Aliases for GNGT2 Gene
- G Protein Subunit Gamma Transducin 2 2 3 5
- Guanine Nucleotide Binding Protein (G Protein), Gamma Transducing Activity Polypeptide 2 2 3
- Guanine Nucleotide Binding Protein Gamma Transducing Activity Polypeptide 2 3 4
- Guanine Nucleotide-Binding Protein G(I)/G(S)/G(O) Subunit Gamma-T2 3 4
- G Gamma-C 3 4
- G-Gamma-9 3 4
- GNGT8 3 4
External Ids for GNGT2 Gene
Previous GeneCards Identifiers for GNGT2 Gene
Phototransduction in rod and cone photoreceptors is regulated by groups of signaling proteins. The encoded protein is thought to play a crucial role in cone phototransduction. It belongs to the G protein gamma family and localized specifically in cones. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Nov 2010]
GeneCards Summary for GNGT2 Gene
GNGT2 (G Protein Subunit Gamma Transducin 2) is a Protein Coding gene. Diseases associated with GNGT2 include Night Blindness, Congenital Stationary, Autosomal Dominant 2 and Retinitis Pigmentosa 17. Among its related pathways are Signaling by GPCR and ADP signalling through P2Y purinoceptor 1. Gene Ontology (GO) annotations related to this gene include GTPase activity and obsolete signal transducer activity. An important paralog of this gene is GNG11.
UniProtKB/Swiss-Prot Summary for GNGT2 Gene
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand binding causes a receptor conformational change, detaching the G protein and switching it 'on'.