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This gene is a member of the guanine nucleotide-binding protein (G protein) gamma family and encodes a lipid-anchored, cell membrane protein. As a member of the heterotrimeric G protein complex, this protein plays a role in this transmembrane signaling system. This protein is also subject to carboxyl-terminal processing. Decreased expression of this gene is associated with sple... See more...
Aliases for GNG11 Gene
Aliases for GNG11 Gene
External Ids for GNG11 Gene
- HGNC: 4403
- Entrez Gene: 2791
- Ensembl: ENSG00000127920
- OMIM: 604390
- UniProtKB: P61952
Previous GeneCards Identifiers for GNG11 Gene
- GC07P092086
- GC07P093149
- GC07P093163
- GC07P093195
- GC07P093388
- GC07P093551
- GC07P088158
Summaries for GNG11 Gene
-
This gene is a member of the guanine nucleotide-binding protein (G protein) gamma family and encodes a lipid-anchored, cell membrane protein. As a member of the heterotrimeric G protein complex, this protein plays a role in this transmembrane signaling system. This protein is also subject to carboxyl-terminal processing. Decreased expression of this gene is associated with splenic marginal zone lymphomas. [provided by RefSeq, Jul 2008]
GeneCards Summary for GNG11 Gene
GNG11 (G Protein Subunit Gamma 11) is a Protein Coding gene. Diseases associated with GNG11 include Splenic Marginal Zone Lymphoma. Among its related pathways are Signaling by GPCR and ADP signalling through P2Y purinoceptor 1. Gene Ontology (GO) annotations related to this gene include GTPase activity and obsolete signal transducer activity. An important paralog of this gene is GNGT1.
UniProtKB/Swiss-Prot Summary for GNG11 Gene
-
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
-
Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand binding causes a receptor conformational change, detaching the G protein and switching it 'on'.
Additional gene information for GNG11 Gene
- Monarch Initiative
- Search for GNG11 at DataMed
- Search for GNG11 at HumanCyc
No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GNG11 Gene
Genomics for GNG11 Gene
GeneHancer (GH) Regulatory Elements for GNG11 Gene
Promoters and enhancers for GNG11 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around GNG11 on UCSC Golden Path with GeneCards custom track
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GNG11
- Top Transcription factor binding sites by QIAGEN in the GNG11 gene promoter:
-
- C/EBPbeta
- E4BP4
- FOXI1
- HFH-3
- Nkx3-1
- Nkx3-1 v1
- Nkx3-1 v2
- Nkx3-1 v3
- Nkx3-1 v4
- STAT5B
Genomic Locations for GNG11 Gene
Genomic Locations for GNG11 Gene
- chr7:93,921,704-93,928,610
- (GRCh38/hg38)
- Size:
- 6,907 bases
- Orientation:
- Plus strand
- chr7:93,551,011-93,557,922
- (GRCh37/hg19)
- Size:
- 6,912 bases
- Orientation:
- Plus strand
Genomic View for GNG11 Gene
Genes around GNG11 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 7q21.3 by HGNC
- 7q21.3 by Entrez Gene
- 7q21.3 by Ensembl
GNG11 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for GNG11 Gene
Proteins for GNG11 Gene
-
Protein details for GNG11 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P61952-GBG11_HUMAN
- Recommended name:
- Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11
- Protein Accession:
- P61952
- P50152
Protein attributes for GNG11 Gene
- Size:
- 73 amino acids
- Molecular mass:
- 8481 Da
- Quaternary structure:
-
- G proteins are composed of 3 units, alpha, beta and gamma. Interacts with beta-1 and beta-3, but not with beta-2.
Protein Expression for GNG11 Gene
Post-translational modifications for GNG11 Gene
Other Protein References for GNG11 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ GNG11 Antibody
- Creative Diagnostics Anti-GNG11 (full length) polyclonal antibody
- Creative Biolabs Recombinant Mouse Anti-Human GNG11 Antibody
- Novus Biologicals Antibodies for GNG11
-
Abcam antibodies for GNG11
- Invitrogen Antibodies for GNG11 (AFLGC-GNG11)
Protein Products
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- ProSpec Recombinant Proteins for GNG11
-
Abcam proteins for GNG11
No data available for DME Specific Peptides for GNG11 Gene
Domains & Families for GNG11 Gene
Gene Families for GNG11 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for GNG11 Gene
- Blocks:
-
- Gamma G-protein (transducin) signature
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for GNG11 Gene
- GenScript: Design optimal peptide antigens:
-
- Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 (GBG11_HUMAN)
- cDNA, FLJ92314, Homo sapiens guanine nucleotide binding protein (G protein), gamma11 (GNG11), mRNA (Q53Y01_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P61952- Family:
-
- Belongs to the G protein gamma family.
Function for GNG11 Gene
Molecular function for GNG11 Gene
- UniProtKB/Swiss-Prot Function:
- Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
Phenotypes From GWAS Catalog for GNG11 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003924 | GTPase activity | IEA | -- |
| GO:0005515 | protein binding | IPI | -- |
| GO:0031681 | G-protein beta-subunit binding | IBA | 21873635 |
Phenotypes for GNG11 Gene
- GenomeRNAi human phenotypes for GNG11:
-
- Increased HPV18 LCR reporter activity
- G0/1 arrest
- Decreased cell number
- Decreased viability
- no effect
- Increased vaccinia virus (VACV) infection
- Resistant to vaccinia virus (VACV-A4L) infection
- Decreased hepcidin::fluc mRNA expression
- Decreased NF-kappaB reporter expression
- shRNA abundance <= 50%
- Increased viability
- Increased transferrin (TF) endocytosis
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for GNG11 - Select products 50% OFF >
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-
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- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for GNG11
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- Overview of 99 available GNG11 gene related products
-
Santa Cruz Biotechnology (SCBT) CRISPR for GNG11
miRNA Products
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Clone Products
- Applied Biological Materials (abm): Clones for GNG11 - Select products 50% OFF >
- * GNG11 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * GNG11 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
- Sino Biological Human cDNA Clone for GNG11
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for GNG11
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- Overview of 99 available GNG11 gene related products
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Cell Line Products
-
Horizon Cell Lines for GNG11
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GNG11 Gene
Localization for GNG11 Gene
Subcellular locations from UniProtKB/Swiss-Prot for GNG11 Gene
- Cell membrane; Lipid-anchor; Cytoplasmic side.
| Compartment | Confidence |
|---|---|
| plasma membrane | 4 |
| cytosol | 3 |
| extracellular | 2 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| nucleus | 1 |
| golgi apparatus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005834 | heterotrimeric G-protein complex | IBA | 21873635 |
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0031680 | G-protein beta/gamma-subunit complex | IBA | 21873635 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for GNG11 Gene
Pathways & Interactions for GNG11 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Development Angiotensin activation of ERK |
Development ACM2 and ACM4 activation of ERK
.73
Development Angiotensin activation of ERK
.73
Development Angiotensin signaling via PYK2
.68
Development G-Proteins mediated regulation MARK-ERK signaling
.65
|
Development EDNRB signaling
.54
Development EPO-induced MAPK pathway
.48
Cell adhesion Integrin inside-out signaling
.45
Signal transduction IP3 signaling
.40
|
| 2 | G-Beta Gamma Signaling |
G-Beta Gamma Signaling
.46
GHRH Signaling
.46
CRHR Pathway
.44
|
Relaxin Pathway
.37
Hedgehog Signaling in Mammals
.32
Signaling in Gap Junctions
.30
|
| 3 | ADP signalling through P2Y purinoceptor 12 |
Signal transduction cAMP signaling
.43
|
|
| 4 | Presynaptic function of Kainate receptors | ||
| 5 | ADP signalling through P2Y purinoceptor 1 |
Development Angiotensin signaling via beta-Arrestin
.39
|
|
Pathways by source for GNG11 Gene
3 BioSystems pathways for GNG11 Gene
47 Reactome pathways for GNG11 Gene
18 KEGG pathways for GNG11 Gene
34 GeneGo (Thomson Reuters) pathways for GNG11 Gene
- Apoptosis and survival BAD phosphorylation
- Cell adhesion Integrin inside-out signaling
- Chemotaxis CXCR4 signaling pathway
- Cytoskeleton remodeling Reverse signaling by ephrin B
- Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation
47 Qiagen pathways for GNG11 Gene
- Actin Nucleation and Branching
- Actin Nucleation by ARP-WASP Complex
- Actin-Based Motility by Rho Family GTPases
- Activation of cAMP-Dependent PKA
- Activation of PKA through GPCR
Interacting Proteins for GNG11 Gene
GPS-Prot Interaction Network for GNG11
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007165 | signal transduction | TAS | 7665596 |
| GO:0007186 | G protein-coupled receptor signaling pathway | IBA | 21873635 |
No data available for SIGNOR curated interactions for GNG11 Gene
Drugs & Compounds for GNG11 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| [D-Trp7,9,10]-Substance P |
|
89430-38-6 |
|
|
||
| G-Protein antagonist peptide |
|
143675-79-0 |
|
|
||
| Gue 1654 |
|
397290-30-1 |
|
|
||
| mastoparan |
|
72093-21-1 |
|
|
||
| SCH 202676 hydrobromide |
|
265980-25-4 |
|
|
(5) Tocris Compounds for GNG11 Gene
| Compound | Action | Cas Number |
|---|---|---|
| [D-Trp7,9,10]-Substance P | Inhibits M1 ACh receptor activation of Gq/11 | 89430-38-6 |
| G-Protein antagonist peptide | Inhibits G protein activation by GPCRs | 143675-79-0 |
| Gue 1654 | Selective inhibitor of OXE-R Gbetagamma signaling | 397290-30-1 |
| Mastoparan | Activates Gi and Go | 72093-21-1 |
| SCH 202676 hydrobromide | Inhibitor of ligand binding to G-protein-coupled receptors | 265980-25-4 |
Transcripts for GNG11 Gene
mRNA/cDNA for GNG11 Gene
- 1 REFSEQ mRNAs :
- 6 NCBI additional mRNA sequence :
- 1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000248564 3019 bps (ENST00000248564.6)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for GNG11 - Select products 50% OFF >
- * GNG11 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
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-
OriGene CRISPR knockouts for GNG11
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for GNG11
- genomics-online: gRNA clones - Search for available GNG11 gRNA products
- Overview of 99 available GNG11 gene related products
-
Santa Cruz Biotechnology (SCBT) CRISPR for GNG11
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for GNG11
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- Overview of 99 available GNG11 gene related products
Clone Products
- Applied Biological Materials (abm): Clones for GNG11 - Select products 50% OFF >
- * GNG11 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * GNG11 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
- Sino Biological Human cDNA Clone for GNG11
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for GNG11
- genomics-online: cdna clones - Search for available GNG11 CDNA products
- Overview of 99 available GNG11 gene related products
- orf clones - Search for available GNG11 ORF products
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Relevant External Links for GNG11 Gene
- GeneLoc Exon Structure for
- GNG11
Expression for GNG11 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Hair (Integumentary System)
- Zigzag Dermal Papilla Cells Dermal Papilla
- Guard Dermal Papilla Cells Dermal Papilla
-
Dermis (Integumentary System)
- Zigzag Dermal Papilla Cells Dermal Papilla
- Guard Dermal Papilla Cells Dermal Papilla
- Endothelium (Cardiovascular System)
-
Uterus (Reproductive System)
-
Placenta (Extraembryonic Tissues)
-
Spleen (Hematopoietic System)
-
Gall Bladder (Hepatobiliary System)
-
Lung (Respiratory System)
-
Adrenal Gland (Endocrine System)
-
Ovary (Reproductive System)
-
Adipose (Muscoskeletal System)
This gene is overexpressed in Platelet (32.7) and Peripheral blood mononuclear cells (22.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GNG11 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GNG11
SOURCE GeneReport for Unigene cluster for GNG11 Gene:
Hs.83381mRNA Expression by UniProt/SwissProt for GNG11 Gene:
P61952-GBG11_HUMAN
Tissue specificity:
Abundantly expressed in all tissues tested except for brain.
Evidence on tissue expression from TISSUES for GNG11 Gene
- Lung(4.4)
Primer Products
-
OriGene qPCR primer pairs and template standards for GNG11
- genomics-online: primer clones - Search for available GNG11 Primer products
- Overview of 99 available GNG11 gene related products
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for GNG11 Gene
Orthologs for GNG11 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | GNG11 31 30 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Gng11 17 31 30 |
|
||
| cow (Bos Taurus) |
Mammalia | GNG11 31 31 30 |
|
OneToMany | |
| rat (Rattus norvegicus) |
Mammalia | LOC100912034 30 |
|
||
| dog (Canis familiaris) |
Mammalia | GNG11 31 30 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | GNG11 30 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | GNG11 31 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | Str.12711 30 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | gngt1 31 |
|
OneToMany |
- Species where no ortholog for GNG11 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for GNG11 Gene
- ENSEMBL:
- Gene Tree for GNG11 (if available)
- TreeFam:
- Gene Tree for GNG11 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for GNG11: view image
Paralogs for GNG11 Gene
Variants for GNG11 Gene
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3614175 | CNV | loss | 21293372 |
| nsv1023193 | CNV | gain | 25217958 |
| nsv607849 | CNV | gain | 21841781 |
Residual Variation Intolerance Score:
68.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.21;
4.65% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for GNG11 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- GNG11
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GNG11 Gene
Disorders for GNG11 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| splenic marginal zone lymphoma |
|
|
Search GNG11 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for GNG11
- Genetic Association Database
- (GAD)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for GNG11 Gene
Publications for GNG11 Gene
- Isolation of cDNA clones encoding eight different human G protein gamma subunits, including three novel forms designated the gamma 4, gamma 10, and gamma 11 subunits. (PMID: 7665596) Ray K … Robishaw JD (The Journal of biological chemistry 1995) 2 3 4 54
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
- The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier LW … Wilson RK (Nature 2003) 3 4 54
- Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 54
- GNG11 (G-protein subunit γ 11) suppresses cell growth with induction of reactive oxygen species and abnormal nuclear morphology in human SUSM-1 cells. (PMID: 28380310) Takauji Y … Ayusawa D (Biochemistry and cell biology = Biochimie et biologie cellulaire 2017) 3 54
ExternalLinks
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- antibodies-online: Show 22 available GNG11 Antibodies ranked by validation data
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- Horizon Cell Lines for GNG11
- genomics-online: cdna clones - Search for available GNG11 CDNA products
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Sources for GNG11 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) H-invDB
- (47) HORDE
- (48) HUGE
- (49) IMGT
- (50) Leiden
- (51) miRBase
- (52) DME
- (53) OriGene
- (54) PubMed
- (55) R&D Systems
- (56) TGDB
- (57) Tocris
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