other GTP-binding proteins, this family is characterized by a circular permutation of the GTPase motifs described by a G4-G1-G3 pattern.
  • Belongs to the TRAFAC class YlqF/YawG GTPase family.
Domain:
  • In contrast to other GTP-binding proteins, this family is characterized by a circular permutation of the GTPase motifs described by a G4-G1-G3 pattern.
Family:
  • Belongs to the TRAFAC class YlqF/YawG GTPase family.
genes like me logo Genes that share domains with GNL3L: view

Function for GNL3L Gene

Molecular function for GNL3L Gene

UniProtKB/Swiss-Prot Function:
Stabilizes TERF1 telomeric association by preventing TERF1 recruitment by PML. Stabilizes TERF1 protein by preventing its ubiquitination and hence proteasomal degradation. Does so by interfering with TERF1-binding to FBXO4 E3 ubiquitin-protein ligase. Required for cell proliferation. By stabilizing TRF1 protein during mitosis, promotes metaphase-to-anaphase transition. Stabilizes MDM2 protein by preventing its ubiquitination, and hence proteasomal degradation. By acting on MDM2, may affect TP53 activity. Required for normal processing of ribosomal pre-rRNA. Binds GTP.

Enzyme Numbers (IUBMB) for GNL3L Gene

Phenotypes From GWAS Catalog for GNL3L Gene

Gene Ontology (GO) - Molecular Function for GNL3L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
GO:0005515 protein binding IPI 16189514
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with GNL3L: view
genes like me logo Genes that share phenotypes with GNL3L: view

Animal Model Products

CRISPR Products

miRNA for GNL3L Gene

miRTarBase miRNAs that target GNL3L

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GNL3L Gene

Localization for GNL3L Gene

Subcellular locations from UniProtKB/Swiss-Prot for GNL3L Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GNL3L gene
Compartment Confidence
nucleus 5
cytosol 5
mitochondrion 2
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (3)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GNL3L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005697 telomerase holoenzyme complex IDA 18082603
GO:0005730 nucleolus IDA,IBA 18082603
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with GNL3L: view

Pathways & Interactions for GNL3L Gene

PathCards logo

SuperPathways for GNL3L Gene

genes like me logo Genes that share pathways with GNL3L: view

Pathways by source for GNL3L Gene

1 KEGG pathway for GNL3L Gene

Gene Ontology (GO) - Biological Process for GNL3L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031397 negative regulation of protein ubiquitination IMP 19487455
GO:0031647 regulation of protein stability IMP 19487455
GO:0032091 negative regulation of protein binding IDA 19487455
GO:0032211 negative regulation of telomere maintenance via telomerase IMP 18082603
GO:0033234 negative regulation of protein sumoylation IMP 22641345
genes like me logo Genes that share ontologies with GNL3L: view

No data available for SIGNOR curated interactions for GNL3L Gene

Drugs & Compounds for GNL3L Gene

(1) Drugs for GNL3L Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with GNL3L: view

Transcripts for GNL3L Gene

mRNA/cDNA for GNL3L Gene

2 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GNL3L Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b
SP1: -
SP2:

Relevant External Links for GNL3L Gene

GeneLoc Exon Structure for
GNL3L

Expression for GNL3L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GNL3L Gene

Protein differential expression in normal tissues from HIPED for GNL3L Gene

This gene is overexpressed in Lung (56.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GNL3L Gene



Protein tissue co-expression partners for GNL3L Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GNL3L

SOURCE GeneReport for Unigene cluster for GNL3L Gene:

Hs.654677

Evidence on tissue expression from TISSUES for GNL3L Gene

  • Lung(4.2)
  • Nervous system(2.5)
genes like me logo Genes that share expression patterns with GNL3L: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GNL3L Gene

Orthologs for GNL3L Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GNL3L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GNL3L 30
  • 92.46 (n)
cow
(Bos Taurus)
Mammalia GNL3L 31 30
  • 90.96 (n)
OneToOne
dog
(Canis familiaris)
Mammalia GNL3L 31 30
  • 90.43 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gnl3l 30
  • 87.19 (n)
mouse
(Mus musculus)
Mammalia Gnl3l 17 31 30
  • 86.9 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia GNL3L 31
  • 54 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GNL3L 31
  • 54 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GNL3L 31
  • 50 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.8285 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.6058 30
zebrafish
(Danio rerio)
Actinopterygii gnl3l 31
  • 47 (a)
OneToOne
Dr.3178 30
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9273 30
fruit fly
(Drosophila melanogaster)
Insecta ns1 31
  • 33 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea nst-1 31
  • 34 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NUG1 33 31
  • 25 (a)
rice
(Oryza sativa)
Liliopsida Os.6742 30
barley
(Hordeum vulgare)
Liliopsida Hv.2571 30
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8939 31
  • 42 (a)
OneToMany
Species where no ortholog for GNL3L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GNL3L Gene

ENSEMBL:
Gene Tree for GNL3L (if available)
TreeFam:
Gene Tree for GNL3L (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GNL3L: view image

Paralogs for GNL3L Gene

Paralogs for GNL3L Gene

(1) SIMAP similar genes for GNL3L Gene using alignment to 2 proteins:

  • GNL3L_HUMAN
  • Q05DU1_HUMAN

Pseudogenes.org Pseudogenes for GNL3L Gene

genes like me logo Genes that share paralogs with GNL3L: view

Variants for GNL3L Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GNL3L Gene

SNP ID Clinical significance and condition Chr 0X pos Variation AA Info Type
773379 Benign: not provided 54,540,229(+) TAAA/T INFRAME_DELETION
rs2298284 - p.Arg320His

Additional dbSNP identifiers (rs#s) for GNL3L Gene

Structural Variations from Database of Genomic Variants (DGV) for GNL3L Gene

Variant ID Type Subtype PubMed ID
esv2675067 CNV deletion 23128226
esv2740175 CNV deletion 23290073
nsv1110084 CNV deletion 24896259
nsv435891 CNV deletion 17901297

Variation tolerance for GNL3L Gene

Residual Variation Intolerance Score: 45.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.56; 30.13% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GNL3L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GNL3L

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GNL3L Gene

Disorders for GNL3L Gene

Additional Disease Information for GNL3L

No disorders were found for GNL3L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GNL3L Gene

Publications for GNL3L Gene

  1. GNL3L stabilizes the TRF1 complex and promotes mitotic transition. (PMID: 19487455) Zhu Q … Tsai RY (The Journal of cell biology 2009) 2 3 4 54
  2. A novel lysine-rich domain and GTP binding motifs regulate the nucleolar retention of human guanine nucleotide binding protein, GNL3L. (PMID: 17034816) Rao MR … Mahalingam S (Journal of molecular biology 2006) 3 4 23 54
  3. The homologous putative GTPases Grn1p from fission yeast and the human GNL3L are required for growth and play a role in processing of nucleolar pre-rRNA. (PMID: 16251348) Du X … Balasundaram D (Molecular biology of the cell 2006) 2 3 4 54
  4. GNL3L depletion destabilizes MDM2 and induces p53-dependent G2/M arrest. (PMID: 21132010) Meng L … Tsai RY (Oncogene 2011) 3 4 54
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54

Products for GNL3L Gene

Sources for GNL3L Gene