The GNL1 gene, identified in the human major histocompatibility complex class I region, shows a high degree of similarity with its mouse counterpart. The GNL1 gene is located less than 2 kb centromeric to HLA-E, in the same transcriptional orientation. GNL1 is telomeric to HLA-B and HLA-C. [provided by RefSeq, Jul 2008] See more...

Aliases for GNL1 Gene

Aliases for GNL1 Gene

  • G Protein Nucleolar 1 (Putative) 2 3 5
  • Guanine Nucleotide-Binding Protein-Like 1 3 4
  • GTP-Binding Protein HSR1 3 4
  • HSR1 3 4
  • Guanine Nucleotide Binding Protein-Like 1 2
  • HSR1 GTP-Binding Protein 3

External Ids for GNL1 Gene

Previous GeneCards Identifiers for GNL1 Gene

  • GC06M030569
  • GC06M030284
  • GC06M030619
  • GC06M030621
  • GC06M030509

Summaries for GNL1 Gene

Entrez Gene Summary for GNL1 Gene

  • The GNL1 gene, identified in the human major histocompatibility complex class I region, shows a high degree of similarity with its mouse counterpart. The GNL1 gene is located less than 2 kb centromeric to HLA-E, in the same transcriptional orientation. GNL1 is telomeric to HLA-B and HLA-C. [provided by RefSeq, Jul 2008]

GeneCards Summary for GNL1 Gene

GNL1 (G Protein Nucleolar 1 (Putative)) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include GTP binding and structural molecule activity. An important paralog of this gene is LSG1.

UniProtKB/Swiss-Prot Summary for GNL1 Gene

  • Possible regulatory or functional link with the histocompatibility cluster.

Additional gene information for GNL1 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GNL1 Gene

Genomics for GNL1 Gene

GeneHancer (GH) Regulatory Elements for GNL1 Gene

Promoters and enhancers for GNL1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GNL1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GNL1

Top Transcription factor binding sites by QIAGEN in the GNL1 gene promoter:
  • AREB6
  • C/EBPalpha
  • MZF-1
  • p53
  • Pax-5
  • SREBP-1a
  • SREBP-1b
  • SREBP-1c

Genomic Locations for GNL1 Gene

Genomic Locations for GNL1 Gene
chr6:30,541,377-30,557,594
(GRCh38/hg38)
Size:
16,218 bases
Orientation:
Minus strand
chr6:30,509,154-30,525,371
(GRCh37/hg19)
Size:
16,218 bases
Orientation:
Minus strand

Genomic View for GNL1 Gene

Genes around GNL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GNL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GNL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for GNL1 Gene

  • Protein details for GNL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P36915-GNL1_HUMAN
    Recommended name:
    Guanine nucleotide-binding protein-like 1
    Protein Accession:
    P36915
    Secondary Accessions:
    • B0S838
    • Q96CT5

    Protein attributes for GNL1 Gene

    Size:
    607 amino acids
    Molecular mass:
    68661 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for GNL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GNL1 Gene

Post-translational modifications for GNL1 Gene

  • Ubiquitination at Lys158
  • Modification sites at PhosphoSitePlus

Other Protein References for GNL1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GNL1 Gene

Domains & Families for GNL1 Gene

Gene Families for GNL1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for GNL1 Gene

Blocks:
  • GTP-binding protein, HSR1-related
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GNL1 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ53828, highly similar to Guanine nucleotide-binding protein-like 1 (A8MPZ0_HUMAN)
  • Guanine nucleotide binding protein-like 1 (B0V0L0_HUMAN)
  • Guanine nucleotide binding protein-like 1 (B0V0L1_HUMAN)
  • cDNA FLJ52448, moderately similar to Guanine nucleotide-binding protein-like 1 (B4DWZ0_HUMAN)
  • GTP-binding protein HSR1 (GNL1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P36915

UniProtKB/Swiss-Prot:

GNL1_HUMAN :
  • In contrast to other GTP-binding proteins, this family is characterized by a circular permutation of the GTPase motifs described by a G4-G1-G3 pattern.
  • Belongs to the TRAFAC class YlqF/YawG GTPase family.
Domain:
  • In contrast to other GTP-binding proteins, this family is characterized by a circular permutation of the GTPase motifs described by a G4-G1-G3 pattern.
Family:
  • Belongs to the TRAFAC class YlqF/YawG GTPase family.
genes like me logo Genes that share domains with GNL1: view

Function for GNL1 Gene

Molecular function for GNL1 Gene

UniProtKB/Swiss-Prot Function:
Possible regulatory or functional link with the histocompatibility cluster.
GENATLAS Biochemistry:
guanine nucleotide binding protein in MHC class I region,43kDa (see HLA-CAT@)

Phenotypes From GWAS Catalog for GNL1 Gene

Gene Ontology (GO) - Molecular Function for GNL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity NAS 8180467
GO:0005525 GTP binding NAS 8180467
genes like me logo Genes that share ontologies with GNL1: view
genes like me logo Genes that share phenotypes with GNL1: view

Animal Model Products

CRISPR Products

miRNA for GNL1 Gene

miRTarBase miRNAs that target GNL1

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GNL1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GNL1 Gene

Localization for GNL1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GNL1 gene
Compartment Confidence
extracellular 5
nucleus 3
cytosol 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for GNL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space NAS 8180467
GO:0005634 nucleus HDA 21630459
genes like me logo Genes that share ontologies with GNL1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for GNL1 Gene

Pathways & Interactions for GNL1 Gene

PathCards logo

SuperPathways for GNL1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for GNL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002456 T cell mediated immunity NAS 8180467
GO:0006974 cellular response to DNA damage stimulus IDA 17525332
GO:0007165 signal transduction NAS 8180467
genes like me logo Genes that share ontologies with GNL1: view

No data available for Pathways by source and SIGNOR curated interactions for GNL1 Gene

Drugs & Compounds for GNL1 Gene

(3) Drugs for GNL1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0
Guanosine monophosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with GNL1: view

Transcripts for GNL1 Gene

mRNA/cDNA for GNL1 Gene

1 REFSEQ mRNAs :
19 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GNL1

Alternative Splicing Database (ASD) splice patterns (SP) for GNL1 Gene

No ASD Table

Relevant External Links for GNL1 Gene

GeneLoc Exon Structure for
GNL1

Expression for GNL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GNL1 Gene

Protein differential expression in normal tissues from HIPED for GNL1 Gene

This gene is overexpressed in Lymph node (9.3), Peripheral blood mononuclear cells (9.1), and Frontal cortex (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GNL1 Gene



Protein tissue co-expression partners for GNL1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GNL1

SOURCE GeneReport for Unigene cluster for GNL1 Gene:

Hs.83147

Evidence on tissue expression from TISSUES for GNL1 Gene

  • Nervous system(4.3)
  • Liver(4.2)
  • Muscle(4.2)
  • Skin(4.2)
  • Blood(4.1)
genes like me logo Genes that share expression patterns with GNL1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GNL1 Gene

Orthologs for GNL1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for GNL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GNL1 31 30
  • 99.73 (n)
OneToOne
cow
(Bos Taurus)
Mammalia GNL1 31 30
  • 92.15 (n)
OneToOne
dog
(Canis familiaris)
Mammalia GNL1 31 30
  • 91.32 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gnl1 30
  • 88.58 (n)
mouse
(Mus musculus)
Mammalia Gnl1 17 31 30
  • 88.3 (n)
oppossum
(Monodelphis domestica)
Mammalia GNL1 31
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 76 (a)
OneToMany
-- 31
  • 76 (a)
OneToMany
chicken
(Gallus gallus)
Aves LOC101751100 30
  • 67.74 (n)
GNL1 31
  • 63 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GNL1 31
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gnl1 30
  • 62.35 (n)
zebrafish
(Danio rerio)
Actinopterygii gnl1 31 30
  • 60.54 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008330 30
  • 54.39 (n)
fruit fly
(Drosophila melanogaster)
Insecta ns4 31 30
  • 51.91 (n)
OneToOne
CG9320 32
  • 43 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes LSG1 31
  • 23 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 50 (a)
OneToOne
Species where no ortholog for GNL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GNL1 Gene

ENSEMBL:
Gene Tree for GNL1 (if available)
TreeFam:
Gene Tree for GNL1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GNL1: view image

Paralogs for GNL1 Gene

Paralogs for GNL1 Gene

(1) SIMAP similar genes for GNL1 Gene using alignment to 3 proteins:

  • GNL1_HUMAN
  • A2AB27_HUMAN
  • Q6P458_HUMAN
genes like me logo Genes that share paralogs with GNL1: view

Variants for GNL1 Gene

Additional dbSNP identifiers (rs#s) for GNL1 Gene

Structural Variations from Database of Genomic Variants (DGV) for GNL1 Gene

Variant ID Type Subtype PubMed ID
esv2670269 CNV deletion 23128226
esv2731791 CNV deletion 23290073
esv3411275 CNV duplication 20981092
nsv1074389 CNV deletion 25765185
nsv1122126 CNV deletion 24896259
nsv1144137 CNV deletion 24896259
nsv601264 CNV loss 21841781
nsv601481 CNV loss 21841781

Variation tolerance for GNL1 Gene

Residual Variation Intolerance Score: 22% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.19; 39.63% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GNL1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GNL1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GNL1 Gene

Disorders for GNL1 Gene

Additional Disease Information for GNL1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for GNL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GNL1 Gene

Publications for GNL1 Gene

  1. Structure and evolution of a member of a new subfamily of GTP-binding proteins mapping to the human MHC class I region. (PMID: 8180467) Vernet C … Pontarotti P (Mammalian genome : official journal of the International Mammalian Genome Society 1994) 2 3 4 54
  2. Subcellular distribution of the human putative nucleolar GTPase GNL1 is regulated by a novel arginine/lysine-rich domain and a GTP binding domain in a cell cycle-dependent manner. (PMID: 22244851) Boddapati N … Mahalingam S (Journal of molecular biology 2012) 2 3 54
  3. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PMID: 19851445) Barcellos LF … Criswell LA (PLoS genetics 2009) 3 41 54
  4. HLA-E gene polymorphism associates with ankylosing spondylitis in Sardinia. (PMID: 19912639) Paladini F … Sorrentino R (Arthritis research & therapy 2009) 3 41 54
  5. ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. (PMID: 17525332) Matsuoka S … Elledge SJ (Science (New York, N.Y.) 2007) 3 4 54

Products for GNL1 Gene

Sources for GNL1 Gene