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GNA12 (G Protein Subunit Alpha 12) is a Protein Coding gene. Diseases associated with GNA12 include Familial Hyperaldosteronism. Among its related pathways are Sweet Taste Signaling and Signal transduction_PKA signaling. Gene Ontology (GO) annotations related to this gene include GTP binding and obsolete signal transducer activity. An important paralog of this gene is GNA13.
Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand binding causes a receptor conformational change, detaching the G protein and switching it 'on'.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000166 | nucleotide binding | IEA | -- |
GO:0001664 | G protein-coupled receptor binding | IBA | 21873635 |
GO:0003924 | GTPase activity | IEA,IBA | 21873635 |
GO:0005515 | protein binding | IPI | 10026210 |
GO:0005525 | GTP binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005737 | cytoplasm | IEA | -- |
GO:0005834 | heterotrimeric G-protein complex | IBA | 21873635 |
GO:0005886 | plasma membrane | TAS | -- |
GO:0005925 | focal adhesion | HDA | 21423176 |
GO:0016020 | membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | fMLP Pathway |
CCR3 Pathway in Eosinophils
.44
VEGF and S-1P Signaling
.44
fMLP Pathway
.43
|
CXCR4 Pathway
.39
Huntington's Disease Pathway
.31
|
2 | G-Beta Gamma Signaling |
G-Beta Gamma Signaling
.46
GHRH Signaling
.46
CRHR Pathway
.44
|
Relaxin Pathway
.37
Hedgehog Signaling in Mammals
.32
|
3 | S1P3 pathway |
.44
.44
|
.36
.01
|
4 | Actin Nucleation by ARP-WASP Complex |
Actin Nucleation and Branching
.66
Actin Nucleation by ARP-WASP Complex
.66
|
CDC42 Pathway
.41
RhoA Pathway
.35
|
5 | Activation of cAMP-Dependent PKA |
Activation of cAMP-Dependent PKA
.77
cAMP Pathway
.77
|
Activation of PKA through GPCR
.71
PKA Signaling
.56
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001701 | in utero embryonic development | IEA | -- |
GO:0007165 | signal transduction | IEA | -- |
GO:0007186 | G protein-coupled receptor signaling pathway | IEA,TAS | -- |
GO:0007188 | adenylate cyclase-modulating G protein-coupled receptor signaling pathway | IBA | 21873635 |
GO:0007266 | Rho protein signal transduction | IBA | 21873635 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
[D-Trp7,9,10]-Substance P |
|
89430-38-6 |
|
|
||
G-Protein antagonist peptide |
|
143675-79-0 |
|
|
||
Gue 1654 |
|
397290-30-1 |
|
|
||
mastoparan |
|
72093-21-1 |
|
|
||
SCH 202676 hydrobromide |
|
265980-25-4 |
|
|
Compound | Action | Cas Number |
---|---|---|
[D-Trp7,9,10]-Substance P | Inhibits M1 ACh receptor activation of Gq/11 | 89430-38-6 |
G-Protein antagonist peptide | Inhibits G protein activation by GPCRs | 143675-79-0 |
Gue 1654 | Selective inhibitor of OXE-R Gbetagamma signaling | 397290-30-1 |
Mastoparan | Activates Gi and Go | 72093-21-1 |
SCH 202676 hydrobromide | Inhibitor of ligand binding to G-protein-coupled receptors | 265980-25-4 |
ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | · | 6c | · | 6d | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | · | 10c | · | 10d | · | 10e |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||
SP2: | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||
SP3: | - | - | |||||||||||||||||||||||||||||||||||
SP4: | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||
SP5: | - | - | - | ||||||||||||||||||||||||||||||||||
SP6: | - | - | |||||||||||||||||||||||||||||||||||
SP7: | |||||||||||||||||||||||||||||||||||||
SP8: | - |
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | GNA12 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | GNA12 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | GNA12 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | GNA12 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | GNA12 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Gna12 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Gna12 30 |
|
||
Chicken (Gallus gallus) |
Aves | GNA12 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | GNA12 31 |
|
OneToOne | |
Zebrafish (Danio rerio) |
Actinopterygii | gna12a 30 31 |
|
OneToOne | |
Fruit Fly (Drosophila melanogaster) |
Insecta | CG40005 31 |
|
ManyToMany | |
cta 31 32 |
|
ManyToMany | |||
Worm (Caenorhabditis elegans) |
Secernentea | gpa-12 30 31 32 |
|
OneToMany | |
gpa-14 32 |
|
|
|||
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | GPA2 31 |
|
OneToMany | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany | |
Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.3611 30 |
|
SNP ID | Clinical significance and condition | Chr 07 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
783488 | Benign: not provided | 2,731,349(-) | G/A | SYNONYMOUS_VARIANT,INTRON_VARIANT | |
rs11552939 | - | p.Ser68Gly | |||
rs45583847 | - | p.Tyr330His | |||
rs45606633 | - | p.Phe242Leu |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2761071 | CNV | loss | 21179565 |
esv3541054 | CNV | deletion | 23714750 |
esv3611852 | CNV | loss | 21293372 |
esv3611853 | CNV | loss | 21293372 |
esv3611854 | CNV | loss | 21293372 |
esv3891011 | CNV | gain | 25118596 |
nsv1074476 | CNV | deletion | 25765185 |
nsv471227 | CNV | loss | 18288195 |
nsv605872 | CNV | loss | 21841781 |
nsv966746 | CNV | duplication | 23825009 |
Disorder | Aliases | PubMed IDs |
---|---|---|
familial hyperaldosteronism |
|
|