This gene encodes a member of the guanine nucleotide-binding, or G protein family. G proteins are heterotrimers consisting of alpha, beta and gamma subunits. The encoded protein is a member of the alpha family of G proteins, more specifically the alpha q subfamily of G proteins. The encoded protein may play a role in pertussis-toxin resistant activation of phospholipase C-beta ... See more...

Aliases for GNA14 Gene

Aliases for GNA14 Gene

  • G Protein Subunit Alpha 14 2 3 5
  • Guanine Nucleotide Binding Protein (G Protein), Alpha 14 2 3
  • Guanine Nucleotide-Binding Protein Subunit Alpha-14 3 4
  • G Alpha-14 3 4
  • Guanine Nucleotide-Binding Protein 14 3
  • G-Protein Subunit Alpha-14 4

External Ids for GNA14 Gene

Previous GeneCards Identifiers for GNA14 Gene

  • GC09M071085
  • GC09M071894
  • GC09M073607
  • GC09M075495
  • GC09M077268
  • GC09M079227
  • GC09M080037
  • GC09M049869

Summaries for GNA14 Gene

Entrez Gene Summary for GNA14 Gene

  • This gene encodes a member of the guanine nucleotide-binding, or G protein family. G proteins are heterotrimers consisting of alpha, beta and gamma subunits. The encoded protein is a member of the alpha family of G proteins, more specifically the alpha q subfamily of G proteins. The encoded protein may play a role in pertussis-toxin resistant activation of phospholipase C-beta and its downstream effectors.[provided by RefSeq, Feb 2009]

GeneCards Summary for GNA14 Gene

GNA14 (G Protein Subunit Alpha 14) is a Protein Coding gene. Diseases associated with GNA14 include Kaposiform Hemangioendothelioma and Angioma, Tufted. Among its related pathways are Toll Comparative Pathway and S1P3 pathway. Gene Ontology (GO) annotations related to this gene include GTP binding and obsolete signal transducer activity. An important paralog of this gene is GNA11.

UniProtKB/Swiss-Prot Summary for GNA14 Gene

  • Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.

Tocris Summary for GNA14 Gene

  • Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand binding causes a receptor conformational change, detaching the G protein and switching it 'on'.

Additional gene information for GNA14 Gene

No data available for CIViC Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GNA14 Gene

Genomics for GNA14 Gene

GeneHancer (GH) Regulatory Elements for GNA14 Gene

Promoters and enhancers for GNA14 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J077647 Promoter/Enhancer 1.2 EPDnew Ensembl ENCODE 750.6 +0.7 708 3.6 CTCF POLR2A ZFX EZH2 YY1 ZNF217 SIN3A ZNF687 RAD21 EGR1 GNA14 RF00026-1123 RNU6-1303P RF00017-7641
GH09J077649 Enhancer 0.3 ENCODE 750.6 -1.3 -1258 0.2 CTCF RAD21 GNA14 piR-51855-043 RF00017-7641
GH09J077594 Enhancer 0.8 Ensembl ENCODE 11.5 +51.7 51674 6.5 GATA3 ZNF217 MNT NCOA3 MAFK CTBP1 POLR2A SP1 PKNOX1 NR2F2 RNU6-1303P GNA14 NUTF2P3 lnc-VPS13A-3 L13714-485 RF00017-7641
GH09J078325 Enhancer 1 Ensembl ENCODE CraniofacialAtlas 4.9 -677.2 -677179 1.4 TEAD4 CBFA2T2 SMARCA4 TRIM24 IKZF1 POLR2A TCF12 ZSCAN29 NCOR1 RCOR1 PSAT1 GNA14 AB372643-012 lnc-GNAQ-8 RF00017-7645 RF00017-7644
GH09J077583 Enhancer 0.9 Ensembl ENCODE 5 +61.9 61921 8.4 TCF7L2 ZNF217 MNT NCOA3 MAFK ZNF639 FOSL2 CREB1 POLR2A RFX1 RNU6-1303P GNAQ GNA14 NUTF2P3 lnc-VPS13A-3 L13714-485 RF00017-7641
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GNA14 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GNA14 gene promoter:
  • AML1a
  • FOXD3
  • ISGF-3
  • Nkx3-1
  • Nkx3-1 v1
  • Nkx3-1 v2
  • Nkx3-1 v3
  • Nkx3-1 v4
  • POU2F1
  • POU2F1a

Genomic Locations for GNA14 Gene

Genomic Locations for GNA14 Gene
chr9:77,423,079-77,648,322
(GRCh38/hg38)
Size:
225,244 bases
Orientation:
Minus strand
chr9:80,037,995-80,263,232
(GRCh37/hg19)
Size:
225,238 bases
Orientation:
Minus strand

Genomic View for GNA14 Gene

Genes around GNA14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GNA14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GNA14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GNA14 Gene

Proteins for GNA14 Gene

  • Protein details for GNA14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95837-GNA14_HUMAN
    Recommended name:
    Guanine nucleotide-binding protein subunit alpha-14
    Protein Accession:
    O95837
    Secondary Accessions:
    • B1ALW3

    Protein attributes for GNA14 Gene

    Size:
    355 amino acids
    Molecular mass:
    41571 Da
    Quaternary structure:
    • G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.

neXtProt entry for GNA14 Gene

Post-translational modifications for GNA14 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GNA14 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GNA14 Gene

Domains & Families for GNA14 Gene

Gene Families for GNA14 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for GNA14 Gene

GenScript: Design optimal peptide antigens:
  • cDNA, FLJ92815, Homo sapiens guanine nucleotide binding protein (G protein), alpha 14 (GNA14), mRNA (B1ALW3_HUMAN)
  • Guanine nucleotide-binding protein subunit alpha-14 (GNA14_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O95837

UniProtKB/Swiss-Prot:

GNA14_HUMAN :
  • Belongs to the G-alpha family. G(q) subfamily.
Family:
  • Belongs to the G-alpha family. G(q) subfamily.
genes like me logo Genes that share domains with GNA14: view

Function for GNA14 Gene

Molecular function for GNA14 Gene

UniProtKB/Swiss-Prot Function:
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.
GENATLAS Biochemistry:
guanine nucleotide binding protein (G protein),alpha 14,expressed in fetal lung,kidney,liver,mediating pertussis toxin-resistant stimulation of phospholipase C beta

Phenotypes From GWAS Catalog for GNA14 Gene

Gene Ontology (GO) - Molecular Function for GNA14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001664 G protein-coupled receptor binding IBA 21873635
GO:0003924 GTPase activity TAS,IBA 21873635
GO:0005515 protein binding IPI 25416956
GO:0005525 GTP binding IEA --
GO:0019001 guanyl nucleotide binding IEA --
genes like me logo Genes that share ontologies with GNA14: view
genes like me logo Genes that share phenotypes with GNA14: view

Human Phenotype Ontology for GNA14 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for GNA14 Gene

Localization for GNA14 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GNA14 gene
Compartment Confidence
plasma membrane 4
cytosol 3
nucleus 1
extracellular 0
mitochondrion 0

Gene Ontology (GO) - Cellular Components for GNA14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005834 heterotrimeric G-protein complex TAS,IBA 21873635
GO:0005886 plasma membrane TAS --
GO:0070062 extracellular exosome HDA 23533145
genes like me logo Genes that share ontologies with GNA14: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for GNA14 Gene

Pathways & Interactions for GNA14 Gene

PathCards logo

SuperPathways for GNA14 Gene

SuperPathway Contained pathways
1 fMLP Pathway
.44
.44
.43
.39
.30
2 G-Beta Gamma Signaling
.46
.46
.44
.37
.32
3 Activation of cAMP-Dependent PKA
.77
.77
.71
.56
4 CREB Pathway
.68
.68
.63
.50
5 GPCR Pathway
.62
.58
.58
.55
genes like me logo Genes that share pathways with GNA14: view

Pathways by source for GNA14 Gene

1 GeneGo (Thomson Reuters) pathway for GNA14 Gene
60 Qiagen pathways for GNA14 Gene
  • Actin Nucleation and Branching
  • Actin Nucleation by ARP-WASP Complex
  • Actin-Based Motility by Rho Family GTPases
  • Activation of cAMP-Dependent PKA
  • Activation of PKA through GPCR

Gene Ontology (GO) - Biological Process for GNA14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 10191087
GO:0007186 G protein-coupled receptor signaling pathway TAS --
GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway IBA 21873635
GO:0030168 platelet activation TAS --
GO:0060158 phospholipase C-activating dopamine receptor signaling pathway IBA 21873635
genes like me logo Genes that share ontologies with GNA14: view

Drugs & Compounds for GNA14 Gene

(3) Drugs for GNA14 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0
Guanosine monophosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0

(5) Additional Compounds for GNA14 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
[D-Trp7,9,10]-Substance P
89430-38-6
G-Protein antagonist peptide
143675-79-0
Gue 1654
397290-30-1
mastoparan
72093-21-1
SCH 202676 hydrobromide
265980-25-4

(5) Tocris Compounds for GNA14 Gene

Compound Action Cas Number
[D-Trp7,9,10]-Substance P Inhibits M1 ACh receptor activation of Gq/11 89430-38-6
G-Protein antagonist peptide Inhibits G protein activation by GPCRs 143675-79-0
Gue 1654 Selective inhibitor of OXE-R Gbetagamma signaling 397290-30-1
Mastoparan Activates Gi and Go 72093-21-1
SCH 202676 hydrobromide Inhibitor of ligand binding to G-protein-coupled receptors 265980-25-4
genes like me logo Genes that share compounds with GNA14: view

Transcripts for GNA14 Gene

mRNA/cDNA for GNA14 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(30) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GNA14 Gene

No ASD Table

Relevant External Links for GNA14 Gene

GeneLoc Exon Structure for
GNA14
ECgene alternative splicing isoforms for
GNA14

Expression for GNA14 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GNA14 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for GNA14 Gene

This gene is overexpressed in Frontal cortex (24.2), Brain (7.4), Lung (6.9), and Heart (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GNA14 Gene



NURSA nuclear receptor signaling pathways regulating expression of GNA14 Gene:

GNA14

SOURCE GeneReport for Unigene cluster for GNA14 Gene:

Hs.657795

Evidence on tissue expression from TISSUES for GNA14 Gene

  • Nervous system(4.6)
  • Pancreas(4.1)
  • Spleen(4.1)
  • Lung(2.3)
genes like me logo Genes that share expression patterns with GNA14: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GNA14 Gene

Orthologs for GNA14 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for GNA14 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GNA14 33 32
  • 99.25 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GNA14 33
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GNA14 33
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GNA14 33 32
  • 92.02 (n)
OneToOne
dog
(Canis familiaris)
Mammalia GNA14 33 32
  • 91.08 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Gna14 17 33 32
  • 89.3 (n)
rat
(Rattus norvegicus)
Mammalia Gna14 32
  • 88.92 (n)
chicken
(Gallus gallus)
Aves GNA14 33 32
  • 80.41 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GNA14 33
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gna14 32
  • 77.97 (n)
African clawed frog
(Xenopus laevis)
Amphibia Gna14 32
zebrafish
(Danio rerio)
Actinopterygii gna11a 33
  • 75 (a)
ManyToMany
gna14a 32
  • 69.68 (n)
fruit fly
(Drosophila melanogaster)
Insecta Galpha49B 33 34
  • 66 (a)
ManyToMany
CG30054 33
  • 63 (a)
ManyToMany
CG17760 33 34
  • 60 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea egl-30 33
  • 74 (a)
OneToMany
gpa-1 34
  • 45 (a)
gpa-6 34
  • 39 (a)
gpa-15 34
  • 39 (a)
gpa-8 34
  • 38 (a)
gpa-10 34
  • 36 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GPA2 33
  • 32 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11283 33
  • 69 (a)
OneToMany
Species where no ortholog for GNA14 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GNA14 Gene

ENSEMBL:
Gene Tree for GNA14 (if available)
TreeFam:
Gene Tree for GNA14 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GNA14: view image

Paralogs for GNA14 Gene

(18) SIMAP similar genes for GNA14 Gene using alignment to 2 proteins:

  • GNA14_HUMAN
  • B1ALW3_HUMAN
genes like me logo Genes that share paralogs with GNA14: view

Variants for GNA14 Gene

Sequence variations from dbSNP and Humsavar for GNA14 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1554685903 likely-pathogenic, Congenital tufted angioma, Kaposiform hemangioendothelioma, Lobular capillary hemangioma 77,429,016(-) T/A coding_sequence_variant, missense_variant
rs746420384 uncertain-significance, Severe Myopia 77,428,952(-) AA/A coding_sequence_variant, frameshift
rs1000035097 -- 77,514,766(-) A/G genic_upstream_transcript_variant, intron_variant
rs1000053305 -- 77,631,293(-) A/C/G genic_upstream_transcript_variant, intron_variant
rs1000067730 -- 77,460,268(-) C/T genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for GNA14 Gene

Variant ID Type Subtype PubMed ID
dgv12771n54 CNV loss 21841781
esv21709 CNV loss 19812545
esv2463816 CNV insertion 19546169
esv2562696 CNV insertion 19546169
esv26092 CNV loss 19812545
esv2669994 CNV deletion 23128226
esv2671344 CNV deletion 23128226
esv2738610 CNV deletion 23290073
esv3306887 CNV mobile element insertion 20981092
esv3430887 CNV insertion 20981092
esv3544962 CNV deletion 23714750
esv3573274 CNV loss 25503493
esv3573276 CNV loss 25503493
esv3576677 CNV gain 25503493
esv3620775 CNV loss 21293372
esv3620776 CNV loss 21293372
esv3620777 CNV loss 21293372
esv7342 OTHER inversion 19470904
nsv1036470 CNV loss 25217958
nsv1041647 CNV gain 25217958
nsv1051079 CNV gain 25217958
nsv1054297 CNV gain 25217958
nsv1115202 CNV deletion 24896259
nsv614730 CNV loss 21841781
nsv831629 CNV gain 17160897

Variation tolerance for GNA14 Gene

Residual Variation Intolerance Score: 64.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.03; 37.35% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GNA14 Gene

Human Gene Mutation Database (HGMD)
GNA14
SNPedia medical, phenotypic, and genealogical associations of SNPs for
GNA14

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GNA14 Gene

Disorders for GNA14 Gene

MalaCards: The human disease database

(6) MalaCards diseases for GNA14 Gene - From: HGMD, Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
kaposiform hemangioendothelioma
  • congenital cutaneous multifocal kaposiform hemangioendothelioma
angioma, tufted
  • tufted angioma
capillary hemangioma
  • cellular hemangioma of infancy
pertussis
  • bordetella infection
choreoacanthocytosis
  • chac
- elite association - COSMIC cancer census association via MalaCards
Search GNA14 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for GNA14

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with GNA14: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GNA14 Gene

Publications for GNA14 Gene

  1. Genomic organization of the human galpha14 and Galphaq genes and mutation analysis in chorea-acanthocytosis (CHAC). (PMID: 10191087) Rubio JP … Monaco AP (Genomics 1999) 2 3 4 56
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 43 56
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 43 56
  4. Identification of hypertension-susceptibility genes and pathways by a systemic multiple candidate gene approach: the millennium genome project for hypertension. (PMID: 18360038) Kohara K … Miki T (Hypertension research : official journal of the Japanese Society of Hypertension 2008) 3 43 56
  5. The importance of N-terminal polycysteine and polybasic sequences for G14alpha and G16alpha palmitoylation, plasma membrane localization, and signaling function. (PMID: 17620339) Pedone KH … Hepler JR (The Journal of biological chemistry 2007) 2 3 56

Products for GNA14 Gene

Sources for GNA14 Gene