Aliases for GNA15 Gene
External Ids for GNA15 Gene
Previous GeneCards Identifiers for GNA15 Gene
GeneCards Summary for GNA15 Gene
GNA15 (G Protein Subunit Alpha 15) is a Protein Coding gene. Diseases associated with GNA15 include Pertussis and Charcot-Marie-Tooth Disease, Dominant Intermediate F. Among its related pathways are Signaling by GPCR and CCR5 Pathway in Macrophages. Gene Ontology (GO) annotations related to this gene include GTP binding and obsolete signal transducer activity. An important paralog of this gene is GNAQ.
UniProtKB/Swiss-Prot Summary for GNA15 Gene
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.
Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand binding causes a receptor conformational change, detaching the G protein and switching it 'on'.