Aliases for GNA13 Gene

Aliases for GNA13 Gene

  • G Protein Subunit Alpha 13 2 3 5
  • Guanine Nucleotide Binding Protein (G Protein), Alpha 13 2 3
  • Guanine Nucleotide-Binding Protein Subunit Alpha-13 3 4
  • G Alpha-13 3 4
  • G-Protein Subunit Alpha-13 4
  • G13 3

External Ids for GNA13 Gene

Previous GeneCards Identifiers for GNA13 Gene

  • GC17P065359
  • GC17P068426
  • GC17M063424
  • GC17M063556
  • GC17M063555
  • GC17M060437
  • GC17M063005
  • GC17M058399

Summaries for GNA13 Gene

GeneCards Summary for GNA13 Gene

GNA13 (G Protein Subunit Alpha 13) is a Protein Coding gene. Diseases associated with GNA13 include Retinitis Pigmentosa 14 and Burkitt Lymphoma. Among its related pathways are G-protein signaling_RhoA regulation pathway and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include GTP binding and obsolete signal transducer activity. An important paralog of this gene is GNA12.

UniProtKB/Swiss-Prot Summary for GNA13 Gene

  • Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems (PubMed:15240885, PubMed:16787920, PubMed:16705036, PubMed:27084452). Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF1/p115RhoGEF, ARHGEF11/PDZ-RhoGEF and ARHGEF12/LARG) (PubMed:15240885, PubMed:12515866). GNA13-dependent Rho signaling subsequently regulates transcription factor AP-1 (activating protein-1) (By similarity). Promotes tumor cell invasion and metastasis by activating RhoA/ROCK signaling pathway (PubMed:16787920, PubMed:16705036, PubMed:27084452). Inhibits CDH1-mediated cell adhesion in process independent from Rho activation (PubMed:11976333).

Tocris Summary for GNA13 Gene

  • Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand binding causes a receptor conformational change, detaching the G protein and switching it 'on'.

Gene Wiki entry for GNA13 Gene

Additional gene information for GNA13 Gene

No data available for Entrez Gene Summary , CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GNA13 Gene

Genomics for GNA13 Gene

GeneHancer (GH) Regulatory Elements for GNA13 Gene

Promoters and enhancers for GNA13 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GNA13 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GNA13

Top Transcription factor binding sites by QIAGEN in the GNA13 gene promoter:
  • c-Myc
  • C/EBPalpha
  • CREB
  • deltaCREB
  • IRF-2
  • Max1
  • Meis-1
  • Msx-1
  • Nkx6-1
  • S8

Genomic Locations for GNA13 Gene

Genomic Locations for GNA13 Gene
chr17:65,009,289-65,056,802
(GRCh38/hg38)
Size:
47,514 bases
Orientation:
Minus strand
chr17:63,005,407-63,052,957
(GRCh37/hg19)
Size:
47,551 bases
Orientation:
Minus strand

Genomic View for GNA13 Gene

Genes around GNA13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GNA13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GNA13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GNA13 Gene

Proteins for GNA13 Gene

  • Protein details for GNA13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14344-GNA13_HUMAN
    Recommended name:
    Guanine nucleotide-binding protein subunit alpha-13
    Protein Accession:
    Q14344
    Secondary Accessions:
    • B2R977
    • B7Z7R0
    • F5H1G8
    • Q8TD70

    Protein attributes for GNA13 Gene

    Size:
    377 amino acids
    Molecular mass:
    44050 Da
    Quaternary structure:
    • G proteins are composed of 3 units; alpha, beta and gamma (PubMed:12399457). The alpha chain contains the guanine nucleotide binding site (By similarity). Interacts with UBXD5 (PubMed:16202387). Interacts with HAX1 (PubMed:15339924). Interacts (in GTP-bound form) with PPP5C (via TPR repeats); activates PPP5C phosphatase activity and translocates PPP5C to the cell membrane. Interacts with RGS22 (PubMed:18703424). Interacts (in GTP-bound form) with ARHGEF1 (PubMed:10747909). Interacts (in GTP-bound form) with ARHGEF11 (via RGS domain) (PubMed:10026210). Interacts (in GTP-bound form) with ARHGEF12 (via RGS domain) (PubMed:11094164). Interacts with CTNND1 (PubMed:15240885). Interacts with GASL2L2 (PubMed:23994616).

    Alternative splice isoforms for GNA13 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GNA13 Gene

Post-translational modifications for GNA13 Gene

  • Palmitoylation is critical for proper membrane localization and signaling.
  • Phosphorylation on Thr-203 by PKA destabilizes the heterotrimer of alpha, beta and gamma, and inhibits Rho activation.
  • Ubiquitination at Lys214 and Lys372
  • Modification sites at PhosphoSitePlus

Other Protein References for GNA13 Gene

No data available for DME Specific Peptides for GNA13 Gene

Domains & Families for GNA13 Gene

Gene Families for GNA13 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for GNA13 Gene

Blocks:
  • Alpha G-protein (transducin) signature
  • G-protein alpha subunit group 12 signature
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GNA13 Gene

GenScript: Design optimal peptide antigens:
  • Guanine nucleotide-binding protein subunit alpha-13 (GNA13_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q14344

UniProtKB/Swiss-Prot:

GNA13_HUMAN :
  • Belongs to the G-alpha family. G(12) subfamily.
Family:
  • Belongs to the G-alpha family. G(12) subfamily.
genes like me logo Genes that share domains with GNA13: view

Function for GNA13 Gene

Molecular function for GNA13 Gene

UniProtKB/Swiss-Prot Function:
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems (PubMed:15240885, PubMed:16787920, PubMed:16705036, PubMed:27084452). Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF1/p115RhoGEF, ARHGEF11/PDZ-RhoGEF and ARHGEF12/LARG) (PubMed:15240885, PubMed:12515866). GNA13-dependent Rho signaling subsequently regulates transcription factor AP-1 (activating protein-1) (By similarity). Promotes tumor cell invasion and metastasis by activating RhoA/ROCK signaling pathway (PubMed:16787920, PubMed:16705036, PubMed:27084452). Inhibits CDH1-mediated cell adhesion in process independent from Rho activation (PubMed:11976333).

Phenotypes From GWAS Catalog for GNA13 Gene

Gene Ontology (GO) - Molecular Function for GNA13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001664 G protein-coupled receptor binding IBA 21873635
GO:0003924 GTPase activity TAS,IBA 21873635
GO:0005515 protein binding IPI 10026210
GO:0005525 GTP binding IEA --
GO:0019001 guanyl nucleotide binding IEA --
genes like me logo Genes that share ontologies with GNA13: view
genes like me logo Genes that share phenotypes with GNA13: view

Animal Models for GNA13 Gene

MGI Knock Outs for GNA13:

Animal Model Products

CRISPR Products

Clone Products

  • Addgene plasmids for GNA13

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GNA13 Gene

Localization for GNA13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GNA13 Gene

Cell membrane; Lipid-anchor. Melanosome. Cytoplasm. Nucleus. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065). Detected in the cytoplasm of Leydig cells and in the seminiferous epithelium, including differentiating cells from the spermatogonia to mature spermatozoa stages (PubMed:18703424). In round spermatids, also present in the nuclei (PubMed:18703424). {ECO:0000269 PubMed:17081065, ECO:0000269 PubMed:18703424}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GNA13 gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 4
extracellular 2
cytoskeleton 2
mitochondrion 1
endosome 1
lysosome 1
peroxisome 0
endoplasmic reticulum 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for GNA13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005623 cell IEA --
GO:0005634 nucleus IDA,IEA 18703424
GO:0005737 cytoplasm IEA,IDA 18703424
GO:0005829 cytosol IDA --
GO:0005834 heterotrimeric G-protein complex IBA 21873635
genes like me logo Genes that share ontologies with GNA13: view

Pathways & Interactions for GNA13 Gene

PathCards logo

SuperPathways for GNA13 Gene

SuperPathway Contained pathways
1 fMLP Pathway
.44
.44
.43
.39
.30
2 G-Beta Gamma Signaling
.46
.46
.44
.37
.32
3 p75 NTR receptor-mediated signalling
4 Activation of cAMP-Dependent PKA
.77
.77
.71
.56
5 GPCR Pathway
.62
.58
.58
.55
genes like me logo Genes that share pathways with GNA13: view

Pathways by source for GNA13 Gene

8 GeneGo (Thomson Reuters) pathways for GNA13 Gene
  • Cell adhesion Integrin inside-out signaling
  • Development G-Proteins mediated regulation MARK-ERK signaling
  • G-protein signaling G-Protein alpha-12 signaling pathway
  • G-protein signaling M-RAS regulation pathway
  • G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins
63 Qiagen pathways for GNA13 Gene
  • Actin Nucleation and Branching
  • Actin Nucleation by ARP-WASP Complex
  • Actin-Based Motility by Rho Family GTPases
  • Activation of cAMP-Dependent PKA
  • Activation of PKA through GPCR

Gene Ontology (GO) - Biological Process for GNA13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEA --
GO:0001569 branching involved in blood vessel morphogenesis IEA --
GO:0001701 in utero embryonic development IEA --
GO:0007165 signal transduction TAS 7791744
GO:0007186 G protein-coupled receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with GNA13: view

Drugs & Compounds for GNA13 Gene

(3) Drugs for GNA13 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0
Guanosine monophosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0

(6) Additional Compounds for GNA13 Gene - From: Tocris and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
[D-Trp7,9,10]-Substance P
89430-38-6
G-Protein antagonist peptide
143675-79-0
Gue 1654
397290-30-1
mastoparan
72093-21-1
SCH 202676 hydrobromide
265980-25-4

(5) Tocris Compounds for GNA13 Gene

Compound Action Cas Number
[D-Trp7,9,10]-Substance P Inhibits M1 ACh receptor activation of Gq/11 89430-38-6
G-Protein antagonist peptide Inhibits G protein activation by GPCRs 143675-79-0
Gue 1654 Selective inhibitor of OXE-R Gbetagamma signaling 397290-30-1
Mastoparan Activates Gi and Go 72093-21-1
SCH 202676 hydrobromide Inhibitor of ligand binding to G-protein-coupled receptors 265980-25-4
genes like me logo Genes that share compounds with GNA13: view

Transcripts for GNA13 Gene

mRNA/cDNA for GNA13 Gene

2 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

  • Addgene plasmids for GNA13

Alternative Splicing Database (ASD) splice patterns (SP) for GNA13 Gene

No ASD Table

Relevant External Links for GNA13 Gene

GeneLoc Exon Structure for
GNA13

Expression for GNA13 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GNA13 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GNA13 Gene

This gene is overexpressed in Whole Blood (x5.0).

Protein differential expression in normal tissues from HIPED for GNA13 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GNA13 Gene



Protein tissue co-expression partners for GNA13 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GNA13

SOURCE GeneReport for Unigene cluster for GNA13 Gene:

Hs.515018

mRNA Expression by UniProt/SwissProt for GNA13 Gene:

Q14344-GNA13_HUMAN
Tissue specificity: Expressed in testis, including in Leydig cells and in the seminiferous epithelium, in differentiating cells from the spermatogonia to mature spermatozoa stages and round spermatids (at protein level). Expressed in 99.2% of spermatozoa from healthy individuals, but only in 28.6% of macrocephalic spermatozoa from infertile patients (at protein level).

Evidence on tissue expression from TISSUES for GNA13 Gene

  • Nervous system(4.8)
  • Lymph node(2.2)
genes like me logo Genes that share expression patterns with GNA13: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for GNA13 Gene

Orthologs for GNA13 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for GNA13 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GNA13 31 30
  • 99.56 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GNA13 31
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GNA13 31 30
  • 92.79 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gna13 30
  • 91.25 (n)
mouse
(Mus musculus)
Mammalia Gna13 17 31 30
  • 90.72 (n)
cow
(Bos Taurus)
Mammalia GNA13 31 30
  • 86.64 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GNA13 31
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves GNA13 31 30
  • 85.5 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GNA13 31
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100145489 30
  • 77.45 (n)
zebrafish
(Danio rerio)
Actinopterygii gna13b 31
  • 84 (a)
OneToMany
gna13a 31 30
  • 74.65 (n)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009457 30
  • 58.41 (n)
fruit fly
(Drosophila melanogaster)
Insecta cta 31 32 30
  • 55.62 (n)
ManyToMany
CG40005 31
  • 55 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea gpa-12 31 32
  • 49 (a)
OneToMany
gpa-14 32
  • 31 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GPA2 31
  • 30 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 62 (a)
OneToMany
Species where no ortholog for GNA13 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GNA13 Gene

ENSEMBL:
Gene Tree for GNA13 (if available)
TreeFam:
Gene Tree for GNA13 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GNA13: view image

Paralogs for GNA13 Gene

(18) SIMAP similar genes for GNA13 Gene using alignment to 2 proteins:

  • GNA13_HUMAN
  • F5H1G8_HUMAN

Pseudogenes.org Pseudogenes for GNA13 Gene

genes like me logo Genes that share paralogs with GNA13: view

Variants for GNA13 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GNA13 Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
773331 Benign: not provided 65,014,290(-) C/T SYNONYMOUS_VARIANT
789341 Benign: not provided 65,053,580(-) T/C SYNONYMOUS_VARIANT
rs1062597 - p.Val221Leu

Additional dbSNP identifiers (rs#s) for GNA13 Gene

Structural Variations from Database of Genomic Variants (DGV) for GNA13 Gene

Variant ID Type Subtype PubMed ID
nsv1066765 CNV gain 25217958
nsv1120054 OTHER inversion 24896259
nsv112105 CNV deletion 16902084
nsv2123 CNV insertion 18451855
nsv478515 CNV novel sequence insertion 20440878
nsv952361 CNV duplication 24416366

Variation tolerance for GNA13 Gene

Residual Variation Intolerance Score: 39.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.04; 37.44% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GNA13 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GNA13

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GNA13 Gene

Disorders for GNA13 Gene

MalaCards: The human disease database

(2) MalaCards diseases for GNA13 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
retinitis pigmentosa 14
  • rp14
burkitt lymphoma
  • bl
- elite association - COSMIC cancer census association via MalaCards
Search GNA13 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for GNA13

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with GNA13: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GNA13 Gene

Publications for GNA13 Gene

  1. Galpha 12 activates Rho GTPase through tyrosine-phosphorylated leukemia-associated RhoGEF. (PMID: 12515866) Suzuki N … Kozasa T (Proceedings of the National Academy of Sciences of the United States of America 2003) 3 4 23 54
  2. Expression of GTP-binding protein alpha subunits in human thymocytes. (PMID: 7791744) Kabouridis PS … Tsoukas CD (Molecular and cellular biochemistry 1995) 2 3 4 54
  3. A novel Gαs-binding protein, Gas-2 like 2, facilitates the signaling of the A2A adenosine receptor. (PMID: 23994616) Wu YC … Chern Y (Biochimica et biophysica acta 2013) 3 4 54
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41 54
  5. RGS22, a novel testis-specific regulator of G-protein signaling involved in human and mouse spermiogenesis along with GNA12/13 subunits. (PMID: 18703424) Hu Y … Sha J (Biology of reproduction 2008) 3 4 54

Products for GNA13 Gene

Sources for GNA13 Gene