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This gene is a member of the guanine nucleotide-binding protein (G protein) gamma family and encodes a lipid-anchored, cell membrane protein. As a member of the heterotrimeric G protein complex, this protein plays a role in this transmembrane signaling system. This protein is also subject to carboxyl-terminal processing. Decreased expression of this gene is associated with splenic marginal zone lymphomas. [provided by RefSeq, Jul 2008]
GNG11 (G Protein Subunit Gamma 11) is a Protein Coding gene. Diseases associated with GNG11 include Splenic Marginal Zone Lymphoma. Among its related pathways are Translation Translation regulation by Alpha-1 adrenergic receptors and Sweet Taste Signaling. Gene Ontology (GO) annotations related to this gene include GTPase activity and obsolete signal transducer activity. An important paralog of this gene is GNGT1.
Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand binding causes a receptor conformational change, detaching the G protein and switching it 'on'.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003924 | GTPase activity | TAS,IEA | -- |
GO:0005515 | protein binding | IPI | -- |
GO:0031681 | G-protein beta-subunit binding | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005834 | heterotrimeric G-protein complex | IBA | 21873635 |
GO:0005886 | plasma membrane | TAS | -- |
GO:0016020 | membrane | IEA | -- |
GO:0031680 | G-protein beta/gamma-subunit complex | IBA | 21873635 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Development Angiotensin activation of ERK |
Development ACM2 and ACM4 activation of ERK
.73
Development Angiotensin activation of ERK
.73
Development Angiotensin signaling via PYK2
.68
Development G-Proteins mediated regulation MARK-ERK signaling
.65
|
Development EDNRB signaling
.54
Development EPO-induced MAPK pathway
.48
Cell adhesion Integrin inside-out signaling
.45
Signal transduction IP3 signaling
.40
|
2 | G-Beta Gamma Signaling |
G-Beta Gamma Signaling
.46
GHRH Signaling
.46
CRHR Pathway
.44
|
Relaxin Pathway
.37
Hedgehog Signaling in Mammals
.32
Signaling in Gap Junctions
.30
|
3 | ADP signalling through P2Y purinoceptor 12 |
Signal transduction cAMP signaling
.43
|
|
4 | Presynaptic function of Kainate receptors | ||
5 | ADP signalling through P2Y purinoceptor 1 |
Development Angiotensin signaling via beta-Arrestin
.39
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0007165 | signal transduction | TAS | 7665596 |
GO:0007186 | G protein-coupled receptor signaling pathway | IBA | 21873635 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
[D-Trp7,9,10]-Substance P |
|
89430-38-6 |
|
|
||
G-Protein antagonist peptide |
|
143675-79-0 |
|
|
||
Gue 1654 |
|
397290-30-1 |
|
|
||
mastoparan |
|
72093-21-1 |
|
|
||
SCH 202676 hydrobromide |
|
265980-25-4 |
|
|
Compound | Action | Cas Number |
---|---|---|
[D-Trp7,9,10]-Substance P | Inhibits M1 ACh receptor activation of Gq/11 | 89430-38-6 |
G-Protein antagonist peptide | Inhibits G protein activation by GPCRs | 143675-79-0 |
Gue 1654 | Selective inhibitor of OXE-R Gbetagamma signaling | 397290-30-1 |
Mastoparan | Activates Gi and Go | 72093-21-1 |
SCH 202676 hydrobromide | Inhibitor of ligand binding to G-protein-coupled receptors | 265980-25-4 |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | GNG11 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Gng11 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Gng11 30 17 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | GNG11 30 31 31 |
|
OneToMany | |
Dog (Canis familiaris) |
Mammalia | GNG11 30 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | GNG11 30 |
|
||
Lizard (Anolis carolinensis) |
Reptilia | GNG11 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | Str.12711 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | gngt1 31 |
|
OneToMany |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv3614175 | CNV | loss | 21293372 |
nsv1023193 | CNV | gain | 25217958 |
nsv607849 | CNV | gain | 21841781 |
Disorder | Aliases | PubMed IDs |
---|---|---|
splenic marginal zone lymphoma |
|
|