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This gene encodes a member of the guanine nucleotide-binding, or G protein family. G proteins are heterotrimers consisting of alpha, beta and gamma subunits. The encoded protein is a member of the alpha family of G proteins, more specifically the alpha q subfamily of G proteins. The encoded protein may play a role in pertussis-toxin resistant activation of phospholipase C-beta ... See more...
Aliases for GNA14 Gene
Aliases for GNA14 Gene
External Ids for GNA14 Gene
- HGNC: 4382
- Entrez Gene: 9630
- Ensembl: ENSG00000156049
- OMIM: 604397
- UniProtKB: O95837
Previous GeneCards Identifiers for GNA14 Gene
- GC09M071085
- GC09M071894
- GC09M073607
- GC09M075495
- GC09M077268
- GC09M079227
- GC09M080037
- GC09M049869
Summaries for GNA14 Gene
-
This gene encodes a member of the guanine nucleotide-binding, or G protein family. G proteins are heterotrimers consisting of alpha, beta and gamma subunits. The encoded protein is a member of the alpha family of G proteins, more specifically the alpha q subfamily of G proteins. The encoded protein may play a role in pertussis-toxin resistant activation of phospholipase C-beta and its downstream effectors.[provided by RefSeq, Feb 2009]
GeneCards Summary for GNA14 Gene
GNA14 (G Protein Subunit Alpha 14) is a Protein Coding gene. Diseases associated with GNA14 include Kaposiform Hemangioendothelioma and Angioma, Tufted. Among its related pathways are Toll Comparative Pathway and S1P3 pathway. Gene Ontology (GO) annotations related to this gene include GTP binding and obsolete signal transducer activity. An important paralog of this gene is GNA11.
UniProtKB/Swiss-Prot Summary for GNA14 Gene
-
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.
-
Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand binding causes a receptor conformational change, detaching the G protein and switching it 'on'.
Additional gene information for GNA14 Gene
- Monarch Initiative
- Search for GNA14 at DataMed
- Search for GNA14 at HumanCyc
No data available for CIViC Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GNA14 Gene
Genomics for GNA14 Gene
GeneHancer (GH) Regulatory Elements for GNA14 Gene
Promoters and enhancers for GNA14 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around GNA14 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the GNA14 gene promoter:
-
- AML1a
- FOXD3
- ISGF-3
- Nkx3-1
- Nkx3-1 v1
- Nkx3-1 v2
- Nkx3-1 v3
- Nkx3-1 v4
- POU2F1
- POU2F1a
Genomic Locations for GNA14 Gene
Genomic Locations for GNA14 Gene
- chr9:77,423,079-77,648,322
- (GRCh38/hg38)
- Size:
- 225,244 bases
- Orientation:
- Minus strand
- chr9:80,037,995-80,263,232
- (GRCh37/hg19)
- Size:
- 225,238 bases
- Orientation:
- Minus strand
Genomic View for GNA14 Gene
Genes around GNA14 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 9q21.2 by HGNC
- 9q21.2 by Entrez Gene
- 9q21.2 by Ensembl
GNA14 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for GNA14 Gene
Proteins for GNA14 Gene
-
Protein details for GNA14 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O95837-GNA14_HUMAN
- Recommended name:
- Guanine nucleotide-binding protein subunit alpha-14
- Protein Accession:
- O95837
- B1ALW3
Protein attributes for GNA14 Gene
- Size:
- 355 amino acids
- Molecular mass:
- 41571 Da
- Quaternary structure:
-
- G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.
Protein Expression for GNA14 Gene
Post-translational modifications for GNA14 Gene
Other Protein References for GNA14 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ GNA14 Antibody
- Novus Biologicals Antibodies for GNA14
- Invitrogen Antibodies for GNA14 (AFLGC-GNA14)
-
Biorbyt antibodies for GNA14
-
Boster Bio Antibodies for GNA14
-
Santa Cruz Biotechnology (SCBT) Antibodies for GNA14
Protein Products
- Creative Biomart Recombinant Human GNA14 cell lysate and Recombinant Human GNA14 protein, GST-tagged
-
OriGene Purified Proteins for GNA14
- Search Origene for MassSpec and Protein Over-expression Lysates for GNA14
- Origene Custom Protein Services for GNA14
-
Abcam proteins for GNA14
No data available for DME Specific Peptides for GNA14 Gene
Domains & Families for GNA14 Gene
Gene Families for GNA14 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for GNA14 Gene
Suggested Antigen Peptide Sequences for GNA14 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA, FLJ92815, Homo sapiens guanine nucleotide binding protein (G protein), alpha 14 (GNA14), mRNA (B1ALW3_HUMAN)
- Guanine nucleotide-binding protein subunit alpha-14 (GNA14_HUMAN)
Graphical View of Domain Structure for InterPro Entry
O95837- Family:
-
- Belongs to the G-alpha family. G(q) subfamily.
Function for GNA14 Gene
Molecular function for GNA14 Gene
- UniProtKB/Swiss-Prot Function:
- Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.
- GENATLAS Biochemistry:
- guanine nucleotide binding protein (G protein),alpha 14,expressed in fetal lung,kidney,liver,mediating pertussis toxin-resistant stimulation of phospholipase C beta
Phenotypes From GWAS Catalog for GNA14 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001664 | G protein-coupled receptor binding | IBA | 21873635 |
| GO:0003924 | GTPase activity | TAS,IBA | 21873635 |
| GO:0005515 | protein binding | IPI | 25416956 |
| GO:0005525 | GTP binding | IEA | -- |
| GO:0019001 | guanyl nucleotide binding | IEA | -- |
Phenotypes for GNA14 Gene
- GenomeRNAi human phenotypes for GNA14:
-
- Decreased shRNA abundance (Z-score < -2)
- Increased shRNA abundance (Z-score > 2)
- Synthetic lethal with c-Myc after tamoxifen stimulation
- Decreased Salmonella enterica Typhimurium invasion
- Decreased Salmonella enterica Typhimurium binding
- Decreased viability
- no effect
- Increased vaccinia virus (VACV) infection
- Decreased NF-kappaB reporter expression
- shRNA abundance <= 50%
- Decreased IL-8 secretion
- Increased viability
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
-
OriGene CRISPR knockouts for GNA14
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for GNA14
- genomics-online: gRNA clones - Search for available GNa14 gRNA products
- Overview of 105 available GNa14 gene related products
- Applied Biological Materials (abm): CRISPR Clones for GNA14 - Select products 50% OFF >
- * GNA14 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * GNA14 CRISPR applications: KO, Activation, Repression, and more - Browse All
-
Santa Cruz Biotechnology (SCBT) CRISPR for GNA14
miRNA for GNA14 Gene
- miRTarBase miRNAs that target GNA14
-
- hsa-mir-335-5p (MIRT018573)
- hsa-mir-335-3p (MIRT610978)
- hsa-mir-5096 (MIRT610979)
- hsa-mir-197-3p (MIRT610980)
- hsa-mir-3941 (MIRT610981)
- hsa-mir-8064 (MIRT610982)
- hsa-mir-153-5p (MIRT610983)
- hsa-mir-6767-3p (MIRT610984)
- hsa-mir-603 (MIRT610985)
- hsa-mir-362-3p (MIRT610986)
- hsa-mir-329-3p (MIRT610987)
- hsa-mir-8485 (MIRT610988)
- hsa-mir-548c-3p (MIRT614159)
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for GNA14
- Browse OriGene Inhibitory RNA Products For GNA14
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GNA14
- genomics-online: shRNA clones - Search for available GNa14 shRNA products
- Overview of 105 available GNa14 gene related products
Clone Products
- Sino Biological Human cDNA Clone for GNA14
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for GNA14
- genomics-online: cdna clones - Search for available GNa14 CDNA products
- Overview of 105 available GNa14 gene related products
- orf clones - Search for available GNa14 ORF products
- Overview of 105 available GNa14 gene related products
- Applied Biological Materials (abm): Clones for GNA14 - Select products 50% OFF >
- * GNA14 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * GNA14 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
Cell Line Products
-
Horizon Cell Lines for GNA14
No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for GNA14 Gene
Localization for GNA14 Gene
| Compartment | Confidence |
|---|---|
| plasma membrane | 4 |
| cytosol | 3 |
| nucleus | 1 |
| extracellular | 0 |
| mitochondrion | 0 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005834 | heterotrimeric G-protein complex | TAS,IBA | 21873635 |
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0070062 | extracellular exosome | HDA | 23533145 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for GNA14 Gene
Pathways & Interactions for GNA14 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | fMLP Pathway |
CCR3 Pathway in Eosinophils
.44
VEGF and S-1P Signaling
.44
fMLP Pathway
.43
|
CXCR4 Pathway
.39
Huntington's Disease Pathway
.30
|
| 2 | G-Beta Gamma Signaling |
G-Beta Gamma Signaling
.46
GHRH Signaling
.46
CRHR Pathway
.44
|
Relaxin Pathway
.37
Hedgehog Signaling in Mammals
.32
|
| 3 | Activation of cAMP-Dependent PKA |
Activation of cAMP-Dependent PKA
.77
cAMP Pathway
.77
|
Activation of PKA through GPCR
.71
PKA Signaling
.56
|
| 4 | CREB Pathway |
CREB Pathway
.68
IP3 Pathway
.68
|
Activation of PKC through GPCR
.63
Intracellular Calcium Signaling
.50
|
| 5 | GPCR Pathway |
GPCR Pathway
.62
Breast Cancer Regulation by Stathmin1
.58
|
NFAT in Immune Response
.58
Estrogen Pathway
.55
|
Pathways by source for GNA14 Gene
6 BioSystems pathways for GNA14 Gene
17 Reactome pathways for GNA14 Gene
3 KEGG pathways for GNA14 Gene
1 GeneGo (Thomson Reuters) pathway for GNA14 Gene
60 Qiagen pathways for GNA14 Gene
- Actin Nucleation and Branching
- Actin Nucleation by ARP-WASP Complex
- Actin-Based Motility by Rho Family GTPases
- Activation of cAMP-Dependent PKA
- Activation of PKA through GPCR
Interacting Proteins for GNA14 Gene
Selected Interacting proteins:
O95837-GNA14_HUMAN
ENSP00000365807
for GNA14 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for GNA14
SIGNOR curated interactions for GNA14 Gene
- Is activated by:
-
- MC5R
- MRGPRX2
- CNR1
- MCHR2
- DRD1
- BDKRB1
- EDNRB
- ADORA2A
- FPR2
- NMUR1
- TBXA2R
- CYSLTR1
- OPRL1
- PRLHR
- PTGER1
- PTGFR
- NMUR2
- S1PR2
- OXGR1
- P2RY11
- S1PR3
- GPR119
- HRH2
- HCRTR2
- ADORA2B
- AGTR1
- GALR2
- HTR2C
- HTR6
- LPAR4
- ADRA1D
- APLNR
- CCKBR
- CHRM1
- CHRM3
- DRD5
- FFAR4
- HRH1
- MC3R
- P2RY13
- UTS2R
- CHRM5
- TACR2
- ADRA1B
- ADRB1
- MC4R
- FPR1
- SSTR2
- MLNR
- HTR1A
- GALR3
- P2RY14
- OXTR
- CCKAR
- F2RL3
- NMBR
- PTAFR
- HCRTR1
- HTR1B
- F2R
- BDKRB2
- CYSLTR2
- F2RL1
- GHSR
- GPR132
- HTR2B
- HTR7
- LPAR1
- LPAR2
- MRGPRX1
- OPRD1
- F2RL2
- P2RY10
- ADRA1A
- EDNRA
- GNRHR
- TACR1
- GRPR
- TACR3
- HTR2A
- MC1R
- HTR4
- KISS1R
- LPAR3
- LPAR6
- LTB4R
- HTR1D
- ADRB2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007165 | signal transduction | TAS | 10191087 |
| GO:0007186 | G protein-coupled receptor signaling pathway | TAS | -- |
| GO:0007188 | adenylate cyclase-modulating G protein-coupled receptor signaling pathway | IBA | 21873635 |
| GO:0030168 | platelet activation | TAS | -- |
| GO:0060158 | phospholipase C-activating dopamine receptor signaling pathway | IBA | 21873635 |
Drugs & Compounds for GNA14 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| [D-Trp7,9,10]-Substance P |
|
89430-38-6 |
|
|
||
| G-Protein antagonist peptide |
|
143675-79-0 |
|
|
||
| Gue 1654 |
|
397290-30-1 |
|
|
||
| mastoparan |
|
72093-21-1 |
|
|
||
| SCH 202676 hydrobromide |
|
265980-25-4 |
|
|
(5) Tocris Compounds for GNA14 Gene
| Compound | Action | Cas Number |
|---|---|---|
| [D-Trp7,9,10]-Substance P | Inhibits M1 ACh receptor activation of Gq/11 | 89430-38-6 |
| G-Protein antagonist peptide | Inhibits G protein activation by GPCRs | 143675-79-0 |
| Gue 1654 | Selective inhibitor of OXE-R Gbetagamma signaling | 397290-30-1 |
| Mastoparan | Activates Gi and Go | 72093-21-1 |
| SCH 202676 hydrobromide | Inhibitor of ligand binding to G-protein-coupled receptors | 265980-25-4 |
Drug Products
- Creative Biomart Recombinant Human GNA14 cell lysate and Recombinant Human GNA14 protein, GST-tagged
Transcripts for GNA14 Gene
mRNA/cDNA for GNA14 Gene
- (1) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (30) Selected AceView cDNA sequences:
- (2) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000341700 2497 bps (ENST00000341700.6)
- ENST00000464095 694 bps (ENST00000464095.1)
CRISPR Products
-
OriGene CRISPR knockouts for GNA14
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for GNA14
- genomics-online: gRNA clones - Search for available GNa14 gRNA products
- Overview of 105 available GNa14 gene related products
- Applied Biological Materials (abm): CRISPR Clones for GNA14 - Select products 50% OFF >
- * GNA14 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * GNA14 CRISPR applications: KO, Activation, Repression, and more - Browse All
-
Santa Cruz Biotechnology (SCBT) CRISPR for GNA14
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for GNA14
- Browse OriGene Inhibitory RNA Products For GNA14
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GNA14
- genomics-online: shRNA clones - Search for available GNa14 shRNA products
- Overview of 105 available GNa14 gene related products
Clone Products
- Sino Biological Human cDNA Clone for GNA14
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for GNA14
- genomics-online: cdna clones - Search for available GNa14 CDNA products
- Overview of 105 available GNa14 gene related products
- orf clones - Search for available GNa14 ORF products
- Overview of 105 available GNa14 gene related products
- Applied Biological Materials (abm): Clones for GNA14 - Select products 50% OFF >
- * GNA14 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * GNA14 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
Expression for GNA14 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Inner Cell Mass (Early Embryonic Tissues)
-
Kidney (Urinary System)
- Cortical Stroma Cells Interstitial Stroma
- Interstitial Stroma
-
Skeletal Muscle (Muscoskeletal System)
- Muscle Progenitor Cells Mandibular Arch Muscles
- Muscle Progenitor Cells Hyoid Arch Muscles
- Gonad
-
Placenta (Extraembryonic Tissues)
- Primordial Germ Cells Allantois
- Lung (Respiratory System)
- Germ Cells (Reproductive System)
This gene is overexpressed in Frontal cortex (24.2), Brain (7.4), Lung (6.9), and Heart (6.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GNA14 Gene
NURSA nuclear receptor signaling pathways regulating expression of GNA14 Gene:
GNA14SOURCE GeneReport for Unigene cluster for GNA14 Gene:
Hs.657795Evidence on tissue expression from TISSUES for GNA14 Gene
- Nervous system(4.6)
- Pancreas(4.1)
- Spleen(4.1)
- Lung(2.3)
Primer Products
-
OriGene qPCR primer pairs for GNA14
-
OriGene qPCR primer pairs and template standards for GNA14
- genomics-online: primer clones - Search for available GNa14 Primer products
- Overview of 105 available GNa14 gene related products
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GNA14 Gene
Orthologs for GNA14 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | GNA14 33 32 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | GNA14 33 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | GNA14 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | GNA14 33 32 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | GNA14 33 32 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Gna14 17 33 32 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Gna14 32 |
|
||
| chicken (Gallus gallus) |
Aves | GNA14 33 32 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | GNA14 33 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | gna14 32 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Gna14 32 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | gna11a 33 |
|
ManyToMany | |
| gna14a 32 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | Galpha49B 33 34 |
|
ManyToMany | |
| CG30054 33 |
|
ManyToMany | |||
| CG17760 33 34 |
|
ManyToMany | |||
| worm (Caenorhabditis elegans) |
Secernentea | egl-30 33 |
|
OneToMany | |
| gpa-1 34 |
|
|
|||
| gpa-6 34 |
|
|
|||
| gpa-15 34 |
|
|
|||
| gpa-8 34 |
|
|
|||
| gpa-10 34 |
|
|
|||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | GPA2 33 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.11283 33 |
|
OneToMany |
- Species where no ortholog for GNA14 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for GNA14 Gene
- ENSEMBL:
- Gene Tree for GNA14 (if available)
- TreeFam:
- Gene Tree for GNA14 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for GNA14: view image
Paralogs for GNA14 Gene
Paralogs for GNA14 Gene
(18) SIMAP similar genes for GNA14 Gene using alignment to 2 proteins:
- GNA14_HUMAN
- B1ALW3_HUMAN
Variants for GNA14 Gene
| SNP ID | Clin | Chr 09 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1554685903 | likely-pathogenic, Congenital tufted angioma, Kaposiform hemangioendothelioma, Lobular capillary hemangioma | 77,429,016(-) | T/A | coding_sequence_variant, missense_variant | |
| rs746420384 | uncertain-significance, Severe Myopia | 77,428,952(-) | AA/A | coding_sequence_variant, frameshift | |
| rs1000035097 | -- | 77,514,766(-) | A/G | genic_upstream_transcript_variant, intron_variant | |
| rs1000053305 | -- | 77,631,293(-) | A/C/G | genic_upstream_transcript_variant, intron_variant | |
| rs1000067730 | -- | 77,460,268(-) | C/T | genic_upstream_transcript_variant, intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv12771n54 | CNV | loss | 21841781 |
| esv21709 | CNV | loss | 19812545 |
| esv2463816 | CNV | insertion | 19546169 |
| esv2562696 | CNV | insertion | 19546169 |
| esv26092 | CNV | loss | 19812545 |
| esv2669994 | CNV | deletion | 23128226 |
| esv2671344 | CNV | deletion | 23128226 |
| esv2738610 | CNV | deletion | 23290073 |
| esv3306887 | CNV | mobile element insertion | 20981092 |
| esv3430887 | CNV | insertion | 20981092 |
| esv3544962 | CNV | deletion | 23714750 |
| esv3573274 | CNV | loss | 25503493 |
| esv3573276 | CNV | loss | 25503493 |
| esv3576677 | CNV | gain | 25503493 |
| esv3620775 | CNV | loss | 21293372 |
| esv3620776 | CNV | loss | 21293372 |
| esv3620777 | CNV | loss | 21293372 |
| esv7342 | OTHER | inversion | 19470904 |
| nsv1036470 | CNV | loss | 25217958 |
| nsv1041647 | CNV | gain | 25217958 |
| nsv1051079 | CNV | gain | 25217958 |
| nsv1054297 | CNV | gain | 25217958 |
| nsv1115202 | CNV | deletion | 24896259 |
| nsv614730 | CNV | loss | 21841781 |
| nsv831629 | CNV | gain | 17160897 |
Residual Variation Intolerance Score:
64.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.03;
37.35% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for GNA14 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GNA14 Gene
Disorders for GNA14 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| kaposiform hemangioendothelioma |
|
|
| angioma, tufted |
|
|
| capillary hemangioma |
|
|
| pertussis |
|
|
| choreoacanthocytosis |
|
|
Search GNA14 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for GNA14
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for GNA14 Gene
Publications for GNA14 Gene
- Genomic organization of the human galpha14 and Galphaq genes and mutation analysis in chorea-acanthocytosis (CHAC). (PMID: 10191087) Rubio JP … Monaco AP (Genomics 1999) 2 3 4 56
- Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 43 56
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 43 56
- Identification of hypertension-susceptibility genes and pathways by a systemic multiple candidate gene approach: the millennium genome project for hypertension. (PMID: 18360038) Kohara K … Miki T (Hypertension research : official journal of the Japanese Society of Hypertension 2008) 3 43 56
- The importance of N-terminal polycysteine and polybasic sequences for G14alpha and G16alpha palmitoylation, plasma membrane localization, and signaling function. (PMID: 17620339) Pedone KH … Hepler JR (The Journal of biological chemistry 2007) 2 3 56
ExternalLinks
Products for GNA14 Gene
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Sources for GNA14 Gene
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