GNG10 Gene (Protein Coding)

G Protein Subunit Gamma 10

GC09P111661
GIFtS:
39
See more...

Aliases for GNG10 Gene

Aliases for GNG10 Gene

  • G Protein Subunit Gamma 10 2 3 5
  • Guanine Nucleotide-Binding Protein G(I)/G(S)/G(O) Subunit Gamma-10 3 4
  • Guanine Nucleotide Binding Protein (G Protein), Gamma 10 2 3
  • Guanine Nucleotide Binding Protein 10 3
  • GNGT10 4
  • GNG10 5

External Ids for GNG10 Gene

Previous GeneCards Identifiers for GNG10 Gene

  • GC09P105192
  • GC09P106125
  • GC09P107851
  • GC09P109773
  • GC09P111473
  • GC09P113435
  • GC09P113437
  • GC09P113439
  • GC09P113441
  • GC09P113443
  • GC09P113463
  • GC09P114423
  • GC09P084022

Summaries for GNG10 Gene

GeneCards Summary for GNG10 Gene

GNG10 (G Protein Subunit Gamma 10) is a Protein Coding gene. Diseases associated with GNG10 include Good Syndrome. Among its related pathways are Translation Translation regulation by Alpha-1 adrenergic receptors and Sweet Taste Signaling. Gene Ontology (GO) annotations related to this gene include GTPase activity and obsolete signal transducer activity. An important paralog of this gene is GNG5.

UniProtKB/Swiss-Prot Summary for GNG10 Gene

  • Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Interacts with beta-1 and beta-2, but not with beta-3.

Tocris Summary for GNG10 Gene

  • Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand binding causes a receptor conformational change, detaching the G protein and switching it 'on'.

Additional gene information for GNG10 Gene

No data available for Entrez Gene Summary , CIViC Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GNG10 Gene

Genomics for GNG10 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for GNG10 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH09J111660 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 624.8 +0.6 605 3.2 TEAD4 ZNF692 POLR2A BACH1 FOXA1 MTA2 ZIC2 RBFOX2 PATZ1 IKZF2 GNG10 lnc-DNAJC25-1 DNAJC25-GNG10 SHOC1
GH09J111669 Promoter 0.3 EPDnew 600.4 +8.2 8232 0.1 GNG10 RF00017-7820 lnc-GNG10-3 DNAJC25-GNG10 SHOC1
GH09J111597 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 16.1 -62.7 -62704 3.4 HNRNPL CTCF PRDM10 REST RFX1 ZIC2 RBFOX2 RAD21 IRF2 SP1 PTGR1 lnc-C9orf84-1 GNG10 LRRC37A5P ZNF483 RF00017-7819 lnc-PTGR1-1
GH09J111794 Promoter/Enhancer 1.2 EPDnew Ensembl ENCODE 24.5 +133.4 133431 1 USF1 E2F4 E2F6 ELK4 MAX NFYA NFYB POLR2A USF2 ZBTB33 HSALNG0073715 SHOC1 GNG10
GH09J111804 Promoter/Enhancer 1.2 EPDnew Ensembl ENCODE 24.6 +144.2 144224 3.7 CREB1 JUND RFX1 CEBPB RUNX3 JUN FOS FOSL1 EP300 FOSL2 SHOC1 GNG10 RNU6-1013P ENSG00000224067 lnc-UGCG-3 HSALNG0073715 lnc-UGCG-2 UGCG
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GNG10 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GNG10

Top Transcription factor binding sites by QIAGEN in the GNG10 gene promoter:
  • Chx10
  • CUTL1
  • FOXJ2
  • FOXJ2 (long isoform)
  • MIF-1
  • RSRFC4
  • Sox9
  • STAT1
  • STAT1alpha
  • STAT1beta

Genomic Locations for GNG10 Gene

Genomic Locations for GNG10 Gene
chr9:111,661,605-111,670,226
(GRCh38/hg38)
Size:
8,622 bases
Orientation:
Plus strand
chr9:114,423,615-114,432,526
(GRCh37/hg19)
Size:
8,912 bases
Orientation:
Plus strand

Genomic View for GNG10 Gene

Genes around GNG10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GNG10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GNG10 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for GNG10 Gene

Proteins for GNG10 Gene

Products:

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  2. Protein
  3. Assay

  • Protein details for GNG10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P50151-GBG10_HUMAN
    Recommended name:
    Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10
    Protein Accession:
    P50151
    Secondary Accessions:
    • Q3B7K2
    • Q4VC27

    Protein attributes for GNG10 Gene

    Size:
    68 amino acids
    Molecular mass:
    7205 Da
    Quaternary structure:
    • G proteins are composed of 3 units, alpha, beta and gamma.

neXtProt entry for GNG10 Gene

Protein Expression for GNG10 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for GNG10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GNG10 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GNG10 Gene

Domains & Families for GNG10 Gene

Gene Families for GNG10 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for GNG10 Gene

InterPro:
Blocks:
  • Gamma G-protein (transducin) signature
ProtoNet:

Suggested Antigen Peptide Sequences for GNG10 Gene

GenScript: Design optimal peptide antigens:
  • Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 (GBG10_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P50151

UniProtKB/Swiss-Prot:

GBG10_HUMAN :
  • Belongs to the G protein gamma family.
Family:
  • Belongs to the G protein gamma family.
genes like me logo Genes that share domains with GNG10: view

Function for GNG10 Gene

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  6. Cell Line

Molecular function for GNG10 Gene

UniProtKB/Swiss-Prot Function:
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Interacts with beta-1 and beta-2, but not with beta-3.

Phenotypes From GWAS Catalog for GNG10 Gene

Gene Ontology (GO) - Molecular Function for GNG10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity TAS,IEA --
GO:0005515 protein binding IPI 25416956
GO:0031681 G-protein beta-subunit binding IBA 21873635
genes like me logo Genes that share ontologies with GNG10: view

Phenotypes for GNG10 Gene

GenomeRNAi human phenotypes for GNG10:
genes like me logo Genes that share phenotypes with GNG10: view

Animal Model Products

CRISPR Products

miRNA for GNG10 Gene

miRTarBase miRNAs that target GNG10

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GNG10

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GNG10 Gene

Localization for GNG10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GNG10 Gene

Cell membrane. Lipid-anchor. Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GNG10 gene
Compartment Confidence
plasma membrane 4
cytosol 2
extracellular 1
cytoskeleton 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for GNG10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005834 heterotrimeric G-protein complex IBA 21873635
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0031680 G-protein beta/gamma-subunit complex IBA 21873635
genes like me logo Genes that share ontologies with GNG10: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GNG10 Gene

Pathways & Interactions for GNG10 Gene

PathCards logo

SuperPathways for GNG10 Gene

SuperPathway Contained pathways
1 Development Angiotensin activation of ERK
Development ACM2 and ACM4 activation of ERK
.73
Development Angiotensin activation of ERK
.73
Development Angiotensin signaling via PYK2
.68
Development G-Proteins mediated regulation MARK-ERK signaling
.65
Development EDNRB signaling
.54
Development EPO-induced MAPK pathway
.48
Cell adhesion Integrin inside-out signaling
.45
Signal transduction IP3 signaling
.40
2 G-Beta Gamma Signaling
G-Beta Gamma Signaling
.46
GHRH Signaling
.46
CRHR Pathway
.44
Relaxin Pathway
.37
Hedgehog Signaling in Mammals
.32
Signaling in Gap Junctions
.30
3 ADP signalling through P2Y purinoceptor 12
ADP signalling through P2Y purinoceptor 12
.73
G-protein activation
.73
Adrenaline,noradrenaline inhibits insulin secretion
.59
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
.57
G alpha (z) signalling events
.45
Signal transduction cAMP signaling
.43
4 Presynaptic function of Kainate receptors
Activation of Kainate Receptors upon glutamate binding
.66
Presynaptic function of Kainate receptors
.66
Glucagon-type ligand receptors
.50
Class B/2 (Secretin family receptors)
.32
G beta-gamma signalling through PLC beta
.01
5 ADP signalling through P2Y purinoceptor 1
ADP signalling through P2Y purinoceptor 1
.78
Thromboxane signalling through TP receptor
.78
Signal amplification
.76
Thrombin signalling through proteinase activated receptors (PARs)
.67
Development Angiotensin signaling via beta-Arrestin
.39
genes like me logo Genes that share pathways with GNG10: view

Pathways by source for GNG10 Gene

1 BioSystems pathway for GNG10 Gene
34 GeneGo (Thomson Reuters) pathways for GNG10 Gene
  • Apoptosis and survival BAD phosphorylation
  • Cell adhesion Integrin inside-out signaling
  • Chemotaxis CXCR4 signaling pathway
  • Cytoskeleton remodeling Reverse signaling by ephrin B
  • Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation
47 Qiagen pathways for GNG10 Gene
  • Actin Nucleation and Branching
  • Actin Nucleation by ARP-WASP Complex
  • Actin-Based Motility by Rho Family GTPases
  • Activation of cAMP-Dependent PKA
  • Activation of PKA through GPCR

Gene Ontology (GO) - Biological Process for GNG10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 7665596
GO:0007186 G protein-coupled receptor signaling pathway IBA 21873635
genes like me logo Genes that share ontologies with GNG10: view

No data available for SIGNOR curated interactions for GNG10 Gene

Drugs & Compounds for GNG10 Gene

Products:

  1. Drug

(3) Drugs for GNG10 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0
Guanosine monophosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0

(5) Additional Compounds for GNG10 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
[D-Trp7,9,10]-Substance P
89430-38-6
G-Protein antagonist peptide
143675-79-0
Gue 1654
397290-30-1
mastoparan
72093-21-1
SCH 202676 hydrobromide
265980-25-4

(5) Tocris Compounds for GNG10 Gene

Compound Action Cas Number
[D-Trp7,9,10]-Substance P Inhibits M1 ACh receptor activation of Gq/11 89430-38-6
G-Protein antagonist peptide Inhibits G protein activation by GPCRs 143675-79-0
Gue 1654 Selective inhibitor of OXE-R Gbetagamma signaling 397290-30-1
Mastoparan Activates Gi and Go 72093-21-1
SCH 202676 hydrobromide Inhibitor of ligand binding to G-protein-coupled receptors 265980-25-4
genes like me logo Genes that share compounds with GNG10: view

Transcripts for GNG10 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for GNG10 Gene

2 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GNG10

Alternative Splicing Database (ASD) splice patterns (SP) for GNG10 Gene

No ASD Table

Relevant External Links for GNG10 Gene

GeneLoc Exon Structure for
GNG10

Expression for GNG10 Gene

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  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GNG10 Gene

mRNA expression in normal human tissues for GNG10 Gene
mRNA expression by GTEx for GNG10 GenemRNA expression by BioGPS for GNG10 Gene

mRNA differential expression in normal tissues according to GTEx for GNG10 Gene

This gene is overexpressed in Whole Blood (x5.6).

Protein differential expression in normal tissues from HIPED for GNG10 Gene

This gene is overexpressed in Pancreas (19.3), Spleen (13.6), and Frontal cortex (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GNG10 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GNG10

SOURCE GeneReport for Unigene cluster for GNG10 Gene:

Hs.534196

mRNA Expression by UniProt/SwissProt for GNG10 Gene:

P50151-GBG10_HUMAN
Tissue specificity: Abundantly and ubiquitously expressed.

Evidence on tissue expression from TISSUES for GNG10 Gene

  • Nervous system(5)
  • Lung(4.6)
  • Pancreas(2.9)
  • Skin(2.3)
  • Kidney(2.2)
genes like me logo Genes that share expression patterns with GNG10: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for GNG10 Gene

Orthologs for GNG10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GNG10 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia GNG10 31
  • 100 (a)
 OneToOne
LOC100611518 30
  • 99.49 (n)
Dog
(Canis familiaris)
 Mammalia GNG10 30 31
  • 92.65 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Gng10 30
  • 90.69 (n)
Oppossum
(Monodelphis domestica)
 Mammalia GNG10 31
  • 90 (a)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Gng10 30 17 31
  • 89.71 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia GNG10 30 31
  • 89.71 (n)
 OneToOne
Chicken
(Gallus gallus)
 Aves GNG10 30 31
  • 81.86 (n)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia GNG10 31
  • 90 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia gng10 30
  • 76.96 (n)
Str.17134 30
African clawed frog
(Xenopus laevis)
 Amphibia MGC68728 30
Zebrafish
(Danio rerio)
 Actinopterygii gng10 30
  • 71.08 (n)
si:ch211-286b5.5 31
  • 47 (a)
 ManyToMany
Dr.16706 30
Species where no ortholog for GNG10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for GNG10 Gene

ENSEMBL:
Gene Tree for GNG10 (if available)
TreeFam:
Gene Tree for GNG10 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GNG10: view image

Paralogs for GNG10 Gene

Paralogs for GNG10 Gene

(10) SIMAP similar genes for GNG10 Gene using alignment to 1 proteins:

  • GBG10_HUMAN

Pseudogenes.org Pseudogenes for GNG10 Gene

genes like me logo Genes that share paralogs with GNG10: view

Variants for GNG10 Gene

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  1. SNP Genotyping and Copy Number Assay

Additional dbSNP identifiers (rs#s) for GNG10 Gene

Structural Variations from Database of Genomic Variants (DGV) for GNG10 Gene

Variant ID Type Subtype PubMed ID
dgv7700n100 CNV gain 25217958
nsv466486 CNV gain 19166990
nsv615193 CNV gain 21841781
nsv825041 CNV gain 20364138

Variation tolerance for GNG10 Gene

Residual Variation Intolerance Score: 55.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.97; 36.46% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GNG10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GNG10

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GNG10 Gene

Disorders for GNG10 Gene

MalaCards: The human disease database

(1) MalaCards diseases for GNG10 Gene - From: DISEASES

Disorder Aliases PubMed IDs
good syndrome
  • thymoma with hypogammaglobulinemia
- elite association - COSMIC cancer census association via MalaCards
Search GNG10 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for GNG10

ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with GNG10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GNG10 Gene

Publications for GNG10 Gene

  1. Isolation of cDNA clones encoding eight different human G protein gamma subunits, including three novel forms designated the gamma 4, gamma 10, and gamma 11 subunits. (PMID: 7665596) Ray K … Robishaw JD (The Journal of biological chemistry 1995) 2 3 4
  2. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray SJ … Dunham I (Nature 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  5. Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations. (PMID: 31515488) Fragoza R … Yu H (Nature communications 2019) 3

ExternalLinks

View latest publications for GNG10 gene in Mastermind

Products for GNG10 Gene

  • Addgene plasmids for GNG10

Sources for GNG10 Gene