Aliases for GNG10 Gene
External Ids for GNG10 Gene
Previous GeneCards Identifiers for GNG10 Gene
GeneCards Summary for GNG10 Gene
GNG10 (G Protein Subunit Gamma 10) is a Protein Coding gene. Diseases associated with GNG10 include Good Syndrome and Lymph Node Cancer. Among its related pathways are Signaling by GPCR and ADP signalling through P2Y purinoceptor 1. Gene Ontology (GO) annotations related to this gene include GTPase activity and obsolete signal transducer activity. An important paralog of this gene is GNG5.
UniProtKB/Swiss-Prot Summary for GNG10 Gene
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Interacts with beta-1 and beta-2, but not with beta-3.
Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand binding causes a receptor conformational change, detaching the G protein and switching it 'on'.