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Aliases for GNG10 Gene

Aliases for GNG10 Gene

  • G Protein Subunit Gamma 10 2 3 5
  • Guanine Nucleotide Binding Protein (G Protein), Gamma 10 2
  • GNGT10 4

External Ids for GNG10 Gene

Previous GeneCards Identifiers for GNG10 Gene

  • GC09P105192
  • GC09P106125
  • GC09P107851
  • GC09P109773
  • GC09P111473
  • GC09P113435
  • GC09P113437
  • GC09P113439
  • GC09P113441
  • GC09P113443
  • GC09P113463
  • GC09P114423
  • GC09P084022

Summaries for GNG10 Gene

GeneCards Summary for GNG10 Gene

GNG10 (G Protein Subunit Gamma 10) is a Protein Coding gene. Among its related pathways are Presynaptic function of Kainate receptors and Translation Translation regulation by Alpha-1 adrenergic receptors. Gene Ontology (GO) annotations related to this gene include GTPase activity and signal transducer activity. An important paralog of this gene is GNG5.

UniProtKB/Swiss-Prot for GNG10 Gene

  • Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Interacts with beta-1 and beta-2, but not with beta-3.

Tocris Summary for GNG10 Gene

  • Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand binding causes a receptor conformational change, detaching the G protein and switching it 'on'.

Additional gene information for GNG10 Gene

No data available for Entrez Gene Summary , CIViC summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GNG10 Gene

Genomics for GNG10 Gene

GeneHancer (GH) Regulatory Elements for GNG10 Gene

Promoters and enhancers for GNG10 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09I111660 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 574.9 +1.1 1065 2.8 SIN3A ZNF48 GLIS2 SP3 GMEB1 SMARCA4 GLIS1 KDM1A SP7 ZNF146 GNG10 GC09P111683 DNAJC25-GNG10
GH09I111597 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 16.1 -62.3 -62250 2.6 SIN3A YY1 GLIS2 ZNF143 RXRA REST SMARCB1 NFIL3 GLIS1 MXD3 PTGR1 GNG10 LRRC37A5P ZNF483 ENSG00000224644
GH09I111804 Enhancer 0.9 Ensembl ENCODE 24.6 +144.8 144775 3.1 MEIS2 JUN FOSL1 GATA3 POLR2A FOSL2 PRDM10 FOS RFX1 ZBED1 GNG10 C9orf84 RNU6-1013P ENSG00000224067 GC09P111818
GH09I111727 Enhancer 0.8 ENCODE 26.3 +67.3 67274 2.6 FOXA2 NEUROD1 SIN3A FOS DEK JUNB CEBPB REST SP1 ZNF217 GNG10 C9orf84 GC09P111683
GH09I111895 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 6.9 +239.0 239014 10.5 HDGF PKNOX1 CLOCK SMAD1 ARNT ARID4B SIN3A DMAP1 YBX1 ZNF2 UGCG RNU6-1013P GNG10 ENSG00000224067 C9orf84 PTGR1 MIR4668
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around GNG10 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GNG10 gene promoter:

Genomic Locations for GNG10 Gene

Genomic Locations for GNG10 Gene
chr9:111,661,335-111,670,246
(GRCh38/hg38)
Size:
8,912 bases
Orientation:
Plus strand
chr9:114,423,615-114,432,526
(GRCh37/hg19)

Genomic View for GNG10 Gene

Genes around GNG10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GNG10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GNG10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GNG10 Gene

Proteins for GNG10 Gene

  • Protein details for GNG10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P50151-GBG10_HUMAN
    Recommended name:
    Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10
    Protein Accession:
    P50151
    Secondary Accessions:
    • Q3B7K2
    • Q4VC27

    Protein attributes for GNG10 Gene

    Size:
    68 amino acids
    Molecular mass:
    7205 Da
    Quaternary structure:
    • G proteins are composed of 3 units, alpha, beta and gamma.

neXtProt entry for GNG10 Gene

Post-translational modifications for GNG10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GNG10 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GNG10 Gene

Domains & Families for GNG10 Gene

Gene Families for GNG10 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for GNG10 Gene

Suggested Antigen Peptide Sequences for GNG10 Gene

Graphical View of Domain Structure for InterPro Entry

P50151

UniProtKB/Swiss-Prot:

GBG10_HUMAN :
  • Belongs to the G protein gamma family.
Family:
  • Belongs to the G protein gamma family.
genes like me logo Genes that share domains with GNG10: view

Function for GNG10 Gene

Molecular function for GNG10 Gene

UniProtKB/Swiss-Prot Function:
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Interacts with beta-1 and beta-2, but not with beta-3.

Phenotypes From GWAS Catalog for GNG10 Gene

Gene Ontology (GO) - Molecular Function for GNG10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity TAS 7665596
GO:0004871 signal transducer activity IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with GNG10: view

Phenotypes for GNG10 Gene

GenomeRNAi human phenotypes for GNG10:
genes like me logo Genes that share phenotypes with GNG10: view

Animal Model Products

CRISPR Products

miRNA for GNG10 Gene

miRTarBase miRNAs that target GNG10

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for GNG10

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GNG10 Gene

Localization for GNG10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GNG10 Gene

Cell membrane; Lipid-anchor; Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GNG10 gene
Compartment Confidence
extracellular 5
plasma membrane 4
cytosol 3

Gene Ontology (GO) - Cellular Components for GNG10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005834 heterotrimeric G-protein complex IEA --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0070062 extracellular exosome HDA,IDA 23376485
genes like me logo Genes that share ontologies with GNG10: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GNG10 Gene

Pathways & Interactions for GNG10 Gene

SuperPathways for GNG10 Gene

genes like me logo Genes that share pathways with GNG10: view

Gene Ontology (GO) - Biological Process for GNG10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 7665596
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0071377 cellular response to glucagon stimulus TAS --
genes like me logo Genes that share ontologies with GNG10: view

No data available for SIGNOR curated interactions for GNG10 Gene

Drugs & Compounds for GNG10 Gene

(3) Drugs for GNG10 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0
Guanosine monophosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0

(5) Additional Compounds for GNG10 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
G-Protein antagonist peptide
143675-79-0

(5) Tocris Compounds for GNG10 Gene

Compound Action Cas Number
[D-Trp7,9,10]-Substance P Inhibits M1 ACh receptor activation of Gq/11 89430-38-6
G-Protein antagonist peptide Inhibits G protein activation by GPCRs 143675-79-0
Gue 1654 Selective inhibitor of OXE-R Gbetagamma signaling 397290-30-1
Mastoparan Activates Gi and Go 72093-21-1
SCH 202676 hydrobromide Inhibitor of ligand binding to G-protein-coupled receptors 265980-25-4
genes like me logo Genes that share compounds with GNG10: view

Transcripts for GNG10 Gene

mRNA/cDNA for GNG10 Gene

Unigene Clusters for GNG10 Gene

Guanine nucleotide binding protein (G protein), gamma 10:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for GNG10

Alternative Splicing Database (ASD) splice patterns (SP) for GNG10 Gene

No ASD Table

Relevant External Links for GNG10 Gene

GeneLoc Exon Structure for
GNG10
ECgene alternative splicing isoforms for
GNG10

Expression for GNG10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GNG10 Gene

mRNA differential expression in normal tissues according to GTEx for GNG10 Gene

This gene is overexpressed in Whole Blood (x5.6).

Protein differential expression in normal tissues from HIPED for GNG10 Gene

This gene is overexpressed in Pancreas (19.3), Spleen (13.6), and Frontal cortex (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GNG10 Gene



NURSA nuclear receptor signaling pathways regulating expression of GNG10 Gene:

GNG10

SOURCE GeneReport for Unigene cluster for GNG10 Gene:

Hs.534196

mRNA Expression by UniProt/SwissProt for GNG10 Gene:

P50151-GBG10_HUMAN
Tissue specificity: Abundantly and ubiquitously expressed.

Evidence on tissue expression from TISSUES for GNG10 Gene

  • Nervous system(4.9)
  • Lung(4.6)
  • Pancreas(2.9)
  • Kidney(2.2)
genes like me logo Genes that share expression patterns with GNG10: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for GNG10 Gene

Orthologs for GNG10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GNG10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GNG10 34
  • 100 (a)
OneToOne
LOC100611518 33
  • 99.49 (n)
dog
(Canis familiaris)
Mammalia GNG10 33 34
  • 92.65 (n)
rat
(Rattus norvegicus)
Mammalia Gng10 33
  • 90.69 (n)
oppossum
(Monodelphis domestica)
Mammalia GNG10 34
  • 90 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GNG10 33 34
  • 89.71 (n)
mouse
(Mus musculus)
Mammalia Gng10 33 16 34
  • 89.71 (n)
chicken
(Gallus gallus)
Aves GNG10 33 34
  • 81.86 (n)
lizard
(Anolis carolinensis)
Reptilia GNG10 34
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gng10 33
  • 76.96 (n)
Str.17134 33
African clawed frog
(Xenopus laevis)
Amphibia MGC68728 33
zebrafish
(Danio rerio)
Actinopterygii gng10 33
  • 71.08 (n)
si:ch211-286b5.5 34
  • 47 (a)
ManyToMany
Dr.16706 33
Species where no ortholog for GNG10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GNG10 Gene

ENSEMBL:
Gene Tree for GNG10 (if available)
TreeFam:
Gene Tree for GNG10 (if available)

Paralogs for GNG10 Gene

Paralogs for GNG10 Gene

(10) SIMAP similar genes for GNG10 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for GNG10 Gene

genes like me logo Genes that share paralogs with GNG10: view

Variants for GNG10 Gene

Sequence variations from dbSNP and Humsavar for GNG10 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1000298525 -- 111,664,316(+) AGAGAG/AGAG intron_variant
rs1000510852 -- 111,665,696(+) T/C intron_variant
rs1000516030 -- 111,668,481(+) C/T intron_variant
rs1000564181 -- 111,664,053(+) T/A intron_variant
rs1000712983 -- 111,660,998(+) A/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for GNG10 Gene

Variant ID Type Subtype PubMed ID
dgv7700n100 CNV gain 25217958
nsv466486 CNV gain 19166990
nsv615193 CNV gain 21841781
nsv825041 CNV gain 20364138

Variation tolerance for GNG10 Gene

Residual Variation Intolerance Score: 55.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.97; 36.46% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GNG10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GNG10

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GNG10 Gene

Disorders for GNG10 Gene

Additional Disease Information for GNG10

No disorders were found for GNG10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GNG10 Gene

Publications for GNG10 Gene

  1. Isolation of cDNA clones encoding eight different human G protein gamma subunits, including three novel forms designated the gamma 4, gamma 10, and gamma 11 subunits. (PMID: 7665596) Ray K … Robishaw JD (The Journal of biological chemistry 1995) 2 3 4 58
  2. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray SJ … Dunham I (Nature 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58

Products for GNG10 Gene

  • Addgene plasmids for GNG10

Sources for GNG10 Gene

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