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Aliases for GNG8 Gene

Aliases for GNG8 Gene

  • G Protein Subunit Gamma 8 2 3 5
  • Guanine Nucleotide Binding Protein (G Protein), Gamma 8 2 3
  • Gamma-9 3 4
  • Guanine Nucleotide-Binding Protein G(I)/G(S)/G(O) Subunit Gamma-8 3
  • GNGT9 4
  • GNG9 4

External Ids for GNG8 Gene

Previous GeneCards Identifiers for GNG8 Gene

  • GC19M047781
  • GC19M047528
  • GC19M051813
  • GC19M051829
  • GC19M047137
  • GC19M043562

Summaries for GNG8 Gene

GeneCards Summary for GNG8 Gene

GNG8 (G Protein Subunit Gamma 8) is a Protein Coding gene. Among its related pathways are Presynaptic function of Kainate receptors and G-protein signaling G-Protein alpha-i signaling cascades. Gene Ontology (GO) annotations related to this gene include GTPase activity and obsolete signal transducer activity. An important paralog of this gene is GNG2.

UniProtKB/Swiss-Prot for GNG8 Gene

  • Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

Tocris Summary for GNG8 Gene

  • Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand binding causes a receptor conformational change, detaching the G protein and switching it 'on'.

Additional gene information for GNG8 Gene

No data available for Entrez Gene Summary , CIViC summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GNG8 Gene

Genomics for GNG8 Gene

GeneHancer (GH) Regulatory Elements for GNG8 Gene

Promoters and enhancers for GNG8 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J046633 Promoter/Enhancer 1.6 Ensembl ENCODE dbSUPER 650.7 +1.2 1159 1.8 PKNOX1 ZNF133 SIN3A GLIS2 ZFP91 SP3 REST GMEB1 ZSCAN16 ZNF184 GNG8 ENSG00000268810 ZC3H4 BICRA QPCTL PTGIR
GH19J046636 Promoter/Enhancer 1.1 EPDnew dbSUPER 650.7 -0.7 -664 0.1 SCRT1 BCOR MEF2B POLR2A ZNF512 SCRT2 IKZF1 ZFP91 ZNF24 PRDM1 GNG8 ENSG00000279161
GH19J046639 Promoter/Enhancer 1 EPDnew dbSUPER 650.7 -1.0 -1008 0.1 ZFP69B POLR2A ZNF692 ZNF24 EBF1 MEF2B CDC5L GNG8 ENSG00000279161
GH19J046637 Enhancer 0.7 ENCODE dbSUPER 650.7 -0.8 -805 0.1 ZNF692 ZNF24 MEF2B CDC5L GNG8 ENSG00000279161
GH19J046600 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 12.3 +33.1 33139 4.6 CLOCK DMAP1 YY1 ZNF213 E2F8 ZNF143 ZNF263 SP3 NFYC ZC3H11A PPP5D1 CALM3 ENSG00000268423 GC19M046598 ZC3H4 CCDC61 ENSG00000268810 FBXO46 ENSG00000269148 CCDC9
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GNG8 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GNG8 gene promoter:
  • PPAR-gamma2
  • PPAR-gamma1
  • SEF-1 (1)
  • aMEF-2
  • MEF-2
  • MEF-2A
  • AP-2gamma
  • c-Ets-1
  • ZIC2
  • Gfi-1

Genomic Locations for GNG8 Gene

Genomic Locations for GNG8 Gene
1,601 bases
Minus strand
610 bases
Minus strand

Genomic View for GNG8 Gene

Genes around GNG8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GNG8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GNG8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GNG8 Gene

Proteins for GNG8 Gene

  • Protein details for GNG8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8
    Protein Accession:
    Secondary Accessions:
    • Q4VBM5

    Protein attributes for GNG8 Gene

    70 amino acids
    Molecular mass:
    7841 Da
    Quaternary structure:
    • G proteins are composed of 3 units, alpha, beta and gamma.

neXtProt entry for GNG8 Gene

Post-translational modifications for GNG8 Gene

No Post-translational modifications

Other Protein References for GNG8 Gene

No data available for DME Specific Peptides for GNG8 Gene

Domains & Families for GNG8 Gene

Gene Families for GNG8 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for GNG8 Gene

Suggested Antigen Peptide Sequences for GNG8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G protein gamma family.
  • Belongs to the G protein gamma family.
genes like me logo Genes that share domains with GNG8: view

Function for GNG8 Gene

Molecular function for GNG8 Gene

UniProtKB/Swiss-Prot Function:
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

Gene Ontology (GO) - Molecular Function for GNG8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity NAS 10819326
GO:0004871 obsolete signal transducer activity NAS --
GO:0005515 protein binding IPI 23773523
genes like me logo Genes that share ontologies with GNG8: view
genes like me logo Genes that share phenotypes with GNG8: view

Animal Models for GNG8 Gene

MGI Knock Outs for GNG8:
  • Gng8 Gng8<tm1(tTA)Rtir>

Animal Model Products

miRNA for GNG8 Gene

miRTarBase miRNAs that target GNG8

Clone Products

  • Addgene plasmids for GNG8

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GNG8 Gene

Localization for GNG8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GNG8 Gene

Cell membrane; Lipid-anchor; Cytoplasmic side.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GNG8 gene
Compartment Confidence
plasma membrane 5
cytosol 3

Gene Ontology (GO) - Cellular Components for GNG8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005834 heterotrimeric G-protein complex IEA --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with GNG8: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GNG8 Gene

Pathways & Interactions for GNG8 Gene

genes like me logo Genes that share pathways with GNG8: view

Gene Ontology (GO) - Biological Process for GNG8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway NAS 10819326
GO:0007399 nervous system development IEA --
GO:0035176 social behavior IEA --
GO:0043584 nose development IEA --
genes like me logo Genes that share ontologies with GNG8: view

No data available for SIGNOR curated interactions for GNG8 Gene

Drugs & Compounds for GNG8 Gene

(3) Drugs for GNG8 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0
Guanosine monophosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0

(5) Additional Compounds for GNG8 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
[D-Trp7,9,10]-Substance P
G-Protein antagonist peptide
Gue 1654
SCH 202676 hydrobromide

(5) Tocris Compounds for GNG8 Gene

Compound Action Cas Number
[D-Trp7,9,10]-Substance P Inhibits M1 ACh receptor activation of Gq/11 89430-38-6
G-Protein antagonist peptide Inhibits G protein activation by GPCRs 143675-79-0
Gue 1654 Selective inhibitor of OXE-R Gbetagamma signaling 397290-30-1
Mastoparan Activates Gi and Go 72093-21-1
SCH 202676 hydrobromide Inhibitor of ligand binding to G-protein-coupled receptors 265980-25-4
genes like me logo Genes that share compounds with GNG8: view

Transcripts for GNG8 Gene

mRNA/cDNA for GNG8 Gene

(5) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GNG8 Gene

Guanine nucleotide binding protein (G protein), gamma 8:
Representative Sequences:

Clone Products

  • Addgene plasmids for GNG8

Alternative Splicing Database (ASD) splice patterns (SP) for GNG8 Gene

No ASD Table

Relevant External Links for GNG8 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GNG8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GNG8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GNG8 Gene

This gene is overexpressed in Brain - Hypothalamus (x5.7).

Protein differential expression in normal tissues from HIPED for GNG8 Gene

This gene is overexpressed in Fetal Brain (65.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GNG8 Gene

Protein tissue co-expression partners for GNG8 Gene

NURSA nuclear receptor signaling pathways regulating expression of GNG8 Gene:


SOURCE GeneReport for Unigene cluster for GNG8 Gene:


Evidence on tissue expression from TISSUES for GNG8 Gene

  • Blood(2.3)
genes like me logo Genes that share expression patterns with GNG8: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GNG8 Gene

Orthologs for GNG8 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GNG8 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia GNG8 34
  • 99 (a)
(Bos Taurus)
Mammalia GNG8 34 33
  • 91.43 (n)
(Mus musculus)
Mammalia Gng8 16 34 33
  • 88.1 (n)
(Rattus norvegicus)
Mammalia Gng8 33
  • 87.62 (n)
(Monodelphis domestica)
Mammalia GNG8 34
  • 85 (a)
(Anolis carolinensis)
Reptilia GNG8 34
  • 86 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia gng8 33
  • 65.71 (n)
(Danio rerio)
Actinopterygii gng8 34 33
  • 70.95 (n)
Species where no ortholog for GNG8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GNG8 Gene

Gene Tree for GNG8 (if available)
Gene Tree for GNG8 (if available)
Evolutionary constrained regions (ECRs) for GNG8: view image

Paralogs for GNG8 Gene

Paralogs for GNG8 Gene

(10) SIMAP similar genes for GNG8 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GNG8: view

Variants for GNG8 Gene

Sequence variations from dbSNP and Humsavar for GNG8 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000142200 -- 46,639,323(-) T/A 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs1000747480 -- 46,638,042(-) C/G 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000961931 -- 46,636,951(-) C/T 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1001158588 -- 46,638,285(-) C/T 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant
rs1001851255 -- 46,635,910(-) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for GNG8 Gene

Variant ID Type Subtype PubMed ID
nsv833849 CNV loss 17160897
nsv953589 CNV deletion 24416366

Variation tolerance for GNG8 Gene

Residual Variation Intolerance Score: 71.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.52; 11.21% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GNG8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GNG8 Gene

Disorders for GNG8 Gene

Additional Disease Information for GNG8

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for GNG8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GNG8 Gene

Publications for GNG8 Gene

  1. Genomic characterization of the human heterotrimeric G protein alpha, beta, and gamma subunit genes. (PMID: 10819326) Hurowitz EH … Shizuya H (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 2 3 4 58
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Evolutionary hierarchy of vertebrate-like heterotrimeric G protein families. (PMID: 26002831) Krishnan A … Schiöth HB (Molecular phylogenetics and evolution 2015) 3 58
  5. Differential G protein subunit expression by prostate cancer cells and their interaction with CXCR5. (PMID: 23773523) El-Haibi CP … Lillard JW (Molecular cancer 2013) 3 58

Products for GNG8 Gene

  • Addgene plasmids for GNG8

Sources for GNG8 Gene

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