Aliases for GNG7 Gene

Aliases for GNG7 Gene

  • G Protein Subunit Gamma 7 2 3 5
  • Guanine Nucleotide-Binding Protein G(I)/G(S)/G(O) Subunit Gamma-7 3 4
  • Guanine Nucleotide Binding Protein (G Protein), Gamma 7 2 3
  • GNGT7 4

External Ids for GNG7 Gene

Previous GeneCards Identifiers for GNG7 Gene

  • GC19M002577
  • GC19M002454
  • GC19M002463
  • GC19M002464
  • GC19M002465
  • GC19M002283

Summaries for GNG7 Gene

GeneCards Summary for GNG7 Gene

GNG7 (G Protein Subunit Gamma 7) is a Protein Coding gene. Diseases associated with GNG7 include Keratinizing Squamous Cell Carcinoma. Among its related pathways are Signaling by GPCR and ADP signalling through P2Y purinoceptor 1. Gene Ontology (GO) annotations related to this gene include obsolete signal transducer activity. An important paralog of this gene is GNG12.

UniProtKB/Swiss-Prot Summary for GNG7 Gene

  • Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Plays a role in the regulation of adenylyl cyclase signaling in certain regions of the brain. Plays a role in the formation or stabilzation of a G protein heterotrimer (G(olf) subunit alpha-beta-gamma-7) that is required for adenylyl cyclase activity in the striatum (By similarity).

Tocris Summary for GNG7 Gene

  • Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand binding causes a receptor conformational change, detaching the G protein and switching it 'on'.

Gene Wiki entry for GNG7 Gene

Additional gene information for GNG7 Gene

No data available for Entrez Gene Summary , CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GNG7 Gene

Genomics for GNG7 Gene

GeneHancer (GH) Regulatory Elements for GNG7 Gene

Promoters and enhancers for GNG7 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GNG7 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GNG7

Top Transcription factor binding sites by QIAGEN in the GNG7 gene promoter:
  • POU2F1
  • POU2F1a
  • RFX1
  • USF-1
  • USF-1:USF-2
  • USF1
  • USF2

Genomic Locations for GNG7 Gene

Genomic Locations for GNG7 Gene
chr19:2,511,219-2,702,748
(GRCh38/hg38)
Size:
191,530 bases
Orientation:
Minus strand
chr19:2,511,217-2,702,707
(GRCh37/hg19)
Size:
191,491 bases
Orientation:
Minus strand

Genomic View for GNG7 Gene

Genes around GNG7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GNG7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GNG7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GNG7 Gene

Proteins for GNG7 Gene

  • Protein details for GNG7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60262-GBG7_HUMAN
    Recommended name:
    Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
    Protein Accession:
    O60262
    Secondary Accessions:
    • B2R496

    Protein attributes for GNG7 Gene

    Size:
    68 amino acids
    Molecular mass:
    7522 Da
    Quaternary structure:
    • G proteins are composed of 3 units, alpha, beta and gamma.

neXtProt entry for GNG7 Gene

Post-translational modifications for GNG7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GNG7 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GNG7 Gene

Domains & Families for GNG7 Gene

Gene Families for GNG7 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for GNG7 Gene

Blocks:
  • Gamma G-protein (transducin) signature
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GNG7 Gene

GenScript: Design optimal peptide antigens:
  • Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 (GBG7_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O60262

UniProtKB/Swiss-Prot:

GBG7_HUMAN :
  • Belongs to the G protein gamma family.
Family:
  • Belongs to the G protein gamma family.
genes like me logo Genes that share domains with GNG7: view

Function for GNG7 Gene

Molecular function for GNG7 Gene

UniProtKB/Swiss-Prot Function:
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Plays a role in the regulation of adenylyl cyclase signaling in certain regions of the brain. Plays a role in the formation or stabilzation of a G protein heterotrimer (G(olf) subunit alpha-beta-gamma-7) that is required for adenylyl cyclase activity in the striatum (By similarity).

Phenotypes From GWAS Catalog for GNG7 Gene

Gene Ontology (GO) - Molecular Function for GNG7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IEA --
GO:0031681 G-protein beta-subunit binding IBA 21873635
genes like me logo Genes that share ontologies with GNG7: view
genes like me logo Genes that share phenotypes with GNG7: view

Animal Models for GNG7 Gene

MGI Knock Outs for GNG7:

Animal Model Products

  • Taconic Biosciences Mouse Models for GNG7

CRISPR Products

miRNA for GNG7 Gene

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GNG7

Clone Products

  • Addgene plasmids for GNG7

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GNG7 Gene

Localization for GNG7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GNG7 Gene

Cell membrane; Lipid-anchor; Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GNG7 gene
Compartment Confidence
plasma membrane 4
cytosol 3
extracellular 2
nucleus 2
cytoskeleton 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for GNG7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005834 heterotrimeric G-protein complex IBA,IEA 21873635
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0031680 G-protein beta/gamma-subunit complex IBA 21873635
GO:0070062 extracellular exosome HDA 19056867
genes like me logo Genes that share ontologies with GNG7: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GNG7 Gene

Pathways & Interactions for GNG7 Gene

PathCards logo

SuperPathways for GNG7 Gene

SuperPathway Contained pathways
1 Development Angiotensin activation of ERK
.73
.73
.68
.65
.54
.48
.45
.40
2 ADP signalling through P2Y purinoceptor 12
.43
3 G-Beta Gamma Signaling
.46
.46
.44
.37
.32
.30
4 Presynaptic function of Kainate receptors
5 ADP signalling through P2Y purinoceptor 1
.39
genes like me logo Genes that share pathways with GNG7: view

Pathways by source for GNG7 Gene

34 GeneGo (Thomson Reuters) pathways for GNG7 Gene
  • Apoptosis and survival BAD phosphorylation
  • Cell adhesion Integrin inside-out signaling
  • Chemotaxis CXCR4 signaling pathway
  • Cytoskeleton remodeling Reverse signaling by ephrin B
  • Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation
47 Qiagen pathways for GNG7 Gene
  • Actin Nucleation and Branching
  • Actin Nucleation by ARP-WASP Complex
  • Actin-Based Motility by Rho Family GTPases
  • Activation of cAMP-Dependent PKA
  • Activation of PKA through GPCR

Gene Ontology (GO) - Biological Process for GNG7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA,IBA 21873635
GO:0008277 regulation of G protein-coupled receptor signaling pathway TAS 9600093
genes like me logo Genes that share ontologies with GNG7: view

No data available for SIGNOR curated interactions for GNG7 Gene

Drugs & Compounds for GNG7 Gene

(3) Drugs for GNG7 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0
Guanosine monophosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0

(5) Additional Compounds for GNG7 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
[D-Trp7,9,10]-Substance P
89430-38-6
G-Protein antagonist peptide
143675-79-0
Gue 1654
397290-30-1
mastoparan
72093-21-1
SCH 202676 hydrobromide
265980-25-4

(5) Tocris Compounds for GNG7 Gene

Compound Action Cas Number
[D-Trp7,9,10]-Substance P Inhibits M1 ACh receptor activation of Gq/11 89430-38-6
G-Protein antagonist peptide Inhibits G protein activation by GPCRs 143675-79-0
Gue 1654 Selective inhibitor of OXE-R Gbetagamma signaling 397290-30-1
Mastoparan Activates Gi and Go 72093-21-1
SCH 202676 hydrobromide Inhibitor of ligand binding to G-protein-coupled receptors 265980-25-4
genes like me logo Genes that share compounds with GNG7: view

Transcripts for GNG7 Gene

mRNA/cDNA for GNG7 Gene

1 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GNG7

Clone Products

  • Addgene plasmids for GNG7

Alternative Splicing Database (ASD) splice patterns (SP) for GNG7 Gene

No ASD Table

Relevant External Links for GNG7 Gene

GeneLoc Exon Structure for
GNG7

Expression for GNG7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GNG7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GNG7 Gene

This gene is overexpressed in Brain - Putamen (basal ganglia) (x11.8), Brain - Caudate (basal ganglia) (x9.8), and Brain - Nucleus accumbens (basal ganglia) (x9.2).

Protein differential expression in normal tissues from HIPED for GNG7 Gene

This gene is overexpressed in Frontal cortex (23.2) and Spinal cord (12.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GNG7 Gene



Protein tissue co-expression partners for GNG7 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GNG7

SOURCE GeneReport for Unigene cluster for GNG7 Gene:

Hs.515544

mRNA Expression by UniProt/SwissProt for GNG7 Gene:

O60262-GBG7_HUMAN
Tissue specificity: Expressed in a variety of tissues. Down-regulated in pancreatic and esophageal cancer.

Evidence on tissue expression from TISSUES for GNG7 Gene

  • Nervous system(4.9)
  • Skin(4)
genes like me logo Genes that share expression patterns with GNG7: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for GNG7 Gene

Orthologs for GNG7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GNG7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GNG7 31 30
  • 98.53 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GNG7 31
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GNG7 31
  • 91 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GNG7 31 30
  • 90.69 (n)
OneToOne
dog
(Canis familiaris)
Mammalia GNG7 31 30
  • 88.73 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Gng7 17 31 30
  • 83.33 (n)
rat
(Rattus norvegicus)
Mammalia Gng7 30
  • 82.84 (n)
chicken
(Gallus gallus)
Aves GNG7 31
  • 91 (a)
OneToOne
LOC100858976 30
  • 82.84 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia gng7 30
  • 76.96 (n)
zebrafish
(Danio rerio)
Actinopterygii gng7 31 30
  • 78.92 (n)
OneToOne
Species where no ortholog for GNG7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GNG7 Gene

ENSEMBL:
Gene Tree for GNG7 (if available)
TreeFam:
Gene Tree for GNG7 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GNG7: view image

Paralogs for GNG7 Gene

Paralogs for GNG7 Gene

(10) SIMAP similar genes for GNG7 Gene using alignment to 2 proteins:

  • GBG7_HUMAN
  • K7ESC6_HUMAN
genes like me logo Genes that share paralogs with GNG7: view

Variants for GNG7 Gene

Additional dbSNP identifiers (rs#s) for GNG7 Gene

Structural Variations from Database of Genomic Variants (DGV) for GNG7 Gene

Variant ID Type Subtype PubMed ID
dgv1688n106 CNV deletion 24896259
dgv6219n54 CNV gain+loss 21841781
dgv6220n54 CNV loss 21841781
dgv6221n54 CNV gain+loss 21841781
dgv6222n54 CNV gain 21841781
dgv6223n54 CNV loss 21841781
dgv6224n54 CNV loss 21841781
dgv6225n54 CNV loss 21841781
esv1406094 CNV insertion 17803354
esv1706865 CNV deletion 17803354
esv2153598 CNV deletion 18987734
esv23824 CNV loss 19812545
esv2444878 CNV deletion 19546169
esv2657598 CNV deletion 23128226
esv2717899 CNV deletion 23290073
esv2717900 CNV deletion 23290073
esv2717901 CNV deletion 23290073
esv2717902 CNV deletion 23290073
esv2717903 CNV deletion 23290073
esv2717904 CNV deletion 23290073
esv2762019 CNV gain 21179565
esv29337 CNV loss 19812545
esv3368818 CNV insertion 20981092
esv3371283 CNV duplication 20981092
esv3555860 CNV deletion 23714750
esv3555863 CNV deletion 23714750
esv3574275 CNV gain 25503493
esv3643429 CNV loss 21293372
esv3643430 CNV loss 21293372
esv3643431 CNV loss 21293372
esv3643432 CNV loss 21293372
esv3643433 CNV loss 21293372
esv3643434 CNV loss 21293372
nsv1056064 CNV loss 25217958
nsv1064930 CNV gain 25217958
nsv1071890 CNV deletion 25765185
nsv1072839 CNV deletion 25765185
nsv1072840 CNV deletion 25765185
nsv1109158 CNV deletion 24896259
nsv1123208 CNV deletion 24896259
nsv1129614 CNV tandem duplication 24896259
nsv1133437 CNV deletion 24896259
nsv1134741 CNV deletion 24896259
nsv1146074 CNV deletion 26484159
nsv458326 CNV gain 19166990
nsv470109 CNV loss 18288195
nsv470111 CNV gain 18288195
nsv509714 CNV insertion 20534489
nsv526820 CNV loss 19592680
nsv578387 CNV gain 21841781
nsv578388 CNV gain+loss 21841781
nsv578390 CNV loss 21841781
nsv578398 CNV gain 21841781
nsv828397 CNV gain 20364138
nsv833708 CNV loss 17160897
nsv953944 CNV deletion 24416366
nsv953945 CNV deletion 24416366
nsv960771 CNV duplication 23825009
nsv978759 CNV duplication 23825009

Variation tolerance for GNG7 Gene

Residual Variation Intolerance Score: 51.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.12; 2.68% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GNG7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GNG7

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GNG7 Gene

Disorders for GNG7 Gene

MalaCards: The human disease database

(1) MalaCards diseases for GNG7 Gene - From: DISEASES

Disorder Aliases PubMed IDs
keratinizing squamous cell carcinoma
  • keratinizing epidermoid carcinoma
- elite association - COSMIC cancer census association via MalaCards
Search GNG7 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for GNG7

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with GNG7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GNG7 Gene

Publications for GNG7 Gene

  1. Identification and cloning of human G-protein gamma 7, down-regulated in pancreatic cancer. (PMID: 9600093) Shibata K … Akiyoshi T (Biochemical and biophysical research communications 1998) 2 3 4 54
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41 54
  3. Clinical significance of the reduced expression of G protein gamma 7 (GNG7) in oesophageal cancer. (PMID: 18219292) Ohta M … Mori M (British journal of cancer 2008) 3 4 54
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54

Products for GNG7 Gene

Sources for GNG7 Gene