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G proteins are trimeric (alpha-beta-gamma) membrane-associated proteins that regulate flow of information from cell surface receptors to a variety of internal metabolic effectors. Interaction of a G protein with its activated receptor promotes exchange of GTP for GDP that is bound to the alpha subunit. The alpha-GTP complex dissociates from the beta-gamma heterodimer so that th... See more...
Aliases for GNG5 Gene
Aliases for GNG5 Gene
External Ids for GNG5 Gene
- HGNC: 4408
- Entrez Gene: 2787
- Ensembl: ENSG00000174021
- OMIM: 600874
- UniProtKB: P63218
Previous GeneCards Identifiers for GNG5 Gene
- GC01P085584
- GC01M084102
- GC01M084252
- GC01M084386
- GC01M084676
- GC01M084964
- GC01M083074
Summaries for GNG5 Gene
-
G proteins are trimeric (alpha-beta-gamma) membrane-associated proteins that regulate flow of information from cell surface receptors to a variety of internal metabolic effectors. Interaction of a G protein with its activated receptor promotes exchange of GTP for GDP that is bound to the alpha subunit. The alpha-GTP complex dissociates from the beta-gamma heterodimer so that the subunits, in turn, may interact with and regulate effector molecules (Gilman, 1987 [PubMed 3113327]; summary by Ahmad et al., 1995) [PubMed 7606925].[supplied by OMIM, Nov 2010]
GeneCards Summary for GNG5 Gene
GNG5 (G Protein Subunit Gamma 5) is a Protein Coding gene. Diseases associated with GNG5 include Echolalia. Among its related pathways are Translation Translation regulation by Alpha-1 adrenergic receptors and ADP signalling through P2Y purinoceptor 12. Gene Ontology (GO) annotations related to this gene include GTPase activity and PDZ domain binding. An important paralog of this gene is GNG10.
UniProtKB/Swiss-Prot Summary for GNG5 Gene
-
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
-
Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand binding causes a receptor conformational change, detaching the G protein and switching it 'on'.
Additional gene information for GNG5 Gene
- HGNC(4408)
- Entrez Gene(2787)
- Ensembl(ENSG00000174021)
- OMIM(600874)
- UniProtKB(P63218)
- Open Targets Platform(ENSG00000174021)
- Search for GNG5 at DataMed
- Search for GNG5 at HumanCyc
No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GNG5 Gene
Genomics for GNG5 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for GNG5 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around GNG5 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GNG5
- Top Transcription factor binding sites by QIAGEN in the GNG5 gene promoter:
-
- AREB6
- Evi-1
- FOXD1
- HNF-1
- HNF-1A
- Nkx3-1
- Nkx3-1 v1
- Nkx3-1 v2
- Nkx3-1 v3
- Nkx3-1 v4
Genomic Locations for GNG5 Gene
Genomic Locations for GNG5 Gene
- chr1:84,498,325-84,506,581
- (GRCh38/hg38)
- Size:
- 8,257 bases
- Orientation:
- Minus strand
- chr1:84,964,006-84,972,262
- (GRCh37/hg19)
- Size:
- 8,257 bases
- Orientation:
- Minus strand
Genomic View for GNG5 Gene
Genes around GNG5 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p22.3 by HGNC
- 1p22.3 by Entrez Gene
- 1p22.3 by Ensembl
GNG5 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for GNG5 Gene
Proteins for GNG5 Gene
-
Protein details for GNG5 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P63218-GBG5_HUMAN
- Recommended name:
- Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
- Protein Accession:
- P63218
- B2R5A0
- P30670
- Q5VX54
- Q61015
Protein attributes for GNG5 Gene
- Size:
- 68 amino acids
- Molecular mass:
- 7318 Da
- Quaternary structure:
-
- G proteins are composed of 3 units, alpha, beta and gamma.
Protein Expression for GNG5 Gene
Post-translational modifications for GNG5 Gene
Other Protein References for GNG5 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ GNG5 Antibody
-
Custom Antibody ServicesOriGene Antibodies for GNG5
- Novus Biologicals Antibodies for GNG5
- Invitrogen Antibodies for GNG5 (AFLGC-GNG5)
- antibodies-online: Show 4 available GNG5 Antibodies ranked by validation data
- Compare Top GNG5 Antibodies
-
Recommended
- 12 IF (p) Antibodies (anti-rat)
- 6 WB Antibodies (anti-rat)
- 3 IHC (p) Antibodies (anti-rat)
- 2 IF/ICC Antibodies (anti-rat)
- 14 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 3 IF/ICC Antibodies (anti-human)
- 3 IHC (p) Antibodies (anti-human)
- 1 IHC Antibody (anti-human)
- 12 IF (p) Antibodies (anti-mouse)
- 6 WB Antibodies (anti-mouse)
- 3 IF/ICC Antibodies (anti-mouse)
- 3 IHC (p) Antibodies (anti-mouse)
-
Biorbyt antibodies for GNG5
-
Santa Cruz Biotechnology (SCBT) Antibodies for GNG5
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for GNG5
- Origene Custom Protein Services for GNG5
No data available for DME Specific Peptides for GNG5 Gene
Domains & Families for GNG5 Gene
Gene Families for GNG5 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for GNG5 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for GNG5 Gene
- GenScript: Design optimal peptide antigens:
-
- Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 (GBG5_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P63218- Family:
-
- Belongs to the G protein gamma family.
Function for GNG5 Gene
Molecular function for GNG5 Gene
- UniProtKB/Swiss-Prot Function:
- Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
- GENATLAS Biochemistry:
- guanine nucleotide binding protein (G protein),gamma,polypeptide 5 with alternative transcriptional start sites resulting from two separate,closely linked 5' promoters
Phenotypes From GWAS Catalog for GNG5 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003924 | GTPase activity | NAS | 10819326 |
| GO:0005515 | protein binding | IPI | 25416956 |
| GO:0030165 | PDZ domain binding | IDA | 23209302 |
| GO:0031681 | G-protein beta-subunit binding | IBA | 21873635 |
Phenotypes for GNG5 Gene
- MGI mutant phenotypes for GNG5:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for GNG5:
-
- no effect
- Decreased vaccinia virus (VACV) infection
- shRNA abundance <= 50%
- Decreased viability ratio
- Increased gamma-H2AX phosphorylation
- shRNA abundance <= 25%
- Increased viability
- Decreased viability after Maraba virus infection
- Increased S DNA content
- Decreased homologous recombination repair frequency
- Cell division defect
- Negative genetic interaction between PTEN-/- and PTEN+/+
Animal Models for GNG5 Gene
- MGI Knock Outs for GNG5:
-
- Gng5 Gng5<tm1.1Rbs>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for GNG5 - Select products 50% OFF >
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-
OriGene CRISPR knockouts for GNG5
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for GNG5
-
Santa Cruz Biotechnology (SCBT) CRISPR for GNG5
miRNA for GNG5 Gene
- miRTarBase miRNAs that target GNG5
-
- hsa-miR-1-3p (MIRT023505)
- hsa-miR-98-5p (MIRT027504)
- hsa-miR-30a-5p (MIRT028436)
- hsa-miR-100-5p (MIRT048451)
- hsa-let-7e-5p (MIRT051558)
- hsa-miR-3149 (MIRT493749)
- hsa-miR-568 (MIRT493750)
- hsa-miR-8074 (MIRT493751)
- hsa-miR-5589-3p (MIRT493752)
- hsa-miR-6855-3p (MIRT493753)
- hsa-miR-4513 (MIRT493754)
- hsa-miR-656-3p (MIRT493755)
- hsa-miR-183-5p (MIRT493756)
- hsa-miR-7151-3p (MIRT502285)
- hsa-miR-5095 (MIRT502286)
- hsa-miR-3152-3p (MIRT502287)
- hsa-miR-4740-5p (MIRT502288)
- hsa-miR-3169 (MIRT502289)
- hsa-miR-4477b (MIRT567418)
- hsa-miR-4756-3p (MIRT567419)
- hsa-miR-3919 (MIRT567420)
- hsa-miR-892c-5p (MIRT567421)
- hsa-miR-6831-5p (MIRT567422)
- hsa-miR-3927-3p (MIRT567423)
- hsa-miR-576-3p (MIRT567424)
- hsa-miR-6856-5p (MIRT567425)
- hsa-miR-6758-5p (MIRT567426)
- hsa-miR-6816-3p (MIRT567427)
- hsa-miR-8080 (MIRT567428)
- hsa-let-7f-5p (MIRT567429)
- hsa-let-7d-5p (MIRT567430)
- hsa-let-7c-5p (MIRT567431)
- hsa-let-7b-5p (MIRT567432)
- hsa-let-7g-5p (MIRT567433)
- hsa-let-7i-5p (MIRT567434)
- hsa-miR-4458 (MIRT567435)
- hsa-let-7a-5p (MIRT567436)
- hsa-miR-4500 (MIRT567437)
- hsa-miR-100-3p (MIRT761061)
- hsa-miR-208a-5p (MIRT763742)
- hsa-miR-208b-5p (MIRT763749)
- hsa-miR-3140-3p (MIRT764980)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for GNG5
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Clone Products
- Applied Biological Materials (abm): Clones for GNG5 - Select products 50% OFF >
- * GNG5 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for GNG5
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for GNG5
Cell Line Products
-
Horizon Cell Lines for GNG5
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GNG5 Gene
Localization for GNG5 Gene
Subcellular locations from UniProtKB/Swiss-Prot for GNG5 Gene
- Cell membrane. Lipid-anchor. Cytoplasmic side.
| Compartment | Confidence |
|---|---|
| plasma membrane | 4 |
| extracellular | 4 |
| nucleus | 2 |
| cytosol | 2 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005834 | heterotrimeric G-protein complex | NAS | 9790912 |
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0016020 | membrane | IEA,HDA | 19946888 |
| GO:0031680 | G-protein beta/gamma-subunit complex | IBA | 21873635 |
| GO:0070062 | extracellular exosome | HDA | 19056867 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for GNG5 Gene
Pathways & Interactions for GNG5 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Development Angiotensin activation of ERK |
Development ACM2 and ACM4 activation of ERK
.73
Development Angiotensin activation of ERK
.73
Development Angiotensin signaling via PYK2
.68
Development G-Proteins mediated regulation MARK-ERK signaling
.65
|
Development EDNRB signaling
.54
Development EPO-induced MAPK pathway
.48
Cell adhesion Integrin inside-out signaling
.45
Signal transduction IP3 signaling
.40
|
| 2 | ADP signalling through P2Y purinoceptor 12 |
Signal transduction cAMP signaling
.43
|
|
| 3 | G-Beta Gamma Signaling |
G-Beta Gamma Signaling
.46
GHRH Signaling
.46
CRHR Pathway
.44
|
Relaxin Pathway
.37
Hedgehog Signaling in Mammals
.32
Signaling in Gap Junctions
.30
|
| 4 | Presynaptic function of Kainate receptors | ||
| 5 | ADP signalling through P2Y purinoceptor 1 |
Development Angiotensin signaling via beta-Arrestin
.39
|
|
Pathways by source for GNG5 Gene
3 BioSystems pathways for GNG5 Gene
55 Reactome pathways for GNG5 Gene
1 PharmGKB pathway for GNG5 Gene
18 KEGG pathways for GNG5 Gene
34 GeneGo (Thomson Reuters) pathways for GNG5 Gene
- Apoptosis and survival BAD phosphorylation
- Cell adhesion Integrin inside-out signaling
- Chemotaxis CXCR4 signaling pathway
- Cytoskeleton remodeling Reverse signaling by ephrin B
- Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation
47 Qiagen pathways for GNG5 Gene
- Actin Nucleation and Branching
- Actin Nucleation by ARP-WASP Complex
- Actin-Based Motility by Rho Family GTPases
- Activation of cAMP-Dependent PKA
- Activation of PKA through GPCR
Interacting Proteins for GNG5 Gene
Selected Interacting proteins:
P63218-GBG5_HUMAN
ENSP00000359675
for GNG5 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for GNG5
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007165 | signal transduction | NAS | 9790912 |
| GO:0007186 | G protein-coupled receptor signaling pathway | NAS | 20277477 |
No data available for SIGNOR curated interactions for GNG5 Gene
Drugs & Compounds for GNG5 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| [D-Trp7,9,10]-Substance P |
|
89430-38-6 |
|
|
||
| G-Protein antagonist peptide |
|
143675-79-0 |
|
|
||
| Gue 1654 |
|
397290-30-1 |
|
|
||
| mastoparan |
|
72093-21-1 |
|
|
||
| SCH 202676 hydrobromide |
|
265980-25-4 |
|
|
(5) Tocris Compounds for GNG5 Gene
| Compound | Action | Cas Number |
|---|---|---|
| [D-Trp7,9,10]-Substance P | Inhibits M1 ACh receptor activation of Gq/11 | 89430-38-6 |
| G-Protein antagonist peptide | Inhibits G protein activation by GPCRs | 143675-79-0 |
| Gue 1654 | Selective inhibitor of OXE-R Gbetagamma signaling | 397290-30-1 |
| Mastoparan | Activates Gi and Go | 72093-21-1 |
| SCH 202676 hydrobromide | Inhibitor of ligand binding to G-protein-coupled receptors | 265980-25-4 |
Transcripts for GNG5 Gene
mRNA/cDNA for GNG5 Gene
- 1 REFSEQ mRNAs :
- 7 NCBI additional mRNA sequence :
- 3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000370641 920 nts (view in UCSC)
- ENST00000370645 806 nts (view in UCSC)
- ENST00000487806 557 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for GNG5 - Select products 50% OFF >
- * GNG5 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for GNG5
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for GNG5
-
Santa Cruz Biotechnology (SCBT) CRISPR for GNG5
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for GNG5
- Browse OriGene Inhibitory RNA Products For GNG5
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GNG5
Clone Products
- Applied Biological Materials (abm): Clones for GNG5 - Select products 50% OFF >
- * GNG5 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for GNG5
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for GNG5
Relevant External Links for GNG5 Gene
- GeneLoc Exon Structure for
- GNG5
Expression for GNG5 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
mRNA differential expression in normal tissues according to GTEx for GNG5 Gene
This gene is overexpressed in Whole Blood (x6.4).
This gene is overexpressed in Nasal epithelium (40.9).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GNG5 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GNG5
SOURCE GeneReport for Unigene cluster for GNG5 Gene:
Hs.645427Evidence on tissue expression from TISSUES for GNG5 Gene
- Blood(4.5)
- Nervous system(4.5)
- Heart(2.8)
- Kidney(2.5)
- Muscle(2.5)
- Lung(2.5)
- Spleen(2.3)
- Skin(2.2)
- Stomach(2.1)
- Intestine(2)
Primer Products
-
OriGene qPCR primer pairs for GNG5
-
OriGene qPCR primer pairs and template standards for GNG5
Gene Expression Assay Products
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GNG5 Gene
Orthologs for GNG5 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | GNG5 30 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
| Cow (Bos Taurus) |
Mammalia | GNG5 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Gng5 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Gng5 30 17 31 |
|
ManyToMany | |
| Gng5-ps 17 |
|
|
|||
| Dog (Canis familiaris) |
Mammalia | GNG5 30 |
|
||
| Chicken (Gallus gallus) |
Aves | -- 31 |
|
OneToMany | |
| GNG5 30 |
|
||||
| Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | gng5 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | gng5 30 31 |
|
OneToMany | |
| iktdsubc_2c12 30 |
|
||||
| Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.13816 30 |
|
- Species where no ortholog for GNG5 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Oppossum (Monodelphis domestica)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for GNG5 Gene
- ENSEMBL:
- Gene Tree for GNG5 (if available)
- TreeFam:
- Gene Tree for GNG5 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for GNG5: view image
Paralogs for GNG5 Gene
(9) SIMAP similar genes for GNG5 Gene using alignment to 1 proteins:
- GBG5_HUMAN
Pseudogenes.org Pseudogenes for GNG5 Gene
Variants for GNG5 Gene
Residual Variation Intolerance Score:
61.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.51;
11.06% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for GNG5 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- GNG5
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GNG5 Gene
Disorders for GNG5 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| echolalia |
|
|
Search GNG5 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for GNG5
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for GNG5 Gene
Publications for GNG5 Gene
- Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 41
- The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
- Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PMID: 12665801) Gevaert K … Vandekerckhove J (Nature biotechnology 2003) 3 4
- Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning. (PMID: 9653160) Mao M … Chen Z (Proceedings of the National Academy of Sciences of the United States of America 1998) 3 4
ExternalLinks
Products for GNG5 Gene
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- OriGene qPCR primer pairs for GNG5
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- High-throughput Antibody Production Service
- Protein Production Service
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- Invitrogen Antibodies for GNG5 (AFLGC-GNG5)
- VectorBuilder Custom and pre-made DNA vectors for GNG5 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for GNG5 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for GNG5 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for GNG5 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for GNG5
- antibodies-online: Show 4 available GNG5 Antibodies ranked by validation data
- Compare Top GNG5 Antibodies
- Recommended
- 12 IF (p) Antibodies (anti-rat)
- 6 WB Antibodies (anti-rat)
- 3 IHC (p) Antibodies (anti-rat)
- 2 IF/ICC Antibodies (anti-rat)
- 14 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 3 IF/ICC Antibodies (anti-human)
- 3 IHC (p) Antibodies (anti-human)
- 1 IHC Antibody (anti-human)
- 12 IF (p) Antibodies (anti-mouse)
- 6 WB Antibodies (anti-mouse)
- 3 IF/ICC Antibodies (anti-mouse)
- 3 IHC (p) Antibodies (anti-mouse)
- antibodies-online: Search results for available GNG5 related products ranked by validation data
- antibodies-online: Show 5 available GNG5 Proteins ranked by validation data
- Compare Top GNG5 Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for GNG5
- Search Santa Cruz Biotechnology (SCBT) for GNG5 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for GNG5
- Horizon Cell Lines for GNG5
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for GNG5
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for GNG5
- Search GeneCopoeia for miRNA 3'UTR Target clone products for GNG5
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GNG5
- Biorbyt antibodies for GNG5
Sources for GNG5 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB