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GNG4 (G Protein Subunit Gamma 4) is a Protein Coding gene. Among its related pathways are Translation Translation regulation by Alpha-1 adrenergic receptors and ADP signalling through P2Y purinoceptor 12. Gene Ontology (GO) annotations related to this gene include obsolete signal transducer activity. An important paralog of this gene is GNG2.
Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand binding causes a receptor conformational change, detaching the G protein and switching it 'on'.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003924 | GTPase activity | IEA | -- |
GO:0005515 | protein binding | IPI | 23021213 |
GO:0031681 | G-protein beta-subunit binding | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005834 | heterotrimeric G-protein complex | IBA | 21873635 |
GO:0005886 | plasma membrane | TAS | -- |
GO:0016020 | membrane | IEA | -- |
GO:0031680 | G-protein beta/gamma-subunit complex | IBA | 21873635 |
GO:0070062 | extracellular exosome | HDA | 23533145 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Development Angiotensin activation of ERK |
Development ACM2 and ACM4 activation of ERK
.73
Development Angiotensin activation of ERK
.73
Development Angiotensin signaling via PYK2
.68
Development G-Proteins mediated regulation MARK-ERK signaling
.65
|
Development EDNRB signaling
.54
Development EPO-induced MAPK pathway
.48
Cell adhesion Integrin inside-out signaling
.45
Signal transduction IP3 signaling
.40
|
2 | ADP signalling through P2Y purinoceptor 12 |
Signal transduction cAMP signaling
.43
|
|
3 | fMLP Pathway |
CCR3 Pathway in Eosinophils
.44
VEGF and S-1P Signaling
.44
fMLP Pathway
.43
Signal transduction Activation of PKC via G-Protein coupled receptor
.42
|
CXCR4 Pathway
.39
Alpha-Adrenergic Signaling
.38
Huntington's Disease Pathway
.31
|
4 | G-Beta Gamma Signaling |
G-Beta Gamma Signaling
.46
GHRH Signaling
.46
CRHR Pathway
.44
|
Relaxin Pathway
.37
Hedgehog Signaling in Mammals
.32
Signaling in Gap Junctions
.30
|
5 | Presynaptic function of Kainate receptors |
G-Protein Signaling through Tubby Protein
.37
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0007165 | signal transduction | IEA | -- |
GO:0007186 | G protein-coupled receptor signaling pathway | IBA | 21873635 |
GO:0008277 | regulation of G protein-coupled receptor signaling pathway | TAS | 7665596 |
GO:0030308 | negative regulation of cell growth | IMP | 15824735 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
[D-Trp7,9,10]-Substance P |
|
89430-38-6 |
|
|
||
G-Protein antagonist peptide |
|
143675-79-0 |
|
|
||
Gue 1654 |
|
397290-30-1 |
|
|
||
mastoparan |
|
72093-21-1 |
|
|
||
SCH 202676 hydrobromide |
|
265980-25-4 |
|
|
Compound | Action | Cas Number |
---|---|---|
[D-Trp7,9,10]-Substance P | Inhibits M1 ACh receptor activation of Gq/11 | 89430-38-6 |
G-Protein antagonist peptide | Inhibits G protein activation by GPCRs | 143675-79-0 |
Gue 1654 | Selective inhibitor of OXE-R Gbetagamma signaling | 397290-30-1 |
Mastoparan | Activates Gi and Go | 72093-21-1 |
SCH 202676 hydrobromide | Inhibitor of ligand binding to G-protein-coupled receptors | 265980-25-4 |
ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | |||||||||||||||
SP2: | - | ||||||||||||||||
SP3: | - | - | - | ||||||||||||||
SP4: |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | GNG4 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | GNG4 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | GNG4 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | GNG4 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Gng4 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Gng4 30 17 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | GNG4 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | GNG4 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | gng4 30 |
|
||
Str.11936 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.24553 30 |
|
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv30n21 | CNV | gain | 19592680 |
esv2471335 | CNV | insertion | 19546169 |
esv3575794 | CNV | gain | 25503493 |
esv3589198 | CNV | loss | 21293372 |
nsv1011288 | CNV | gain | 25217958 |
nsv1013413 | CNV | gain | 25217958 |
nsv1013571 | CNV | gain | 25217958 |
nsv1068233 | CNV | deletion | 25765185 |
nsv1122460 | CNV | deletion | 24896259 |
nsv476824 | CNV | novel sequence insertion | 20440878 |
nsv549392 | CNV | gain | 21841781 |
nsv832936 | CNV | gain | 17160897 |
No disorders were found for GNG4 Gene.