Heterotrimeric G proteins, which consist of alpha (see MIM 139320), beta (see MIM 139380), and gamma subunits, function as signal transducers for the 7-transmembrane-helix G protein-coupled receptors. GNG13 is a gamma subunit that is expressed in taste, retinal, and neuronal tissues and plays a key role in taste transduction (Li et al., 2006 [PubMed 16473877]).[supplied by OMIM... See more...

Aliases for GNG13 Gene

Aliases for GNG13 Gene

  • G Protein Subunit Gamma 13 2 3 5
  • Guanine Nucleotide-Binding Protein G(I)/G(S)/G(O) Subunit Gamma-13 3 4
  • Guanine Nucleotide Binding Protein (G Protein), Gamma 13 2 3
  • G Gamma Subunit, Clone:H2-35 2 3
  • G(Gamma)13 2 3
  • H2-35 2 3
  • Guanine Nucleotide Binding Protein 13, Gamma 3
  • GNG13 5

External Ids for GNG13 Gene

Previous GeneCards Identifiers for GNG13 Gene

  • GC16M000867
  • GC16M000788
  • GC16M000848
  • GC16M000770
  • GC16M000806
  • GC16M000825
  • GC16M001000
  • GC16M001018
  • GC16M001034
  • GC16M001079
  • GC16M000846
  • GC16M000869
  • GC16M000886
  • GC16M000908
  • GC16M000923
  • GC16M000941
  • GC16M000962
  • GC16M000984
  • GC16M001136
  • GC16M001195

Summaries for GNG13 Gene

Entrez Gene Summary for GNG13 Gene

  • Heterotrimeric G proteins, which consist of alpha (see MIM 139320), beta (see MIM 139380), and gamma subunits, function as signal transducers for the 7-transmembrane-helix G protein-coupled receptors. GNG13 is a gamma subunit that is expressed in taste, retinal, and neuronal tissues and plays a key role in taste transduction (Li et al., 2006 [PubMed 16473877]).[supplied by OMIM, Oct 2009]

GeneCards Summary for GNG13 Gene

GNG13 (G Protein Subunit Gamma 13) is a Protein Coding gene. Among its related pathways are Apelin signaling pathway and G-Beta Gamma Signaling. Gene Ontology (GO) annotations related to this gene include obsolete signal transducer activity and G-protein beta-subunit binding.

UniProtKB/Swiss-Prot Summary for GNG13 Gene

  • Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

Tocris Summary for GNG13 Gene

  • Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand binding causes a receptor conformational change, detaching the G protein and switching it 'on'.

Gene Wiki entry for GNG13 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GNG13 Gene

Genomics for GNG13 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for GNG13 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J000800 Promoter 1.1 EPDnew Ensembl 250.7 +0.1 133 0.8 ZNF600 ZIC2 ZNF341 ZFP64 SIN3A KLF9 POLR2A GLIS1 EGR2 ZFHX2 GNG13 MSLN CHTF18 HSALNG0108803 RPUSD1
GH16J000562 Enhancer 0.5 FANTOM5 35 +238.6 238595 0.2 ZNF600 ZBTB33 NFATC1 GMEB1 ZBTB26 GNG13 PRR35 RGS11 ARHGDIG RHBDL1 HSALNG0108751 PIGQ
GH16J000787 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 0.4 +12.3 12320 3.2 SP1 ZNF207 MYC ZNF600 ZNF580 POLR2A ZNF10 ZSCAN16 NFIC MXD4 CHTF18 HSALNG0108803 RPUSD1 ENSG00000261505 NME3 AXIN1 RHOT2 LUC7L NUBP2 TELO2
GH16J000795 Enhancer 0.7 ENCODE 0.7 +5.0 4978 0.2 EZH2 SIX4 ZNF217 HES1 CTBP1 SIN3A E4F1 SMARCE1 MAZ POLR2A TELO2 WASH4P CRAMP1 RHOT2 ENSG00000268836 NUBP2 ENSG00000260051 UNKL WDR24 ENSG00000269482
GH16J000804 Enhancer 0.5 Ensembl 0.7 -3.4 -3367 0.6 ZFP69B KLF10 ZNF692 ZNF266 ZNF335 PRR25 ENSG00000261505 ENSG00000260051 RHOT2 ENSG00000260954 TELO2 SPSB3 AXIN1 WASH4P CRAMP1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GNG13 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GNG13

Top Transcription factor binding sites by QIAGEN in the GNG13 gene promoter:
  • AML1a
  • AREB6
  • c-Myc
  • LUN-1
  • Max1
  • Nkx2-5
  • POU2F1
  • POU2F1a

Genomic Locations for GNG13 Gene

Latest Assembly
chr16:798,041-800,734
(GRCh38/hg38)
Size:
2,694 bases
Orientation:
Minus strand

Previous Assembly
chr16:848,041-850,734
(GRCh37/hg19 by Entrez Gene)
Size:
2,694 bases
Orientation:
Minus strand

chr16:848,041-850,733
(GRCh37/hg19 by Ensembl)
Size:
2,693 bases
Orientation:
Minus strand

Genomic View for GNG13 Gene

Genes around GNG13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GNG13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GNG13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GNG13 Gene

Proteins for GNG13 Gene

  • Protein details for GNG13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P2W3-GBG13_HUMAN
    Recommended name:
    Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13
    Protein Accession:
    Q9P2W3
    Secondary Accessions:
    • B2R5C8
    • Q52LX0
    • Q9UJJ3

    Protein attributes for GNG13 Gene

    Size:
    67 amino acids
    Molecular mass:
    7949 Da
    Quaternary structure:
    • G proteins are composed of 3 units, alpha, beta and gamma.

neXtProt entry for GNG13 Gene

Post-translational modifications for GNG13 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GNG13 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GNG13 Gene

Domains & Families for GNG13 Gene

Gene Families for GNG13 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for GNG13 Gene

InterPro:
Blocks:
  • Gamma G-protein (transducin) signature

Suggested Antigen Peptide Sequences for GNG13 Gene

GenScript: Design optimal peptide antigens:
  • Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 (GBG13_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9P2W3

UniProtKB/Swiss-Prot:

GBG13_HUMAN :
  • Belongs to the G protein gamma family.
Family:
  • Belongs to the G protein gamma family.
genes like me logo Genes that share domains with GNG13: view

Function for GNG13 Gene

Molecular function for GNG13 Gene

UniProtKB/Swiss-Prot Function:
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

Phenotypes From GWAS Catalog for GNG13 Gene

Gene Ontology (GO) - Molecular Function for GNG13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IEA --
GO:0005515 protein binding IPI 32296183
GO:0031681 G-protein beta-subunit binding IPI 12606627
genes like me logo Genes that share ontologies with GNG13: view
genes like me logo Genes that share phenotypes with GNG13: view

Animal Models for GNG13 Gene

MGI Knock Outs for GNG13:
  • Gng13 Gng13<tm1.1(KOMP)Vlcg>
  • Gng13 Gng13<tm1(KOMP)Vlcg>

miRNA for GNG13 Gene

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GNG13

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GNG13 Gene

Localization for GNG13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GNG13 Gene

Cell membrane. Lipid-anchor. Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GNG13 gene
Compartment Confidence
plasma membrane 4
cytosol 3
extracellular 1
cytoskeleton 1
nucleus 1
mitochondrion 0

Gene Ontology (GO) - Cellular Components for GNG13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005834 heterotrimeric G-protein complex IEA --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0030425 dendrite IEA --
genes like me logo Genes that share ontologies with GNG13: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GNG13 Gene

Pathways & Interactions for GNG13 Gene

PathCards logo

SuperPathways for GNG13 Gene

SuperPathway Contained pathways
1 Development Angiotensin activation of ERK
.73
.73
.68
.65
.54
.48
.45
.40
2 G-Beta Gamma Signaling
.46
.46
.44
.37
.32
.30
3 ADP signalling through P2Y purinoceptor 12
.43
4 Presynaptic function of Kainate receptors
5 ADP signalling through P2Y purinoceptor 1
.39
genes like me logo Genes that share pathways with GNG13: view

Pathways by source for GNG13 Gene

34 GeneGo (Thomson Reuters) pathways for GNG13 Gene
  • Apoptosis and survival BAD phosphorylation
  • Cell adhesion Integrin inside-out signaling
  • Chemotaxis CXCR4 signaling pathway
  • Cytoskeleton remodeling Reverse signaling by ephrin B
  • Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation
48 Qiagen pathways for GNG13 Gene
  • Actin Nucleation and Branching
  • Actin Nucleation by ARP-WASP Complex
  • Actin-Based Motility by Rho Family GTPases
  • Activation of cAMP-Dependent PKA
  • Activation of PKA through GPCR

Gene Ontology (GO) - Biological Process for GNG13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway IEA --
GO:0050909 sensory perception of taste IEA --
genes like me logo Genes that share ontologies with GNG13: view

No data available for SIGNOR curated interactions for GNG13 Gene

Drugs & Compounds for GNG13 Gene

(3) Drugs for GNG13 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0
Guanosine monophosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0

(5) Additional Compounds for GNG13 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
[D-Trp7,9,10]-Substance P
89430-38-6
G-Protein antagonist peptide
143675-79-0
Gue 1654
397290-30-1
mastoparan
72093-21-1
SCH 202676 hydrobromide
265980-25-4

(5) Tocris Compounds for GNG13 Gene

Compound Action Cas Number
[D-Trp7,9,10]-Substance P Inhibits M1 ACh receptor activation of Gq/11 89430-38-6
G-Protein antagonist peptide Inhibits G protein activation by GPCRs 143675-79-0
Gue 1654 Selective inhibitor of OXE-R Gbetagamma signaling 397290-30-1
Mastoparan Activates Gi and Go 72093-21-1
SCH 202676 hydrobromide Inhibitor of ligand binding to G-protein-coupled receptors 265980-25-4
genes like me logo Genes that share compounds with GNG13: view

Transcripts for GNG13 Gene

mRNA/cDNA for GNG13 Gene

1 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GNG13

Alternative Splicing Database (ASD) splice patterns (SP) for GNG13 Gene

No ASD Table

Relevant External Links for GNG13 Gene

GeneLoc Exon Structure for
GNG13

Expression for GNG13 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GNG13 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GNG13 Gene

This gene is overexpressed in Brain - Cerebellum (x22.5), Brain - Cerebellar Hemisphere (x9.9), Brain - Frontal Cortex (BA9) (x6.0), and Brain - Cortex (x5.0).

Protein differential expression in normal tissues from HIPED for GNG13 Gene

This gene is overexpressed in Retina (63.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GNG13 Gene



Protein tissue co-expression partners for GNG13 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GNG13

SOURCE GeneReport for Unigene cluster for GNG13 Gene:

Hs.247888

Evidence on tissue expression from TISSUES for GNG13 Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with GNG13: view

Primer products for research

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GNG13 Gene

Orthologs for GNG13 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GNG13 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia GNG13 29 30
  • 99.5 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia GNG13 30
  • 96 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Gng13 29
  • 91.54 (n)
Dog
(Canis familiaris)
Mammalia GNG13 29 30
  • 91.54 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Gng13 29 16 30
  • 90.05 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia GNG13 29 30
  • 90.05 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia GNG13 30
  • 88 (a)
OneToOne
Chicken
(Gallus gallus)
Aves GNG13 29 30
  • 84.08 (n)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia gng13 29
  • 81.09 (n)
Str.2935 29
African clawed frog
(Xenopus laevis)
Amphibia gng13-prov 29
Zebrafish
(Danio rerio)
Actinopterygii gng13b 29 30
  • 77.61 (n)
OneToMany
gng13a 30
  • 55 (a)
OneToMany
Dr.14190 29
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3115 29
Species where no ortholog for GNG13 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for GNG13 Gene

ENSEMBL:
Gene Tree for GNG13 (if available)
TreeFam:
Gene Tree for GNG13 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GNG13: view image
Alliance of Genome Resources:
Additional Orthologs for GNG13

Paralogs for GNG13 Gene

(1) SIMAP similar genes for GNG13 Gene using alignment to 1 proteins:

  • GBG13_HUMAN
genes like me logo Genes that share paralogs with GNG13: view

No data available for Paralogs for GNG13 Gene

Variants for GNG13 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for GNG13 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for GNG13 Gene

Variant ID Type Subtype PubMed ID
dgv4827n54 CNV loss 21841781
dgv4828n54 CNV gain 21841781
esv2422427 CNV duplication 17116639
esv3570042 CNV gain 25503493
esv3637582 CNV gain 21293372
esv3637584 CNV loss 21293372
esv3637585 CNV gain 21293372
esv3637586 CNV loss 21293372
esv3637587 CNV gain 21293372
esv3637588 CNV loss 21293372
nsv1160325 CNV duplication 26073780
nsv1160326 CNV duplication 26073780
nsv471063 CNV loss 18288195
nsv482184 CNV gain 20164927
nsv517488 CNV loss 19592680
nsv526903 CNV loss 19592680
nsv571042 CNV loss 21841781
nsv571043 CNV loss 21841781
nsv571045 CNV gain 21841781
nsv817712 CNV loss 17921354
nsv9321 CNV gain+loss 18304495
nsv952898 CNV deletion 24416366

Variation tolerance for GNG13 Gene

Residual Variation Intolerance Score: 73.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.58; 12.42% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GNG13 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GNG13
Leiden Open Variation Database (LOVD)
GNG13

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GNG13 Gene

Disorders for GNG13 Gene

Additional Disease Information for GNG13

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform

No disorders were found for GNG13 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GNG13 Gene

Publications for GNG13 Gene

  1. Ggamma13 colocalizes with gustducin in taste receptor cells and mediates IP3 responses to bitter denatonium. (PMID: 10570481) Huang L … Margolskee RF (Nature neuroscience 1999) 2 3 4
  2. The sequence and analysis of duplication-rich human chromosome 16. (PMID: 15616553) Martin J … Pennacchio LA (Nature 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16. (PMID: 11157797) Daniels RJ … Higgs DR (Human molecular genetics 2001) 3 4
  5. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3

Products for GNG13 Gene

Sources for GNG13 Gene