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Heterotrimeric G proteins, which consist of alpha (see MIM 139320), beta (see MIM 139380), and gamma subunits, function as signal transducers for the 7-transmembrane-helix G protein-coupled receptors. GNG13 is a gamma subunit that is expressed in taste, retinal, and neuronal tissues and plays a key role in taste transduction (Li et al., 2006 [PubMed 16473877]).[supplied by OMIM, Oct 2009]
GNG13 (G Protein Subunit Gamma 13) is a Protein Coding gene. Among its related pathways are Translation Translation regulation by Alpha-1 adrenergic receptors and Sweet Taste Signaling. Gene Ontology (GO) annotations related to this gene include obsolete signal transducer activity and G-protein beta-subunit binding.
Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand binding causes a receptor conformational change, detaching the G protein and switching it 'on'.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH16J000800 | Promoter | 1.1 | EPDnew Ensembl | 600.7 | +0.1 | 133 | 0.8 | ZIC2 ZNF600 ZNF341 KLF9 ZBTB20 POLR2A EGR1 EZH2 ZFHX2 ZNF335 | GNG13 MSLN CHTF18 RPUSD1 | |
GH16J000562 | Enhancer | 0.5 | FANTOM5 | 35 | +238.6 | 238595 | 0.2 | ZNF600 ZBTB26 KDM1A ZBTB33 NFATC1 GMEB1 | GNG13 PRR35 RGS11 ARHGDIG RHBDL1 LOC107987233 | |
GH16J000795 | Enhancer | 0.7 | ENCODE | 0.7 | +5.0 | 4978 | 0.2 | SCRT2 HES1 CTBP1 ZNF444 ESRRA E4F1 KLF4 ZNF217 GATAD2B SIN3A | GNG13 CHTF18 RPUSD1 | |
GH16J000804 | Enhancer | 0.5 | Ensembl | 0.7 | -3.7 | -3667 | 0.8 | ZNF692 ZNF600 ZNF341 ZNF266 ZNF335 ZFP69B KLF10 CTCF | PRR25 ENSG00000261505 ENSG00000260051 RHOT2 ENSG00000260954 TELO2 SPSB3 AXIN1 WASH4P CRAMP1 | |
GH16J000797 | Enhancer | 0.5 | ENCODE | 0.7 | +3.5 | 3518 | 0.1 | SCRT2 KLF9 POLR2A KLF8 KLF1 | GNG13 CHTF18 RPUSD1 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003924 | GTPase activity | IEA | -- |
GO:0031681 | G-protein beta-subunit binding | IPI | 12606627 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005834 | heterotrimeric G-protein complex | IEA | -- |
GO:0005886 | plasma membrane | TAS | -- |
GO:0016020 | membrane | IEA | -- |
GO:0030425 | dendrite | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Development Angiotensin activation of ERK |
Development ACM2 and ACM4 activation of ERK
.73
Development Angiotensin activation of ERK
.73
Development Angiotensin signaling via PYK2
.68
Development G-Proteins mediated regulation MARK-ERK signaling
.65
|
Development EDNRB signaling
.54
Development EPO-induced MAPK pathway
.48
Cell adhesion Integrin inside-out signaling
.45
Signal transduction IP3 signaling
.40
|
2 | G-Beta Gamma Signaling |
G-Beta Gamma Signaling
.46
GHRH Signaling
.46
CRHR Pathway
.44
|
Relaxin Pathway
.37
Hedgehog Signaling in Mammals
.32
Signaling in Gap Junctions
.30
|
3 | ADP signalling through P2Y purinoceptor 12 |
Signal transduction cAMP signaling
.43
|
|
4 | Presynaptic function of Kainate receptors | ||
5 | ADP signalling through P2Y purinoceptor 1 |
Development Angiotensin signaling via beta-Arrestin
.39
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0007165 | signal transduction | IEA | -- |
GO:0007186 | G protein-coupled receptor signaling pathway | IEA | -- |
GO:0007200 | phospholipase C-activating G protein-coupled receptor signaling pathway | IEA | -- |
GO:0050909 | sensory perception of taste | IEA | -- |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
[D-Trp7,9,10]-Substance P |
|
89430-38-6 |
|
|
||
G-Protein antagonist peptide |
|
143675-79-0 |
|
|
||
Gue 1654 |
|
397290-30-1 |
|
|
||
mastoparan |
|
72093-21-1 |
|
|
||
SCH 202676 hydrobromide |
|
265980-25-4 |
|
|
Compound | Action | Cas Number |
---|---|---|
[D-Trp7,9,10]-Substance P | Inhibits M1 ACh receptor activation of Gq/11 | 89430-38-6 |
G-Protein antagonist peptide | Inhibits G protein activation by GPCRs | 143675-79-0 |
Gue 1654 | Selective inhibitor of OXE-R Gbetagamma signaling | 397290-30-1 |
Mastoparan | Activates Gi and Go | 72093-21-1 |
SCH 202676 hydrobromide | Inhibitor of ligand binding to G-protein-coupled receptors | 265980-25-4 |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | GNG13 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | GNG13 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Gng13 30 |
|
||
Dog (Canis familiaris) |
Mammalia | GNG13 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Gng13 30 17 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | GNG13 30 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | GNG13 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | GNG13 30 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | gng13 30 |
|
||
Str.2935 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | gng13-prov 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | gng13b 30 31 |
|
OneToMany | |
gng13a 31 |
|
OneToMany | |||
Dr.14190 30 |
|
||||
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.3115 30 |
|
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv4827n54 | CNV | loss | 21841781 |
dgv4828n54 | CNV | gain | 21841781 |
esv2422427 | CNV | duplication | 17116639 |
esv3570042 | CNV | gain | 25503493 |
esv3637582 | CNV | gain | 21293372 |
esv3637584 | CNV | loss | 21293372 |
esv3637585 | CNV | gain | 21293372 |
esv3637586 | CNV | loss | 21293372 |
esv3637587 | CNV | gain | 21293372 |
esv3637588 | CNV | loss | 21293372 |
nsv1160325 | CNV | duplication | 26073780 |
nsv1160326 | CNV | duplication | 26073780 |
nsv471063 | CNV | loss | 18288195 |
nsv482184 | CNV | gain | 20164927 |
nsv517488 | CNV | loss | 19592680 |
nsv526903 | CNV | loss | 19592680 |
nsv571042 | CNV | loss | 21841781 |
nsv571043 | CNV | loss | 21841781 |
nsv571045 | CNV | gain | 21841781 |
nsv817712 | CNV | loss | 17921354 |
nsv9321 | CNV | gain+loss | 18304495 |
nsv952898 | CNV | deletion | 24416366 |
No disorders were found for GNG13 Gene.