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GNG10 (G Protein Subunit Gamma 10) is a Protein Coding gene. Diseases associated with GNG10 include Good Syndrome. Among its related pathways are Beta-Adrenergic Signaling and ERK Signaling. Gene Ontology (GO) annotations related to this gene include GTPase activity and obsolete signal transducer activity. An important paralog of this gene is GNG2.
Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand binding causes a receptor conformational change, detaching the G protein and switching it 'on'.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003924 | GTPase activity | TAS | 7665596 |
GO:0005515 | protein binding | IPI | 25416956 |
GO:0031681 | G-protein beta-subunit binding | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005834 | heterotrimeric G-protein complex | IBA | 21873635 |
GO:0005886 | plasma membrane | TAS | -- |
GO:0016020 | membrane | IEA | -- |
GO:0031680 | G-protein beta/gamma-subunit complex | IBA | 21873635 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Development Angiotensin activation of ERK |
Development ACM2 and ACM4 activation of ERK
.73
Development Angiotensin activation of ERK
.73
Development Angiotensin signaling via PYK2
.68
Development G-Proteins mediated regulation MARK-ERK signaling
.65
|
Development EDNRB signaling
.54
Development EPO-induced MAPK pathway
.48
Cell adhesion Integrin inside-out signaling
.45
Signal transduction IP3 signaling
.40
|
2 | G-Beta Gamma Signaling |
G-Beta Gamma Signaling
.46
GHRH Signaling
.46
CRHR Pathway
.44
|
Relaxin Pathway
.37
Hedgehog Signaling in Mammals
.32
Signaling in Gap Junctions
.30
|
3 | ADP signalling through P2Y purinoceptor 12 |
Signal transduction cAMP signaling
.43
|
|
4 | Presynaptic function of Kainate receptors | ||
5 | ADP signalling through P2Y purinoceptor 1 |
Development Angiotensin signaling via beta-Arrestin
.39
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0007165 | signal transduction | TAS | 7665596 |
GO:0007186 | G protein-coupled receptor signaling pathway | IBA | 21873635 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
[D-Trp7,9,10]-Substance P |
|
89430-38-6 |
|
|
||
G-Protein antagonist peptide |
|
143675-79-0 |
|
|
||
Gue 1654 |
|
397290-30-1 |
|
|
||
mastoparan |
|
72093-21-1 |
|
|
||
SCH 202676 hydrobromide |
|
265980-25-4 |
|
|
Compound | Action | Cas Number |
---|---|---|
[D-Trp7,9,10]-Substance P | Inhibits M1 ACh receptor activation of Gq/11 | 89430-38-6 |
G-Protein antagonist peptide | Inhibits G protein activation by GPCRs | 143675-79-0 |
Gue 1654 | Selective inhibitor of OXE-R Gbetagamma signaling | 397290-30-1 |
Mastoparan | Activates Gi and Go | 72093-21-1 |
SCH 202676 hydrobromide | Inhibitor of ligand binding to G-protein-coupled receptors | 265980-25-4 |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | GNG10 31 |
|
OneToOne | |
LOC100611518 30 |
|
||||
Dog (Canis familiaris) |
Mammalia | GNG10 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Gng10 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | GNG10 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Gng10 30 17 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | GNG10 30 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | GNG10 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | GNG10 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | gng10 30 |
|
||
Str.17134 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | MGC68728 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | gng10 30 |
|
||
si:ch211-286b5.5 31 |
|
ManyToMany | |||
Dr.16706 30 |
|
Disorder | Aliases | PubMed IDs |
---|---|---|
good syndrome |
|
|