Aliases for GNA12 Gene
Aliases for GNA12 Gene
External Ids for GNA12 Gene
- HGNC: 4380
- Entrez Gene: 2768
- Ensembl: ENSG00000146535
- OMIM: 604394
- UniProtKB: Q03113
Previous GeneCards Identifiers for GNA12 Gene
- GC07M002415
- GC07M002515
- GC07M002512
- GC07M002540
- GC07M002734
- GC07M002767
- GC07M002686
Summaries for GNA12 Gene
GeneCards Summary for GNA12 Gene
GNA12 (G Protein Subunit Alpha 12) is a Protein Coding gene. Diseases associated with GNA12 include Familial Hyperaldosteronism. Among its related pathways are Integrin Pathway and Akt Signaling. Gene Ontology (GO) annotations related to this gene include GTP binding and signal transducer activity. An important paralog of this gene is GNA13.
UniProtKB/Swiss-Prot for GNA12 Gene
-
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems (PubMed:22609986, PubMed:15525651, PubMed:15240885, PubMed:17565996, PubMed:12515866, PubMed:16787920, PubMed:16705036, PubMed:23762476, PubMed:27084452). Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF12/LARG) (PubMed:15240885, PubMed:12515866, PubMed:16202387). GNA12-dependent Rho signaling subsequently regulates transcription factor AP-1 (activating protein-1) (By similarity). GNA12-dependent Rho signaling also regulates protein phosphatese 2A activation causing dephosphorylation of its target proteins (PubMed:15525651, PubMed:17565996). Promotes tumor cell invasion and metastasis by activating RhoA/ROCK signaling pathway and up-regulating proinflammatory cytokine production (PubMed:23762476, PubMed:16787920, PubMed:16705036, PubMed:27084452). Inhibits CDH1-mediated cell adhesion in process independent from Rho activation (PubMed:11976333, PubMed:16787920). Together with NAPA promotes CDH5 localization to plasma membrane (PubMed:15980433). May play a role in the control of cell migration through the TOR signaling cascade (PubMed:22609986).
-
Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand binding causes a receptor conformational change, detaching the G protein and switching it 'on'.
Additional gene information for GNA12 Gene
- Monarch Initiative
- Search for GNA12 at DataMed
- Search for GNA12 at HumanCyc
No data available for Entrez Gene Summary , CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GNA12 Gene
Genomics for GNA12 Gene
GeneHancer (GH) Regulatory Elements for GNA12 Gene
Promoters and enhancers for GNA12 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around GNA12 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for GNA12 Gene
Genomic Locations for GNA12 Gene
- chr7:2,728,105-2,870,656
- (GRCh38/hg38)
- Size:
- 142,552 bases
- Orientation:
- Minus strand
- chr7:2,767,739-2,883,959
- (GRCh37/hg19)
Genomic View for GNA12 Gene
Genes around GNA12 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 7p22.2 by Ensembl
- 7p22.3-p22.2 by Entrez Gene
- 7p22.3-p22.2 by HGNC
GNA12 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for GNA12 Gene
Proteins for GNA12 Gene
-
Protein details for GNA12 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q03113-GNA12_HUMAN
- Recommended name:
- Guanine nucleotide-binding protein subunit alpha-12
- Protein Accession:
- Q03113
- A4D204
- B3KXS2
- B7Z3F7
- Q2T9L1
- Q5PPR5
- Q86UM8
- Q8TD71
- Q9UDU9
Protein attributes for GNA12 Gene
- Size:
- 381 amino acids
- Molecular mass:
- 44279 Da
- Quaternary structure:
-
- G proteins are composed of 3 units; alpha, beta and gamma (PubMed:10026210). The alpha chain contains the guanine nucleotide binding site (By similarity). Interacts with UBXD5 (PubMed:16202387). Interacts (in GTP-bound form) with PPP5C (via TPR repeats); activates PPP5C phosphatase activity and translocates PPP5C to the cell membrane. Interacts with RGS22 (PubMed:18703424). Interacts (via N-terminus) with NAPA; the interaction promotes CDH5 localization to plasma membrane (PubMed:15980433). Interacts with CTNND1 (via N-terminus); the interaction regulates CDH1-mediated cell-cell adhesion (PubMed:15240885). Interacts with PPP2R1A; the interaction promotes protein phosphatase 2A activation causing dephosphorylation of MAPT (PubMed:15525651). Interacts (in GTP-bound form) with ARHGEF1 (By similarity). Interacts (in GTP-bound form) with ARHGEF11 (via RGS domain) (PubMed:10026210). Interacts (in GTP-bound form) with ARHGEF12 (via RGS domain) (PubMed:11094164).
Protein Expression for GNA12 Gene
Post-translational modifications for GNA12 Gene
Other Protein References for GNA12 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for GNA12
- Novus Biologicals Antibodies for GNA12
-
Abcam antibodies for GNA12
- Invitrogen Antibodies for GNA12
- GeneTex GNA12 antibody for GNA12
-
Santa Cruz Biotechnology (SCBT) Antibodies for GNA12
Protein Products
-
OriGene Purified Proteins for GNA12
- Search Origene for MassSpec and Protein Over-expression Lysates for GNA12
- Origene Custom Protein Services for GNA12
- Novus Biologicals lysates for GNA12
- Search GeneTex for Proteins for GNA12
Assay Products
No data available for DME Specific Peptides for GNA12 Gene
Domains & Families for GNA12 Gene
Gene Families for GNA12 Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for GNA12 Gene
Suggested Antigen Peptide Sequences for GNA12 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ45945 fis, clone PLACE7006498, highly similar to Guanine nucleotide-binding protein alpha-12 subunit (B3KXS2_HUMAN)
- cDNA FLJ55846, highly similar to Guanine nucleotide-binding protein alpha-12 subunit (B7Z3F7_HUMAN)
- Guanine nucleotide-binding protein subunit alpha-12 (GNA12_HUMAN)
- Guanine nucleotide binding protein (G protein) alpha 12 (Q5PPR5_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q03113- Family:
-
- Belongs to the G-alpha family. G(12) subfamily.
Function for GNA12 Gene
Molecular function for GNA12 Gene
- UniProtKB/Swiss-Prot Function:
- Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems (PubMed:22609986, PubMed:15525651, PubMed:15240885, PubMed:17565996, PubMed:12515866, PubMed:16787920, PubMed:16705036, PubMed:23762476, PubMed:27084452). Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF12/LARG) (PubMed:15240885, PubMed:12515866, PubMed:16202387). GNA12-dependent Rho signaling subsequently regulates transcription factor AP-1 (activating protein-1) (By similarity). GNA12-dependent Rho signaling also regulates protein phosphatese 2A activation causing dephosphorylation of its target proteins (PubMed:15525651, PubMed:17565996). Promotes tumor cell invasion and metastasis by activating RhoA/ROCK signaling pathway and up-regulating proinflammatory cytokine production (PubMed:23762476, PubMed:16787920, PubMed:16705036, PubMed:27084452). Inhibits CDH1-mediated cell adhesion in process independent from Rho activation (PubMed:11976333, PubMed:16787920). Together with NAPA promotes CDH5 localization to plasma membrane (PubMed:15980433). May play a role in the control of cell migration through the TOR signaling cascade (PubMed:22609986).
Phenotypes From GWAS Catalog for GNA12 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001664 | G-protein coupled receptor binding | IEA | -- |
| GO:0003924 | GTPase activity | TAS,IEA | -- |
| GO:0004871 | signal transducer activity | IEA,IBA | -- |
| GO:0005515 | protein binding | IPI | 10026210 |
| GO:0005525 | GTP binding | IEA | -- |
Phenotypes for GNA12 Gene
- MGI mutant phenotypes for GNA12:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for GNA12:
Animal Model Products
-
Taconic Biosciences Mouse Models for GNA12
- Cyagen custom Knockout/knockin (KOKI) mouse models for GNA12
-
-
ViGene Biosciences lentiviral particle packaged cDNA for GNA12 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for GNA12 gene
- Search ViGene Biosciences for GNA12
CRISPR Products
-
OriGene CRISPR knockouts for GNA12
- genomics-online: gRNA clones - Search results for 94 available GNA12 gene related products
- Overview of 94 available GNA12 gene related products
- Applied Biological Materials CRISPR for GNA12
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for GNA12
- GenScript: Design CRISPR guide RNA sequences for GNA12
miRNA for GNA12 Gene
- miRTarBase miRNAs that target GNA12
-
- hsa-mir-124-3p (MIRT023075)
- hsa-mir-98-5p (MIRT027790)
- hsa-mir-93-5p (MIRT028098)
- hsa-mir-149-5p (MIRT045616)
- hsa-mir-23b-3p (MIRT046311)
- hsa-mir-218-5p (MIRT440559)
- hsa-mir-335-3p (MIRT616790)
- hsa-mir-1305 (MIRT616791)
- hsa-mir-4309 (MIRT616792)
- hsa-mir-3198 (MIRT616793)
- hsa-mir-4653-3p (MIRT616794)
- hsa-mir-4424 (MIRT616795)
- hsa-mir-432-5p (MIRT616796)
- hsa-mir-335-5p (MIRT616797)
- hsa-mir-1266-5p (MIRT736703)
- hsa-mir-211-3p (MIRT738927)
- hsa-mir-3664-3p (MIRT742022)
- hsa-mir-4270 (MIRT743565)
- hsa-mir-4441 (MIRT744532)
- hsa-mir-4518 (MIRT745776)
- hsa-mir-6754-5p (MIRT754707)
- hsa-mir-7-5p (MIRT759430)
- hsa-mir-8087 (MIRT760261)
- hsa-mir-9500 (MIRT760883)
miRNA Products
- Search ViGene Biosciences for GNA12
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for GNA12
- Browse OriGene Inhibitory RNA Products For GNA12
- genomics-online: shRNA clones - Search results for 94 available GNA12 gene related products
- Overview of 94 available GNA12 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for GNA12 gene
Clone Products
- VectorBuilder custom plasmid, inducible vectors for GNA12
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for GNA12
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for GNA12
- Applied Biological Materials Clones for GNA12
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for GNA12
-
ViGene Biosciences adenoviral particle packaged cDNA for GNA12 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for GNA12 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for GNA12 gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GNA12 Gene
Localization for GNA12 Gene
Subcellular locations from UniProtKB/Swiss-Prot for GNA12 Gene
- Cell membrane; Lipid-anchor. Lateral cell membrane; Lipid-anchor. Cytoplasm. Note=CDH1 enhances cell membrane localization. {ECO:0000269 PubMed:15240885}.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| cytosol | 4 |
| mitochondrion | 3 |
| peroxisome | 2 |
- Cytosol (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005834 | heterotrimeric G-protein complex | IBA | -- |
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0005925 | focal adhesion | HDA,IDA | 21423176 |
| GO:0016020 | membrane | IEA | -- |
Pathways & Interactions for GNA12 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | fMLP Pathway |
.43
|
.39
|
| 2 | G-Beta Gamma Signaling |
.46
.44
|
.37
|
| 3 | S1P3 pathway |
.44
.44
|
.36
.01
|
| 4 | Actin Nucleation by ARP-WASP Complex |
.41
.35
|
|
| 5 | Activation of cAMP-Dependent PKA |
.77
|
.56
|
Pathways by source for GNA12 Gene
11 BioSystems pathways for GNA12 Gene
7 Reactome pathways for GNA12 Gene
1 PharmGKB pathway for GNA12 Gene
8 KEGG pathways for GNA12 Gene
8 GeneGo (Thomson Reuters) pathways for GNA12 Gene
Interacting Proteins for GNA12 Gene
Selected Interacting proteins:
ENSP00000275364
Q03113-GNA12_HUMAN
for GNA12 Gene via
STRING
MINT
IID
SIGNOR curated interactions for GNA12 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001701 | in utero embryonic development | IEA | -- |
| GO:0007165 | signal transduction | IEA | -- |
| GO:0007186 | G-protein coupled receptor signaling pathway | TAS,IEA | -- |
| GO:0007188 | adenylate cyclase-modulating G-protein coupled receptor signaling pathway | IBA | -- |
| GO:0007264 | small GTPase mediated signal transduction | IEA | -- |
Drugs & Compounds for GNA12 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| G-Protein antagonist peptide |
|
143675-79-0 |
|
|
(5) Tocris Compounds for GNA12 Gene
| Compound | Action | Cas Number |
|---|---|---|
| [D-Trp7,9,10]-Substance P | Inhibits M1 ACh receptor activation of Gq/11 | 89430-38-6 |
| G-Protein antagonist peptide | Inhibits G protein activation by GPCRs | 143675-79-0 |
| Gue 1654 | Selective inhibitor of OXE-R Gbetagamma signaling | 397290-30-1 |
| Mastoparan | Activates Gi and Go | 72093-21-1 |
| SCH 202676 hydrobromide | Inhibitor of ligand binding to G-protein-coupled receptors | 265980-25-4 |
Transcripts for GNA12 Gene
mRNA/cDNA for GNA12 Gene
- (6) REFSEQ mRNAs :
- (20) Additional mRNA sequences :
- (303) Selected AceView cDNA sequences:
- (8) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for GNA12 Gene
CRISPR Products
-
OriGene CRISPR knockouts for GNA12
- genomics-online: gRNA clones - Search results for 94 available GNA12 gene related products
- Overview of 94 available GNA12 gene related products
- Applied Biological Materials CRISPR for GNA12
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for GNA12
- GenScript: Design CRISPR guide RNA sequences for GNA12
miRNA Products
- Search ViGene Biosciences for GNA12
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for GNA12
- Browse OriGene Inhibitory RNA Products For GNA12
- genomics-online: shRNA clones - Search results for 94 available GNA12 gene related products
- Overview of 94 available GNA12 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for GNA12 gene
Clone Products
- VectorBuilder custom plasmid, inducible vectors for GNA12
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for GNA12
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for GNA12
- Applied Biological Materials Clones for GNA12
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | · | 6c | · | 6d | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | · | 10c | · | 10d | · | 10e |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||
| SP5: | - | - | - | ||||||||||||||||||||||||||||||||||
| SP6: | - | - | |||||||||||||||||||||||||||||||||||
| SP7: | |||||||||||||||||||||||||||||||||||||
| SP8: | - |
Expression for GNA12 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Brain (Nervous System)
- Myelinating Oligodendrocyte Cells Forebrain White Matter
-
Glial Cells
- Myelinating Oligodendrocyte Cells Forebrain White Matter
- Blood (Hematopoietic System)
-
Placenta (Extraembryonic Tissues)
-
Ovary (Reproductive System)
This gene is overexpressed in Brain (28.8), Pancreas (12.9), and Bone (9.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GNA12 Gene
NURSA nuclear receptor signaling pathways regulating expression of GNA12 Gene:
GNA12SOURCE GeneReport for Unigene cluster for GNA12 Gene:
Hs.487341Evidence on tissue expression from TISSUES for GNA12 Gene
- Nervous system(4.8)
- Pancreas(4.2)
- Lung(2)
Primer Products
-
OriGene qPCR primer pairs for GNA12
-
OriGene qPCR primer pairs and template standards for GNA12
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GNA12 Gene
Orthologs for GNA12 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | GNA12 33 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | GNA12 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | GNA12 34 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | GNA12 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | GNA12 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Gna12 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Gna12 33 |
|
||
| chicken (Gallus gallus) |
Aves | GNA12 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | GNA12 34 |
|
OneToOne | |
| zebrafish (Danio rerio) |
Actinopterygii | gna12a 33 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | CG40005 34 |
|
ManyToMany | |
| cta 35 34 |
|
||||
| worm (Caenorhabditis elegans) |
Secernentea | gpa-12 35 33 34 |
|
||
| gpa-14 35 |
|
|
|||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | GPA2 34 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany | |
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.3611 33 |
|
- Species where no ortholog for GNA12 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
Paralogs for GNA12 Gene
Paralogs for GNA12 Gene
(19) SIMAP similar genes for GNA12 Gene using alignment to 7 proteins:
Variants for GNA12 Gene
| SNP ID | Clin | Chr 07 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000020775 | -- | 2,785,718(-) | A/T | genic_upstream_transcript_variant, intron_variant | |
| rs1000034868 | -- | 2,847,574(-) | C/T | genic_upstream_transcript_variant, intron_variant | |
| rs1000036162 | -- | 2,863,707(-) | C/G | genic_upstream_transcript_variant, intron_variant | |
| rs1000044845 | -- | 2,844,593(-) | C/T | genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant | |
| rs1000052206 | -- | 2,741,217(-) | G/T | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2761071 | CNV | loss | 21179565 |
| esv3541054 | CNV | deletion | 23714750 |
| esv3611852 | CNV | loss | 21293372 |
| esv3611853 | CNV | loss | 21293372 |
| esv3611854 | CNV | loss | 21293372 |
| esv3891011 | CNV | gain | 25118596 |
| nsv1074476 | CNV | deletion | 25765185 |
| nsv471227 | CNV | loss | 18288195 |
| nsv605872 | CNV | loss | 21841781 |
| nsv966746 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
54.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.52;
11.24% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for GNA12 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- GNA12
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GNA12 Gene
Disorders for GNA12 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| familial hyperaldosteronism |
|
|
Search GNA12 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for GNA12
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for GNA12 Gene
Publications for GNA12 Gene
- Identification of 20 novel SNPs in the guanine nucleotide binding protein alpha 12 gene locus. (PMID: 15221642) Iida A … Nakamura Y (Journal of human genetics 2004) 3 22 44 58
- Expression cDNA cloning of a transforming gene encoding the wild-type G alpha 12 gene product. (PMID: 8423800) Chan AM … Aaronson SA (Molecular and cellular biology 1993) 2 3 4 58
- Gα₁₂ drives invasion of oral squamous cell carcinoma through up-regulation of proinflammatory cytokines. (PMID: 23762476) Jian SL … Juang JL (PloS one 2013) 3 4 58
- PRR5L degradation promotes mTORC2-mediated PKC-δ phosphorylation and cell migration downstream of Gα12. (PMID: 22609986) Gan X … Wu D (Nature cell biology 2012) 3 4 58
- Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. (PMID: 21297633) Anderson CA … Rioux JD (Nature genetics 2011) 3 44 58
Products for GNA12 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Human Proteins and Enzymes
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
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- Browse Proteome Profiler Antibody Arrays
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- Custom Antibody ServicesOriGene Antibodies for GNA12
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for GNA12
- Search Origene for MassSpec and Protein Over-expression Lysates for GNA12
- Origene Custom Protein Services for GNA12
- Origene shrna, sirna, and RNAi products in human, mouse, rat for GNA12
- Browse OriGene Inhibitory RNA Products For GNA12
- OriGene qPCR primer pairs and template standards for GNA12
- OriGene qPCR primer pairs for GNA12
- OriGene CRISPR knockouts for GNA12
- OriGene ORF clones in human for GNA12
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For GNA12
- GenScript: Next-day shipping of latest version cDNA ORF clones for GNA12 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for GNA12
- GenScript Custom Assay Services for GNA12
- GenScript Custom overexpressing Cell Line Services for GNA12
- GenScript: Design CRISPR guide RNA sequences for GNA12
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for GNA12
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Cell Lysates
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- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse Sino Biological ELISA Kits
- Browse Sino Biological ELISA Pair Sets
- Browse Sino Biological CRO Services
- Browse Sino Biological Control Vectors
- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for GNA12
- Novus Biologicals lysates for GNA12
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for GNA12
- Find your target
- Browse Primary Antibodies
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- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Browse Antibodies at Cloud-Clone Corp.
- Browse Proteins at Cloud-Clone Corp.
- Browse Assay Kits at Cloud-Clone Corp.
- Browse Knockouts at Cloud-Clone Corp.
- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Taconic Biosciences Mouse Models for GNA12
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for GNA12
- Cyagen custom Knockout/knockin (KOKI) mouse models for GNA12
- VectorBuilder custom plasmid, inducible vectors for GNA12
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for GNA12
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for GNA12
- antibodies-online: Search results for 53 available GNA12 Antibodies ranked by validation data
- Compare Top GNA12 Antibodies
- antibodies-online: Search results for available GNA12 related products ranked by validation data
- antibodies-online: Search results for available GNA12 related products ranked by validation data
- GeneTex GNA12 antibody for GNA12
- Search GeneTex for Proteins for GNA12
- ViGene Biosciences adenoviral particle packaged cDNA for GNA12 gene
- ViGene Biosciences lentiviral particle packaged cDNA for GNA12 gene
- ViGene Biosciences ready-to-package AAV shRNAs for GNA12 gene
- Search ViGene Biosciences for GNA12
- Santa Cruz Biotechnology (SCBT) Antibodies for GNA12
- Search Santa Cruz Biotechnology (SCBT) for GNA12 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for GNA12
- Horizon Cell Lines for GNA12
- genomics-online: cdna clones - Search results for 94 available GNA12 gene related products
- Overview of 94 available GNA12 gene related products
- orf clones - Search results for 94 available GNA12 gene related products
- Overview of 94 available GNA12 gene related products
- genomics-online: gRNA clones - Search results for 94 available GNA12 gene related products
- Overview of 94 available GNA12 gene related products
- genomics-online: primer clones - Search results for 94 available GNA12 gene related products
- Overview of 94 available GNA12 gene related products
- genomics-online: shRNA clones - Search results for 94 available GNA12 gene related products
- Overview of 94 available GNA12 gene related products
Sources for GNA12 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems