Aliases for GNG13 Gene
External Ids for GNG13 Gene
Previous GeneCards Identifiers for GNG13 Gene
Heterotrimeric G proteins, which consist of alpha (see MIM 139320), beta (see MIM 139380), and gamma subunits, function as signal transducers for the 7-transmembrane-helix G protein-coupled receptors. GNG13 is a gamma subunit that is expressed in taste, retinal, and neuronal tissues and plays a key role in taste transduction (Li et al., 2006 [PubMed 16473877]).[supplied by OMIM, Oct 2009]
GeneCards Summary for GNG13 Gene
GNG13 (G Protein Subunit Gamma 13) is a Protein Coding gene. Diseases associated with GNG13 include Night Blindness, Congenital Stationary, Autosomal Dominant 2 and Night Blindness, Congenital Stationary, Type 1A. Among its related pathways are Signaling by GPCR and ADP signalling through P2Y purinoceptor 1. Gene Ontology (GO) annotations related to this gene include obsolete signal transducer activity and G-protein beta-subunit binding.
UniProtKB/Swiss-Prot Summary for GNG13 Gene
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand binding causes a receptor conformational change, detaching the G protein and switching it 'on'.