Aliases for GNAI2 Gene
External Ids for GNAI2 Gene
Previous HGNC Symbols for GNAI2 Gene
Previous GeneCards Identifiers for GNAI2 Gene
The protein encoded by this gene is an alpha subunit of guanine nucleotide binding proteins (G proteins). The encoded protein contains the guanine nucleotide binding site and is involved in the hormonal regulation of adenylate cyclase. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]
GeneCards Summary for GNAI2 Gene
GNAI2 (G Protein Subunit Alpha I2) is a Protein Coding gene. Diseases associated with GNAI2 include Ventricular Tachycardia, Familial and Granulosa Cell Tumor Of The Ovary. Among its related pathways are Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics and DAG and IP3 signaling. Gene Ontology (GO) annotations related to this gene include GTP binding and obsolete signal transducer activity. An important paralog of this gene is GNAI1.
UniProtKB/Swiss-Prot Summary for GNAI2 Gene
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. May play a role in cell division.
[Isoform sGi2]: Regulates the cell surface density of dopamine receptors DRD2 by sequestrating them as an intracellular pool.
Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand binding causes a receptor conformational change, detaching the G protein and switching it 'on'.