Aliases for GNB1 Gene
- G Protein Subunit Beta 1 2 3 5
- Guanine Nucleotide-Binding Protein G(I)/G(S)/G(T) Subunit Beta-1 2 3 4
- Transducin Beta Chain 1 2 3 4
- Guanine Nucleotide Binding Protein (G Protein), Beta Polypeptide 1 2 3
- Beta Subunit, Signal-Transducing Proteins GS/GI 3
- Testicular Tissue Protein Li 72 3
- MRD42 3
- GNB1 5
- MDS 3
External Ids for GNB1 Gene
Previous GeneCards Identifiers for GNB1 Gene
Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
GeneCards Summary for GNB1 Gene
GNB1 (G Protein Subunit Beta 1) is a Protein Coding gene. Diseases associated with GNB1 include Mental Retardation, Autosomal Dominant 42 and Myelodysplastic Syndrome. Among its related pathways are Apelin signaling pathway and G-Beta Gamma Signaling. Gene Ontology (GO) annotations related to this gene include GTPase activity. An important paralog of this gene is GNB2.
UniProtKB/Swiss-Prot Summary for GNB1 Gene
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand binding causes a receptor conformational change, detaching the G protein and switching it 'on'.