Aliases for GNB4 Gene
External Ids for GNB4 Gene
Previous GeneCards Identifiers for GNB4 Gene
Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. [provided by RefSeq, Jul 2008]
GeneCards Summary for GNB4 Gene
GNB4 (G Protein Subunit Beta 4) is a Protein Coding gene. Diseases associated with GNB4 include Charcot-Marie-Tooth Disease, Dominant Intermediate F and Charcot-Marie-Tooth Disease. Among its related pathways are Signaling by GPCR and CCR5 Pathway in Macrophages. Gene Ontology (GO) annotations related to this gene include obsolete signal transducer activity. An important paralog of this gene is GNB1.
UniProtKB/Swiss-Prot Summary for GNB4 Gene
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand binding causes a receptor conformational change, detaching the G protein and switching it 'on'.