G proteins are trimeric (alpha-beta-gamma) membrane-associated proteins that regulate flow of information from cell surface receptors to a variety of internal metabolic effectors. Interaction of a G protein with its activated receptor promotes exchange of GTP for GDP that is bound to the alpha subunit. The alpha-GTP complex dissociates from the beta-gamma heterodimer so that th... See more...

Aliases for GNG5 Gene

Aliases for GNG5 Gene

  • G Protein Subunit Gamma 5 2 3 5
  • Guanine Nucleotide-Binding Protein G(I)/G(S)/G(O) Subunit Gamma-5 3 4
  • Guanine Nucleotide Binding Protein (G Protein), Gamma 5 2 3
  • GNGT5 4

External Ids for GNG5 Gene

Previous GeneCards Identifiers for GNG5 Gene

  • GC01P085584
  • GC01M084102
  • GC01M084252
  • GC01M084386
  • GC01M084676
  • GC01M084964
  • GC01M083074

Summaries for GNG5 Gene

Entrez Gene Summary for GNG5 Gene

  • G proteins are trimeric (alpha-beta-gamma) membrane-associated proteins that regulate flow of information from cell surface receptors to a variety of internal metabolic effectors. Interaction of a G protein with its activated receptor promotes exchange of GTP for GDP that is bound to the alpha subunit. The alpha-GTP complex dissociates from the beta-gamma heterodimer so that the subunits, in turn, may interact with and regulate effector molecules (Gilman, 1987 [PubMed 3113327]; summary by Ahmad et al., 1995) [PubMed 7606925].[supplied by OMIM, Nov 2010]

GeneCards Summary for GNG5 Gene

GNG5 (G Protein Subunit Gamma 5) is a Protein Coding gene. Among its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and CCR5 Pathway in Macrophages. Gene Ontology (GO) annotations related to this gene include GTPase activity and PDZ domain binding. An important paralog of this gene is GNG10.

UniProtKB/Swiss-Prot Summary for GNG5 Gene

  • Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

Tocris Summary for GNG5 Gene

  • Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand binding causes a receptor conformational change, detaching the G protein and switching it 'on'.

Gene Wiki entry for GNG5 Gene

Additional gene information for GNG5 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GNG5 Gene

Genomics for GNG5 Gene

GeneHancer (GH) Regulatory Elements for GNG5 Gene

Promoters and enhancers for GNG5 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GNG5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GNG5 gene promoter:
  • AREB6
  • Evi-1
  • FOXD1
  • HNF-1
  • HNF-1A
  • Nkx3-1
  • Nkx3-1 v1
  • Nkx3-1 v2
  • Nkx3-1 v3
  • Nkx3-1 v4

Genomic Locations for GNG5 Gene

Genomic Locations for GNG5 Gene
chr1:84,498,323-84,506,581
(GRCh38/hg38)
Size:
8,259 bases
Orientation:
Minus strand
chr1:84,964,006-84,972,262
(GRCh37/hg19)
Size:
8,257 bases
Orientation:
Minus strand

Genomic View for GNG5 Gene

Genes around GNG5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GNG5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GNG5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GNG5 Gene

Proteins for GNG5 Gene

  • Protein details for GNG5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P63218-GBG5_HUMAN
    Recommended name:
    Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
    Protein Accession:
    P63218
    Secondary Accessions:
    • B2R5A0
    • P30670
    • Q5VX54
    • Q61015

    Protein attributes for GNG5 Gene

    Size:
    68 amino acids
    Molecular mass:
    7318 Da
    Quaternary structure:
    • G proteins are composed of 3 units, alpha, beta and gamma.

neXtProt entry for GNG5 Gene

Post-translational modifications for GNG5 Gene

  • Ubiquitination at Lys11, Lys12, and Lys36
  • Modification sites at PhosphoSitePlus

Other Protein References for GNG5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GNG5 Gene

Domains & Families for GNG5 Gene

Gene Families for GNG5 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for GNG5 Gene

Suggested Antigen Peptide Sequences for GNG5 Gene

GenScript: Design optimal peptide antigens:
  • Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 (GBG5_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P63218

UniProtKB/Swiss-Prot:

GBG5_HUMAN :
  • Belongs to the G protein gamma family.
Family:
  • Belongs to the G protein gamma family.
genes like me logo Genes that share domains with GNG5: view

Function for GNG5 Gene

Molecular function for GNG5 Gene

UniProtKB/Swiss-Prot Function:
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
GENATLAS Biochemistry:
guanine nucleotide binding protein (G protein),gamma,polypeptide 5 with alternative transcriptional start sites resulting from two separate,closely linked 5' promoters

Phenotypes From GWAS Catalog for GNG5 Gene

Gene Ontology (GO) - Molecular Function for GNG5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity NAS 10819326
GO:0005515 protein binding IPI 25416956
GO:0030165 PDZ domain binding IDA 23209302
GO:0031681 G-protein beta-subunit binding IBA 21873635
genes like me logo Genes that share ontologies with GNG5: view
genes like me logo Genes that share phenotypes with GNG5: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GNG5

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GNG5 Gene

Localization for GNG5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GNG5 Gene

Cell membrane; Lipid-anchor; Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GNG5 gene
Compartment Confidence
plasma membrane 4
cytosol 2
extracellular 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for GNG5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005834 heterotrimeric G-protein complex NAS 9790912
GO:0005886 plasma membrane TAS --
GO:0016020 membrane HDA,IEA 19946888
GO:0031680 G-protein beta/gamma-subunit complex IBA 21873635
GO:0070062 extracellular exosome HDA 19056867
genes like me logo Genes that share ontologies with GNG5: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GNG5 Gene

Pathways & Interactions for GNG5 Gene

genes like me logo Genes that share pathways with GNG5: view

Gene Ontology (GO) - Biological Process for GNG5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction NAS 9790912
GO:0007186 G protein-coupled receptor signaling pathway NAS 20277477
genes like me logo Genes that share ontologies with GNG5: view

No data available for SIGNOR curated interactions for GNG5 Gene

Drugs & Compounds for GNG5 Gene

(3) Drugs for GNG5 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0
Guanosine monophosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0

(5) Additional Compounds for GNG5 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
[D-Trp7,9,10]-Substance P
89430-38-6
G-Protein antagonist peptide
143675-79-0
Gue 1654
397290-30-1
mastoparan
72093-21-1
SCH 202676 hydrobromide
265980-25-4

(5) Tocris Compounds for GNG5 Gene

Compound Action Cas Number
[D-Trp7,9,10]-Substance P Inhibits M1 ACh receptor activation of Gq/11 89430-38-6
G-Protein antagonist peptide Inhibits G protein activation by GPCRs 143675-79-0
Gue 1654 Selective inhibitor of OXE-R Gbetagamma signaling 397290-30-1
Mastoparan Activates Gi and Go 72093-21-1
SCH 202676 hydrobromide Inhibitor of ligand binding to G-protein-coupled receptors 265980-25-4
genes like me logo Genes that share compounds with GNG5: view

Transcripts for GNG5 Gene

mRNA/cDNA for GNG5 Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(423) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GNG5

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GNG5 Gene

No ASD Table

Relevant External Links for GNG5 Gene

GeneLoc Exon Structure for
GNG5
ECgene alternative splicing isoforms for
GNG5

Expression for GNG5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GNG5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GNG5 Gene

This gene is overexpressed in Whole Blood (x6.4).

Protein differential expression in normal tissues from HIPED for GNG5 Gene

This gene is overexpressed in Nasal epithelium (40.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GNG5 Gene



Protein tissue co-expression partners for GNG5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GNG5 Gene:

GNG5

SOURCE GeneReport for Unigene cluster for GNG5 Gene:

Hs.645427

Evidence on tissue expression from TISSUES for GNG5 Gene

  • Blood(4.4)
  • Nervous system(4.3)
  • Heart(2.4)
  • Spleen(2.3)
  • Lung(2.2)
  • Kidney(2.1)
  • Liver(2)
  • Muscle(2)
genes like me logo Genes that share expression patterns with GNG5: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GNG5 Gene

Orthologs for GNG5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GNG5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GNG5 33 32
  • 100 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 33
  • 97 (a)
OneToMany
cow
(Bos Taurus)
Mammalia GNG5 33 32
  • 94.61 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gng5 32
  • 93.63 (n)
mouse
(Mus musculus)
Mammalia Gng5 33 32
  • 93.14 (n)
ManyToMany
Gng5-ps 17
dog
(Canis familiaris)
Mammalia GNG5 32
  • 92.16 (n)
chicken
(Gallus gallus)
Aves -- 33
  • 93 (a)
OneToMany
GNG5 32
  • 80.88 (n)
lizard
(Anolis carolinensis)
Reptilia -- 33
  • 90 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia gng5 32
  • 80.39 (n)
zebrafish
(Danio rerio)
Actinopterygii gng5 33 32
  • 72.55 (n)
OneToMany
iktdsubc_2c12 32
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13816 32
Species where no ortholog for GNG5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GNG5 Gene

ENSEMBL:
Gene Tree for GNG5 (if available)
TreeFam:
Gene Tree for GNG5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GNG5: view image

Paralogs for GNG5 Gene

Paralogs for GNG5 Gene

(9) SIMAP similar genes for GNG5 Gene using alignment to 1 proteins:

  • GBG5_HUMAN
genes like me logo Genes that share paralogs with GNG5: view

Variants for GNG5 Gene

Sequence variations from dbSNP and Humsavar for GNG5 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000162749 -- 84,502,854(-) G/C intron_variant
rs1000484855 -- 84,499,206(-) T/C intron_variant
rs1000619714 -- 84,503,204(-) G/T intron_variant
rs1000656357 -- 84,503,946(-) T/C intron_variant
rs1001336357 -- 84,499,475(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for GNG5 Gene

Variant ID Type Subtype PubMed ID
nsv830437 CNV gain+loss 17160897
nsv946037 CNV duplication 23825009

Variation tolerance for GNG5 Gene

Residual Variation Intolerance Score: 61.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.51; 11.06% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GNG5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GNG5

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GNG5 Gene

Disorders for GNG5 Gene

Additional Disease Information for GNG5

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for GNG5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GNG5 Gene

Publications for GNG5 Gene

  1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 43 56
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 56
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 56
  4. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PMID: 12665801) Gevaert K … Vandekerckhove J (Nature biotechnology 2003) 3 4 56
  5. Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning. (PMID: 9653160) Mao M … Chen Z (Proceedings of the National Academy of Sciences of the United States of America 1998) 3 4 56

Products for GNG5 Gene

Sources for GNG5 Gene