Aliases for GNL2 Gene

Aliases for GNL2 Gene

  • G Protein Nucleolar 2 2 3 5
  • Guanine Nucleotide Binding Protein-Like 2 (Nucleolar) 2 3
  • Nucleolar GTP-Binding Protein 2 3 4
  • Autoantigen NGP-1 3 4
  • Nucleostemin-2 2 3
  • NGP1 3 4
  • Novel Nucleolar Guanosine 5'-Triphosphate Binding Protein Autoantigen 3
  • Nucleolar G-Protein Gene 1 3
  • Nucleolar GTPase 3
  • HUMAUANTIG 3
  • Ngp-1 3
  • Nog2 3
  • Nug2 3

External Ids for GNL2 Gene

Previous GeneCards Identifiers for GNL2 Gene

  • GC01M037701
  • GC01M037805
  • GC01M038032
  • GC01M036149

Summaries for GNL2 Gene

GeneCards Summary for GNL2 Gene

GNL2 (G Protein Nucleolar 2) is a Protein Coding gene. Diseases associated with GNL2 include Robinow Syndrome, Autosomal Dominant 1 and Siberian Tick Typhus. Among its related pathways are Ribosome biogenesis in eukaryotes. Gene Ontology (GO) annotations related to this gene include GTPase activity. An important paralog of this gene is GNL3L.

UniProtKB/Swiss-Prot Summary for GNL2 Gene

  • GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation (By similarity). May promote cell proliferation possibly by increasing p53/TP53 protein levels, and consequently those of its downstream product CDKN1A/p21, and decreasing RPL23A protein levels (PubMed:26203195).

Gene Wiki entry for GNL2 Gene

Additional gene information for GNL2 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GNL2 Gene

Genomics for GNL2 Gene

GeneHancer (GH) Regulatory Elements for GNL2 Gene

Promoters and enhancers for GNL2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GNL2 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GNL2

Top Transcription factor binding sites by QIAGEN in the GNL2 gene promoter:
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • FAC1
  • FOXD3
  • Nkx2-5
  • Olf-1

Genomic Locations for GNL2 Gene

Genomic Locations for GNL2 Gene
chr1:37,566,812-37,595,985
(GRCh38/hg38)
Size:
29,174 bases
Orientation:
Minus strand
chr1:38,032,413-38,061,586
(GRCh37/hg19)
Size:
29,174 bases
Orientation:
Minus strand

Genomic View for GNL2 Gene

Genes around GNL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GNL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GNL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GNL2 Gene

Proteins for GNL2 Gene

  • Protein details for GNL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13823-NOG2_HUMAN
    Recommended name:
    Nucleolar GTP-binding protein 2
    Protein Accession:
    Q13823
    Secondary Accessions:
    • Q9BWN7

    Protein attributes for GNL2 Gene

    Size:
    731 amino acids
    Molecular mass:
    83655 Da
    Quaternary structure:
    • Interacts with LYAR and RPL23A (PubMed:26203195). Interacts with the nuclear importin-beta receptor and, at a lower extent, with importin-alpha (PubMed:21495629).

neXtProt entry for GNL2 Gene

Post-translational modifications for GNL2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GNL2 Gene

No data available for DME Specific Peptides for GNL2 Gene

Domains & Families for GNL2 Gene

Gene Families for GNL2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for GNL2 Gene

Blocks:
  • GTP-binding protein, HSR1-related
  • NGP1, N-terminal
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GNL2 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ54985, highly similar to Nucleolar GTP-binding protein 2 (B4DPI9_HUMAN)
  • Autoantigen NGP-1 (NOG2_HUMAN)
  • cDNA, FLJ93364, Homo sapiens nucleolar GTPase (HUMAUANTIG), mRNA (Q5T0F3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q13823

UniProtKB/Swiss-Prot:

NOG2_HUMAN :
  • Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.
Family:
  • Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.
genes like me logo Genes that share domains with GNL2: view

Function for GNL2 Gene

Molecular function for GNL2 Gene

UniProtKB/Swiss-Prot Function:
GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation (By similarity). May promote cell proliferation possibly by increasing p53/TP53 protein levels, and consequently those of its downstream product CDKN1A/p21, and decreasing RPL23A protein levels (PubMed:26203195).

Phenotypes From GWAS Catalog for GNL2 Gene

Gene Ontology (GO) - Molecular Function for GNL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
GO:0003924 GTPase activity NAS 8822211
GO:0005525 GTP binding IEA,NAS 8822211
genes like me logo Genes that share ontologies with GNL2: view
genes like me logo Genes that share phenotypes with GNL2: view

Animal Model Products

CRISPR Products

miRNA for GNL2 Gene

miRTarBase miRNAs that target GNL2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GNL2 Gene

Localization for GNL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GNL2 Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GNL2 gene
Compartment Confidence
nucleus 5
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for GNL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 8822211
GO:0005730 nucleolus IDA,IEA --
GO:0016020 membrane HDA,IEA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GNL2: view

Pathways & Interactions for GNL2 Gene

PathCards logo

SuperPathways for GNL2 Gene

genes like me logo Genes that share pathways with GNL2: view

Pathways by source for GNL2 Gene

1 KEGG pathway for GNL2 Gene

Gene Ontology (GO) - Biological Process for GNL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0042254 ribosome biogenesis IEA --
genes like me logo Genes that share ontologies with GNL2: view

No data available for SIGNOR curated interactions for GNL2 Gene

Drugs & Compounds for GNL2 Gene

(1) Drugs for GNL2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with GNL2: view

Transcripts for GNL2 Gene

mRNA/cDNA for GNL2 Gene

3 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GNL2 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b ^ 13 ^ 14 ^
SP1: - - - -
SP2: - - - -
SP3: - - - -
SP4: - - - - -
SP5: - - -
SP6: -
SP7: - - - -
SP8: -
SP9:
SP10:
SP11:
SP12: - -
SP13: -
SP14:
SP15:

ExUns: 15 ^ 16a · 16b · 16c ^ 17 ^ 18 ^ 19
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:

Relevant External Links for GNL2 Gene

GeneLoc Exon Structure for
GNL2

Expression for GNL2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GNL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for GNL2 Gene

This gene is overexpressed in Lung (58.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GNL2 Gene



Protein tissue co-expression partners for GNL2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GNL2

SOURCE GeneReport for Unigene cluster for GNL2 Gene:

Hs.75528

mRNA Expression by UniProt/SwissProt for GNL2 Gene:

Q13823-NOG2_HUMAN
Tissue specificity: Widely expressed, with the highest expression level in testis.

Evidence on tissue expression from TISSUES for GNL2 Gene

  • Muscle(4.4)
  • Kidney(4.3)
  • Nervous system(4.2)
  • Lung(2.7)
  • Skin(2.1)
genes like me logo Genes that share expression patterns with GNL2: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for GNL2 Gene

Orthologs for GNL2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GNL2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GNL2 31 30
  • 99.77 (n)
OneToOne
dog
(Canis familiaris)
Mammalia GNL2 31 30
  • 88.45 (n)
OneToOne
cow
(Bos Taurus)
Mammalia GNL2 31 30
  • 87.19 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Gnl2 17 31 30
  • 84.57 (n)
rat
(Rattus norvegicus)
Mammalia Gnl2 30
  • 83.65 (n)
oppossum
(Monodelphis domestica)
Mammalia GNL2 31
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GNL2 31
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves GNL2 31 30
  • 73.68 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GNL2 31
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gnl2 30
  • 69.16 (n)
Str.15036 30
African clawed frog
(Xenopus laevis)
Amphibia 1i973-prov 30
zebrafish
(Danio rerio)
Actinopterygii gnl2 31
  • 67 (a)
OneToOne
LOC100536859 30
  • 66.43 (n)
Dr.16124 30
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011309 30
  • 54.58 (n)
fruit fly
(Drosophila melanogaster)
Insecta ns2 31 30
  • 54.29 (n)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea ngp-1 31 30
  • 56.65 (n)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NOG2 33 31 30
  • 57.62 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABR120C 30
  • 55.94 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C18843g 30
  • 54.97 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G52980 30
  • 57.31 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.7772 30
rice
(Oryza sativa)
Liliopsida Os03g0352400 30
  • 57.27 (n)
Os.26043 30
barley
(Hordeum vulgare)
Liliopsida Hv.3131 30
wheat
(Triticum aestivum)
Liliopsida Ta.2915 30
corn
(Zea mays)
Liliopsida Zm.6589 30
bread mold
(Neurospora crassa)
Ascomycetes NCU02546 30
  • 55.81 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC6F6.03c 30
  • 55.21 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 45 (a)
OneToOne
Species where no ortholog for GNL2 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for GNL2 Gene

ENSEMBL:
Gene Tree for GNL2 (if available)
TreeFam:
Gene Tree for GNL2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GNL2: view image

Paralogs for GNL2 Gene

Paralogs for GNL2 Gene

Pseudogenes.org Pseudogenes for GNL2 Gene

genes like me logo Genes that share paralogs with GNL2: view

Variants for GNL2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GNL2 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs12025870 - p.Gln452His

Additional dbSNP identifiers (rs#s) for GNL2 Gene

Structural Variations from Database of Genomic Variants (DGV) for GNL2 Gene

Variant ID Type Subtype PubMed ID
esv3585754 CNV loss 21293372
nsv1137751 CNV deletion 24896259
nsv524834 CNV gain 19592680
nsv834746 CNV loss 17160897

Variation tolerance for GNL2 Gene

Residual Variation Intolerance Score: 21.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.40; 42.50% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GNL2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GNL2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GNL2 Gene

Disorders for GNL2 Gene

MalaCards: The human disease database

(3) MalaCards diseases for GNL2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
robinow syndrome, autosomal dominant 1
  • drs1
siberian tick typhus
  • manchurian typhus
robinow syndrome
  • robinow dwarfism
- elite association - COSMIC cancer census association via MalaCards
Search GNL2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for GNL2

genes like me logo Genes that share disorders with GNL2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GNL2 Gene

Publications for GNL2 Gene

  1. Cloning of a novel nucleolar guanosine 5'-triphosphate binding protein autoantigen from a breast tumor. (PMID: 8822211) Racevskis J … Fineberg SA (Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1996) 2 3 4 54
  2. Nucleolar GTP-binding Protein-1 (NGP-1) Promotes G1 to S Phase Transition by Activating Cyclin-dependent Kinase Inhibitor p21 Cip1/Waf1. (PMID: 26203195) Datta D … Mahalingam S (The Journal of biological chemistry 2015) 3 4 54
  3. Coupled GTPase and remodelling ATPase activities form a checkpoint for ribosome export. (PMID: 24240281) Matsuo Y … Hurt E (Nature 2014) 2 3 54
  4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 54
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54

Products for GNL2 Gene

Sources for GNL2 Gene