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Aliases for GNL1 Gene

Aliases for GNL1 Gene

  • G Protein Nucleolar 1 (Putative) 2 3 5
  • GTP-Binding Protein HSR1 3 4
  • HSR1 3 4
  • Guanine Nucleotide Binding Protein-Like 1 2
  • Guanine Nucleotide-Binding Protein-Like 1 3
  • HSR1 GTP-Binding Protein 3

External Ids for GNL1 Gene

Previous GeneCards Identifiers for GNL1 Gene

  • GC06M030569
  • GC06M030284
  • GC06M030619
  • GC06M030621
  • GC06M030509

Summaries for GNL1 Gene

Entrez Gene Summary for GNL1 Gene

  • The GNL1 gene, identified in the human major histocompatibility complex class I region, shows a high degree of similarity with its mouse counterpart. The GNL1 gene is located less than 2 kb centromeric to HLA-E, in the same transcriptional orientation. GNL1 is telomeric to HLA-B and HLA-C. [provided by RefSeq, Jul 2008]

GeneCards Summary for GNL1 Gene

GNL1 (G Protein Nucleolar 1 (Putative)) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include GTP binding and structural molecule activity. An important paralog of this gene is LSG1.

UniProtKB/Swiss-Prot for GNL1 Gene

  • Possible regulatory or functional link with the histocompatibility cluster.

Additional gene information for GNL1 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GNL1 Gene

Genomics for GNL1 Gene

GeneHancer (GH) Regulatory Elements for GNL1 Gene

Promoters and enhancers for GNL1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06I030554 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 550.8 +1.0 970 3.6 CLOCK DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 SSRP1 GLIS1 GNL1 PIR57735 PRR3 DDX39B TRIM39 DHX16 PPP1R10 NRM ZNRD1 MDC1
GH06I030162 Promoter/Enhancer 1.5 EPDnew ENCODE 31.1 +393.8 393828 2.8 ZFP64 ARID4B DMAP1 YY1 SLC30A9 ZNF213 ZNF302 SP3 SP5 ZC3H11A TRIM10 TRIM15 MDC1 GTF2H4 HCG18 ZNRD1ASP PPP1R10 TRIM39 ETF1P1 PAIP1P1
GH06I031196 Promoter/Enhancer 1.8 Ensembl ENCODE dbSUPER 20.7 -640.3 -640304 3.1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 ZNF548 SP3 NFYC ZNF610 ENSG00000272501 GC06M031194 HCG27 PSORS1C3 POU5F1 PSORS1C2 PRRT1 CCHCR1 HLA-C GNL1
GH06I030715 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 13.6 -161.9 -161932 7.7 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 MDC1 TUBB DDX39B TRIM39 DHX16 LY6G5B PPP1R10 ZNRD1 PAIP1P1 NRM
GH06I029940 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 13.6 +615.3 615333 3.7 HDGF PKNOX1 SMAD1 ARID4B DMAP1 ZNF2 YY1 GLIS2 ZNF143 ATF7 HLA-A HCG4P5 PIR61557 HLA-J HLA-T HLA-G HLA-H HLA-W HLA-K HCG4P3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around GNL1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GNL1 gene promoter:

Genomic Locations for GNL1 Gene

Genomic Locations for GNL1 Gene
16,218 bases
Minus strand

Genomic View for GNL1 Gene

Genes around GNL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GNL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GNL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for GNL1 Gene

  • Protein details for GNL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Guanine nucleotide-binding protein-like 1
    Protein Accession:
    Secondary Accessions:
    • B0S838
    • Q96CT5

    Protein attributes for GNL1 Gene

    607 amino acids
    Molecular mass:
    68661 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for GNL1 Gene


neXtProt entry for GNL1 Gene

Post-translational modifications for GNL1 Gene

  • Ubiquitination at posLast=158158
  • Modification sites at PhosphoSitePlus

Other Protein References for GNL1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GNL1 Gene

Domains & Families for GNL1 Gene

Gene Families for GNL1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for GNL1 Gene

Graphical View of Domain Structure for InterPro Entry



  • In contrast to other GTP-binding proteins, this family is characterized by a circular permutation of the GTPase motifs described by a G4-G1-G3 pattern.
  • Belongs to the TRAFAC class YlqF/YawG GTPase family.
  • In contrast to other GTP-binding proteins, this family is characterized by a circular permutation of the GTPase motifs described by a G4-G1-G3 pattern.
  • Belongs to the TRAFAC class YlqF/YawG GTPase family.
genes like me logo Genes that share domains with GNL1: view

Function for GNL1 Gene

Molecular function for GNL1 Gene

GENATLAS Biochemistry:
guanine nucleotide binding protein in MHC class I region,43kDa (see HLA-CAT@)
UniProtKB/Swiss-Prot Function:
Possible regulatory or functional link with the histocompatibility cluster.

Phenotypes From GWAS Catalog for GNL1 Gene

Gene Ontology (GO) - Molecular Function for GNL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IBA --
GO:0005198 structural molecule activity NAS 8180467
GO:0005525 GTP binding NAS 8180467
genes like me logo Genes that share ontologies with GNL1: view

Phenotypes for GNL1 Gene

GenomeRNAi human phenotypes for GNL1:
genes like me logo Genes that share phenotypes with GNL1: view

Animal Model Products

CRISPR Products

miRNA for GNL1 Gene

miRTarBase miRNAs that target GNL1

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GNL1 Gene

Localization for GNL1 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GNL1 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 2
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for GNL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space NAS 8180467
GO:0005634 nucleus IDA,HDA 21630459
genes like me logo Genes that share ontologies with GNL1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for GNL1 Gene

Pathways & Interactions for GNL1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for GNL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002456 T cell mediated immunity NAS 8180467
GO:0006974 cellular response to DNA damage stimulus IDA 17525332
GO:0007165 signal transduction NAS 8180467
GO:0042254 ribosome biogenesis IBA --
genes like me logo Genes that share ontologies with GNL1: view

No data available for Pathways by source and SIGNOR curated interactions for GNL1 Gene

Drugs & Compounds for GNL1 Gene

(3) Drugs for GNL1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0
Guanosine monophosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with GNL1: view

Transcripts for GNL1 Gene

Unigene Clusters for GNL1 Gene

Guanine nucleotide binding protein-like 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for GNL1 Gene

No ASD Table

Relevant External Links for GNL1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GNL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GNL1 Gene

Protein differential expression in normal tissues from HIPED for GNL1 Gene

This gene is overexpressed in Lymph node (9.3), Peripheral blood mononuclear cells (9.1), and Frontal cortex (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GNL1 Gene

Protein tissue co-expression partners for GNL1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GNL1 Gene:


SOURCE GeneReport for Unigene cluster for GNL1 Gene:


Evidence on tissue expression from TISSUES for GNL1 Gene

  • Nervous system(4.3)
  • Liver(4.2)
  • Muscle(4.2)
  • Skin(4.2)
  • Blood(4.1)
genes like me logo Genes that share expression patterns with GNL1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GNL1 Gene

Orthologs for GNL1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for GNL1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GNL1 33 34
  • 99.73 (n)
(Bos Taurus)
Mammalia GNL1 33 34
  • 92.15 (n)
(Canis familiaris)
Mammalia GNL1 33 34
  • 91.32 (n)
(Rattus norvegicus)
Mammalia Gnl1 33
  • 88.58 (n)
(Mus musculus)
Mammalia Gnl1 33 16 34
  • 88.3 (n)
(Monodelphis domestica)
Mammalia GNL1 34
  • 80 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 76 (a)
-- 34
  • 76 (a)
(Gallus gallus)
Aves LOC101751100 33
  • 67.74 (n)
GNL1 34
  • 63 (a)
(Anolis carolinensis)
Reptilia GNL1 34
  • 66 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia gnl1 33
  • 62.35 (n)
(Danio rerio)
Actinopterygii gnl1 33 34
  • 60.54 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008330 33
  • 54.39 (n)
fruit fly
(Drosophila melanogaster)
Insecta ns4 33 34
  • 51.91 (n)
CG9320 35
  • 43 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes LSG1 34
  • 23 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 50 (a)
Species where no ortholog for GNL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GNL1 Gene

Gene Tree for GNL1 (if available)
Gene Tree for GNL1 (if available)

Paralogs for GNL1 Gene

Paralogs for GNL1 Gene

(1) SIMAP similar genes for GNL1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with GNL1: view

Variants for GNL1 Gene

Sequence variations from dbSNP and Humsavar for GNL1 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1001235962 -- 30,559,153(-) G/A upstream_transcript_variant
rs1001394831 -- 30,558,297(-) A/G upstream_transcript_variant
rs1001406535 -- 30,551,937(-) A/T intron_variant
rs1001418217 -- 30,544,101(-) G/A 3_prime_UTR_variant
rs1001476892 -- 30,543,792(-) C/T 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for GNL1 Gene

Variant ID Type Subtype PubMed ID
esv2670269 CNV deletion 23128226
esv2731791 CNV deletion 23290073
esv3411275 CNV duplication 20981092
nsv1074389 CNV deletion 25765185
nsv1122126 CNV deletion 24896259
nsv1144137 CNV deletion 24896259
nsv601264 CNV loss 21841781
nsv601481 CNV loss 21841781

Variation tolerance for GNL1 Gene

Residual Variation Intolerance Score: 22% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.19; 39.63% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GNL1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GNL1 Gene

Disorders for GNL1 Gene

Additional Disease Information for GNL1

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for GNL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GNL1 Gene

Publications for GNL1 Gene

  1. Structure and evolution of a member of a new subfamily of GTP-binding proteins mapping to the human MHC class I region. (PMID: 8180467) Vernet C … Pontarotti P (Mammalian genome : official journal of the International Mammalian Genome Society 1994) 2 3 4 58
  2. Subcellular distribution of the human putative nucleolar GTPase GNL1 is regulated by a novel arginine/lysine-rich domain and a GTP binding domain in a cell cycle-dependent manner. (PMID: 22244851) Boddapati N … Mahalingam S (Journal of molecular biology 2012) 2 3 58
  3. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PMID: 19851445) Barcellos LF … Criswell LA (PLoS genetics 2009) 3 44 58
  4. HLA-E gene polymorphism associates with ankylosing spondylitis in Sardinia. (PMID: 19912639) Paladini F … Sorrentino R (Arthritis research & therapy 2009) 3 44 58
  5. ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. (PMID: 17525332) Matsuoka S … Elledge SJ (Science (New York, N.Y.) 2007) 3 4 58

Products for GNL1 Gene

Sources for GNL1 Gene

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