Aliases for GNA12 Gene
Aliases for GNA12 Gene
External Ids for GNA12 Gene
- HGNC: 4380
- Entrez Gene: 2768
- Ensembl: ENSG00000146535
- OMIM: 604394
- UniProtKB: Q03113
Previous GeneCards Identifiers for GNA12 Gene
- GC07M002415
- GC07M002515
- GC07M002512
- GC07M002540
- GC07M002734
- GC07M002767
- GC07M002686
Summaries for GNA12 Gene
GeneCards Summary for GNA12 Gene
GNA12 (G Protein Subunit Alpha 12) is a Protein Coding gene. Diseases associated with GNA12 include Familial Hyperaldosteronism. Among its related pathways are GPCR Pathway and Long-term depression. Gene Ontology (GO) annotations related to this gene include GTP binding and obsolete signal transducer activity. An important paralog of this gene is GNA13.
UniProtKB/Swiss-Prot for GNA12 Gene
-
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems (PubMed:22609986, PubMed:15525651, PubMed:15240885, PubMed:17565996, PubMed:12515866, PubMed:16787920, PubMed:16705036, PubMed:23762476, PubMed:27084452). Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF12/LARG) (PubMed:15240885, PubMed:12515866, PubMed:16202387). GNA12-dependent Rho signaling subsequently regulates transcription factor AP-1 (activating protein-1) (By similarity). GNA12-dependent Rho signaling also regulates protein phosphatese 2A activation causing dephosphorylation of its target proteins (PubMed:15525651, PubMed:17565996). Promotes tumor cell invasion and metastasis by activating RhoA/ROCK signaling pathway and up-regulating proinflammatory cytokine production (PubMed:23762476, PubMed:16787920, PubMed:16705036, PubMed:27084452). Inhibits CDH1-mediated cell adhesion in process independent from Rho activation (PubMed:11976333, PubMed:16787920). Together with NAPA promotes CDH5 localization to plasma membrane (PubMed:15980433). May play a role in the control of cell migration through the TOR signaling cascade (PubMed:22609986).
-
Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand binding causes a receptor conformational change, detaching the G protein and switching it 'on'.
Additional gene information for GNA12 Gene
- Monarch Initiative
- Search for GNA12 at DataMed
- Search for GNA12 at HumanCyc
No data available for Entrez Gene Summary , CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GNA12 Gene
Genomics for GNA12 Gene
GeneHancer (GH) Regulatory Elements for GNA12 Gene
Promoters and enhancers for GNA12 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around GNA12 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the GNA12 gene promoter:
-
- AREB6
- Bach2
- CUTL1
- FOXI1
- FOXO1
- FOXO1a
- HFH-3
- HNF-1
- HNF-1A
- Zic1
Genomic Locations for GNA12 Gene
Genomic Locations for GNA12 Gene
- chr7:2,728,105-2,870,656
- (GRCh38/hg38)
- Size:
- 142,552 bases
- Orientation:
- Minus strand
- chr7:2,767,739-2,883,959
- (GRCh37/hg19)
- Size:
- 116,221 bases
- Orientation:
- Minus strand
Genomic View for GNA12 Gene
Genes around GNA12 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 7p22.3-p22.2 by HGNC
- 7p22.3-p22.2 by Entrez Gene
- 7p22.2 by Ensembl
GNA12 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for GNA12 Gene
Proteins for GNA12 Gene
-
Protein details for GNA12 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q03113-GNA12_HUMAN
- Recommended name:
- Guanine nucleotide-binding protein subunit alpha-12
- Protein Accession:
- Q03113
- A4D204
- B3KXS2
- B7Z3F7
- Q2T9L1
- Q5PPR5
- Q86UM8
- Q8TD71
- Q9UDU9
Protein attributes for GNA12 Gene
- Size:
- 381 amino acids
- Molecular mass:
- 44279 Da
- Quaternary structure:
-
- G proteins are composed of 3 units; alpha, beta and gamma (PubMed:10026210). The alpha chain contains the guanine nucleotide binding site (By similarity). Interacts with UBXD5 (PubMed:16202387). Interacts (in GTP-bound form) with PPP5C (via TPR repeats); activates PPP5C phosphatase activity and translocates PPP5C to the cell membrane. Interacts with RGS22 (PubMed:18703424). Interacts (via N-terminus) with NAPA; the interaction promotes CDH5 localization to plasma membrane (PubMed:15980433). Interacts with CTNND1 (via N-terminus); the interaction regulates CDH1-mediated cell-cell adhesion (PubMed:15240885). Interacts with PPP2R1A; the interaction promotes protein phosphatase 2A activation causing dephosphorylation of MAPT (PubMed:15525651). Interacts (in GTP-bound form) with ARHGEF1 (By similarity). Interacts (in GTP-bound form) with ARHGEF11 (via RGS domain) (PubMed:10026210). Interacts (in GTP-bound form) with ARHGEF12 (via RGS domain) (PubMed:11094164).
Protein Expression for GNA12 Gene
Post-translational modifications for GNA12 Gene
Other Protein References for GNA12 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for GNA12
- Novus Biologicals Antibodies for GNA12
- Invitrogen Antibodies for GNA12 (AFLGC-GNA12)
-
Santa Cruz Biotechnology (SCBT) Antibodies for GNA12
Protein Products
-
OriGene Purified Proteins for GNA12
- Search Origene for MassSpec and Protein Over-expression Lysates for GNA12
- Origene Custom Protein Services for GNA12
- Novus Biologicals lysates for GNA12
No data available for DME Specific Peptides for GNA12 Gene
Domains & Families for GNA12 Gene
Gene Families for GNA12 Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for GNA12 Gene
Suggested Antigen Peptide Sequences for GNA12 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ45945 fis, clone PLACE7006498, highly similar to Guanine nucleotide-binding protein alpha-12 subunit (B3KXS2_HUMAN)
- cDNA FLJ55846, highly similar to Guanine nucleotide-binding protein alpha-12 subunit (B7Z3F7_HUMAN)
- Guanine nucleotide-binding protein subunit alpha-12 (GNA12_HUMAN)
- Guanine nucleotide binding protein (G protein) alpha 12 (Q5PPR5_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q03113- Family:
-
- Belongs to the G-alpha family. G(12) subfamily.
Function for GNA12 Gene
Molecular function for GNA12 Gene
- UniProtKB/Swiss-Prot Function:
- Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems (PubMed:22609986, PubMed:15525651, PubMed:15240885, PubMed:17565996, PubMed:12515866, PubMed:16787920, PubMed:16705036, PubMed:23762476, PubMed:27084452). Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF12/LARG) (PubMed:15240885, PubMed:12515866, PubMed:16202387). GNA12-dependent Rho signaling subsequently regulates transcription factor AP-1 (activating protein-1) (By similarity). GNA12-dependent Rho signaling also regulates protein phosphatese 2A activation causing dephosphorylation of its target proteins (PubMed:15525651, PubMed:17565996). Promotes tumor cell invasion and metastasis by activating RhoA/ROCK signaling pathway and up-regulating proinflammatory cytokine production (PubMed:23762476, PubMed:16787920, PubMed:16705036, PubMed:27084452). Inhibits CDH1-mediated cell adhesion in process independent from Rho activation (PubMed:11976333, PubMed:16787920). Together with NAPA promotes CDH5 localization to plasma membrane (PubMed:15980433). May play a role in the control of cell migration through the TOR signaling cascade (PubMed:22609986).
Phenotypes From GWAS Catalog for GNA12 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001664 | G protein-coupled receptor binding | IBA | 21873635 |
| GO:0003924 | GTPase activity | IEA,IBA | 21873635 |
| GO:0005515 | protein binding | IPI | 10026210 |
| GO:0005525 | GTP binding | IEA | -- |
| GO:0019001 | guanyl nucleotide binding | IEA | -- |
Phenotypes for GNA12 Gene
- MGI mutant phenotypes for GNA12:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for GNA12:
-
- Dynamic nuclei (hole, folded or small irregular)
- Synthetic lethal with c-Myc after tamoxifen stimulation
- Reduced mammosphere formation
- Decreased ionizing radiation sensitivity
- Decreased Salmonella enterica Typhimurium invasion
- Decreased viability
- no effect
- Increased vaccinia virus (VACV) infection
- shRNA abundance <= 50%
- Lamellipodia cells
Animal Model Products
-
Taconic Biosciences Mouse Models for GNA12
- Cyagen custom Knockout/knockin (KOKI) mouse models for GNA12
-
CRISPR Products
-
OriGene CRISPR knockouts for GNA12
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for GNA12
- genomics-online: gRNA clones - Search results for 94 available GNA12 gene related products
- Overview of 94 available GNA12 gene related products
- Applied Biological Materials (abm): CRISPR Clones for GNA12 - Now 50% OFF >
- * GNA12 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * GNA12 CRISPR applications: KO, Activation, Repression, and more - Browse All
-
Santa Cruz Biotechnology (SCBT) CRISPR for GNA12
miRNA for GNA12 Gene
- miRTarBase miRNAs that target GNA12
-
- hsa-mir-124-3p (MIRT023075)
- hsa-mir-98-5p (MIRT027790)
- hsa-mir-93-5p (MIRT028098)
- hsa-mir-149-5p (MIRT045616)
- hsa-mir-23b-3p (MIRT046311)
- hsa-mir-218-5p (MIRT440559)
- hsa-mir-335-3p (MIRT616790)
- hsa-mir-1305 (MIRT616791)
- hsa-mir-4309 (MIRT616792)
- hsa-mir-3198 (MIRT616793)
- hsa-mir-4653-3p (MIRT616794)
- hsa-mir-4424 (MIRT616795)
- hsa-mir-432-5p (MIRT616796)
- hsa-mir-335-5p (MIRT616797)
- hsa-mir-1266-5p (MIRT736703)
- hsa-mir-211-3p (MIRT738927)
- hsa-mir-3664-3p (MIRT742022)
- hsa-mir-4270 (MIRT743565)
- hsa-mir-4441 (MIRT744532)
- hsa-mir-4518 (MIRT745776)
- hsa-mir-6754-5p (MIRT754707)
- hsa-mir-7-5p (MIRT759430)
- hsa-mir-8087 (MIRT760261)
- hsa-mir-9500 (MIRT760883)
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for GNA12
- Browse OriGene Inhibitory RNA Products For GNA12
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GNA12
- genomics-online: shRNA clones - Search results for 94 available GNA12 gene related products
- Overview of 94 available GNA12 gene related products
Clone Products
- Applied Biological Materials (abm): Clones for GNA12 - Now 50% OFF >
- * GNA12 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * GNA12 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
-
- MG225752
- MR225752
- MR225752L1
- MR225752L1V
- MR225752L2
- MR225752L2V
- MR225752L3
- MR225752L3V
- MR225752L4
- MR225752L4V
- RC210511
- RC210511L1
- RC210511L1V
- RC210511L2
- RC210511L2V
- RC210511L3
- RC210511L3V
- RC210511L4
- RC210511L4V
- RC237337
- RC237443
- RC237736
- RG210511
- RR208404
- RR208404L1
- RR208404L1V
- RR208404L2
- RR208404L2V
- RR208404L3
- RR208404L3V
- RR208404L4
- RR208404L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for GNA12
- Addgene plasmids for GNA12
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for GNA12
Cell Line Products
-
Horizon Cell Lines for GNA12
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GNA12 Gene
Localization for GNA12 Gene
Subcellular locations from UniProtKB/Swiss-Prot for GNA12 Gene
- Cell membrane; Lipid-anchor. Lateral cell membrane; Lipid-anchor. Cytoplasm. Note=CDH1 enhances cell membrane localization. {ECO:0000269 PubMed:15240885}.
| Compartment | Confidence |
|---|---|
| plasma membrane | 4 |
| cytosol | 3 |
| mitochondrion | 2 |
| peroxisome | 1 |
- Cytosol (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005834 | heterotrimeric G-protein complex | IBA | 21873635 |
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0005925 | focal adhesion | HDA | 21423176 |
| GO:0016020 | membrane | IEA | -- |
Pathways & Interactions for GNA12 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | fMLP Pathway |
.43
|
.39
|
| 2 | G-Beta Gamma Signaling |
.46
.44
|
.37
|
| 3 | S1P3 pathway |
.44
.44
|
.36
.01
|
| 4 | Actin Nucleation by ARP-WASP Complex |
.41
.35
|
|
| 5 | Activation of cAMP-Dependent PKA |
.77
|
.56
|
Pathways by source for GNA12 Gene
11 BioSystems pathways for GNA12 Gene
7 Reactome pathways for GNA12 Gene
1 PharmGKB pathway for GNA12 Gene
10 KEGG pathways for GNA12 Gene
8 GeneGo (Thomson Reuters) pathways for GNA12 Gene
Interacting Proteins for GNA12 Gene
Selected Interacting proteins:
ENSP00000275364
Q03113-GNA12_HUMAN
for GNA12 Gene via
STRING
IID
MINT
GPS-Prot Interaction Network for GNA12
SIGNOR curated interactions for GNA12 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001701 | in utero embryonic development | IEA | -- |
| GO:0007165 | signal transduction | IEA | -- |
| GO:0007186 | G protein-coupled receptor signaling pathway | TAS,IEA | -- |
| GO:0007188 | adenylate cyclase-modulating G protein-coupled receptor signaling pathway | IBA | 21873635 |
| GO:0007266 | Rho protein signal transduction | IBA | 21873635 |
Drugs & Compounds for GNA12 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| [D-Trp7,9,10]-Substance P |
|
89430-38-6 |
|
|
||
| G-Protein antagonist peptide |
|
143675-79-0 |
|
|
||
| Gue 1654 |
|
397290-30-1 |
|
|
||
| mastoparan |
|
72093-21-1 |
|
|
||
| SCH 202676 hydrobromide |
|
265980-25-4 |
|
|
(5) Tocris Compounds for GNA12 Gene
| Compound | Action | Cas Number |
|---|---|---|
| [D-Trp7,9,10]-Substance P | Inhibits M1 ACh receptor activation of Gq/11 | 89430-38-6 |
| G-Protein antagonist peptide | Inhibits G protein activation by GPCRs | 143675-79-0 |
| Gue 1654 | Selective inhibitor of OXE-R Gbetagamma signaling | 397290-30-1 |
| Mastoparan | Activates Gi and Go | 72093-21-1 |
| SCH 202676 hydrobromide | Inhibitor of ligand binding to G-protein-coupled receptors | 265980-25-4 |
Transcripts for GNA12 Gene
mRNA/cDNA for GNA12 Gene
- (4) REFSEQ mRNAs :
- (20) Additional mRNA sequences :
- (303) Selected AceView cDNA sequences:
- (8) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000275364 4369 bps (ENST00000275364.7)
- ENST00000491117 3375 bps (ENST00000491117.5)
- ENST00000407904 3918 bps (ENST00000407904.7)
- ENST00000407653 3785 bps (ENST00000407653.1)
- ENST00000496740 2450 bps (ENST00000496740.6)
Unigene Clusters for GNA12 Gene
CRISPR Products
-
OriGene CRISPR knockouts for GNA12
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for GNA12
- genomics-online: gRNA clones - Search results for 94 available GNA12 gene related products
- Overview of 94 available GNA12 gene related products
- Applied Biological Materials (abm): CRISPR Clones for GNA12 - Now 50% OFF >
- * GNA12 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * GNA12 CRISPR applications: KO, Activation, Repression, and more - Browse All
-
Santa Cruz Biotechnology (SCBT) CRISPR for GNA12
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for GNA12
- Browse OriGene Inhibitory RNA Products For GNA12
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GNA12
- genomics-online: shRNA clones - Search results for 94 available GNA12 gene related products
- Overview of 94 available GNA12 gene related products
Clone Products
- Applied Biological Materials (abm): Clones for GNA12 - Now 50% OFF >
- * GNA12 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * GNA12 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
-
- MG225752
- MR225752
- MR225752L1
- MR225752L1V
- MR225752L2
- MR225752L2V
- MR225752L3
- MR225752L3V
- MR225752L4
- MR225752L4V
- RC210511
- RC210511L1
- RC210511L1V
- RC210511L2
- RC210511L2V
- RC210511L3
- RC210511L3V
- RC210511L4
- RC210511L4V
- RC237337
- RC237443
- RC237736
- RG210511
- RR208404
- RR208404L1
- RR208404L1V
- RR208404L2
- RR208404L2V
- RR208404L3
- RR208404L3V
- RR208404L4
- RR208404L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for GNA12
- Addgene plasmids for GNA12
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for GNA12
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | · | 6c | · | 6d | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | · | 10c | · | 10d | · | 10e |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||
| SP5: | - | - | - | ||||||||||||||||||||||||||||||||||
| SP6: | - | - | |||||||||||||||||||||||||||||||||||
| SP7: | |||||||||||||||||||||||||||||||||||||
| SP8: | - |
Expression for GNA12 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Brain (Nervous System)
- Myelinating Oligodendrocyte Cells Forebrain White Matter
-
Glial Cells
- Myelinating Oligodendrocyte Cells Forebrain White Matter
- Blood (Hematopoietic System)
-
Placenta (Extraembryonic Tissues)
-
Ovary (Reproductive System)
This gene is overexpressed in Brain (28.8), Pancreas (12.9), and Bone (9.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GNA12 Gene
NURSA nuclear receptor signaling pathways regulating expression of GNA12 Gene:
GNA12SOURCE GeneReport for Unigene cluster for GNA12 Gene:
Hs.487341Evidence on tissue expression from TISSUES for GNA12 Gene
- Nervous system(4.8)
- Pancreas(4.2)
- Lung(2)
Primer Products
-
OriGene qPCR primer pairs for GNA12
-
OriGene qPCR primer pairs and template standards for GNA12
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GNA12 Gene
Orthologs for GNA12 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | GNA12 35 34 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | GNA12 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | GNA12 35 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | GNA12 35 34 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | GNA12 35 34 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Gna12 17 35 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Gna12 34 |
|
||
| chicken (Gallus gallus) |
Aves | GNA12 35 34 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | GNA12 35 |
|
OneToOne | |
| zebrafish (Danio rerio) |
Actinopterygii | gna12a 35 34 |
|
OneToOne | |
| fruit fly (Drosophila melanogaster) |
Insecta | CG40005 35 |
|
ManyToMany | |
| cta 35 36 |
|
ManyToMany | |||
| worm (Caenorhabditis elegans) |
Secernentea | gpa-12 35 36 34 |
|
OneToMany | |
| gpa-14 36 |
|
|
|||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | GPA2 35 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
OneToMany | |
| Cin.3611 34 |
|
||||
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.3611 34 |
|
- Species where no ortholog for GNA12 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
Evolution for GNA12 Gene
- ENSEMBL:
- Gene Tree for GNA12 (if available)
- TreeFam:
- Gene Tree for GNA12 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for GNA12: view image
Paralogs for GNA12 Gene
Paralogs for GNA12 Gene
(19) SIMAP similar genes for GNA12 Gene using alignment to 7 proteins:
- GNA12_HUMAN
- B3KXS2_HUMAN
- B7Z3F7_HUMAN
- C9J2Y7_HUMAN
- E7EUG4_HUMAN
- E9PC54_HUMAN
- Q5PPR5_HUMAN
Variants for GNA12 Gene
| SNP ID | Clin | Chr 07 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000020775 | -- | 2,785,718(-) | A/T | genic_upstream_transcript_variant, intron_variant | |
| rs1000034868 | -- | 2,847,574(-) | C/T | genic_upstream_transcript_variant, intron_variant | |
| rs1000036162 | -- | 2,863,707(-) | C/G/T | genic_upstream_transcript_variant, intron_variant | |
| rs1000044845 | -- | 2,844,593(-) | C/T | genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant | |
| rs1000052206 | -- | 2,741,217(-) | G/T | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2761071 | CNV | loss | 21179565 |
| esv3541054 | CNV | deletion | 23714750 |
| esv3611852 | CNV | loss | 21293372 |
| esv3611853 | CNV | loss | 21293372 |
| esv3611854 | CNV | loss | 21293372 |
| esv3891011 | CNV | gain | 25118596 |
| nsv1074476 | CNV | deletion | 25765185 |
| nsv471227 | CNV | loss | 18288195 |
| nsv605872 | CNV | loss | 21841781 |
| nsv966746 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
54.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.52;
11.24% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for GNA12 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- GNA12
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GNA12 Gene
Disorders for GNA12 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| familial hyperaldosteronism |
|
|
Search GNA12 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for GNA12
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for GNA12 Gene
Publications for GNA12 Gene
- Identification of 20 novel SNPs in the guanine nucleotide binding protein alpha 12 gene locus. (PMID: 15221642) Iida A … Nakamura Y (Journal of human genetics 2004) 3 23 45 58
- Expression cDNA cloning of a transforming gene encoding the wild-type G alpha 12 gene product. (PMID: 8423800) Chan AM … Aaronson SA (Molecular and cellular biology 1993) 2 3 4 58
- Gα₁₂ drives invasion of oral squamous cell carcinoma through up-regulation of proinflammatory cytokines. (PMID: 23762476) Jian SL … Juang JL (PloS one 2013) 3 4 58
- PRR5L degradation promotes mTORC2-mediated PKC-δ phosphorylation and cell migration downstream of Gα12. (PMID: 22609986) Gan X … Wu D (Nature cell biology 2012) 3 4 58
- Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. (PMID: 21297633) Anderson CA … Rioux JD (Nature genetics 2011) 3 45 58
ExternalLinks
Products for GNA12 Gene
- View all R&D Systems custom services
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- MG225752
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- Taconic Biosciences Mouse Models for GNA12
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- antibodies-online: Search results for 53 available GNA12 Antibodies ranked by validation data
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- genomics-online: cdna clones - Search results for 94 available GNA12 gene related products
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- Overview of 94 available GNA12 gene related products
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- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for GNA12
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Sources for GNA12 Gene
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