Aliases for GNG4 Gene
External Ids for GNG4 Gene
Previous GeneCards Identifiers for GNG4 Gene
GeneCards Summary for GNG4 Gene
GNG4 (G Protein Subunit Gamma 4) is a Protein Coding gene. Among its related pathways are Translation Translation regulation by Alpha-1 adrenergic receptors and ADP signalling through P2Y purinoceptor 12. Gene Ontology (GO) annotations related to this gene include obsolete signal transducer activity. An important paralog of this gene is GNG2.
UniProtKB/Swiss-Prot Summary for GNG4 Gene
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand binding causes a receptor conformational change, detaching the G protein and switching it 'on'.