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GNA14 Gene(Protein Coding)

G Protein Subunit Alpha 14

GCID:
GC09M077423
GIFtS:
50
Genes Participants
UDN Logo

Aliases for GNA14 Gene

Aliases for GNA14 Gene

  • G Protein Subunit Alpha 14 2 3 5
  • Guanine Nucleotide Binding Protein (G Protein), Alpha 14 2
  • G-Protein Subunit Alpha-14 4
  • G Alpha-14 4

External Ids for GNA14 Gene

Previous GeneCards Identifiers for GNA14 Gene

  • GC09M071085
  • GC09M071894
  • GC09M073607
  • GC09M075495
  • GC09M077268
  • GC09M079227
  • GC09M080037
  • GC09M049869

Summaries for GNA14 Gene

Entrez Gene Summary for GNA14 Gene

  • This gene encodes a member of the guanine nucleotide-binding, or G protein family. G proteins are heterotrimers consisting of alpha, beta and gamma subunits. The encoded protein is a member of the alpha family of G proteins, more specifically the alpha q subfamily of G proteins. The encoded protein may play a role in pertussis-toxin resistant activation of phospholipase C-beta and its downstream effectors.[provided by RefSeq, Feb 2009]

GeneCards Summary for GNA14 Gene

GNA14 (G Protein Subunit Alpha 14) is a Protein Coding gene. Diseases associated with GNA14 include Kaposiform Hemangioendothelioma and Angioma, Tufted. Among its related pathways are Toll-like receptor signaling pathway and Integrin Pathway. Gene Ontology (GO) annotations related to this gene include GTP binding and signal transducer activity. An important paralog of this gene is GNA11.

UniProtKB/Swiss-Prot for GNA14 Gene

  • Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.

Tocris Summary for GNA14 Gene

  • Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand binding causes a receptor conformational change, detaching the G protein and switching it 'on'.

Additional gene information for GNA14 Gene

No data available for CIViC summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GNA14 Gene

Genomics for GNA14 Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for GNA14 Gene

Promoters and enhancers for GNA14 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH09I077647 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 550.8 -0.2 -205 1.8 CTCF ZNF687 SIN3A RAD21 NR2F2 YY1 E2F1 ZNF217 POLR2A ZNF444 GNA14 GC09M077717
GH09I077649 Enhancer 0.5 ENCODE 550.8 -1.3 -1264 0.2 CTCF ATF4 RAD21 EZH2 GNA14 GC09M077717
GH09I077544 Enhancer 0.3 FANTOM5 15.8 +103.4 103447 0.4 FOS GNA14 RNU6-1303P GC09M077511 NUTF2P3
GH09I077532 Enhancer 1 Ensembl ENCODE 4.2 +113.7 113731 3.5 ELF3 PKNOX1 FOXA2 ARID4B RARA CREM THAP11 MIXL1 SP5 MIER2 GC09M077511 RNU6-1303P GNA14 NUTF2P3
GH09I077673 Enhancer 0.3 ENCODE 12.3 -25.8 -25780 0.8 NR2F2 GNA14 RNU6-1303P GC09M077717
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around GNA14 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GNA14 gene promoter:

Genomic Locations for GNA14 Gene

Genomic Locations for GNA14 Gene
chr9:77,423,079-77,648,316
(GRCh38/hg38)
Size:
225,238 bases
Orientation:
Minus strand
chr9:80,037,995-80,263,232
(GRCh37/hg19)

Genomic View for GNA14 Gene

Genes around GNA14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GNA14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GNA14 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for GNA14 Gene

Proteins for GNA14 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for GNA14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95837-GNA14_HUMAN
    Recommended name:
    Guanine nucleotide-binding protein subunit alpha-14
    Protein Accession:
    O95837
    Secondary Accessions:
    • B1ALW3

    Protein attributes for GNA14 Gene

    Size:
    355 amino acids
    Molecular mass:
    41571 Da
    Quaternary structure:
    • G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.

neXtProt entry for GNA14 Gene

Protein Expression for GNA14 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for GNA14 Gene

No Post-translational modifications

Other Protein References for GNA14 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GNA14 Gene

Domains & Families for GNA14 Gene

Gene Families for GNA14 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for GNA14 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for GNA14 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O95837

UniProtKB/Swiss-Prot:

GNA14_HUMAN :
  • Belongs to the G-alpha family. G(q) subfamily.
Family:
  • Belongs to the G-alpha family. G(q) subfamily.
genes like me logo Genes that share domains with GNA14: view

Function for GNA14 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for GNA14 Gene

GENATLAS Biochemistry:
guanine nucleotide binding protein (G protein),alpha 14,expressed in fetal lung,kidney,liver,mediating pertussis toxin-resistant stimulation of phospholipase C beta
UniProtKB/Swiss-Prot Function:
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.

Phenotypes From GWAS Catalog for GNA14 Gene

Gene Ontology (GO) - Molecular Function for GNA14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001664 G-protein coupled receptor binding IBA --
GO:0003924 GTPase activity TAS --
GO:0004871 signal transducer activity NAS,IBA --
GO:0005515 protein binding IPI 25416956
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with GNA14: view
genes like me logo Genes that share phenotypes with GNA14: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GNA14 Gene

Localization for GNA14 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GNA14 gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytosol 3
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for GNA14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005834 heterotrimeric G-protein complex TAS 1946421
GO:0005886 plasma membrane TAS --
GO:0070062 extracellular exosome HDA,IDA 23533145
genes like me logo Genes that share ontologies with GNA14: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for GNA14 Gene

Pathways & Interactions for GNA14 Gene

genes like me logo Genes that share pathways with GNA14: view

Gene Ontology (GO) - Biological Process for GNA14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 10191087
GO:0007186 G-protein coupled receptor signaling pathway TAS --
GO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway IBA --
GO:0030168 platelet activation TAS --
GO:0060158 phospholipase C-activating dopamine receptor signaling pathway IBA --
genes like me logo Genes that share ontologies with GNA14: view

No data available for SIGNOR curated interactions for GNA14 Gene

Drugs & Compounds for GNA14 Gene

Products:

  1. Drug

(3) Drugs for GNA14 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0
Guanosine monophosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0

(5) Additional Compounds for GNA14 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
G-Protein antagonist peptide
143675-79-0

(5) Tocris Compounds for GNA14 Gene

Compound Action Cas Number
[D-Trp7,9,10]-Substance P Inhibits M1 ACh receptor activation of Gq/11 89430-38-6
G-Protein antagonist peptide Inhibits G protein activation by GPCRs 143675-79-0
Gue 1654 Selective inhibitor of OXE-R Gbetagamma signaling 397290-30-1
Mastoparan Activates Gi and Go 72093-21-1
SCH 202676 hydrobromide Inhibitor of ligand binding to G-protein-coupled receptors 265980-25-4
genes like me logo Genes that share compounds with GNA14: view

Transcripts for GNA14 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for GNA14 Gene

(3) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(30) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GNA14 Gene

Guanine nucleotide binding protein (G protein), alpha 14:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GNA14 Gene

No ASD Table

Relevant External Links for GNA14 Gene

GeneLoc Exon Structure for
GNA14
ECgene alternative splicing isoforms for
GNA14

Expression for GNA14 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GNA14 Gene

mRNA expression in normal human tissues for GNA14 Gene
mRNA expression by BioGPS for GNA14 GenemRNA expression by GTEx for GNA14 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for GNA14 Gene

This gene is overexpressed in Frontal cortex (24.2), Brain (7.4), Lung (6.9), and Heart (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GNA14 Gene



NURSA nuclear receptor signaling pathways regulating expression of GNA14 Gene:

GNA14

SOURCE GeneReport for Unigene cluster for GNA14 Gene:

Hs.657795

Evidence on tissue expression from TISSUES for GNA14 Gene

  • Nervous system(4.6)
  • Pancreas(4.1)
  • Spleen(4.1)
  • Lung(2.3)
genes like me logo Genes that share expression patterns with GNA14: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GNA14 Gene

Orthologs for GNA14 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for GNA14 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia GNA14 33 34
  • 99.25 (n)
oppossum
(Monodelphis domestica)
 Mammalia GNA14 34
  • 96 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia GNA14 34
  • 96 (a)
 OneToOne
cow
(Bos Taurus)
 Mammalia GNA14 33 34
  • 92.02 (n)
dog
(Canis familiaris)
 Mammalia GNA14 33 34
  • 91.08 (n)
mouse
(Mus musculus)
 Mammalia Gna14 33 16 34
  • 89.3 (n)
rat
(Rattus norvegicus)
 Mammalia Gna14 33
  • 88.92 (n)
chicken
(Gallus gallus)
 Aves GNA14 33 34
  • 80.41 (n)
lizard
(Anolis carolinensis)
 Reptilia GNA14 34
  • 75 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia gna14 33
  • 77.97 (n)
African clawed frog
(Xenopus laevis)
 Amphibia Gna14 33
zebrafish
(Danio rerio)
 Actinopterygii gna11a 34
  • 75 (a)
 ManyToMany
gna14a 33
  • 69.68 (n)
fruit fly
(Drosophila melanogaster)
 Insecta Galpha49B 35 34
  • 72 (a)
CG30054 34
  • 63 (a)
 ManyToMany
CG17760 35 34
  • 51 (a)
worm
(Caenorhabditis elegans)
 Secernentea egl-30 34
  • 74 (a)
 OneToMany
gpa-1 35
  • 45 (a)
gpa-15 35
  • 39 (a)
gpa-6 35
  • 39 (a)
gpa-8 35
  • 38 (a)
gpa-10 35
  • 36 (a)
baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes GPA2 34
  • 32 (a)
 OneToMany
sea squirt
(Ciona savignyi)
 Ascidiacea CSA.11283 34
  • 69 (a)
 OneToMany
Species where no ortholog for GNA14 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GNA14 Gene

ENSEMBL:
Gene Tree for GNA14 (if available)
TreeFam:
Gene Tree for GNA14 (if available)

Paralogs for GNA14 Gene

Paralogs for GNA14 Gene

(18) SIMAP similar genes for GNA14 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with GNA14: view

Variants for GNA14 Gene

Sequence variations from dbSNP and Humsavar for GNA14 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1000035097 -- 77,514,766(-) A/G genic_upstream_transcript_variant, intron_variant
rs1000053305 -- 77,631,293(-) A/G genic_upstream_transcript_variant, intron_variant
rs1000067730 -- 77,460,268(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000088709 -- 77,574,831(-) AG/ genic_upstream_transcript_variant, intron_variant
rs1000112376 -- 77,476,614(-) C/T genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for GNA14 Gene

Variant ID Type Subtype PubMed ID
nsv831629 CNV gain 17160897
nsv614730 CNV loss 21841781
nsv1115202 CNV deletion 24896259
nsv1054297 CNV gain 25217958
nsv1051079 CNV gain 25217958
nsv1041647 CNV gain 25217958
nsv1036470 CNV loss 25217958
esv7342 OTHER inversion 19470904
esv3620777 CNV loss 21293372
esv3620776 CNV loss 21293372
esv3620775 CNV loss 21293372
esv3576677 CNV gain 25503493
esv3573276 CNV loss 25503493
esv3573274 CNV loss 25503493
esv3544962 CNV deletion 23714750
esv3430887 CNV insertion 20981092
esv3306887 CNV mobile element insertion 20981092
esv2738610 CNV deletion 23290073
esv2671344 CNV deletion 23128226
esv2669994 CNV deletion 23128226
esv26092 CNV loss 19812545
esv2562696 CNV insertion 19546169
esv2463816 CNV insertion 19546169
esv21709 CNV loss 19812545
dgv12771n54 CNV loss 21841781

Variation tolerance for GNA14 Gene

Residual Variation Intolerance Score: 64.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.03; 37.35% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GNA14 Gene

Human Gene Mutation Database (HGMD)
GNA14
SNPedia medical, phenotypic, and genealogical associations of SNPs for
GNA14

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GNA14 Gene

Disorders for GNA14 Gene

MalaCards: The human disease database

(4) MalaCards diseases for GNA14 Gene - From: HGMD, Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
kaposiform hemangioendothelioma
  • congenital cutaneous multifocal kaposiform hemangioendothelioma
angioma, tufted
  • tufted angioma
pertussis
  • bordetella infection
choreoacanthocytosis
  • chac
- elite association - COSMIC cancer census association via MalaCards
Search GNA14 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for GNA14

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with GNA14: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GNA14 Gene

Publications for GNA14 Gene

  1. Genomic organization of the human galpha14 and Galphaq genes and mutation analysis in chorea-acanthocytosis (CHAC). (PMID: 10191087) Rubio JP … Monaco AP (Genomics 1999) 2 3 4 58
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  4. Identification of hypertension-susceptibility genes and pathways by a systemic multiple candidate gene approach: the millennium genome project for hypertension. (PMID: 18360038) Kohara K … Miki T (Hypertension research : official journal of the Japanese Society of Hypertension 2008) 3 44 58
  5. The importance of N-terminal polycysteine and polybasic sequences for G14alpha and G16alpha palmitoylation, plasma membrane localization, and signaling function. (PMID: 17620339) Pedone KH … Hepler JR (The Journal of biological chemistry 2007) 2 3 58

Products for GNA14 Gene

Sources for GNA14 Gene

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