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Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling pathways. G proteins are composed of 3 units: alpha, beta and gamma. This gene encodes an alpha subunit and belongs to the G-alpha family. Mutation in this gene, resulting in a gly40-to-arg substitution, is associated with auriculocondylar syndrome, and ... See more...
Aliases for GNAI3 Gene
Aliases for GNAI3 Gene
External Ids for GNAI3 Gene
- HGNC: 4387
- Entrez Gene: 2773
- Ensembl: ENSG00000065135
- OMIM: 139370
- UniProtKB: P08754
Previous GeneCards Identifiers for GNAI3 Gene
- GC01P110570
- GC01P109020
- GC01P109193
- GC01P109390
- GC01P109803
- GC01P110091
- GC01P107983
Summaries for GNAI3 Gene
-
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling pathways. G proteins are composed of 3 units: alpha, beta and gamma. This gene encodes an alpha subunit and belongs to the G-alpha family. Mutation in this gene, resulting in a gly40-to-arg substitution, is associated with auriculocondylar syndrome, and shown to affect downstream targets in the G protein-coupled endothelin receptor pathway. [provided by RefSeq, Jun 2012]
GeneCards Summary for GNAI3 Gene
GNAI3 (G Protein Subunit Alpha I3) is a Protein Coding gene. Diseases associated with GNAI3 include Auriculocondylar Syndrome 1 and Auriculo-Condylar Syndrome. Among its related pathways are Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics and DAG and IP3 signaling. Gene Ontology (GO) annotations related to this gene include GTP binding and obsolete signal transducer activity. An important paralog of this gene is GNAI1.
UniProtKB/Swiss-Prot Summary for GNAI3 Gene
-
Heterotrimeric guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins (PubMed:8774883, PubMed:18434541, PubMed:19478087). Signaling is mediated via effector proteins, such as adenylate cyclase. Inhibits adenylate cyclase activity, leading to decreased intracellular cAMP levels (PubMed:19478087). Stimulates the activity of receptor-regulated K(+) channels (PubMed:2535845). The active GTP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division (PubMed:17635935).
-
Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand binding causes a receptor conformational change, detaching the G protein and switching it 'on'.
Additional gene information for GNAI3 Gene
- HGNC(4387)
- Entrez Gene(2773)
- Ensembl(ENSG00000065135)
- OMIM(139370)
- UniProtKB(P08754)
- Open Targets Platform(ENSG00000065135)
- Monarch Initiative
- Search for GNAI3 at DataMed
- Search for GNAI3 at HumanCyc
No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GNAI3 Gene
Genomics for GNAI3 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for GNAI3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around GNAI3 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GNAI3
- Top Transcription factor binding sites by QIAGEN in the GNAI3 gene promoter:
-
- AP-2alpha
- AP-2alphaA
- AP-2beta
- AP-2gamma
- ATF6
- ER-alpha
- HEN1
- Ik-2
- Pax-4a
- SRY
Genomic Locations for GNAI3 Gene
Genomic Locations for GNAI3 Gene
- chr1:109,548,615-109,600,195
- (GRCh38/hg38)
- Size:
- 51,581 bases
- Orientation:
- Plus strand
- chr1:110,091,186-110,138,452
- (GRCh37/hg19)
- Size:
- 47,267 bases
- Orientation:
- Plus strand
Genomic View for GNAI3 Gene
Genes around GNAI3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p13.3 by HGNC
- 1p13.3 by Entrez Gene
- 1p13.3 by Ensembl
GNAI3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for GNAI3 Gene
Proteins for GNAI3 Gene
-
Protein details for GNAI3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P08754-GNAI3_HUMAN
- Recommended name:
- Guanine nucleotide-binding protein G(i) subunit alpha
- Protein Accession:
- P08754
- P17539
- Q5TZX1
Protein attributes for GNAI3 Gene
- Size:
- 354 amino acids
- Molecular mass:
- 40532 Da
- Quaternary structure:
-
- Heterotrimeric G proteins are composed of 3 units; alpha, beta and gamma. The alpha subunit contains the guanine nucleotide binding site. GTP binding causes dissociation of the heterotrimer, liberating the individual subunits so that they can interact with downstream effector proteins. Forms a complex with CCDC88A/GIV and EGFR which leads to enhanced EGFR signaling and triggering of cell migration; ligand stimulation is required for recruitment of GNAI3 to the complex (PubMed:20462955). Interacts (inactive GDP-bound form) with CCDC88A/GIV (via GBA motif); the interaction leads to activation of GNAI3 (PubMed:19211784, PubMed:20462955). Interacts (inactive GDP-bound form) with CCDC88C/DAPLE (via GBA motif); the interaction leads to activation of GNAI3 (PubMed:26126266). Interacts (inactive GDP-bound form) with NUCB1 (via GBA motif) and NUCB2 (via GBA motif); the interaction leads to activation of GNAI3 (By similarity). Interacts (inactive GDP-bound form) with PLCD4 (via GBA motif); the interaction leads to activation of GNAI3 (PubMed:30194280). Interacts with INSR; the interaction is probably mediated by CCDC88A/GIV (PubMed:25187647). Interacts with GPSM1 (By similarity). Interacts (GDP-bound form) with GPSM2 (via GoLoco domains) (PubMed:22952234). Does not interact with RGS2 (PubMed:19478087). Interacts with RGS8 and RGS10; this strongly enhances the intrinsic GTPase activity (PubMed:8774883, PubMed:18434541). Interacts with RGS16; this strongly enhances the intrinsic GTPase activity (PubMed:19478087). Interacts with RGS12 (By similarity). Interacts (via active GTP- or inactive GDP-bound form) with RGS14 (By similarity).
Protein Expression for GNAI3 Gene
Post-translational modifications for GNAI3 Gene
- (Microbial infection) Deamidated at Gln-204 by Photorhabdus asymbiotica toxin PAU_02230, blocking GTP hydrolysis of heterotrimeric GNAQ or GNA11 and G-alphai (GNAI1, GNAI2 or GNAI3) proteins, thereby activating RhoA.
-
Ubiquitination at Lys92, Lys128, Lys192, and Lys349
- NX_P08754 (NX_P08754-1)
- Modification sites at PhosphoSitePlus
Other Protein References for GNAI3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- LifeSpan BioSciences GNAI3 Antibody
- G Biosciences Immunotag™ GNAI3 Antibody
-
Custom Antibody ServicesOriGene Antibodies for GNAI3
- Novus Biologicals Antibodies for GNAI3
-
Abcam antibodies for GNAI3
- Invitrogen Antibodies for GNAI3 (AFLGC-GNAI3)
- antibodies-online: Show 37 available GNAI3 Antibodies ranked by validation data
- Compare Top GNAI3 Antibodies
-
Recommended
- 23 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 2 IHC Antibodies (anti-mouse)
- 1 ICC Antibody (anti-mouse)
- 45 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 2 IHC Antibodies (anti-human)
- 1 ICC Antibody (anti-human)
- 22 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 2 IHC Antibodies (anti-rat)
- 1 ICC Antibody (anti-rat)
-
Santa Cruz Biotechnology (SCBT) Antibodies for GNAI3
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for GNAI3
- Origene Custom Protein Services for GNAI3
- ProSpec Recombinant Proteins for GNAI3
-
Abcam proteins for GNAI3
Assay Products
- antibodies-online: Show 4 available GNAI3 Elisa Kits ranked by validation data
- Compare Top GNAI3 Elisa Kits
-
Quality Products:
-
Signalway ELISA kits for GNAI3
No data available for DME Specific Peptides for GNAI3 Gene
Domains & Families for GNAI3 Gene
Gene Families for GNAI3 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Disease related genes
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for GNAI3 Gene
- InterPro:
- Blocks:
-
- Alpha G-protein (transducin) signature
- G-protein alpha subunit group I signature
- ProtoNet:
Suggested Antigen Peptide Sequences for GNAI3 Gene
- GenScript: Design optimal peptide antigens:
-
- G(i) alpha-3 (GNAI3_HUMAN)
- cDNA, FLJ92547, Homo sapiens guanine nucleotide binding protein (G protein), alphainhibiting activity polypeptide 3 (GNAI3), mRNA (Q5TZX1_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P08754- Family:
-
- Belongs to the G-alpha family. G(i/o/t/z) subfamily.
Function for GNAI3 Gene
Molecular function for GNAI3 Gene
- UniProtKB/Swiss-Prot Function:
- Heterotrimeric guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins (PubMed:8774883, PubMed:18434541, PubMed:19478087). Signaling is mediated via effector proteins, such as adenylate cyclase. Inhibits adenylate cyclase activity, leading to decreased intracellular cAMP levels (PubMed:19478087). Stimulates the activity of receptor-regulated K(+) channels (PubMed:2535845). The active GTP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division (PubMed:17635935).
- GENATLAS Biochemistry:
- guanine nucleotide binding protein (G protein),alpha inhibiting activity,polypeptide 3
Phenotypes From GWAS Catalog for GNAI3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | -- |
| GO:0001664 | G protein-coupled receptor binding | IBA | 21873635 |
| GO:0003924 | GTPase activity | TAS,IDA | 19478087 |
| GO:0005515 | protein binding | IPI | 18434541 |
| GO:0005525 | GTP binding | IEA | -- |
Phenotypes for GNAI3 Gene
- MGI mutant phenotypes for GNAI3:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for GNAI3:
-
- Increased vaccinia virus (VACV) infection
- no effect
- Decreased viability
- Resistant to vaccinia virus (VACV-A4L) infection
- Strongly decreased CFP-tsO45G cell surface transport
- Negative genetic interaction between MUS81-/- and MUS81+/+
- Increased nuclear migration speed
- Increased Sindbis virus (SINV) infection
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for GNAI3 - Select products 50% OFF >
- * GNAI3 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for GNAI3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for GNAI3
-
Santa Cruz Biotechnology (SCBT) CRISPR for GNAI3
miRNA for GNAI3 Gene
- miRTarBase miRNAs that target GNAI3
-
- hsa-miR-124-3p (MIRT002679)
- mmu-miR-451a (MIRT008393)
- hsa-miR-1-3p (MIRT023926)
- hsa-miR-181a-5p (MIRT025197)
- hsa-miR-431-5p (MIRT445888)
- hsa-miR-219b-5p (MIRT445889)
- hsa-miR-3691-3p (MIRT445890)
- hsa-miR-222-3p (MIRT731118)
- hsa-miR-103a-3p (MIRT735807)
- hsa-miR-107 (MIRT735843)
- hsa-miR-130a-5p (MIRT737297)
- hsa-miR-141-5p (MIRT737589)
- hsa-miR-23a-3p (MIRT739183)
- hsa-miR-23b-3p (MIRT739193)
- hsa-miR-23c (MIRT739203)
- hsa-miR-3065-3p (MIRT739704)
- hsa-miR-1273h-5p (MIRT762043)
- hsa-miR-1288-5p (MIRT762256)
- hsa-miR-149-3p (MIRT762790)
- hsa-miR-1827 (MIRT763049)
- hsa-miR-1910-3p (MIRT763288)
- hsa-miR-30b-3p (MIRT764581)
- hsa-miR-30c-1-3p (MIRT764658)
- hsa-miR-30c-2-3p (MIRT764703)
- hsa-miR-3122 (MIRT764807)
- hsa-miR-3689a-3p (MIRT766809)
- hsa-miR-3689b-3p (MIRT766897)
- hsa-miR-3689c (MIRT766985)
- hsa-miR-3913-5p (MIRT767611)
- hsa-miR-3929 (MIRT767771)
- hsa-miR-4419b (MIRT768767)
- hsa-miR-4478 (MIRT769518)
- hsa-miR-450a-1-3p (MIRT769845)
- hsa-miR-4514 (MIRT769904)
- hsa-miR-4649-3p (MIRT770630)
- hsa-miR-4692 (MIRT771110)
- hsa-miR-4728-5p (MIRT771705)
- hsa-miR-485-5p (MIRT772607)
- hsa-miR-6511a-5p (MIRT776786)
- hsa-miR-6513-5p (MIRT776997)
- hsa-miR-665 (MIRT777555)
- hsa-miR-6779-5p (MIRT778886)
- hsa-miR-6780a-5p (MIRT778977)
- hsa-miR-6785-5p (MIRT779115)
- hsa-miR-6788-5p (MIRT779235)
- hsa-miR-6798-5p (MIRT779375)
- hsa-miR-6799-5p (MIRT779412)
- hsa-miR-6808-5p (MIRT779667)
- hsa-miR-6883-5p (MIRT780911)
- hsa-miR-6884-5p (MIRT780995)
- hsa-miR-6893-5p (MIRT781200)
- hsa-miR-7106-5p (MIRT781342)
- hsa-miR-7160-5p (MIRT781603)
- hsa-miR-887-5p (MIRT782556)
- hsa-miR-940 (MIRT782894)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for GNAI3
- Browse OriGene Inhibitory RNA Products For GNAI3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GNAI3
Clone Products
- Applied Biological Materials (abm): Clones for GNAI3 - Select products 50% OFF >
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- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for GNAI3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for GNAI3
Cell Line Products
-
Horizon Cell Lines for GNAI3
No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for GNAI3 Gene
Localization for GNAI3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for GNAI3 Gene
- Cytoplasm. Cell membrane. Lipid-anchor. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localizes in the centrosomes of interphase and mitotic cells. Detected at the cleavage furrow and/or the midbody. {ECO:0000269 PubMed:17635935}.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| cytoskeleton | 5 |
| extracellular | 4 |
| lysosome | 4 |
| cytosol | 3 |
| golgi apparatus | 3 |
| mitochondrion | 1 |
| nucleus | 1 |
| endoplasmic reticulum | 1 |
| peroxisome | 0 |
- Centrosome (2)
- Nucleoli (2)
- Nucleoplasm (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000139 | colocalizes_with Golgi membrane | IDA | 12642577 |
| GO:0005737 | cytoplasm | IEA,IDA | 17635935 |
| GO:0005765 | lysosomal membrane | HDA | 17897319 |
| GO:0005789 | colocalizes_with endoplasmic reticulum membrane | IDA | 12642577 |
| GO:0005794 | Golgi apparatus | IEA | -- |
Pathways & Interactions for GNAI3 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | ADP signalling through P2Y purinoceptor 12 |
Signal transduction cAMP signaling
.43
|
|
| 2 | G-Beta Gamma Signaling |
G-Beta Gamma Signaling
.46
GHRH Signaling
.46
CRHR Pathway
.44
|
Relaxin Pathway
.37
Hedgehog Signaling in Mammals
.32
Signaling in Gap Junctions
.30
|
| 3 | S1P3 pathway |
.44
.44
.41
|
.36
.01
|
| 4 | DAG and IP3 signaling |
Inhibitory action of Lipoxin A4 on PDGF, EGF and LTD4 signaling
.33
|
|
| 5 | Development Angiotensin activation of ERK |
Development ACM2 and ACM4 activation of ERK
.73
Development Angiotensin activation of ERK
.73
Development G-Proteins mediated regulation MARK-ERK signaling
.65
|
Development EDNRB signaling
.54
Cell adhesion Integrin inside-out signaling
.45
|
Pathways by source for GNAI3 Gene
3 Sino Biological pathways for GNAI3 Gene
13 BioSystems pathways for GNAI3 Gene
26 Reactome pathways for GNAI3 Gene
40 KEGG pathways for GNAI3 Gene
25 GeneGo (Thomson Reuters) pathways for GNAI3 Gene
- Cell adhesion Ephrins signaling
- Cell adhesion Integrin inside-out signaling
- Chemotaxis CXCR4 signaling pathway
- Cytoskeleton remodeling Reverse signaling by ephrin B
- Development A1 receptor signaling
57 Qiagen pathways for GNAI3 Gene
- Actin Nucleation and Branching
- Actin Nucleation by ARP-WASP Complex
- Actin-Based Motility by Rho Family GTPases
- Activation of cAMP-Dependent PKA
- Activation of PKA through GPCR
Interacting Proteins for GNAI3 Gene
Selected Interacting proteins:
P08754-GNAI3_HUMAN
ENSP00000358867
for GNAI3 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for GNAI3
SIGNOR curated interactions for GNAI3 Gene
- Activates:
- Inactivates:
- Is activated by:
-
- GNRHR
- GPR119
- GPR132
- GPR17
- GPR183
- GPR34
- GPR35
- GPR84
- GRPR
- HCRTR1
- HCRTR2
- HRH1
- HRH2
- HRH3
- HRH4
- HTR1A
- HTR1B
- HTR1D
- HTR1E
- HTR1F
- HTR2A
- HTR2B
- HTR2C
- HTR4
- HTR7
- LPAR1
- LPAR2
- LPAR3
- LPAR4
- LPAR5
- LPAR6
- LTB4R2
- LTB4R
- MC3R
- MC4R
- MC5R
- MCHR1
- MCHR2
- MLNR
- MRGPRX1
- MRGPRX2
- MTNR1A
- MTNR1B
- NMBR
- NMUR2
- NPBWR1
- NPFFR1
- NPFFR2
- OPRD1
- OPRK1
- OPRL1
- OPRM1
- OXGR1
- OXTR
- P2RY10
- P2RY11
- P2RY12
- P2RY14
- P2RY4
- PRLHR
- PTAFR
- PTGER3
- S1PR1
- S1PR2
- S1PR3
- S1PR5
- SMO
- SSTR1
- SSTR2
- SSTR3
- SSTR4
- SSTR5
- TACR1
- TACR2
- TACR3
- UTS2R
- ADORA1
- ADORA2A
- ADORA2B
- ADORA3
- ADRA2A
- ADRA2B
- ADRA2C
- AGTR1
- APLNR
- AVPR1B
- BDKRB1
- BDKRB2
- CCKAR
- CCKBR
- CHRM1
- CHRM2
- CHRM3
- CHRM4
- CHRM5
- CNR1
- CNR2
- CYSLTR1
- CYSLTR2
- DRD1
- DRD2
- DRD3
- DRD4
- DRD5
- EDNRA
- EDNRB
- F2RL1
- F2RL2
- F2RL3
- F2R
- FFAR3
- FFAR4
- FPR1
- FPR2
- GALR1
- GALR2
- GALR3
- GHSR
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006457 | protein folding | TAS | -- |
| GO:0006906 | vesicle fusion | IEA | -- |
| GO:0007049 | cell cycle | IEA | -- |
| GO:0007165 | signal transduction | IEA | -- |
| GO:0007186 | G protein-coupled receptor signaling pathway | TAS | -- |
Drugs & Compounds for GNAI3 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| [D-Trp7,9,10]-Substance P |
|
89430-38-6 |
|
|
||
| G-Protein antagonist peptide |
|
143675-79-0 |
|
|
||
| Gue 1654 |
|
397290-30-1 |
|
|
||
| mastoparan |
|
72093-21-1 |
|
|
||
| SCH 202676 hydrobromide |
|
265980-25-4 |
|
|
(5) Tocris Compounds for GNAI3 Gene
| Compound | Action | Cas Number |
|---|---|---|
| [D-Trp7,9,10]-Substance P | Inhibits M1 ACh receptor activation of Gq/11 | 89430-38-6 |
| G-Protein antagonist peptide | Inhibits G protein activation by GPCRs | 143675-79-0 |
| Gue 1654 | Selective inhibitor of OXE-R Gbetagamma signaling | 397290-30-1 |
| Mastoparan | Activates Gi and Go | 72093-21-1 |
| SCH 202676 hydrobromide | Inhibitor of ligand binding to G-protein-coupled receptors | 265980-25-4 |
Transcripts for GNAI3 Gene
mRNA/cDNA for GNAI3 Gene
- 1 REFSEQ mRNAs :
- 19 NCBI additional mRNA sequence :
- 1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000369851 9044 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for GNAI3 - Select products 50% OFF >
- * GNAI3 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for GNAI3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for GNAI3
-
Santa Cruz Biotechnology (SCBT) CRISPR for GNAI3
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for GNAI3
- Browse OriGene Inhibitory RNA Products For GNAI3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GNAI3
Clone Products
- Applied Biological Materials (abm): Clones for GNAI3 - Select products 50% OFF >
- * GNAI3 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for GNAI3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for GNAI3
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10a | · | 10b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||||||||||||
| SP3: | - | ||||||||||||||||||||||||||||||
| SP4: |
Relevant External Links for GNAI3 Gene
- GeneLoc Exon Structure for
- GNAI3
Expression for GNAI3 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
-
Blood (Hematopoietic System)
- Granulocytes Peripheral Blood
- Hematopoietic Bone Marrow
-
Bone (Muscoskeletal System)
- Prechondrocytic Mesenchymal Cells Distal Rib
-
Cartilage (Muscoskeletal System)
- Prechondrocytic Mesenchymal Cells Distal Rib
-
Testis (Reproductive System)
- Leydig Cells Testis Interstitium
- Neural Tube (Nervous System)
- Intestine (Gastrointestinal Tract)
- Pancreas (Endocrine System)
-
Placenta (Extraembryonic Tissues)
-
Esophagus (Gastrointestinal Tract)
This gene is overexpressed in Fetal Brain (6.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GNAI3 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GNAI3
SOURCE GeneReport for Unigene cluster for GNAI3 Gene:
Hs.73799Evidence on tissue expression from TISSUES for GNAI3 Gene
- Nervous system(4.8)
- Liver(4.5)
- Kidney(4.2)
- Skin(3.8)
- Lung(3.6)
- Blood(3.1)
- Intestine(2.7)
- Spleen(2.6)
- Heart(2.3)
- Muscle(2.2)
- Stomach(2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for GNAI3 Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- digestive
- integumentary
- nervous
- respiratory
- skeletal muscle
- skeleton
Regions:
Head and neck:
- brain
- cheek
- chin
- ear
- epiglottis
- face
- head
- jaw
- larynx
- lip
- mandible
- maxilla
- mouth
- neck
- outer ear
- pharynx
- skull
- tongue
- tooth
- vocal cord
Thorax:
- lung
- trachea
General:
- skin
Primer Products
-
OriGene qPCR primer pairs for GNAI3
-
OriGene qPCR primer pairs and template standards for GNAI3
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for GNAI3 Gene
Orthologs for GNAI3 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | GNAI3 30 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | GNAI3 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | GNAI3 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | GNAI3 30 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | GNAI3 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Gnai3 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Gnai3 30 |
|
||
| Chicken (Gallus gallus) |
Aves | GNAI3 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | GNAI3 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | gnai3 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | gnai3 30 31 |
|
OneToOne | |
| Fruit Fly (Drosophila melanogaster) |
Insecta | G-ialpha65A 31 32 |
|
OneToMany | |
| G-oalpha47A 32 |
|
|
|||
| Galpha73B 32 |
|
|
|||
| Worm (Caenorhabditis elegans) |
Secernentea | goa-1 32 |
|
|
|
| gpa-4 32 |
|
|
|||
| gpa-7 32 |
|
|
|||
| gpa-3 32 |
|
|
|||
| odr-3 32 |
|
|
|||
| gpa-1 32 |
|
|
|||
| gpa-15 32 |
|
|
|||
| gpa-2 32 |
|
|
|||
| gpa-11 32 |
|
|
|||
| gpa-8 32 |
|
|
|||
| gpa-6 32 |
|
|
|||
| gpa-9 32 |
|
|
|||
| gpa-10 32 |
|
|
|||
| gpa-14 32 |
|
|
|||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.10341 31 |
|
OneToMany |
- Species where no ortholog for GNAI3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for GNAI3 Gene
- ENSEMBL:
- Gene Tree for GNAI3 (if available)
- TreeFam:
- Gene Tree for GNAI3 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for GNAI3: view image
Paralogs for GNAI3 Gene
Paralogs for GNAI3 Gene
(19) SIMAP similar genes for GNAI3 Gene using alignment to 2 proteins:
- GNAI3_HUMAN
- Q5TZX1_HUMAN
Variants for GNAI3 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GNAI3 Gene
| SNP ID | Clinical significance and condition | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 718422 | Benign: not provided | 109,592,155(+) | G/A | SYNONYMOUS_VARIANT | |
| 725932 | Likely Benign: not provided | 109,582,484(+) | C/T | MISSENSE_VARIANT | |
| 740509 | Likely Benign: not provided | 109,574,003(+) | G/A | MISSENSE_VARIANT | |
| rs1553223897 | Uncertain Significance: not specified | 109,573,758(+) | G/A | MISSENSE_VARIANT | |
| rs1553223899 | Uncertain Significance: Auriculocondylar syndrome 1 | 109,573,764(+) | T/C | MISSENSE_VARIANT |
Residual Variation Intolerance Score:
29.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.77;
16.32% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for GNAI3 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GNAI3 Gene
Disorders for GNAI3 Gene
(9) MalaCards diseases for GNAI3 Gene - From: UniProtKB/Swiss-Prot, OMIM, ClinVar, GTR, Orphanet, DISEASES, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| auriculocondylar syndrome 1 |
|
|
| auriculo-condylar syndrome |
|
|
| short-rib thoracic dysplasia 5 with or without polydactyly |
|
|
| ankylosis |
|
|
| ear malformation |
|
|
Search GNAI3 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
GNAI3_HUMAN- Auriculocondylar syndrome 1 (ARCND1) [MIM:602483]: An autosomal dominant craniofacial malformation syndrome characterized by variable mandibular anomalies, including mild to severe micrognathia, temporomandibular joint ankylosis, cleft palate, and a characteristic ear malformation that consists of separation of the lobule from the external ear, giving the appearance of a question mark (question-mark ear). Other frequently described features include prominent cheeks, cupped and posteriorly rotated ears, preauricular tags, and microstomia. {ECO:0000269 PubMed:22560091}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for GNAI3
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for Genatlas for GNAI3 Gene
Publications for GNAI3 Gene
- Molecular cloning of a new human G protein. Evidence for two Gi alpha-like protein families. (PMID: 3109953) Didsbury JR … Snyderman R (FEBS letters 1987) 2 3 4
- A biochemical and genetic discovery pipeline identifies PLCδ4b as a nonreceptor activator of heterotrimeric G-proteins. (PMID: 30194280) Maziarz M … Garcia-Marcos M (The Journal of biological chemistry 2018) 3 4
- Membrane Recruitment of the Non-receptor Protein GIV/Girdin (Gα-interacting, Vesicle-associated Protein/Girdin) Is Sufficient for Activating Heterotrimeric G Protein Signaling. (PMID: 27864364) Parag-Sharma K … Garcia-Marcos M (The Journal of biological chemistry 2016) 3 4
- Daple is a novel non-receptor GEF required for trimeric G protein activation in Wnt signaling. (PMID: 26126266) Aznar N … Ghosh P (eLife 2015) 3 4
- Structural basis for activation of trimeric Gi proteins by multiple growth factor receptors via GIV/Girdin. (PMID: 25187647) Lin C … Ghosh P (Molecular biology of the cell 2014) 3 4
ExternalLinks
Products for GNAI3 Gene
- Custom Antibody ServicesOriGene Antibodies for GNAI3
- Browse OriGene ELISA Kits
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- Browse OriGene Inhibitory RNA Products For GNAI3
- OriGene qPCR primer pairs for GNAI3
- OriGene qPCR primer pairs and template standards for GNAI3
- OriGene CRISPR knockouts for GNAI3
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For GNAI3
- Sino Biological Human cDNA Clone for GNAI3
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- Novus Biologicals proteins and lysates for GNAI3
- Browse Antibodies
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- Abcam antibodies for GNAI3
- Abcam proteins for GNAI3
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- VectorBuilder Custom and pre-made DNA vectors for GNAI3 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for GNAI3 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for GNAI3 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for GNAI3 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for GNAI3
- antibodies-online: Show 37 available GNAI3 Antibodies ranked by validation data
- Compare Top GNAI3 Antibodies
- Recommended
- 23 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 2 IHC Antibodies (anti-mouse)
- 1 ICC Antibody (anti-mouse)
- 45 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 2 IHC Antibodies (anti-human)
- 1 ICC Antibody (anti-human)
- 22 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 2 IHC Antibodies (anti-rat)
- 1 ICC Antibody (anti-rat)
- antibodies-online: Show 4 available GNAI3 Elisa Kits ranked by validation data
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- Quality Products:
- antibodies-online: Show 10 available GNAI3 Proteins ranked by validation data
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- Santa Cruz Biotechnology (SCBT) Antibodies for GNAI3
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- Santa Cruz Biotechnology (SCBT) CRISPR for GNAI3
- Horizon Cell Lines for GNAI3
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for GNAI3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for GNAI3
- Search GeneCopoeia for miRNA 3'UTR Target clone products for GNAI3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GNAI3
Sources for GNAI3 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
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- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
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- (83) Illumina
- (84) COMPARTMENTS
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- (98) ProteomicsDB
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- (100) DGIdb
- (101) ClinicalTrials
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- (104) diseasecard
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- (136) Human Protein Atlas
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- (156) Mastermind
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- (159) GeneImprint
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- (163) LncBase
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