Aliases for GNG13 Gene
External Ids for GNG13 Gene
Previous GeneCards Identifiers for GNG13 Gene
Heterotrimeric G proteins, which consist of alpha (see MIM 139320), beta (see MIM 139380), and gamma subunits, function as signal transducers for the 7-transmembrane-helix G protein-coupled receptors. GNG13 is a gamma subunit that is expressed in taste, retinal, and neuronal tissues and plays a key role in taste transduction (Li et al., 2006 [PubMed 16473877]).[supplied by OMIM, Oct 2009]
GeneCards Summary for GNG13 Gene
GNG13 (G Protein Subunit Gamma 13) is a Protein Coding gene. Among its related pathways are Translation Translation regulation by Alpha-1 adrenergic receptors and Sweet Taste Signaling. Gene Ontology (GO) annotations related to this gene include obsolete signal transducer activity and G-protein beta-subunit binding.
UniProtKB/Swiss-Prot Summary for GNG13 Gene
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand binding causes a receptor conformational change, detaching the G protein and switching it 'on'.