This gene is a member of the guanine nucleotide-binding protein (G protein) gamma family and encodes a lipid-anchored, cell membrane protein. As a member of the heterotrimeric G protein complex, this protein plays a role in this transmembrane signaling system. This protein is also subject to carboxyl-terminal processing. Decreased expression of this gene is associated with sple... See more...

Aliases for GNG11 Gene

Aliases for GNG11 Gene

  • G Protein Subunit Gamma 11 2 3 5
  • Guanine Nucleotide-Binding Protein G(I)/G(S)/G(O) Subunit Gamma-11 3 4
  • Guanine Nucleotide-Binding Protein G(I)/G(S)/G(O) Gamma-11 Subunit 2 3
  • Guanine Nucleotide Binding Protein (G Protein), Gamma 11 2 3
  • G Protein Gamma-11 Subunit 2 3
  • GNGT11 3 4

External Ids for GNG11 Gene

Previous GeneCards Identifiers for GNG11 Gene

  • GC07P092086
  • GC07P093149
  • GC07P093163
  • GC07P093195
  • GC07P093388
  • GC07P093551
  • GC07P088158

Summaries for GNG11 Gene

Entrez Gene Summary for GNG11 Gene

  • This gene is a member of the guanine nucleotide-binding protein (G protein) gamma family and encodes a lipid-anchored, cell membrane protein. As a member of the heterotrimeric G protein complex, this protein plays a role in this transmembrane signaling system. This protein is also subject to carboxyl-terminal processing. Decreased expression of this gene is associated with splenic marginal zone lymphomas. [provided by RefSeq, Jul 2008]

GeneCards Summary for GNG11 Gene

GNG11 (G Protein Subunit Gamma 11) is a Protein Coding gene. Diseases associated with GNG11 include Splenic Marginal Zone Lymphoma. Among its related pathways are Signaling by GPCR and ADP signalling through P2Y purinoceptor 1. Gene Ontology (GO) annotations related to this gene include GTPase activity and obsolete signal transducer activity. An important paralog of this gene is GNGT1.

UniProtKB/Swiss-Prot Summary for GNG11 Gene

  • Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

Tocris Summary for GNG11 Gene

  • Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand binding causes a receptor conformational change, detaching the G protein and switching it 'on'.

Gene Wiki entry for GNG11 Gene

Additional gene information for GNG11 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GNG11 Gene

Genomics for GNG11 Gene

GeneHancer (GH) Regulatory Elements for GNG11 Gene

Promoters and enhancers for GNG11 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J093919 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 508.8 +0.8 750 5.1 TCF12 PHF8 ZIC2 REST ZBTB10 POLR2A ZNF423 ZBTB26 KLF7 EP300 GNG11 ENSG00000234695 TFPI2 LOC105375402
GH07J094003 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 11.4 +82.2 82196 3 FOXK2 ZBTB40 ZNF217 SIN3A POLR2G SP1 PHF8 SIX5 ZFX ZNF639 BET1 GNG11 lnc-TFPI2-2 ENSG00000236861
GH07J093889 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE CraniofacialAtlas 11.1 -31.4 -31355 2.3 TCF12 PHF8 FOS ZIC2 ZBTB26 EZH2 HDAC2 MXI1 ZNF341 CTCF ENSG00000234695 LOC105375401 lnc-BET1-3 TFPI2 GNG11 GNGT1
GH07J093943 Enhancer 1 Ensembl ENCODE 15.8 +25.0 24971 7.3 HNRNPK JUND FOS EP300 MEF2A MXI1 NCOR1 NFIC GATA3 BRCA1 GNG11 SGCE HSALNG0059596 ENSG00000278959
GH07J094055 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 11.4 +137.6 137615 7 ZBTB40 FOS TEAD4 BCL11A ZNF316 CBFB SRF YY1 ARNT CEBPB BET1 GNG11 ENSG00000234695 TFPI2 CASD1 ENSG00000236938 ENSG00000236453
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GNG11 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GNG11

Top Transcription factor binding sites by QIAGEN in the GNG11 gene promoter:
  • C/EBPbeta
  • E4BP4
  • FOXI1
  • HFH-3
  • Nkx3-1
  • Nkx3-1 v1
  • Nkx3-1 v2
  • Nkx3-1 v3
  • Nkx3-1 v4
  • STAT5B

Genomic Locations for GNG11 Gene

Genomic Locations for GNG11 Gene
chr7:93,921,704-93,928,610
(GRCh38/hg38)
Size:
6,907 bases
Orientation:
Plus strand
chr7:93,551,011-93,557,922
(GRCh37/hg19)
Size:
6,912 bases
Orientation:
Plus strand

Genomic View for GNG11 Gene

Genes around GNG11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GNG11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GNG11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GNG11 Gene

Proteins for GNG11 Gene

  • Protein details for GNG11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P61952-GBG11_HUMAN
    Recommended name:
    Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11
    Protein Accession:
    P61952
    Secondary Accessions:
    • P50152

    Protein attributes for GNG11 Gene

    Size:
    73 amino acids
    Molecular mass:
    8481 Da
    Quaternary structure:
    • G proteins are composed of 3 units, alpha, beta and gamma. Interacts with beta-1 and beta-3, but not with beta-2.

neXtProt entry for GNG11 Gene

Post-translational modifications for GNG11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GNG11 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GNG11 Gene

Domains & Families for GNG11 Gene

Gene Families for GNG11 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for GNG11 Gene

Blocks:
  • Gamma G-protein (transducin) signature
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GNG11 Gene

GenScript: Design optimal peptide antigens:
  • Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 (GBG11_HUMAN)
  • cDNA, FLJ92314, Homo sapiens guanine nucleotide binding protein (G protein), gamma11 (GNG11), mRNA (Q53Y01_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P61952

UniProtKB/Swiss-Prot:

GBG11_HUMAN :
  • Belongs to the G protein gamma family.
Family:
  • Belongs to the G protein gamma family.
genes like me logo Genes that share domains with GNG11: view

Function for GNG11 Gene

Molecular function for GNG11 Gene

UniProtKB/Swiss-Prot Function:
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

Phenotypes From GWAS Catalog for GNG11 Gene

Gene Ontology (GO) - Molecular Function for GNG11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IEA --
GO:0005515 protein binding IPI --
GO:0031681 G-protein beta-subunit binding IBA 21873635
genes like me logo Genes that share ontologies with GNG11: view
genes like me logo Genes that share phenotypes with GNG11: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GNG11 Gene

Localization for GNG11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GNG11 Gene

Cell membrane; Lipid-anchor; Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GNG11 gene
Compartment Confidence
plasma membrane 4
cytosol 3
extracellular 2
cytoskeleton 1
mitochondrion 1
nucleus 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for GNG11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005834 heterotrimeric G-protein complex IBA 21873635
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0031680 G-protein beta/gamma-subunit complex IBA 21873635
genes like me logo Genes that share ontologies with GNG11: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GNG11 Gene

Pathways & Interactions for GNG11 Gene

PathCards logo

SuperPathways for GNG11 Gene

SuperPathway Contained pathways
1 Development Angiotensin activation of ERK
.73
.73
.68
.65
.54
.48
.45
.40
2 G-Beta Gamma Signaling
.46
.46
.44
.37
.32
.30
3 ADP signalling through P2Y purinoceptor 12
.43
4 Presynaptic function of Kainate receptors
5 ADP signalling through P2Y purinoceptor 1
.39
genes like me logo Genes that share pathways with GNG11: view

Pathways by source for GNG11 Gene

34 GeneGo (Thomson Reuters) pathways for GNG11 Gene
  • Apoptosis and survival BAD phosphorylation
  • Cell adhesion Integrin inside-out signaling
  • Chemotaxis CXCR4 signaling pathway
  • Cytoskeleton remodeling Reverse signaling by ephrin B
  • Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation
47 Qiagen pathways for GNG11 Gene
  • Actin Nucleation and Branching
  • Actin Nucleation by ARP-WASP Complex
  • Actin-Based Motility by Rho Family GTPases
  • Activation of cAMP-Dependent PKA
  • Activation of PKA through GPCR

Gene Ontology (GO) - Biological Process for GNG11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 7665596
GO:0007186 G protein-coupled receptor signaling pathway IBA 21873635
genes like me logo Genes that share ontologies with GNG11: view

No data available for SIGNOR curated interactions for GNG11 Gene

Drugs & Compounds for GNG11 Gene

(3) Drugs for GNG11 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0
Guanosine monophosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0

(5) Additional Compounds for GNG11 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
[D-Trp7,9,10]-Substance P
89430-38-6
G-Protein antagonist peptide
143675-79-0
Gue 1654
397290-30-1
mastoparan
72093-21-1
SCH 202676 hydrobromide
265980-25-4

(5) Tocris Compounds for GNG11 Gene

Compound Action Cas Number
[D-Trp7,9,10]-Substance P Inhibits M1 ACh receptor activation of Gq/11 89430-38-6
G-Protein antagonist peptide Inhibits G protein activation by GPCRs 143675-79-0
Gue 1654 Selective inhibitor of OXE-R Gbetagamma signaling 397290-30-1
Mastoparan Activates Gi and Go 72093-21-1
SCH 202676 hydrobromide Inhibitor of ligand binding to G-protein-coupled receptors 265980-25-4
genes like me logo Genes that share compounds with GNG11: view

Transcripts for GNG11 Gene

mRNA/cDNA for GNG11 Gene

1 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GNG11 Gene

No ASD Table

Relevant External Links for GNG11 Gene

GeneLoc Exon Structure for
GNG11

Expression for GNG11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GNG11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for GNG11 Gene

This gene is overexpressed in Platelet (32.7) and Peripheral blood mononuclear cells (22.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GNG11 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GNG11

SOURCE GeneReport for Unigene cluster for GNG11 Gene:

Hs.83381

mRNA Expression by UniProt/SwissProt for GNG11 Gene:

P61952-GBG11_HUMAN
Tissue specificity: Abundantly expressed in all tissues tested except for brain.

Evidence on tissue expression from TISSUES for GNG11 Gene

  • Lung(4.4)
genes like me logo Genes that share expression patterns with GNG11: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for GNG11 Gene

Orthologs for GNG11 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GNG11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GNG11 31 30
  • 100 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Gng11 17 31 30
  • 91.78 (n)
cow
(Bos Taurus)
Mammalia GNG11 31 31 30
  • 91.78 (n)
OneToMany
rat
(Rattus norvegicus)
Mammalia LOC100912034 30
  • 91.78 (n)
dog
(Canis familiaris)
Mammalia GNG11 31 30
  • 91.32 (n)
OneToOne
chicken
(Gallus gallus)
Aves GNG11 30
  • 76.26 (n)
lizard
(Anolis carolinensis)
Reptilia GNG11 31
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.12711 30
zebrafish
(Danio rerio)
Actinopterygii gngt1 31
  • 60 (a)
OneToMany
Species where no ortholog for GNG11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GNG11 Gene

ENSEMBL:
Gene Tree for GNG11 (if available)
TreeFam:
Gene Tree for GNG11 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GNG11: view image

Paralogs for GNG11 Gene

Paralogs for GNG11 Gene

(11) SIMAP similar genes for GNG11 Gene using alignment to 2 proteins:

  • GBG11_HUMAN
  • Q53Y01_HUMAN
genes like me logo Genes that share paralogs with GNG11: view

Variants for GNG11 Gene

Additional dbSNP identifiers (rs#s) for GNG11 Gene

Structural Variations from Database of Genomic Variants (DGV) for GNG11 Gene

Variant ID Type Subtype PubMed ID
esv3614175 CNV loss 21293372
nsv1023193 CNV gain 25217958
nsv607849 CNV gain 21841781

Variation tolerance for GNG11 Gene

Residual Variation Intolerance Score: 68.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.21; 4.65% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GNG11 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GNG11

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GNG11 Gene

Disorders for GNG11 Gene

MalaCards: The human disease database

(1) MalaCards diseases for GNG11 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
splenic marginal zone lymphoma
  • smzl
- elite association - COSMIC cancer census association via MalaCards
Search GNG11 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for GNG11

genes like me logo Genes that share disorders with GNG11: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GNG11 Gene

Publications for GNG11 Gene

  1. Isolation of cDNA clones encoding eight different human G protein gamma subunits, including three novel forms designated the gamma 4, gamma 10, and gamma 11 subunits. (PMID: 7665596) Ray K … Robishaw JD (The Journal of biological chemistry 1995) 2 3 4 54
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  3. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier LW … Wilson RK (Nature 2003) 3 4 54
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 54
  5. GNG11 (G-protein subunit γ 11) suppresses cell growth with induction of reactive oxygen species and abnormal nuclear morphology in human SUSM-1 cells. (PMID: 28380310) Takauji Y … Ayusawa D (Biochemistry and cell biology = Biochimie et biologie cellulaire 2017) 3 54

Products for GNG11 Gene

Sources for GNG11 Gene