Aliases for GNGT1 Gene
External Ids for GNGT1 Gene
Previous GeneCards Identifiers for GNGT1 Gene
This gene encodes the gamma subunit of transducin, a guanine nucleotide-binding protein (G protein) that is found in rod outer segments. Transducin, also known as GMPase, mediates the activation of a cyclic GTP-specific (guanosine monophosphate) phosphodiesterase by rhodopsin. [provided by RefSeq, Jul 2016]
GeneCards Summary for GNGT1 Gene
GNGT1 (G Protein Subunit Gamma Transducin 1) is a Protein Coding gene. Diseases associated with GNGT1 include Citrullinemia, Type Ii, Neonatal-Onset and Night Blindness, Congenital Stationary, Autosomal Dominant 2. Among its related pathways are Apelin signaling pathway and G-Beta Gamma Signaling. Gene Ontology (GO) annotations related to this gene include GTPase activity and obsolete signal transducer activity. An important paralog of this gene is GNG11.
UniProtKB/Swiss-Prot Summary for GNGT1 Gene
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand binding causes a receptor conformational change, detaching the G protein and switching it 'on'.