Aliases for GNA15 Gene

Aliases for GNA15 Gene

  • G Protein Subunit Alpha 15 2 3 5
  • GNA16 2 3 4
  • Guanine Nucleotide Binding Protein (G Protein), Alpha 15 (Gq Class) 2 3
  • Guanine Nucleotide-Binding Protein Subunit Alpha-15 3 4
  • Guanine Nucleotide-Binding Protein Subunit Alpha-16 3 4
  • Epididymis Tissue Protein Li 17E 3 4
  • G-Protein Subunit Alpha-16 3 4
  • G Alpha-15 3 4
  • G Alpha-16 3 4
  • Epididymis Secretory Sperm Binding Protein 3
  • G-Protein Subunit Alpha-15 4
  • GNA15 5

External Ids for GNA15 Gene

Previous GeneCards Identifiers for GNA15 Gene

  • GC19P003228
  • GC19P003076
  • GC19P003087
  • GC19P003140
  • GC19P002905
  • GC19P003142
  • GC19P003144
  • GC19P003149

Summaries for GNA15 Gene

GeneCards Summary for GNA15 Gene

GNA15 (G Protein Subunit Alpha 15) is a Protein Coding gene. Diseases associated with GNA15 include Pertussis and Charcot-Marie-Tooth Disease, Dominant Intermediate F. Among its related pathways are Sweet Taste Signaling and Integrin Pathway. Gene Ontology (GO) annotations related to this gene include GTP binding and obsolete signal transducer activity. An important paralog of this gene is GNAQ.

UniProtKB/Swiss-Prot Summary for GNA15 Gene

  • Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.

Tocris Summary for GNA15 Gene

  • Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand binding causes a receptor conformational change, detaching the G protein and switching it 'on'.

No data available for Entrez Gene Summary , CIViC Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GNA15 Gene

Genomics for GNA15 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for GNA15 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GNA15 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GNA15

Top Transcription factor binding sites by QIAGEN in the GNA15 gene promoter:
  • COUP-TF
  • COUP-TF1
  • Evi-1
  • HNF-4alpha1
  • HNF-4alpha2
  • HOXA3
  • MZF-1
  • POU2F1
  • POU2F1a
  • YY1

Genomic Locations for GNA15 Gene

Genomic Locations for GNA15 Gene
chr19:3,136,033-3,163,749
(GRCh38/hg38)
Size:
27,717 bases
Orientation:
Plus strand
chr19:3,136,191-3,163,767
(GRCh37/hg19)
Size:
27,577 bases
Orientation:
Plus strand

Genomic View for GNA15 Gene

Genes around GNA15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GNA15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GNA15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GNA15 Gene

Proteins for GNA15 Gene

  • Protein details for GNA15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P30679-GNA15_HUMAN
    Recommended name:
    Guanine nucleotide-binding protein subunit alpha-15
    Protein Accession:
    P30679
    Secondary Accessions:
    • E9KL40
    • E9KL47
    • O75247
    • Q53XK2

    Protein attributes for GNA15 Gene

    Size:
    374 amino acids
    Molecular mass:
    43568 Da
    Quaternary structure:
    • G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.

neXtProt entry for GNA15 Gene

Post-translational modifications for GNA15 Gene

  • Ubiquitination at Lys201 and Lys213
  • Modification sites at PhosphoSitePlus

Other Protein References for GNA15 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GNA15 Gene

Domains & Families for GNA15 Gene

Gene Families for GNA15 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for GNA15 Gene

InterPro:
Blocks:
  • Alpha G-protein (transducin) signature
  • G-protein alpha subunit group Q signature
ProtoNet:

Suggested Antigen Peptide Sequences for GNA15 Gene

GenScript: Design optimal peptide antigens:
  • Guanine nucleotide-binding protein subunit alpha-16 (GNA15_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P30679

UniProtKB/Swiss-Prot:

GNA15_HUMAN :
  • Belongs to the G-alpha family. G(q) subfamily.
Family:
  • Belongs to the G-alpha family. G(q) subfamily.
genes like me logo Genes that share domains with GNA15: view

Function for GNA15 Gene

Molecular function for GNA15 Gene

UniProtKB/Swiss-Prot Function:
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.
GENATLAS Biochemistry:
guanine nucleotide binding protein (G protein),alpha 15 (Gq class),mediating pertussis toxin-resistant stimulation of phospholipase C beta

Phenotypes From GWAS Catalog for GNA15 Gene

Gene Ontology (GO) - Molecular Function for GNA15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0001664 G protein-coupled receptor binding IDA 10571060
GO:0003924 GTPase activity TAS,IBA 21873635
GO:0005525 GTP binding IEA --
GO:0019001 guanyl nucleotide binding IEA --
genes like me logo Genes that share ontologies with GNA15: view
genes like me logo Genes that share phenotypes with GNA15: view

Animal Models for GNA15 Gene

MGI Knock Outs for GNA15:

Animal Model Products

CRISPR Products

miRNA for GNA15 Gene

miRTarBase miRNAs that target GNA15

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GNA15

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GNA15 Gene

Localization for GNA15 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GNA15 gene
Compartment Confidence
plasma membrane 4
cytosol 4
mitochondrion 3
extracellular 2
cytoskeleton 2
nucleus 2
endoplasmic reticulum 2
peroxisome 1
endosome 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for GNA15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005623 cell IEA --
GO:0005834 heterotrimeric G-protein complex NAS 10571060
GO:0005886 plasma membrane TAS --
GO:0045202 synapse IEA --
genes like me logo Genes that share ontologies with GNA15: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for GNA15 Gene

Pathways & Interactions for GNA15 Gene

PathCards logo

SuperPathways for GNA15 Gene

SuperPathway Contained pathways
1 fMLP Pathway
.44
.44
.43
.39
.31
2 G-Beta Gamma Signaling
.46
.46
.44
.37
.32
3 Activation of cAMP-Dependent PKA
.77
.77
.71
.56
4 CREB Pathway
.68
.68
.63
.50
5 GPCR Pathway
.62
.58
.58
.55
genes like me logo Genes that share pathways with GNA15: view

Pathways by source for GNA15 Gene

5 GeneGo (Thomson Reuters) pathways for GNA15 Gene
  • Development A1 receptor signaling
  • Development Activation of ERK by Alpha-1 adrenergic receptors
  • G-protein signaling G-Protein beta/gamma signaling cascades
  • Immune response ICOS pathway in T-helper cell
  • Inhibitory action of Lipoxins on Superoxide production in neutrophils
60 Qiagen pathways for GNA15 Gene
  • Actin Nucleation and Branching
  • Actin Nucleation by ARP-WASP Complex
  • Actin-Based Motility by Rho Family GTPases
  • Activation of cAMP-Dependent PKA
  • Activation of PKA through GPCR

Gene Ontology (GO) - Biological Process for GNA15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001508 action potential IBA 21873635
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway TAS --
GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway IBA 21873635
GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with GNA15: view

Drugs & Compounds for GNA15 Gene

(3) Drugs for GNA15 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0
Guanosine monophosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0

(5) Additional Compounds for GNA15 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
[D-Trp7,9,10]-Substance P
89430-38-6
G-Protein antagonist peptide
143675-79-0
Gue 1654
397290-30-1
mastoparan
72093-21-1
SCH 202676 hydrobromide
265980-25-4

(5) Tocris Compounds for GNA15 Gene

Compound Action Cas Number
[D-Trp7,9,10]-Substance P Inhibits M1 ACh receptor activation of Gq/11 89430-38-6
G-Protein antagonist peptide Inhibits G protein activation by GPCRs 143675-79-0
Gue 1654 Selective inhibitor of OXE-R Gbetagamma signaling 397290-30-1
Mastoparan Activates Gi and Go 72093-21-1
SCH 202676 hydrobromide Inhibitor of ligand binding to G-protein-coupled receptors 265980-25-4
genes like me logo Genes that share compounds with GNA15: view

Transcripts for GNA15 Gene

mRNA/cDNA for GNA15 Gene

1 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GNA15

Alternative Splicing Database (ASD) splice patterns (SP) for GNA15 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8
SP1: -
SP2:

Relevant External Links for GNA15 Gene

GeneLoc Exon Structure for
GNA15

Expression for GNA15 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GNA15 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Testis (Reproductive System)
  • Thymus (Hematopoietic System)

mRNA differential expression in normal tissues according to GTEx for GNA15 Gene

This gene is overexpressed in Esophagus - Mucosa (x10.8), Whole Blood (x8.0), Skin - Not Sun Exposed (Suprapubic) (x5.1), and Skin - Sun Exposed (Lower leg) (x4.2).

Protein differential expression in normal tissues from HIPED for GNA15 Gene

This gene is overexpressed in Cervix (56.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GNA15 Gene



Protein tissue co-expression partners for GNA15 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GNA15

SOURCE GeneReport for Unigene cluster for GNA15 Gene:

Hs.73797

mRNA Expression by UniProt/SwissProt for GNA15 Gene:

P30679-GNA15_HUMAN
Tissue specificity: Specifically expressed in hematopoietic cells. Expressed in epididymis (at protein level).

Evidence on tissue expression from TISSUES for GNA15 Gene

  • Liver(4.4)
  • Lung(4.4)
  • Nervous system(2.8)
  • Muscle(2.8)
  • Heart(2.7)
  • Blood(2.6)
  • Skin(2.6)
  • Bone marrow(2.4)
  • Eye(2.3)
  • Kidney(2.3)
  • Intestine(2.3)
  • Lymph node(2.2)
  • Spleen(2.2)
genes like me logo Genes that share expression patterns with GNA15: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for GNA15 Gene

Orthologs for GNA15 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for GNA15 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia GNA15 31
  • 100 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia GNA15 31
  • 95 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia GNA15 30 31
  • 87.17 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia GNA15 31
  • 86 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Gna15 30
  • 83.16 (n)
Mouse
(Mus musculus)
Mammalia Gna15 30 17 31
  • 82.35 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia GNA15 31
  • 67 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia LOC100496529 30
  • 62.24 (n)
Zebrafish
(Danio rerio)
Actinopterygii gna15.1 30 31
  • 61.81 (n)
OneToMany
gna15.2 31
  • 54 (a)
OneToMany
gna15.3 31
  • 50 (a)
OneToMany
Fruit Fly
(Drosophila melanogaster)
Insecta Galpha73B 32
  • 37 (a)
Worm
(Caenorhabditis elegans)
Secernentea gpa-16 31
  • 45 (a)
ManyToMany
gpa-7 31
  • 42 (a)
ManyToMany
gpa-1 31
  • 42 (a)
ManyToMany
gpa-4 31
  • 39 (a)
ManyToMany
odr-3 31
  • 38 (a)
ManyToMany
gpa-3 31
  • 38 (a)
ManyToMany
gpa-2 31
  • 37 (a)
ManyToMany
gpa-11 32
  • 37 (a)
gpa-15 31
  • 36 (a)
ManyToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GPA2 31
  • 30 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 41 (a)
OneToOne
Species where no ortholog for GNA15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for GNA15 Gene

ENSEMBL:
Gene Tree for GNA15 (if available)
TreeFam:
Gene Tree for GNA15 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GNA15: view image

Paralogs for GNA15 Gene

(16) SIMAP similar genes for GNA15 Gene using alignment to 2 proteins:

  • GNA15_HUMAN
  • K7EP74_HUMAN
genes like me logo Genes that share paralogs with GNA15: view

Variants for GNA15 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GNA15 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
786961 Benign: not provided 3,150,141(+) G/A MISSENSE_VARIANT
788012 Benign: not provided 3,157,796(+) C/T SYNONYMOUS_VARIANT
790433 Benign: not provided 3,151,782(+) G/A MISSENSE_VARIANT
rs310680 - p.Tyr147Cys

Additional dbSNP identifiers (rs#s) for GNA15 Gene

Structural Variations from Database of Genomic Variants (DGV) for GNA15 Gene

Variant ID Type Subtype PubMed ID
dgv47n68 CNV loss 17160897
esv1660661 CNV insertion 17803354
esv2584592 CNV insertion 19546169
esv2717923 CNV deletion 23290073
nsv1072842 CNV deletion 25765185
nsv509716 CNV insertion 20534489
nsv953947 CNV deletion 24416366

Variation tolerance for GNA15 Gene

Residual Variation Intolerance Score: 34.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.18; 39.52% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GNA15 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GNA15

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GNA15 Gene

Disorders for GNA15 Gene

MalaCards: The human disease database

(15) MalaCards diseases for GNA15 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
pertussis
  • bordetella infection
charcot-marie-tooth disease, dominant intermediate f
  • cmtdif
pseudopseudohypoparathyroidism
  • pphp
pseudohypoparathyroidism, type ia
  • php1a
endometrial mucinous adenocarcinoma
  • uterine corpus mucinous adenocarcinoma
- elite association - COSMIC cancer census association via MalaCards
Search GNA15 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for GNA15

genes like me logo Genes that share disorders with GNA15: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GNA15 Gene

Publications for GNA15 Gene

  1. Systematic mapping and functional analysis of a family of human epididymal secretory sperm-located proteins. (PMID: 20736409) Li J … Liu Y (Molecular & cellular proteomics : MCP 2010) 3 4
  2. Association of genome-wide variation with the risk of incident heart failure in adults of European and African ancestry: a prospective meta-analysis from the cohorts for heart and aging research in genomic epidemiology (CHARGE) consortium. (PMID: 20445134) Smith NL … Vasan RS (Circulation. Cardiovascular genetics 2010) 3 41
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 3 4
  5. Evolution of the mammalian G protein alpha subunit multigene family. (PMID: 1302014) Wilkie TM … Simon MI (Nature genetics 1992) 2 3

Products for GNA15 Gene

  • Signalway Proteins for GNA15

Sources for GNA15 Gene