GNG5 Gene (Protein Coding)

G Protein Subunit Gamma 5

GC01M084498
GIFtS:
40
G proteins are trimeric (alpha-beta-gamma) membrane-associated proteins that regulate flow of information from cell surface receptors to a variety of internal metabolic effectors. Interaction of a G protein with its activated receptor promotes exchange of GTP for GDP that is bound to the alpha subunit. The alpha-GTP complex dissociates from the beta-gamma heterodimer so that th... See more...

Aliases for GNG5 Gene

Aliases for GNG5 Gene

  • G Protein Subunit Gamma 5 2 3 5
  • Guanine Nucleotide-Binding Protein G(I)/G(S)/G(O) Subunit Gamma-5 3 4
  • Guanine Nucleotide Binding Protein (G Protein), Gamma 5 2 3
  • GNGT5 4
  • GNG5 5

External Ids for GNG5 Gene

Previous GeneCards Identifiers for GNG5 Gene

  • GC01P085584
  • GC01M084102
  • GC01M084252
  • GC01M084386
  • GC01M084676
  • GC01M084964
  • GC01M083074

Summaries for GNG5 Gene

Entrez Gene Summary for GNG5 Gene

  • G proteins are trimeric (alpha-beta-gamma) membrane-associated proteins that regulate flow of information from cell surface receptors to a variety of internal metabolic effectors. Interaction of a G protein with its activated receptor promotes exchange of GTP for GDP that is bound to the alpha subunit. The alpha-GTP complex dissociates from the beta-gamma heterodimer so that the subunits, in turn, may interact with and regulate effector molecules (Gilman, 1987 [PubMed 3113327]; summary by Ahmad et al., 1995) [PubMed 7606925].[supplied by OMIM, Nov 2010]

GeneCards Summary for GNG5 Gene

GNG5 (G Protein Subunit Gamma 5) is a Protein Coding gene. Diseases associated with GNG5 include Echolalia. Among its related pathways are Translation Translation regulation by Alpha-1 adrenergic receptors and ADP signalling through P2Y purinoceptor 12. Gene Ontology (GO) annotations related to this gene include GTPase activity and PDZ domain binding. An important paralog of this gene is GNG10.

UniProtKB/Swiss-Prot Summary for GNG5 Gene

  • Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

Tocris Summary for GNG5 Gene

  • Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand binding causes a receptor conformational change, detaching the G protein and switching it 'on'.

Gene Wiki entry for GNG5 Gene

Additional gene information for GNG5 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GNG5 Gene

Genomics for GNG5 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for GNG5 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GNG5 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GNG5

Top Transcription factor binding sites by QIAGEN in the GNG5 gene promoter:
  • AREB6
  • Evi-1
  • FOXD1
  • HNF-1
  • HNF-1A
  • Nkx3-1
  • Nkx3-1 v1
  • Nkx3-1 v2
  • Nkx3-1 v3
  • Nkx3-1 v4

Genomic Locations for GNG5 Gene

Genomic Locations for GNG5 Gene
chr1:84,498,325-84,506,581
(GRCh38/hg38)
Size:
8,257 bases
Orientation:
Minus strand
chr1:84,964,006-84,972,262
(GRCh37/hg19)
Size:
8,257 bases
Orientation:
Minus strand

Genomic View for GNG5 Gene

Genes around GNG5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GNG5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GNG5 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for GNG5 Gene

Proteins for GNG5 Gene

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  • Protein details for GNG5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P63218-GBG5_HUMAN
    Recommended name:
    Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
    Protein Accession:
    P63218
    Secondary Accessions:
    • B2R5A0
    • P30670
    • Q5VX54
    • Q61015

    Protein attributes for GNG5 Gene

    Size:
    68 amino acids
    Molecular mass:
    7318 Da
    Quaternary structure:
    • G proteins are composed of 3 units, alpha, beta and gamma.

neXtProt entry for GNG5 Gene

Protein Expression for GNG5 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for GNG5 Gene

  • Ubiquitination at Lys11, Lys12, and Lys36
  • Modification sites at PhosphoSitePlus

Other Protein References for GNG5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GNG5 Gene

Domains & Families for GNG5 Gene

Gene Families for GNG5 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for GNG5 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GNG5 Gene

GenScript: Design optimal peptide antigens:
  • Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 (GBG5_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P63218

UniProtKB/Swiss-Prot:

GBG5_HUMAN :
  • Belongs to the G protein gamma family.
Family:
  • Belongs to the G protein gamma family.
genes like me logo Genes that share domains with GNG5: view

Function for GNG5 Gene

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Molecular function for GNG5 Gene

UniProtKB/Swiss-Prot Function:
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
GENATLAS Biochemistry:
guanine nucleotide binding protein (G protein),gamma,polypeptide 5 with alternative transcriptional start sites resulting from two separate,closely linked 5' promoters

Phenotypes From GWAS Catalog for GNG5 Gene

Gene Ontology (GO) - Molecular Function for GNG5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity NAS 10819326
GO:0005515 protein binding IPI 25416956
GO:0030165 PDZ domain binding IDA 23209302
GO:0031681 G-protein beta-subunit binding IBA 21873635
genes like me logo Genes that share ontologies with GNG5: view
genes like me logo Genes that share phenotypes with GNG5: view

Animal Models for GNG5 Gene

MGI Knock Outs for GNG5:
  • Gng5 Gng5<tm1.1Rbs>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GNG5

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GNG5 Gene

Localization for GNG5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GNG5 Gene

Cell membrane. Lipid-anchor. Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GNG5 gene
Compartment Confidence
plasma membrane 4
extracellular 4
nucleus 2
cytosol 2
cytoskeleton 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for GNG5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005834 heterotrimeric G-protein complex NAS 9790912
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA,HDA 19946888
GO:0031680 G-protein beta/gamma-subunit complex IBA 21873635
GO:0070062 extracellular exosome HDA 19056867
genes like me logo Genes that share ontologies with GNG5: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GNG5 Gene

Pathways & Interactions for GNG5 Gene

PathCards logo

SuperPathways for GNG5 Gene

SuperPathway Contained pathways
1 Development Angiotensin activation of ERK
Development ACM2 and ACM4 activation of ERK
.73
Development Angiotensin activation of ERK
.73
Development Angiotensin signaling via PYK2
.68
Development G-Proteins mediated regulation MARK-ERK signaling
.65
Development EDNRB signaling
.54
Development EPO-induced MAPK pathway
.48
Cell adhesion Integrin inside-out signaling
.45
Signal transduction IP3 signaling
.40
2 ADP signalling through P2Y purinoceptor 12
ADP signalling through P2Y purinoceptor 12
.73
G-protein activation
.73
Adrenaline,noradrenaline inhibits insulin secretion
.59
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
.57
G alpha (z) signalling events
.45
Signal transduction cAMP signaling
.43
Beta-agonist/Beta-blocker Pathway, Pharmacodynamics
.34
3 G-Beta Gamma Signaling
G-Beta Gamma Signaling
.46
GHRH Signaling
.46
CRHR Pathway
.44
Relaxin Pathway
.37
Hedgehog Signaling in Mammals
.32
Signaling in Gap Junctions
.30
4 Presynaptic function of Kainate receptors
Activation of Kainate Receptors upon glutamate binding
.66
Presynaptic function of Kainate receptors
.66
Glucagon-type ligand receptors
.50
Class B/2 (Secretin family receptors)
.32
G beta-gamma signalling through PLC beta
.01
5 ADP signalling through P2Y purinoceptor 1
ADP signalling through P2Y purinoceptor 1
.78
Thromboxane signalling through TP receptor
.78
Signal amplification
.76
Thrombin signalling through proteinase activated receptors (PARs)
.67
Development Angiotensin signaling via beta-Arrestin
.39
genes like me logo Genes that share pathways with GNG5: view

Pathways by source for GNG5 Gene

1 PharmGKB pathway for GNG5 Gene
34 GeneGo (Thomson Reuters) pathways for GNG5 Gene
  • Apoptosis and survival BAD phosphorylation
  • Cell adhesion Integrin inside-out signaling
  • Chemotaxis CXCR4 signaling pathway
  • Cytoskeleton remodeling Reverse signaling by ephrin B
  • Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation
47 Qiagen pathways for GNG5 Gene
  • Actin Nucleation and Branching
  • Actin Nucleation by ARP-WASP Complex
  • Actin-Based Motility by Rho Family GTPases
  • Activation of cAMP-Dependent PKA
  • Activation of PKA through GPCR

Gene Ontology (GO) - Biological Process for GNG5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction NAS 9790912
GO:0007186 G protein-coupled receptor signaling pathway NAS 20277477
genes like me logo Genes that share ontologies with GNG5: view

No data available for SIGNOR curated interactions for GNG5 Gene

Drugs & Compounds for GNG5 Gene

Products:

  1. Drug

(3) Drugs for GNG5 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0
Guanosine monophosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0

(5) Additional Compounds for GNG5 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
[D-Trp7,9,10]-Substance P
89430-38-6
G-Protein antagonist peptide
143675-79-0
Gue 1654
397290-30-1
mastoparan
72093-21-1
SCH 202676 hydrobromide
265980-25-4

(5) Tocris Compounds for GNG5 Gene

Compound Action Cas Number
[D-Trp7,9,10]-Substance P Inhibits M1 ACh receptor activation of Gq/11 89430-38-6
G-Protein antagonist peptide Inhibits G protein activation by GPCRs 143675-79-0
Gue 1654 Selective inhibitor of OXE-R Gbetagamma signaling 397290-30-1
Mastoparan Activates Gi and Go 72093-21-1
SCH 202676 hydrobromide Inhibitor of ligand binding to G-protein-coupled receptors 265980-25-4
genes like me logo Genes that share compounds with GNG5: view

Transcripts for GNG5 Gene

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  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for GNG5 Gene

1 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GNG5

Alternative Splicing Database (ASD) splice patterns (SP) for GNG5 Gene

No ASD Table

Relevant External Links for GNG5 Gene

GeneLoc Exon Structure for
GNG5

Expression for GNG5 Gene

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  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GNG5 Gene

mRNA expression in normal human tissues for GNG5 Gene
mRNA expression by GTEx for GNG5 GenemRNA expression by BioGPS for GNG5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GNG5 Gene

This gene is overexpressed in Whole Blood (x6.4).

Protein differential expression in normal tissues from HIPED for GNG5 Gene

This gene is overexpressed in Nasal epithelium (40.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GNG5 Gene



Protein tissue co-expression partners for GNG5 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GNG5

SOURCE GeneReport for Unigene cluster for GNG5 Gene:

Hs.645427

Evidence on tissue expression from TISSUES for GNG5 Gene

  • Blood(4.5)
  • Nervous system(4.5)
  • Heart(2.8)
  • Kidney(2.5)
  • Muscle(2.5)
  • Lung(2.5)
  • Spleen(2.3)
  • Skin(2.2)
  • Stomach(2.1)
  • Intestine(2)
genes like me logo Genes that share expression patterns with GNG5: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GNG5 Gene

Orthologs for GNG5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GNG5 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia GNG5 30 31
  • 100 (n)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia -- 31
  • 97 (a)
 OneToMany
Cow
(Bos Taurus)
 Mammalia GNG5 30 31
  • 94.61 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Gng5 30
  • 93.63 (n)
Mouse
(Mus musculus)
 Mammalia Gng5 30 17 31
  • 93.14 (n)
 ManyToMany
Gng5-ps 17
Dog
(Canis familiaris)
 Mammalia GNG5 30
  • 92.16 (n)
Chicken
(Gallus gallus)
 Aves -- 31
  • 93 (a)
 OneToMany
GNG5 30
  • 80.88 (n)
Lizard
(Anolis carolinensis)
 Reptilia -- 31
  • 90 (a)
 OneToMany
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia gng5 30
  • 80.39 (n)
Zebrafish
(Danio rerio)
 Actinopterygii gng5 30 31
  • 72.55 (n)
 OneToMany
iktdsubc_2c12 30
Rainbow Trout
(Oncorhynchus mykiss)
 Actinopterygii Omy.13816 30
Species where no ortholog for GNG5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for GNG5 Gene

ENSEMBL:
Gene Tree for GNG5 (if available)
TreeFam:
Gene Tree for GNG5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GNG5: view image

Paralogs for GNG5 Gene

Paralogs for GNG5 Gene

(9) SIMAP similar genes for GNG5 Gene using alignment to 1 proteins:

  • GBG5_HUMAN

Pseudogenes.org Pseudogenes for GNG5 Gene

genes like me logo Genes that share paralogs with GNG5: view

Variants for GNG5 Gene

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Additional dbSNP identifiers (rs#s) for GNG5 Gene

Structural Variations from Database of Genomic Variants (DGV) for GNG5 Gene

Variant ID Type Subtype PubMed ID
nsv830437 CNV gain+loss 17160897
nsv946037 CNV duplication 23825009

Variation tolerance for GNG5 Gene

Residual Variation Intolerance Score: 61.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.51; 11.06% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GNG5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GNG5

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GNG5 Gene

Disorders for GNG5 Gene

MalaCards: The human disease database

(1) MalaCards diseases for GNG5 Gene - From: DISEASES

Disorder Aliases PubMed IDs
echolalia
- elite association - COSMIC cancer census association via MalaCards
Search GNG5 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for GNG5

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with GNG5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GNG5 Gene

Publications for GNG5 Gene

  1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 41
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PMID: 12665801) Gevaert K … Vandekerckhove J (Nature biotechnology 2003) 3 4
  5. Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning. (PMID: 9653160) Mao M … Chen Z (Proceedings of the National Academy of Sciences of the United States of America 1998) 3 4

ExternalLinks

View latest publications for GNG5 gene in Mastermind

Products for GNG5 Gene

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