Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction rece... See more...

Aliases for GNB1 Gene

Aliases for GNB1 Gene

  • G Protein Subunit Beta 1 2 3 5
  • Guanine Nucleotide-Binding Protein G(I)/G(S)/G(T) Subunit Beta-1 2 3 4
  • Transducin Beta Chain 1 2 3 4
  • Guanine Nucleotide Binding Protein (G Protein), Beta Polypeptide 1 2 3
  • Beta Subunit, Signal-Transducing Proteins GS/GI 3
  • Testicular Tissue Protein Li 72 3
  • MRD42 3
  • GNB1 5

External Ids for GNB1 Gene

Previous GeneCards Identifiers for GNB1 Gene

  • GC01M001274
  • GC01M001521
  • GC01M001585
  • GC01M001665
  • GC01M001748
  • GC01M000993

Summaries for GNB1 Gene

Entrez Gene Summary for GNB1 Gene

  • Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

GeneCards Summary for GNB1 Gene

GNB1 (G Protein Subunit Beta 1) is a Protein Coding gene. Diseases associated with GNB1 include Mental Retardation, Autosomal Dominant 42 and Hypotonia. Among its related pathways are Translation Translation regulation by Alpha-1 adrenergic receptors and ADP signalling through P2Y purinoceptor 12. Gene Ontology (GO) annotations related to this gene include GTPase activity. An important paralog of this gene is GNB4.

UniProtKB/Swiss-Prot Summary for GNB1 Gene

  • Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

Tocris Summary for GNB1 Gene

  • Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand binding causes a receptor conformational change, detaching the G protein and switching it 'on'.

Gene Wiki entry for GNB1 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GNB1 Gene

Genomics for GNB1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for GNB1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GNB1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GNB1

Top Transcription factor binding sites by QIAGEN in the GNB1 gene promoter:
  • AP-1
  • ATF-2
  • c-Jun
  • Sp1

Genomic Locations for GNB1 Gene

Genomic Locations for GNB1 Gene
chr1:1,785,285-1,891,117
(GRCh38/hg38)
Size:
105,833 bases
Orientation:
Minus strand
chr1:1,716,725-1,822,526
(GRCh37/hg19)
Size:
105,802 bases
Orientation:
Minus strand

Genomic View for GNB1 Gene

Genes around GNB1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GNB1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GNB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GNB1 Gene

Proteins for GNB1 Gene

  • Protein details for GNB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62873-GBB1_HUMAN
    Recommended name:
    Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
    Protein Accession:
    P62873
    Secondary Accessions:
    • B1AJZ7
    • P04697
    • P04901
    • Q1RMY8

    Protein attributes for GNB1 Gene

    Size:
    340 amino acids
    Molecular mass:
    37377 Da
    Quaternary structure:
    • G proteins are composed of 3 units, alpha, beta and gamma. Interacts with ARHGEF18 and RASD2 (PubMed:14512443, PubMed:19255495). The heterodimer formed by GNB1 and GNG2 interacts with ARHGEF5 (PubMed:19713215).

    Three dimensional structures from OCA and Proteopedia for GNB1 Gene

    Alternative splice isoforms for GNB1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GNB1 Gene

Post-translational modifications for GNB1 Gene

  • Phosphorylation at His-266 by NDKB contributes to G protein activation by increasing the high energetic phosphate transfer onto GDP.
  • Ubiquitination at Lys15, Lys23, Lys209, Lys280, and Lys301
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for GNB1 Gene

Domains & Families for GNB1 Gene

Gene Families for GNB1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Plasma proteins
  • Potential drug targets
  • Predicted intracellular proteins
  • Transporters

Suggested Antigen Peptide Sequences for GNB1 Gene

GenScript: Design optimal peptide antigens:
  • Transducin beta chain 1 (GBB1_HUMAN)
  • GNB1 protein (Q1RMY8_HUMAN)
  • Guanine nucleotide binding protein (G protein), beta polypeptide 1 (Q5QPT1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P62873

UniProtKB/Swiss-Prot:

GBB1_HUMAN :
  • Belongs to the WD repeat G protein beta family.
Family:
  • Belongs to the WD repeat G protein beta family.
genes like me logo Genes that share domains with GNB1: view

Function for GNB1 Gene

Molecular function for GNB1 Gene

UniProtKB/Swiss-Prot Function:
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
GENATLAS Biochemistry:
guanine nucleotide binding protein (G protein),beta,polypeptide 1

Phenotypes From GWAS Catalog for GNB1 Gene

Gene Ontology (GO) - Molecular Function for GNB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IDA 1543505
GO:0005515 protein binding IEA,IPI 16782902
GO:0030507 spectrin binding IEA --
GO:0031682 G-protein gamma-subunit binding IBA 21873635
GO:0044877 protein-containing complex binding IDA 23209302
genes like me logo Genes that share ontologies with GNB1: view
genes like me logo Genes that share phenotypes with GNB1: view

Human Phenotype Ontology for GNB1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GNB1

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for GNB1 Gene

Localization for GNB1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GNB1 gene
Compartment Confidence
plasma membrane 5
cytosol 5
extracellular 4
lysosome 4
nucleus 2
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GNB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001750 photoreceptor outer segment IEA --
GO:0001917 photoreceptor inner segment IEA --
GO:0005623 cell IEA --
GO:0005737 cytoplasm IBA 21873635
GO:0005765 lysosomal membrane HDA 17897319
genes like me logo Genes that share ontologies with GNB1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for GNB1 Gene

Pathways & Interactions for GNB1 Gene

PathCards logo

SuperPathways for GNB1 Gene

SuperPathway Contained pathways
1 Development Angiotensin activation of ERK
.73
.73
.68
.65
.54
.48
.45
.40
2 ADP signalling through P2Y purinoceptor 12
.43
3 fMLP Pathway
.44
.44
.43
.42
.39
.38
.31
4 G-Beta Gamma Signaling
.46
.46
.44
.37
.32
.30
5 Presynaptic function of Kainate receptors
.37
genes like me logo Genes that share pathways with GNB1: view

Pathways by source for GNB1 Gene

34 GeneGo (Thomson Reuters) pathways for GNB1 Gene
  • Apoptosis and survival BAD phosphorylation
  • Cell adhesion Integrin inside-out signaling
  • Chemotaxis CXCR4 signaling pathway
  • Cytoskeleton remodeling Reverse signaling by ephrin B
  • Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation
71 Qiagen pathways for GNB1 Gene
  • Actin Nucleation and Branching
  • Actin Nucleation by ARP-WASP Complex
  • Actin-Based Motility by Rho Family GTPases
  • Activation of cAMP-Dependent PKA
  • Activation of PKA through GPCR

SIGNOR curated interactions for GNB1 Gene

Activates:
Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for GNB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding TAS --
GO:0007165 signal transduction IEA,TAS 7649993
GO:0007186 G protein-coupled receptor signaling pathway TAS --
GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway ISS --
GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with GNB1: view

Drugs & Compounds for GNB1 Gene

(3) Drugs for GNB1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0
Guanosine monophosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0

(5) Additional Compounds for GNB1 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
[D-Trp7,9,10]-Substance P
89430-38-6
G-Protein antagonist peptide
143675-79-0
Gue 1654
397290-30-1
mastoparan
72093-21-1
SCH 202676 hydrobromide
265980-25-4

(5) Tocris Compounds for GNB1 Gene

Compound Action Cas Number
[D-Trp7,9,10]-Substance P Inhibits M1 ACh receptor activation of Gq/11 89430-38-6
G-Protein antagonist peptide Inhibits G protein activation by GPCRs 143675-79-0
Gue 1654 Selective inhibitor of OXE-R Gbetagamma signaling 397290-30-1
Mastoparan Activates Gi and Go 72093-21-1
SCH 202676 hydrobromide Inhibitor of ligand binding to G-protein-coupled receptors 265980-25-4
genes like me logo Genes that share compounds with GNB1: view

Transcripts for GNB1 Gene

mRNA/cDNA for GNB1 Gene

3 REFSEQ mRNAs :
21 NCBI additional mRNA sequence :
10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GNB1

Alternative Splicing Database (ASD) splice patterns (SP) for GNB1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b
SP1: - - -
SP2: - - - -
SP3: - - -
SP4: - -
SP5:
SP6:
SP7: - -

Relevant External Links for GNB1 Gene

GeneLoc Exon Structure for
GNB1

Expression for GNB1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GNB1 Gene

Protein differential expression in normal tissues from HIPED for GNB1 Gene

This gene is overexpressed in Retina (12.0), Frontal cortex (8.1), and Fetal Brain (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GNB1 Gene



Protein tissue co-expression partners for GNB1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GNB1

SOURCE GeneReport for Unigene cluster for GNB1 Gene:

Hs.430425

Evidence on tissue expression from TISSUES for GNB1 Gene

  • Nervous system(5)
  • Liver(4.5)
  • Muscle(4.5)
  • Lung(4.2)
  • Eye(4)
  • Skin(3.6)
  • Pancreas(2.8)
  • Heart(2.7)
  • Blood(2.6)
  • Kidney(2.6)
  • Spleen(2.5)
  • Lymph node(2.5)
  • Intestine(2.4)
  • Bone marrow(2.4)
  • Thyroid gland(2.3)
  • Adrenal gland(2.3)
  • Stomach(2.2)
genes like me logo Genes that share expression patterns with GNB1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GNB1 Gene

Orthologs for GNB1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GNB1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia GNB1 30
  • 99.67 (n)
Oppossum
(Monodelphis domestica)
Mammalia GNB1 31
  • 99 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia GNB1 31
  • 99 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia GNB1 30 31
  • 91.67 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia GNB1 30 31
  • 90.88 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Gnb1 30
  • 90.49 (n)
Mouse
(Mus musculus)
Mammalia Gnb1 30 17 31
  • 90.2 (n)
OneToOne
Chicken
(Gallus gallus)
Aves GNB1 30 31
  • 82.55 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia GNB1 31
  • 82 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia gnb1 30
  • 81.18 (n)
Str.17087 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.4840 30
Zebrafish
(Danio rerio)
Actinopterygii gnb1b 31 31
  • 98 (a)
OneToMany
gnb1a 30 31
  • 83.63 (n)
OneToMany
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3545 30
Fruit Fly
(Drosophila melanogaster)
Insecta G&bgr;13F 32
  • 83 (a)
Gbeta13F 30 31
  • 70.39 (n)
OneToMany
G&bgr;76C 32
  • 43 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005911 30
  • 73.24 (n)
Worm
(Caenorhabditis elegans)
Secernentea gpb-1 30 31 32
  • 70.2 (n)
OneToMany
Thale Cress
(Arabidopsis thaliana)
eudicotyledons AGB1 30
  • 51.38 (n)
Rice
(Oryza sativa)
Liliopsida Os03g0669200 30
  • 53.86 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.10536 31
  • 78 (a)
OneToMany
Bread mold
(Neurospora crassa)
Ascomycetes NCU00440 30
  • 62.72 (n)
Species where no ortholog for GNB1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for GNB1 Gene

ENSEMBL:
Gene Tree for GNB1 (if available)
TreeFam:
Gene Tree for GNB1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GNB1: view image

Paralogs for GNB1 Gene

Paralogs for GNB1 Gene

(7) SIMAP similar genes for GNB1 Gene using alignment to 6 proteins:

  • GBB1_HUMAN
  • B1AKQ8_HUMAN
  • F6UT28_HUMAN
  • F6X3N5_HUMAN
  • L8E8V9_HUMAN
  • Q1RMY8_HUMAN
genes like me logo Genes that share paralogs with GNB1: view

Variants for GNB1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GNB1 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
638348 Uncertain Significance: Mental retardation, autosomal dominant 42 1,825,420(-) C/T MISSENSE_VARIANT,FIVE_PRIME_UTR_VARIANT
711748 Likely Benign: not provided 1,789,249(-) T/C SYNONYMOUS_VARIANT
730077 Benign: not provided 1,815,818(-) C/T SYNONYMOUS_VARIANT,INTRON_VARIANT
731032 Likely Benign: not provided 1,789,228(-) G/A SYNONYMOUS_VARIANT
739491 Likely Benign: not provided 1,804,587(-) G/GA INTRON_VARIANT

Additional dbSNP identifiers (rs#s) for GNB1 Gene

Structural Variations from Database of Genomic Variants (DGV) for GNB1 Gene

Variant ID Type Subtype PubMed ID
dgv10n100 CNV gain 25217958
dgv5n111 CNV deletion 26073780
esv2619193 CNV deletion 19546169
esv2658596 CNV deletion 23128226
esv2666680 CNV deletion 23128226
esv2758913 CNV gain+loss 17122850
esv3556343 CNV deletion 23714750
esv3577695 CNV loss 25503493
esv3577696 CNV loss 25503493
esv3585018 CNV loss 21293372
nsv10272 CNV gain 18304495
nsv1075000 CNV deletion 25765185
nsv1113059 CNV deletion 24896259
nsv1118095 CNV deletion 24896259
nsv1121741 CNV deletion 24896259
nsv1133790 CNV deletion 24896259
nsv1160797 CNV duplication 26073780
nsv1160926 CNV duplication 26073780
nsv478764 CNV novel sequence insertion 20440878
nsv482937 CNV loss 15286789
nsv834091 CNV loss 17160897
nsv834335 CNV loss 17160897
nsv951380 CNV deletion 24416366
nsv951400 CNV deletion 24416366

Variation tolerance for GNB1 Gene

Residual Variation Intolerance Score: 26.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.02; 0.37% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GNB1 Gene

Human Gene Mutation Database (HGMD)
GNB1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
GNB1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GNB1 Gene

Disorders for GNB1 Gene

MalaCards: The human disease database

(24) MalaCards diseases for GNB1 Gene - From: UniProtKB/Swiss-Prot, OMIM, ClinVar, GTR, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
mental retardation, autosomal dominant 42
  • mrd42
hypotonia
cerebral visual impairment
  • cortical visual impairment
rare hypothyroidism
strabismus
  • strabismus, susceptibility to
- elite association - COSMIC cancer census association via MalaCards
Search GNB1 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

GBB1_HUMAN
  • Mental retardation, autosomal dominant 42 (MRD42) [MIM:616973]: A form of mental retardation, a disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRD42 patients manifest global developmental delay commonly accompanied by hypotonia, seizures of various types, ophthalmological manifestations, and poor growth. {ECO:0000269 PubMed:25485910, ECO:0000269 PubMed:27108799, ECO:0000269 PubMed:27668284, ECO:0000269 PubMed:28087732}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for GNB1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with GNB1: view

No data available for Genatlas for GNB1 Gene

Publications for GNB1 Gene

  1. A screen for mutations in the transducin gene GNB1 in patients with autosomal dominant retinitis pigmentosa. (PMID: 17167406) Mylvaganam GH … Dryja TP (Molecular vision 2006) 3 23 41
  2. Novel GNB1 mutations disrupt assembly and function of G protein heterotrimers and cause global developmental delay in humans. (PMID: 28087732) Lohmann K … Martemyanov KA (Human molecular genetics 2017) 3 4
  3. Germline De Novo Mutations in GNB1 Cause Severe Neurodevelopmental Disability, Hypotonia, and Seizures. (PMID: 27108799) Petrovski S … Goldstein DB (American journal of human genetics 2016) 3 4
  4. Mutations in G protein β subunits promote transformation and kinase inhibitor resistance. (PMID: 25485910) Yoda A … Lane AA (Nature medicine 2015) 3 4
  5. The cationic region of Rhes mediates its interactions with specific Gbeta subunits. (PMID: 19255495) Hill C … Davey J (Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2009) 3 4

Products for GNB1 Gene

  • Signalway Proteins for GNB1

Sources for GNB1 Gene