GNG4 Gene (Protein Coding)

G Protein Subunit Gamma 4

GC01M235547
GIFtS:
39
See more...

Aliases for GNG4 Gene

Aliases for GNG4 Gene

  • G Protein Subunit Gamma 4 2 3 5
  • Guanine Nucleotide-Binding Protein G(I)/G(S)/G(O) Subunit Gamma-4 3 4
  • Guanine Nucleotide Binding Protein (G Protein), Gamma 4 2 3
  • Guanine Nucleotide Binding Protein 4 3
  • GNGT4 4
  • GNG4 5

External Ids for GNG4 Gene

Previous GeneCards Identifiers for GNG4 Gene

  • GC01M233846
  • GC01M231167
  • GC01M232010
  • GC01M232755
  • GC01M232040
  • GC01M235710
  • GC01M206162

Summaries for GNG4 Gene

GeneCards Summary for GNG4 Gene

GNG4 (G Protein Subunit Gamma 4) is a Protein Coding gene. Among its related pathways are Translation Translation regulation by Alpha-1 adrenergic receptors and ADP signalling through P2Y purinoceptor 12. Gene Ontology (GO) annotations related to this gene include obsolete signal transducer activity. An important paralog of this gene is GNG2.

UniProtKB/Swiss-Prot Summary for GNG4 Gene

  • Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

Tocris Summary for GNG4 Gene

  • Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand binding causes a receptor conformational change, detaching the G protein and switching it 'on'.

Gene Wiki entry for GNG4 Gene

Additional gene information for GNG4 Gene

No data available for Entrez Gene Summary , CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GNG4 Gene

Genomics for GNG4 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for GNG4 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GNG4 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GNG4

Top Transcription factor binding sites by QIAGEN in the GNG4 gene promoter:
  • AML1a
  • FOXF2
  • HNF-3beta
  • IRF-2
  • RSRFC4

Genomic Locations for GNG4 Gene

Genomic Locations for GNG4 Gene
chr1:235,547,685-235,650,754
(GRCh38/hg38)
Size:
103,070 bases
Orientation:
Minus strand
chr1:235,710,985-235,814,054
(GRCh37/hg19)
Size:
103,070 bases
Orientation:
Minus strand

Genomic View for GNG4 Gene

Genes around GNG4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GNG4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GNG4 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for GNG4 Gene

Proteins for GNG4 Gene

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  2. Protein
  3. Assay

  • Protein details for GNG4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P50150-GBG4_HUMAN
    Recommended name:
    Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
    Protein Accession:
    P50150

    Protein attributes for GNG4 Gene

    Size:
    75 amino acids
    Molecular mass:
    8389 Da
    Quaternary structure:
    • G proteins are composed of 3 units, alpha, beta and gamma. Interacts with beta-1 and beta-2, but not with beta-3 (PubMed:7665596). Interacts with KCNK1 (By similarity).

neXtProt entry for GNG4 Gene

Protein Expression for GNG4 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for GNG4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GNG4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GNG4 Gene

Domains & Families for GNG4 Gene

Gene Families for GNG4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for GNG4 Gene

InterPro:
Blocks:
  • Gamma G-protein (transducin) signature
ProtoNet:

Suggested Antigen Peptide Sequences for GNG4 Gene

GenScript: Design optimal peptide antigens:
  • cDNA, FLJ92042, Homo sapiens guanine nucleotide binding protein (G protein), gamma4 (GNG4), mRNA (B1APZ0_HUMAN)
  • Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 (GBG4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P50150

UniProtKB/Swiss-Prot:

GBG4_HUMAN :
  • Belongs to the G protein gamma family.
Family:
  • Belongs to the G protein gamma family.
genes like me logo Genes that share domains with GNG4: view

Function for GNG4 Gene

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  2. CRISPR
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  6. Cell Line

Molecular function for GNG4 Gene

UniProtKB/Swiss-Prot Function:
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

Phenotypes From GWAS Catalog for GNG4 Gene

Gene Ontology (GO) - Molecular Function for GNG4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IEA --
GO:0005515 protein binding IPI 23021213
GO:0031681 G-protein beta-subunit binding IBA 21873635
genes like me logo Genes that share ontologies with GNG4: view
genes like me logo Genes that share phenotypes with GNG4: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GNG4

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GNG4 Gene

Localization for GNG4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GNG4 Gene

Cell membrane. Lipid-anchor. Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GNG4 gene
Compartment Confidence
plasma membrane 4
extracellular 4
cytosol 3
nucleus 2
cytoskeleton 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for GNG4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005834 heterotrimeric G-protein complex IBA 21873635
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0031680 G-protein beta/gamma-subunit complex IBA 21873635
GO:0070062 extracellular exosome HDA 23533145
genes like me logo Genes that share ontologies with GNG4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GNG4 Gene

Pathways & Interactions for GNG4 Gene

PathCards logo

SuperPathways for GNG4 Gene

SuperPathway Contained pathways
1 Development Angiotensin activation of ERK
Development ACM2 and ACM4 activation of ERK
.73
Development Angiotensin activation of ERK
.73
Development Angiotensin signaling via PYK2
.68
Development G-Proteins mediated regulation MARK-ERK signaling
.65
Development EDNRB signaling
.54
Development EPO-induced MAPK pathway
.48
Cell adhesion Integrin inside-out signaling
.45
Signal transduction IP3 signaling
.40
2 ADP signalling through P2Y purinoceptor 12
ADP signalling through P2Y purinoceptor 12
.73
G-protein activation
.73
Adrenaline,noradrenaline inhibits insulin secretion
.59
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
.57
G alpha (z) signalling events
.45
Signal transduction cAMP signaling
.43
Beta-agonist/Beta-blocker Pathway, Pharmacodynamics
.34
3 fMLP Pathway
CCR3 Pathway in Eosinophils
.44
VEGF and S-1P Signaling
.44
fMLP Pathway
.43
Signal transduction Activation of PKC via G-Protein coupled receptor
.42
CXCR4 Pathway
.39
Alpha-Adrenergic Signaling
.38
Huntington's Disease Pathway
.31
4 G-Beta Gamma Signaling
G-Beta Gamma Signaling
.46
GHRH Signaling
.46
CRHR Pathway
.44
Relaxin Pathway
.37
Hedgehog Signaling in Mammals
.32
Signaling in Gap Junctions
.30
5 Presynaptic function of Kainate receptors
Activation of Kainate Receptors upon glutamate binding
.66
Presynaptic function of Kainate receptors
.66
Glucagon-type ligand receptors
.50
G-Protein Signaling through Tubby Protein
.37
Class B/2 (Secretin family receptors)
.32
G beta-gamma signalling through PLC beta
.01
genes like me logo Genes that share pathways with GNG4: view

Pathways by source for GNG4 Gene

1 PharmGKB pathway for GNG4 Gene
34 GeneGo (Thomson Reuters) pathways for GNG4 Gene
  • Apoptosis and survival BAD phosphorylation
  • Cell adhesion Integrin inside-out signaling
  • Chemotaxis CXCR4 signaling pathway
  • Cytoskeleton remodeling Reverse signaling by ephrin B
  • Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation
70 Qiagen pathways for GNG4 Gene
  • Actin Nucleation and Branching
  • Actin Nucleation by ARP-WASP Complex
  • Actin-Based Motility by Rho Family GTPases
  • Activation of cAMP-Dependent PKA
  • Activation of PKA through GPCR

Gene Ontology (GO) - Biological Process for GNG4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IBA 21873635
GO:0008277 regulation of G protein-coupled receptor signaling pathway TAS 7665596
GO:0030308 negative regulation of cell growth IMP 15824735
genes like me logo Genes that share ontologies with GNG4: view

No data available for SIGNOR curated interactions for GNG4 Gene

Drugs & Compounds for GNG4 Gene

Products:

  1. Drug

(3) Drugs for GNG4 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0
Guanosine monophosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0

(5) Additional Compounds for GNG4 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
[D-Trp7,9,10]-Substance P
89430-38-6
G-Protein antagonist peptide
143675-79-0
Gue 1654
397290-30-1
mastoparan
72093-21-1
SCH 202676 hydrobromide
265980-25-4

(5) Tocris Compounds for GNG4 Gene

Compound Action Cas Number
[D-Trp7,9,10]-Substance P Inhibits M1 ACh receptor activation of Gq/11 89430-38-6
G-Protein antagonist peptide Inhibits G protein activation by GPCRs 143675-79-0
Gue 1654 Selective inhibitor of OXE-R Gbetagamma signaling 397290-30-1
Mastoparan Activates Gi and Go 72093-21-1
SCH 202676 hydrobromide Inhibitor of ligand binding to G-protein-coupled receptors 265980-25-4
genes like me logo Genes that share compounds with GNG4: view

Transcripts for GNG4 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for GNG4 Gene

3 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GNG4

Alternative Splicing Database (ASD) splice patterns (SP) for GNG4 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c
SP1: - -
SP2: -
SP3: - - -
SP4:

Relevant External Links for GNG4 Gene

GeneLoc Exon Structure for
GNG4

Expression for GNG4 Gene

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  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GNG4 Gene

mRNA expression in normal human tissues for GNG4 Gene
mRNA expression by BioGPS for GNG4 GenemRNA expression by GTEx for GNG4 Gene

mRNA differential expression in normal tissues according to GTEx for GNG4 Gene

This gene is overexpressed in Brain - Hypothalamus (x5.1), Brain - Amygdala (x5.0), Pituitary (x4.1), and Brain - Nucleus accumbens (basal ganglia) (x4.1).

Protein differential expression in normal tissues from HIPED for GNG4 Gene

This gene is overexpressed in Retina (21.1), Fetal Brain (14.2), Islet of Langerhans (9.8), Pancreas (8.5), and Ovary (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GNG4 Gene



Protein tissue co-expression partners for GNG4 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GNG4

SOURCE GeneReport for Unigene cluster for GNG4 Gene:

Hs.159711

mRNA Expression by UniProt/SwissProt for GNG4 Gene:

P50150-GBG4_HUMAN
Tissue specificity: Brain, kidney, pancreas, skeletal muscle and faintly in cardiac muscle.

Evidence on tissue expression from TISSUES for GNG4 Gene

  • Nervous system(4.9)
genes like me logo Genes that share expression patterns with GNG4: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for GNG4 Gene

Orthologs for GNG4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GNG4 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia GNG4 30 31
  • 99.56 (n)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia GNG4 31
  • 95 (a)
 OneToOne
Cow
(Bos Taurus)
 Mammalia GNG4 30 31
  • 92 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia GNG4 30 31
  • 91.56 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Gng4 30
  • 90.67 (n)
Mouse
(Mus musculus)
 Mammalia Gng4 30 17 31
  • 89.78 (n)
 OneToOne
Chicken
(Gallus gallus)
 Aves GNG4 30 31
  • 76.13 (n)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia GNG4 31
  • 84 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia gng4 30
  • 79.11 (n)
Str.11936 30
African clawed frog
(Xenopus laevis)
 Amphibia Xl.24553 30
Species where no ortholog for GNG4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for GNG4 Gene

ENSEMBL:
Gene Tree for GNG4 (if available)
TreeFam:
Gene Tree for GNG4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GNG4: view image

Paralogs for GNG4 Gene

Paralogs for GNG4 Gene

(10) SIMAP similar genes for GNG4 Gene using alignment to 2 proteins:

  • GBG4_HUMAN
  • B1APZ0_HUMAN
genes like me logo Genes that share paralogs with GNG4: view

Variants for GNG4 Gene

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Additional dbSNP identifiers (rs#s) for GNG4 Gene

Structural Variations from Database of Genomic Variants (DGV) for GNG4 Gene

Variant ID Type Subtype PubMed ID
dgv30n21 CNV gain 19592680
esv2471335 CNV insertion 19546169
esv3575794 CNV gain 25503493
esv3589198 CNV loss 21293372
nsv1011288 CNV gain 25217958
nsv1013413 CNV gain 25217958
nsv1013571 CNV gain 25217958
nsv1068233 CNV deletion 25765185
nsv1122460 CNV deletion 24896259
nsv476824 CNV novel sequence insertion 20440878
nsv549392 CNV gain 21841781
nsv832936 CNV gain 17160897

Variation tolerance for GNG4 Gene

Residual Variation Intolerance Score: 61.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.09; 1.97% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GNG4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GNG4

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GNG4 Gene

Disorders for GNG4 Gene

Additional Disease Information for GNG4

Genetic Association Database
(GAD)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform

No disorders were found for GNG4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GNG4 Gene

Publications for GNG4 Gene

  1. Isolation of cDNA clones encoding eight different human G protein gamma subunits, including three novel forms designated the gamma 4, gamma 10, and gamma 11 subunits. (PMID: 7665596) Ray K … Robishaw JD (The Journal of biological chemistry 1995) 2 3 4
  2. Genetic correlates of longevity and selected age-related phenotypes: a genome-wide association study in the Framingham Study. (PMID: 17903295) Lunetta KL … Murabito JM (BMC medical genetics 2007) 3 41
  3. Identification of novel VHL target genes and relationship to hypoxic response pathways. (PMID: 15824735) Maina EN … Maher ER (Oncogene 2005) 3 23
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3

ExternalLinks

View latest publications for GNG4 gene in Mastermind

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