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Aliases for GNG11 Gene

Aliases for GNG11 Gene

  • G Protein Subunit Gamma 11 2 3 5
  • Guanine Nucleotide-Binding Protein G(I)/G(S)/G(O) Gamma-11 Subunit 2 3
  • Guanine Nucleotide Binding Protein (G Protein), Gamma 11 2 3
  • G Protein Gamma-11 Subunit 2 3
  • GNGT11 3 4
  • Guanine Nucleotide-Binding Protein G(I)/G(S)/G(O) Subunit Gamma-11 3

External Ids for GNG11 Gene

Previous GeneCards Identifiers for GNG11 Gene

  • GC07P092086
  • GC07P093149
  • GC07P093163
  • GC07P093195
  • GC07P093388
  • GC07P093551
  • GC07P088158

Summaries for GNG11 Gene

Entrez Gene Summary for GNG11 Gene

  • This gene is a member of the guanine nucleotide-binding protein (G protein) gamma family and encodes a lipid-anchored, cell membrane protein. As a member of the heterotrimeric G protein complex, this protein plays a role in this transmembrane signaling system. This protein is also subject to carboxyl-terminal processing. Decreased expression of this gene is associated with splenic marginal zone lymphomas. [provided by RefSeq, Jul 2008]

GeneCards Summary for GNG11 Gene

GNG11 (G Protein Subunit Gamma 11) is a Protein Coding gene. Among its related pathways are Presynaptic function of Kainate receptors and G-protein signaling G-Protein alpha-i signaling cascades. Gene Ontology (GO) annotations related to this gene include GTPase activity and obsolete signal transducer activity. An important paralog of this gene is GNGT1.

UniProtKB/Swiss-Prot for GNG11 Gene

  • Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

Tocris Summary for GNG11 Gene

  • Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand binding causes a receptor conformational change, detaching the G protein and switching it 'on'.

Gene Wiki entry for GNG11 Gene

Additional gene information for GNG11 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GNG11 Gene

Genomics for GNG11 Gene

GeneHancer (GH) Regulatory Elements for GNG11 Gene

Promoters and enhancers for GNG11 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J093919 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 658.8 +0.7 656 4.9 PKNOX1 SIN3A GLI4 ZNF2 YY1 GLIS2 KLF7 REST SMARCB1 ZNF610 GNG11 TFPI2 LOC105375401 LOC105375402
GH07J094003 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 11.4 +82.5 82502 2 FOXA2 ARID4B SIN3A DMAP1 IRF4 YY1 POLR2B E2F8 ZNF143 KLF13 BET1 GNG11 LOC105375403
GH07J093889 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 11.1 -31.3 -31255 2.1 KLF17 SIN3A ZNF335 GLIS2 EGR1 ZNF366 SCRT2 RCOR1 FOS EGR2 LOC105375401 TFPI2 GNG11 GC07M093797 GNGT1
GH07J094055 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 11 +135.5 135537 2.8 JUN MAX BACH1 ZBTB40 ZNF316 POLR2A FOS NFE2 MAFK NFE2L2 BET1 GNG11 TFPI2 LOC105375401 ENSG00000236938 ENSG00000236453
GH07J094059 Enhancer 1.1 FANTOM5 ENCODE dbSUPER 11.4 +138.7 138725 2.2 BATF IRF4 EED ATF7 ETV6 IKZF2 CREM RUNX3 ZBED1 NR2F1 BET1 GNG11 TFPI2 LOC105375401 ENSG00000236938 ENSG00000236453
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GNG11 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GNG11 gene promoter:
  • E4BP4
  • C/EBPbeta
  • STAT5B
  • FOXI1
  • HFH-3
  • Nkx3-1
  • Nkx3-1 v1
  • Nkx3-1 v2
  • Nkx3-1 v3
  • Nkx3-1 v4

Genomic Locations for GNG11 Gene

Genomic Locations for GNG11 Gene
6,912 bases
Plus strand
6,912 bases
Plus strand

Genomic View for GNG11 Gene

Genes around GNG11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GNG11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GNG11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GNG11 Gene

Proteins for GNG11 Gene

  • Protein details for GNG11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11
    Protein Accession:
    Secondary Accessions:
    • P50152

    Protein attributes for GNG11 Gene

    73 amino acids
    Molecular mass:
    8481 Da
    Quaternary structure:
    • G proteins are composed of 3 units, alpha, beta and gamma. Interacts with beta-1 and beta-3, but not with beta-2.

neXtProt entry for GNG11 Gene

Post-translational modifications for GNG11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GNG11 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GNG11 Gene

Domains & Families for GNG11 Gene

Gene Families for GNG11 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for GNG11 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G protein gamma family.
  • Belongs to the G protein gamma family.
genes like me logo Genes that share domains with GNG11: view

Function for GNG11 Gene

Molecular function for GNG11 Gene

UniProtKB/Swiss-Prot Function:
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

Phenotypes From GWAS Catalog for GNG11 Gene

Gene Ontology (GO) - Molecular Function for GNG11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity TAS 7665596
GO:0004871 obsolete signal transducer activity IEA --
GO:0005515 protein binding IPI --
genes like me logo Genes that share ontologies with GNG11: view
genes like me logo Genes that share phenotypes with GNG11: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GNG11 Gene

Localization for GNG11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GNG11 Gene

Cell membrane; Lipid-anchor; Cytoplasmic side.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GNG11 gene
Compartment Confidence
plasma membrane 4
cytosol 3
extracellular 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for GNG11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005834 heterotrimeric G-protein complex IEA --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with GNG11: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GNG11 Gene

Pathways & Interactions for GNG11 Gene

genes like me logo Genes that share pathways with GNG11: view

Gene Ontology (GO) - Biological Process for GNG11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 7665596
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0071377 cellular response to glucagon stimulus TAS --
genes like me logo Genes that share ontologies with GNG11: view

No data available for SIGNOR curated interactions for GNG11 Gene

Drugs & Compounds for GNG11 Gene

(3) Drugs for GNG11 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0
Guanosine monophosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0

(5) Additional Compounds for GNG11 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
[D-Trp7,9,10]-Substance P
G-Protein antagonist peptide
Gue 1654
SCH 202676 hydrobromide

(5) Tocris Compounds for GNG11 Gene

Compound Action Cas Number
[D-Trp7,9,10]-Substance P Inhibits M1 ACh receptor activation of Gq/11 89430-38-6
G-Protein antagonist peptide Inhibits G protein activation by GPCRs 143675-79-0
Gue 1654 Selective inhibitor of OXE-R Gbetagamma signaling 397290-30-1
Mastoparan Activates Gi and Go 72093-21-1
SCH 202676 hydrobromide Inhibitor of ligand binding to G-protein-coupled receptors 265980-25-4
genes like me logo Genes that share compounds with GNG11: view

Transcripts for GNG11 Gene

mRNA/cDNA for GNG11 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(120) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GNG11 Gene

Guanine nucleotide binding protein (G protein), gamma 11:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GNG11 Gene

No ASD Table

Relevant External Links for GNG11 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GNG11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GNG11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for GNG11 Gene

This gene is overexpressed in Platelet (32.7) and Peripheral blood mononuclear cells (22.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GNG11 Gene

NURSA nuclear receptor signaling pathways regulating expression of GNG11 Gene:


SOURCE GeneReport for Unigene cluster for GNG11 Gene:


mRNA Expression by UniProt/SwissProt for GNG11 Gene:

Tissue specificity: Abundantly expressed in all tissues tested except for brain.

Evidence on tissue expression from TISSUES for GNG11 Gene

  • Lung(4.4)
genes like me logo Genes that share expression patterns with GNG11: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for GNG11 Gene

Orthologs for GNG11 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GNG11 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GNG11 34 33
  • 100 (n)
(Mus musculus)
Mammalia Gng11 16 34 33
  • 91.78 (n)
(Bos Taurus)
Mammalia GNG11 34 34 33
  • 91.78 (n)
(Rattus norvegicus)
Mammalia Gng11 33
  • 91.78 (n)
(Canis familiaris)
Mammalia GNG11 34 33
  • 91.32 (n)
(Gallus gallus)
Aves GNG11 33
  • 76.26 (n)
(Anolis carolinensis)
Reptilia GNG11 34
  • 86 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.12711 33
(Danio rerio)
Actinopterygii gngt1 34
  • 60 (a)
Species where no ortholog for GNG11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GNG11 Gene

Gene Tree for GNG11 (if available)
Gene Tree for GNG11 (if available)
Evolutionary constrained regions (ECRs) for GNG11: view image

Paralogs for GNG11 Gene

Paralogs for GNG11 Gene

(11) SIMAP similar genes for GNG11 Gene using alignment to 2 proteins:

  • Q53Y01_HUMAN
genes like me logo Genes that share paralogs with GNG11: view

Variants for GNG11 Gene

Sequence variations from dbSNP and Humsavar for GNG11 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000016433 -- 93,921,801(+) G/T 5_prime_UTR_variant
rs1000139722 -- 93,925,827(+) GACCAACGACCAAC/GACCAAC intron_variant
rs1000536198 -- 93,921,333(+) C/T upstream_transcript_variant
rs1000975201 -- 93,926,984(+) C/T downstream_transcript_variant
rs1001048813 -- 93,925,023(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for GNG11 Gene

Variant ID Type Subtype PubMed ID
esv3614175 CNV loss 21293372
nsv1023193 CNV gain 25217958
nsv607849 CNV gain 21841781

Variation tolerance for GNG11 Gene

Residual Variation Intolerance Score: 68.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.21; 4.65% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GNG11 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GNG11 Gene

Disorders for GNG11 Gene

Additional Disease Information for GNG11

No disorders were found for GNG11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GNG11 Gene

Publications for GNG11 Gene

  1. Isolation of cDNA clones encoding eight different human G protein gamma subunits, including three novel forms designated the gamma 4, gamma 10, and gamma 11 subunits. (PMID: 7665596) Ray K … Robishaw JD (The Journal of biological chemistry 1995) 2 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier LW … Wilson RK (Nature 2003) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. GNG11 (G-protein subunit γ 11) suppresses cell growth with induction of reactive oxygen species and abnormal nuclear morphology in human SUSM-1 cells. (PMID: 28380310) Takauji Y … Ayusawa D (Biochemistry and cell biology = Biochimie et biologie cellulaire 2017) 3 58

Products for GNG11 Gene

Sources for GNG11 Gene

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