Free for academic non-profit institutions. Other users need a Commercial license

Aliases for GNL3 Gene

Aliases for GNL3 Gene

  • G Protein Nucleolar 3 2 3 5
  • Nucleostemin 2 3 4
  • Guanine Nucleotide Binding Protein-Like 3 (Nucleolar) 2 3
  • Nucleolar GTP-Binding Protein 3 3 4
  • Novel Nucleolar Protein 47 3 4
  • E2-Induced Gene 3 Protein 3 4
  • E2IG3 3 4
  • NNP47 3 4
  • NS 3 4
  • Estradiol-Induced Nucleotide Binding Protein 3
  • Guanine Nucleotide-Binding Protein-Like 3 3
  • C77032 3

External Ids for GNL3 Gene

Previous GeneCards Identifiers for GNL3 Gene

  • GC03P052695
  • GC03P052718

Summaries for GNL3 Gene

Entrez Gene Summary for GNL3 Gene

  • The protein encoded by this gene may interact with p53 and may be involved in tumorigenesis. The encoded protein also appears to be important for stem cell proliferation. This protein is found in both the nucleus and nucleolus. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]

GeneCards Summary for GNL3 Gene

GNL3 (G Protein Nucleolar 3) is a Protein Coding gene. Among its related pathways are Ribosome biogenesis in eukaryotes and Neural Stem Cell Differentiation Pathways and Lineage-specific Markers. Gene Ontology (GO) annotations related to this gene include GTPase activity. An important paralog of this gene is GNL3L.

UniProtKB/Swiss-Prot for GNL3 Gene

  • May be required to maintain the proliferative capacity of stem cells. Stabilizes MDM2 by preventing its ubiquitination, and hence proteasomal degradation (By similarity).

Gene Wiki entry for GNL3 Gene

Additional gene information for GNL3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GNL3 Gene

Genomics for GNL3 Gene

GeneHancer (GH) Regulatory Elements for GNL3 Gene

Promoters and enhancers for GNL3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I052683 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 563 +5.2 5165 5 HDGF PKNOX1 CLOCK SMAD1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 PBRM1 GNL3 RRP9 RFT1 ABHD14B ITIH1 ENSG00000280904
GH03I052681 Enhancer 1.3 Ensembl ENCODE dbSUPER 556.2 +0.7 675 2.5 FOXA2 MLX ARID4B SIN3A DMAP1 IRF4 YY1 ZNF143 RUNX3 RXRA GNL3 PBRM1 ITIH4 NT5DC2 ITIH1
GH03I052680 Enhancer 0.5 Ensembl dbSUPER 550.8 -1.1 -1055 0.2 FOSL1 GNL3 PBRM1 RNU6ATAC16P
GH03I052679 Enhancer 0.4 ENCODE 550.8 -1.8 -1825 0.1 ATF4 CEBPG GNL3 PBRM1 RNU6ATAC16P
GH03I053345 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE 10.1 +666.2 666169 2.7 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF416 DCP1A NISCH PBRM1 ENSG00000271976 RFT1 PHF7 ENSG00000212608 PRKCD NEK4 ACTR8
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around GNL3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GNL3 gene promoter:

Genomic Locations for GNL3 Gene

Genomic Locations for GNL3 Gene
chr3:52,681,156-52,694,497
(GRCh38/hg38)
Size:
13,342 bases
Orientation:
Plus strand
chr3:52,715,172-52,728,513
(GRCh37/hg19)

Genomic View for GNL3 Gene

Genes around GNL3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GNL3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GNL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GNL3 Gene

Proteins for GNL3 Gene

  • Protein details for GNL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BVP2-GNL3_HUMAN
    Recommended name:
    Guanine nucleotide-binding protein-like 3
    Protein Accession:
    Q9BVP2
    Secondary Accessions:
    • B2RDC1
    • Q5PU80
    • Q96SV6
    • Q96SV7
    • Q9UJY0

    Protein attributes for GNL3 Gene

    Size:
    549 amino acids
    Molecular mass:
    61993 Da
    Quaternary structure:
    • Interacts with MDM2; this interaction stabilizes MDM2. Interaction with MDM2 occurs in the nucleoplasm and is triggered by a nucleolar release mechanism, such as mitosis-induced nucleolar disassembly (By similarity). Indirectly interacts with TP53, via MDM2-binding (By similarity).
    SequenceCaution:
    • Sequence=AAF09482.1; Type=Frameshift; Positions=516; Evidence={ECO:0000305};

    Alternative splice isoforms for GNL3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GNL3 Gene

Post-translational modifications for GNL3 Gene

Other Protein References for GNL3 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for GNL3 (GNL3)

No data available for DME Specific Peptides for GNL3 Gene

Domains & Families for GNL3 Gene

Gene Families for GNL3 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for GNL3 Gene

Graphical View of Domain Structure for InterPro Entry

Q9BVP2

UniProtKB/Swiss-Prot:

GNL3_HUMAN :
  • The basic domain (B) allows nucleolar localization in the absence of GTP. The intermediate domain (I) inhibits nucleolar localization by the B domain and is required for exit from the nucleolus. Exit from the nucleolus to the nucleoplasm requires both the I and the acidic (A) domains, and may be triggered by GTP hydrolysis (By similarity).
  • Belongs to the TRAFAC class YlqF/YawG GTPase family.
Domain:
  • The basic domain (B) allows nucleolar localization in the absence of GTP. The intermediate domain (I) inhibits nucleolar localization by the B domain and is required for exit from the nucleolus. Exit from the nucleolus to the nucleoplasm requires both the I and the acidic (A) domains, and may be triggered by GTP hydrolysis (By similarity).
  • In contrast to other GTP-binding proteins, this family is characterized by a circular permutation of the GTPase motifs described by a G4-G1-G3 pattern.
Family:
  • Belongs to the TRAFAC class YlqF/YawG GTPase family.
genes like me logo Genes that share domains with GNL3: view

Function for GNL3 Gene

Molecular function for GNL3 Gene

UniProtKB/Swiss-Prot Function:
May be required to maintain the proliferative capacity of stem cells. Stabilizes MDM2 by preventing its ubiquitination, and hence proteasomal degradation (By similarity).

Phenotypes From GWAS Catalog for GNL3 Gene

Gene Ontology (GO) - Molecular Function for GNL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA,HDA 22658674
GO:0003924 GTPase activity IBA --
GO:0005515 protein binding IPI 16097049
GO:0005525 GTP binding ISS --
GO:0048027 mRNA 5-UTR binding IDA 16213212
genes like me logo Genes that share ontologies with GNL3: view
genes like me logo Genes that share phenotypes with GNL3: view

Animal Models for GNL3 Gene

MGI Knock Outs for GNL3:

Animal Model Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GNL3 Gene

Localization for GNL3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GNL3 Gene

Nucleus. Nucleus, nucleolus. Note=Shuttles between the nucleus and nucleolus. {ECO:0000250 UniProtKB:Q811S9}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GNL3 gene
Compartment Confidence
extracellular 5
nucleus 5
cytoskeleton 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (4)
  • Nuclear bodies (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GNL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA,IDA 22664934
GO:0005634 nucleus ISS --
GO:0005654 nucleoplasm IEA --
GO:0005730 nucleolus ISS --
GO:0016020 membrane HDA,IDA 19946888
genes like me logo Genes that share ontologies with GNL3: view

Pathways & Interactions for GNL3 Gene

genes like me logo Genes that share pathways with GNL3: view

Pathways by source for GNL3 Gene

Gene Ontology (GO) - Biological Process for GNL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008283 cell proliferation IEA --
GO:0017145 stem cell division IDA 25522312
GO:0019827 stem cell population maintenance IMP 25522312
GO:0032206 positive regulation of telomere maintenance IMP 22641345
GO:0033235 positive regulation of protein sumoylation IMP 22641345
genes like me logo Genes that share ontologies with GNL3: view

No data available for SIGNOR curated interactions for GNL3 Gene

Drugs & Compounds for GNL3 Gene

(1) Drugs for GNL3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with GNL3: view

Transcripts for GNL3 Gene

Unigene Clusters for GNL3 Gene

Guanine nucleotide binding protein-like 3 (nucleolar):
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GNL3 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b · 12c ·
SP1: - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - -
SP4: - - - - - -
SP5: - - - - -
SP6: - - - - - - -
SP7: - - - - - -
SP8: - - - - -
SP9: - - - -
SP10: - - - -
SP11: - -
SP12: -
SP13: - -
SP14:
SP15:
SP16:
SP17:

ExUns: 12d ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19a · 19b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:

Relevant External Links for GNL3 Gene

GeneLoc Exon Structure for
GNL3
ECgene alternative splicing isoforms for
GNL3

Expression for GNL3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GNL3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for GNL3 Gene

This gene is overexpressed in Lung (49.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GNL3 Gene



Protein tissue co-expression partners for GNL3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GNL3 Gene:

GNL3

SOURCE GeneReport for Unigene cluster for GNL3 Gene:

Hs.313544

mRNA Expression by UniProt/SwissProt for GNL3 Gene:

Q9BVP2-GNL3_HUMAN
Tissue specificity: Increased levels in lung tissue in cancer patients.

Evidence on tissue expression from TISSUES for GNL3 Gene

  • Liver(4.6)
  • Nervous system(4.6)
  • Eye(4.4)
  • Intestine(3.1)
  • Lung(2.7)
  • Bone marrow(2.2)
  • Muscle(2.1)
  • Skin(2)
genes like me logo Genes that share expression patterns with GNL3: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for GNL3 Gene

Orthologs for GNL3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for GNL3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GNL3 33 34
  • 99.51 (n)
cow
(Bos Taurus)
Mammalia GNL3 33 34
  • 85.63 (n)
dog
(Canis familiaris)
Mammalia GNL3 33 34
  • 83.33 (n)
rat
(Rattus norvegicus)
Mammalia Gnl3 33
  • 81.41 (n)
mouse
(Mus musculus)
Mammalia Gnl3 33 16 34
  • 79.86 (n)
oppossum
(Monodelphis domestica)
Mammalia GNL3 34
  • 58 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GNL3 34
  • 54 (a)
OneToOne
chicken
(Gallus gallus)
Aves GNL3 33 34
  • 59.42 (n)
lizard
(Anolis carolinensis)
Reptilia GNL3 34
  • 49 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gnl3 33
  • 54.89 (n)
zebrafish
(Danio rerio)
Actinopterygii gnl3 33 34
  • 53.11 (n)
wufc55d07 33
fruit fly
(Drosophila melanogaster)
Insecta ns1 34
  • 31 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea nst-1 34
  • 31 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NUG1 34
  • 28 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8939 34
  • 38 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4890 33
Species where no ortholog for GNL3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GNL3 Gene

ENSEMBL:
Gene Tree for GNL3 (if available)
TreeFam:
Gene Tree for GNL3 (if available)

Paralogs for GNL3 Gene

Paralogs for GNL3 Gene

(1) SIMAP similar genes for GNL3 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for GNL3 Gene

genes like me logo Genes that share paralogs with GNL3: view

Variants for GNL3 Gene

Sequence variations from dbSNP and Humsavar for GNL3 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000172490 -- 52,684,145(+) G/A upstream_transcript_variant
rs1000590781 -- 52,690,344(+) G/A intron_variant
rs1001115371 -- 52,685,713(+) G/A upstream_transcript_variant
rs1001766671 -- 52,689,929(+) G/A intron_variant
rs1002056045 -- 52,692,913(+) T/C coding_sequence_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for GNL3 Gene

Variant ID Type Subtype PubMed ID
esv3596161 CNV loss 21293372

Variation tolerance for GNL3 Gene

Residual Variation Intolerance Score: 63.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 16.46; 97.74% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GNL3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GNL3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GNL3 Gene

Disorders for GNL3 Gene

Additional Disease Information for GNL3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for GNL3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GNL3 Gene

Publications for GNL3 Gene

  1. A nucleolar mechanism controlling cell proliferation in stem cells and cancer cells. (PMID: 12464630) Tsai RY … McKay RD (Genes & development 2002) 2 3 4 22 58
  2. Cloning of the nucleostemin gene and its function in transforming human embryonic bone marrow mesenchymal stem cells into F6 tumor cells. (PMID: 16012751) Han C … Chen Y (International journal of molecular medicine 2005) 3 4 22 58
  3. Effects of estrogen on global gene expression: identification of novel targets of estrogen action. (PMID: 11085516) Charpentier AH … Aldaz CM (Cancer research 2000) 2 3 4 58
  4. Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. (PMID: 22479202) Dastani Z … Kathiresan S (PLoS genetics 2012) 3 44 58
  5. Expression of nucleostemin, epidermal growth factor and epidermal growth factor receptor in human esophageal squamous cell carcinoma tissues. (PMID: 19823871) Zhang G … Wu W (Journal of cancer research and clinical oncology 2010) 3 22 58

Products for GNL3 Gene

Sources for GNL3 Gene

Content
Loading form....