GNG11 Gene (Protein Coding)

G Protein Subunit Gamma 11

GC07P093921
GIFtS:
39
This gene is a member of the guanine nucleotide-binding protein (G protein) gamma family and encodes a lipid-anchored, cell membrane protein. As a member of the heterotrimeric G protein complex, this protein plays a role in this transmembrane signaling system. This protein is also subject to carboxyl-terminal processing. Decreased expression of this gene is associated with sple... See more...

Aliases for GNG11 Gene

Aliases for GNG11 Gene

  • G Protein Subunit Gamma 11 2 3 5
  • GNGT11 2 3 4
  • Guanine Nucleotide-Binding Protein G(I)/G(S)/G(O) Gamma-11 Subunit 2 3
  • Guanine Nucleotide-Binding Protein G(I)/G(S)/G(O) Subunit Gamma-11 3 4
  • Guanine Nucleotide Binding Protein (G Protein), Gamma 11 2 3
  • G Protein Gamma-11 Subunit 2 3
  • GNG11 5

External Ids for GNG11 Gene

Previous GeneCards Identifiers for GNG11 Gene

  • GC07P092086
  • GC07P093149
  • GC07P093163
  • GC07P093195
  • GC07P093388
  • GC07P093551
  • GC07P088158

Summaries for GNG11 Gene

Entrez Gene Summary for GNG11 Gene

  • This gene is a member of the guanine nucleotide-binding protein (G protein) gamma family and encodes a lipid-anchored, cell membrane protein. As a member of the heterotrimeric G protein complex, this protein plays a role in this transmembrane signaling system. This protein is also subject to carboxyl-terminal processing. Decreased expression of this gene is associated with splenic marginal zone lymphomas. [provided by RefSeq, Jul 2008]

GeneCards Summary for GNG11 Gene

GNG11 (G Protein Subunit Gamma 11) is a Protein Coding gene. Diseases associated with GNG11 include Splenic Marginal Zone Lymphoma. Among its related pathways are Apelin signaling pathway and G-Beta Gamma Signaling. Gene Ontology (GO) annotations related to this gene include GTPase activity and obsolete signal transducer activity. An important paralog of this gene is GNGT1.

UniProtKB/Swiss-Prot Summary for GNG11 Gene

  • Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

Tocris Summary for GNG11 Gene

  • Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand binding causes a receptor conformational change, detaching the G protein and switching it 'on'.

Gene Wiki entry for GNG11 Gene

Additional gene information for GNG11 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GNG11 Gene

Genomics for GNG11 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for GNG11 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH07J093919 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 258.7 +0.8 819 5.3 ZNF600 ZNF580 POLR2A ZIC2 ZBTB10 ZNF341 KLF7 MAX ZNF513 ZNF610 GNG11 TFPI2 TFPI2-DT HSALNG0059594 LOC105375402 BET1
GH07J094003 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 11.4 +82.2 82165 3 BCLAF1 SP1 MYC ZNF600 SIX5 ATF2 POLR2A CEBPA ATF3 BRCA1 BET1 GNG11 lnc-TFPI2-2 LOC107986820 BET1-AS1
GH07J093890 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE CraniofacialAtlas 11.1 -31.5 -31486 2.5 ZIC2 ZNF341 CTCF REST MAFF SP2 ZNF316 RAD21 MAFK ZBTB48 TFPI2 TFPI2-DT lnc-BET1-3 GNG11 HSALNG0059589 GNGT1
GH07J094055 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 11.4 +137.5 137524 6.8 BCL11A CEBPB MAX EP300 GABPA IRF4 YY1 ZNF316 CBFB NFE2 BET1 GNG11 TFPI2 TFPI2-DT CASD1 HSALNG0059603 ENSG00000236938 ENSG00000236453 LOC107986820 COL1A2
GH07J093943 Enhancer 0.9 Ensembl ENCODE 15.8 +24.9 24940 7.3 NCOR1 IKZF1 JUND BRCA1 NFIC CEBPB EP300 RAD21 RFX5 TAL1 GNG11 SGCE HSALNG0059596 HSALNG0059597 BET1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GNG11 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GNG11

Top Transcription factor binding sites by QIAGEN in the GNG11 gene promoter:
  • C/EBPbeta
  • E4BP4
  • FOXI1
  • HFH-3
  • Nkx3-1
  • Nkx3-1 v1
  • Nkx3-1 v2
  • Nkx3-1 v3
  • Nkx3-1 v4
  • STAT5B

Genomic Locations for GNG11 Gene

Latest Assembly
chr7:93,921,735-93,928,610
(GRCh38/hg38)
Size:
6,876 bases
Orientation:
Plus strand

Previous Assembly
chr7:93,551,047-93,557,922
(GRCh37/hg19 by Entrez Gene)
Size:
6,876 bases
Orientation:
Plus strand

chr7:93,551,011-93,557,922
(GRCh37/hg19 by Ensembl)
Size:
6,912 bases
Orientation:
Plus strand

Genomic View for GNG11 Gene

Genes around GNG11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GNG11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GNG11 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for GNG11 Gene

Proteins for GNG11 Gene

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  • Protein details for GNG11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P61952-GBG11_HUMAN
    Recommended name:
    Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11
    Protein Accession:
    P61952
    Secondary Accessions:
    • P50152

    Protein attributes for GNG11 Gene

    Size:
    73 amino acids
    Molecular mass:
    8481 Da
    Quaternary structure:
    • G proteins are composed of 3 units, alpha, beta and gamma. Interacts with beta-1 and beta-3, but not with beta-2.

neXtProt entry for GNG11 Gene

Protein Expression for GNG11 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for GNG11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GNG11 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GNG11 Gene

Domains & Families for GNG11 Gene

Gene Families for GNG11 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for GNG11 Gene

InterPro:
Blocks:
  • Gamma G-protein (transducin) signature

Suggested Antigen Peptide Sequences for GNG11 Gene

GenScript: Design optimal peptide antigens:
  • Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 (GBG11_HUMAN)
  • cDNA, FLJ92314, Homo sapiens guanine nucleotide binding protein (G protein), gamma11 (GNG11), mRNA (Q53Y01_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P61952

UniProtKB/Swiss-Prot:

GBG11_HUMAN :
  • Belongs to the G protein gamma family.
Family:
  • Belongs to the G protein gamma family.
genes like me logo Genes that share domains with GNG11: view

Function for GNG11 Gene

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Molecular function for GNG11 Gene

UniProtKB/Swiss-Prot Function:
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

Phenotypes From GWAS Catalog for GNG11 Gene

Gene Ontology (GO) - Molecular Function for GNG11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity TAS 7665596
GO:0005515 protein binding IPI 32296183
GO:0031681 G-protein beta-subunit binding IBA 21873635
genes like me logo Genes that share ontologies with GNG11: view
genes like me logo Genes that share phenotypes with GNG11: view

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GNG11

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GNG11 Gene

Localization for GNG11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GNG11 Gene

Cell membrane. Lipid-anchor. Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GNG11 gene
Compartment Confidence
plasma membrane 4
cytosol 3
extracellular 2
cytoskeleton 1
mitochondrion 1
nucleus 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for GNG11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005834 heterotrimeric G-protein complex IBA 21873635
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0031680 G-protein beta/gamma-subunit complex IBA 21873635
genes like me logo Genes that share ontologies with GNG11: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GNG11 Gene

Pathways & Interactions for GNG11 Gene

PathCards logo

SuperPathways for GNG11 Gene

SuperPathway Contained pathways
1 Development Angiotensin activation of ERK
Development ACM2 and ACM4 activation of ERK
.73
Development Angiotensin activation of ERK
.73
Development Angiotensin signaling via PYK2
.68
Development G-Proteins mediated regulation MARK-ERK signaling
.65
Development EDNRB signaling
.54
Development EPO-induced MAPK pathway
.48
Cell adhesion Integrin inside-out signaling
.45
Signal transduction IP3 signaling
.40
2 G-Beta Gamma Signaling
G-Beta Gamma Signaling
.46
GHRH Signaling
.46
CRHR Pathway
.44
Relaxin Pathway
.37
Hedgehog Signaling in Mammals
.32
Signaling in Gap Junctions
.30
3 ADP signalling through P2Y purinoceptor 12
ADP signalling through P2Y purinoceptor 12
.73
G-protein activation
.73
Adrenaline,noradrenaline inhibits insulin secretion
.59
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
.57
G alpha (z) signalling events
.45
Signal transduction cAMP signaling
.43
4 Presynaptic function of Kainate receptors
Activation of Kainate Receptors upon glutamate binding
.66
Presynaptic function of Kainate receptors
.66
Glucagon-type ligand receptors
.50
Class B/2 (Secretin family receptors)
.32
G beta-gamma signalling through PLC beta
.01
5 ADP signalling through P2Y purinoceptor 1
ADP signalling through P2Y purinoceptor 1
.78
Thromboxane signalling through TP receptor
.78
Signal amplification
.76
Thrombin signalling through proteinase activated receptors (PARs)
.67
Development Angiotensin signaling via beta-Arrestin
.39
genes like me logo Genes that share pathways with GNG11: view

Pathways by source for GNG11 Gene

34 GeneGo (Thomson Reuters) pathways for GNG11 Gene
  • Apoptosis and survival BAD phosphorylation
  • Cell adhesion Integrin inside-out signaling
  • Chemotaxis CXCR4 signaling pathway
  • Cytoskeleton remodeling Reverse signaling by ephrin B
  • Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation
47 Qiagen pathways for GNG11 Gene
  • Actin Nucleation and Branching
  • Actin Nucleation by ARP-WASP Complex
  • Actin-Based Motility by Rho Family GTPases
  • Activation of cAMP-Dependent PKA
  • Activation of PKA through GPCR

Gene Ontology (GO) - Biological Process for GNG11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 7665596
GO:0007186 G protein-coupled receptor signaling pathway IBA 21873635
genes like me logo Genes that share ontologies with GNG11: view

No data available for SIGNOR curated interactions for GNG11 Gene

Drugs & Compounds for GNG11 Gene

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(3) Drugs for GNG11 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0
Guanosine monophosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0

(5) Additional Compounds for GNG11 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
[D-Trp7,9,10]-Substance P
89430-38-6
G-Protein antagonist peptide
143675-79-0
Gue 1654
397290-30-1
mastoparan
72093-21-1
SCH 202676 hydrobromide
265980-25-4

(5) Tocris Compounds for GNG11 Gene

Compound Action Cas Number
[D-Trp7,9,10]-Substance P Inhibits M1 ACh receptor activation of Gq/11 89430-38-6
G-Protein antagonist peptide Inhibits G protein activation by GPCRs 143675-79-0
Gue 1654 Selective inhibitor of OXE-R Gbetagamma signaling 397290-30-1
Mastoparan Activates Gi and Go 72093-21-1
SCH 202676 hydrobromide Inhibitor of ligand binding to G-protein-coupled receptors 265980-25-4
genes like me logo Genes that share compounds with GNG11: view

Transcripts for GNG11 Gene

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mRNA/cDNA for GNG11 Gene

1 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GNG11

Alternative Splicing Database (ASD) splice patterns (SP) for GNG11 Gene

No ASD Table

Relevant External Links for GNG11 Gene

GeneLoc Exon Structure for
GNG11

Expression for GNG11 Gene

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mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GNG11 Gene

mRNA expression in normal human tissues for GNG11 Gene
mRNA expression by GTEx for GNG11 GenemRNA expression by BioGPS for GNG11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for GNG11 Gene

This gene is overexpressed in Platelet (32.7) and Peripheral blood mononuclear cells (22.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GNG11 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GNG11

SOURCE GeneReport for Unigene cluster for GNG11 Gene:

Hs.83381

mRNA Expression by UniProt/SwissProt for GNG11 Gene:

P61952-GBG11_HUMAN
Tissue specificity: Abundantly expressed in all tissues tested except for brain.

Evidence on tissue expression from TISSUES for GNG11 Gene

  • Lung(4.5)
  • Heart(2.4)
  • Muscle(2.3)
  • Nervous system(2.2)
  • Blood(2.2)
  • Spleen(2.2)
genes like me logo Genes that share expression patterns with GNG11: view

Primer products for research

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for GNG11 Gene

Orthologs for GNG11 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GNG11 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia GNG11 29 30
  • 100 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Gng11 29
  • 91.78 (n)
Mouse
(Mus musculus)
 Mammalia Gng11 29 16 30
  • 91.78 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia GNG11 29 30 30
  • 91.78 (n)
 OneToMany
Dog
(Canis familiaris)
 Mammalia GNG11 29 30
  • 91.32 (n)
 OneToOne
Chicken
(Gallus gallus)
 Aves GNG11 29
  • 76.26 (n)
Lizard
(Anolis carolinensis)
 Reptilia GNG11 30
  • 86 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia Str.12711 29
Zebrafish
(Danio rerio)
 Actinopterygii gngt1 30
  • 60 (a)
 OneToMany
Species where no ortholog for GNG11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for GNG11 Gene

ENSEMBL:
Gene Tree for GNG11 (if available)
TreeFam:
Gene Tree for GNG11 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GNG11: view image
Alliance of Genome Resources:
Additional Orthologs for GNG11

Paralogs for GNG11 Gene

Paralogs for GNG11 Gene

(11) SIMAP similar genes for GNG11 Gene using alignment to 2 proteins:

  • GBG11_HUMAN
  • Q53Y01_HUMAN
genes like me logo Genes that share paralogs with GNG11: view

Variants for GNG11 Gene

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dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for GNG11 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for GNG11 Gene

Variant ID Type Subtype PubMed ID
esv3614175 CNV loss 21293372
nsv1023193 CNV gain 25217958
nsv607849 CNV gain 21841781

Variation tolerance for GNG11 Gene

Residual Variation Intolerance Score: 68.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.21; 4.65% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GNG11 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GNG11
Leiden Open Variation Database (LOVD)
GNG11

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GNG11 Gene

Disorders for GNG11 Gene

MalaCards: The human disease database

(1) MalaCards diseases for GNG11 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
splenic marginal zone lymphoma
  • smzl
- elite association - COSMIC cancer census association via MalaCards
Search GNG11 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for GNG11

Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with GNG11: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GNG11 Gene

Publications for GNG11 Gene

  1. Isolation of cDNA clones encoding eight different human G protein gamma subunits, including three novel forms designated the gamma 4, gamma 10, and gamma 11 subunits. (PMID: 7665596) Ray K … Robishaw JD (The Journal of biological chemistry 1995) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  3. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier LW … Wilson RK (Nature 2003) 3 4
  4. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3

ExternalLinks

View latest publications for GNG11 gene in Mastermind

Products for GNG11 Gene

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