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Aliases for GNA12 Gene
Aliases for GNA12 Gene
External Ids for GNA12 Gene
- HGNC: 4380
- NCBI Entrez Gene: 2768
- Ensembl: ENSG00000146535
- OMIM®: 604394
- UniProtKB/Swiss-Prot: Q03113
Previous GeneCards Identifiers for GNA12 Gene
- GC07M002415
- GC07M002515
- GC07M002512
- GC07M002540
- GC07M002734
- GC07M002767
- GC07M002686
Summaries for GNA12 Gene
GeneCards Summary for GNA12 Gene
GNA12 (G Protein Subunit Alpha 12) is a Protein Coding gene. Diseases associated with GNA12 include Familial Hyperaldosteronism. Among its related pathways are G-protein signaling M-RAS regulation pathway and Integrin Pathway. Gene Ontology (GO) annotations related to this gene include GTP binding and obsolete signal transducer activity. An important paralog of this gene is GNA13.
UniProtKB/Swiss-Prot Summary for GNA12 Gene
-
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems (PubMed:22609986, PubMed:15525651, PubMed:15240885, PubMed:17565996, PubMed:12515866, PubMed:16787920, PubMed:16705036, PubMed:23762476, PubMed:27084452). Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF12/LARG) (PubMed:15240885, PubMed:12515866, PubMed:16202387). GNA12-dependent Rho signaling subsequently regulates transcription factor AP-1 (activating protein-1) (By similarity). GNA12-dependent Rho signaling also regulates protein phosphatese 2A activation causing dephosphorylation of its target proteins (PubMed:15525651, PubMed:17565996). Promotes tumor cell invasion and metastasis by activating RhoA/ROCK signaling pathway and up-regulating proinflammatory cytokine production (PubMed:23762476, PubMed:16787920, PubMed:16705036, PubMed:27084452). Inhibits CDH1-mediated cell adhesion in process independent from Rho activation (PubMed:11976333, PubMed:16787920). Together with NAPA promotes CDH5 localization to plasma membrane (PubMed:15980433). May play a role in the control of cell migration through the TOR signaling cascade (PubMed:22609986).
-
Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand binding causes a receptor conformational change, detaching the G protein and switching it 'on'.
Additional gene information for GNA12 Gene
No data available for Entrez Gene Summary , CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GNA12 Gene
Genomics for GNA12 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for GNA12 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around GNA12 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GNA12
- Top Transcription factor binding sites by QIAGEN in the GNA12 gene promoter:
-
- AREB6
- Bach2
- CUTL1
- FOXI1
- FOXO1
- FOXO1a
- HFH-3
- HNF-1
- HNF-1A
- Zic1
Genomic Locations for GNA12 Gene
Latest Assembly
- chr7:2,728,105-2,844,308
- (GRCh38/hg38)
- Size:
- 116,204 bases
- Orientation:
- Minus strand
Previous Assembly
- chr7:2,767,739-2,883,942
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 116,204 bases
- Orientation:
- Minus strand
Genomic View for GNA12 Gene
Genes around GNA12 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 7p22.3-p22.2 by HGNC
- 7p22.3-p22.2 by Entrez Gene
- 7p22.2 by Ensembl
GNA12 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for GNA12 Gene
Proteins for GNA12 Gene
-
Protein details for GNA12 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q03113-GNA12_HUMAN
- Recommended name:
- Guanine nucleotide-binding protein subunit alpha-12
- Protein Accession:
- Q03113
- A4D204
- B3KXS2
- B7Z3F7
- Q2T9L1
- Q5PPR5
- Q86UM8
- Q8TD71
- Q9UDU9
Protein attributes for GNA12 Gene
- Size:
- 381 amino acids
- Molecular mass:
- 44279 Da
- Quaternary structure:
-
- G proteins are composed of 3 units; alpha, beta and gamma (PubMed:10026210). The alpha chain contains the guanine nucleotide binding site (By similarity). Interacts with UBXD5 (PubMed:16202387). Interacts (in GTP-bound form) with PPP5C (via TPR repeats); activates PPP5C phosphatase activity and translocates PPP5C to the cell membrane. Interacts with RGS22 (PubMed:18703424). Interacts (via N-terminus) with NAPA; the interaction promotes CDH5 localization to plasma membrane (PubMed:15980433). Interacts with CTNND1 (via N-terminus); the interaction regulates CDH1-mediated cell-cell adhesion (PubMed:15240885). Interacts with PPP2R1A; the interaction promotes protein phosphatase 2A activation causing dephosphorylation of MAPT (PubMed:15525651). Interacts (in GTP-bound form) with ARHGEF1 (By similarity). Interacts (in GTP-bound form) with ARHGEF11 (via RGS domain) (PubMed:10026210). Interacts (in GTP-bound form) with ARHGEF12 (via RGS domain) (PubMed:11094164).
Protein Expression for GNA12 Gene
Post-translational modifications for GNA12 Gene
Other Protein References for GNA12 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- LifeSpan BioSciences GNA12 Antibody (LS-B9130) and GNA12 Antibody (LS-B16719)
- G Biosciences Immunotag™ GNA12 Antibody
-
Custom Antibody ServicesOriGene Antibodies for GNA12
- Novus Biologicals Antibodies for GNA12
- Invitrogen Antibodies for GNA12 (AFLGC-GNA12)
-
Boster Bio Antibodies for GNA12
-
Santa Cruz Biotechnology (SCBT) Antibodies for GNA12
Protein products for research
-
OriGene Purified Proteins for GNA12
- Search Origene for MassSpec and Protein Over-expression Lysates for GNA12
- Origene Custom Protein Services for GNA12
- Novus Biologicals lysates for GNA12
Assay products for research
No data available for DME Specific Peptides for GNA12 Gene
Domains & Families for GNA12 Gene
Gene Families for GNA12 Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for GNA12 Gene
- InterPro:
- Blocks:
-
- Alpha G-protein (transducin) signature
- G-protein alpha subunit group 12 signature
Suggested Antigen Peptide Sequences for GNA12 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ45945 fis, clone PLACE7006498, highly similar to Guanine nucleotide-binding protein alpha-12 subunit (B3KXS2_HUMAN)
- cDNA FLJ55846, highly similar to Guanine nucleotide-binding protein alpha-12 subunit (B7Z3F7_HUMAN)
- Guanine nucleotide-binding protein subunit alpha-12 (GNA12_HUMAN)
- Guanine nucleotide binding protein (G protein) alpha 12 (Q5PPR5_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q03113- Family:
-
- Belongs to the G-alpha family. G(12) subfamily.
Function for GNA12 Gene
Molecular function for GNA12 Gene
- UniProtKB/Swiss-Prot Function:
- Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems (PubMed:22609986, PubMed:15525651, PubMed:15240885, PubMed:17565996, PubMed:12515866, PubMed:16787920, PubMed:16705036, PubMed:23762476, PubMed:27084452). Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF12/LARG) (PubMed:15240885, PubMed:12515866, PubMed:16202387). GNA12-dependent Rho signaling subsequently regulates transcription factor AP-1 (activating protein-1) (By similarity). GNA12-dependent Rho signaling also regulates protein phosphatese 2A activation causing dephosphorylation of its target proteins (PubMed:15525651, PubMed:17565996). Promotes tumor cell invasion and metastasis by activating RhoA/ROCK signaling pathway and up-regulating proinflammatory cytokine production (PubMed:23762476, PubMed:16787920, PubMed:16705036, PubMed:27084452). Inhibits CDH1-mediated cell adhesion in process independent from Rho activation (PubMed:11976333, PubMed:16787920). Together with NAPA promotes CDH5 localization to plasma membrane (PubMed:15980433). May play a role in the control of cell migration through the TOR signaling cascade (PubMed:22609986).
Phenotypes From GWAS Catalog for GNA12 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | -- |
| GO:0001664 | G protein-coupled receptor binding | IBA | 21873635 |
| GO:0003924 | GTPase activity | IEA,IBA | 21873635 |
| GO:0005515 | protein binding | IPI | 10026210 |
| GO:0005525 | GTP binding | IEA | -- |
Phenotypes for GNA12 Gene
- MGI mutant phenotypes for GNA12:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for GNA12:
-
- Increased vaccinia virus (VACV) infection
- shRNA abundance <= 50%
- Reduced mammosphere formation
- no effect
- Increased ionizing radiation sensitivity
- Increased nuclear migration distance, increased nuclear migration speed
- Synthetic lethal with c-Myc after tamoxifen stimulation
- Decreased Salmonella enterica Typhimurium invasion
- Bright nuclei
Animal Models for research
-
Taconic Biosciences Mouse Models for GNA12
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for GNA12 - Starting at $85 >
- * GNA12 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for GNA12
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for GNA12
-
Santa Cruz Biotechnology (SCBT) CRISPR for GNA12
miRNA for GNA12 Gene
- miRTarBase miRNAs that target GNA12
-
- hsa-miR-124-3p (MIRT023075)
- hsa-miR-98-5p (MIRT027790)
- hsa-miR-93-5p (MIRT028098)
- hsa-miR-149-5p (MIRT045616)
- hsa-miR-23b-3p (MIRT046311)
- hsa-miR-218-5p (MIRT440559)
- hsa-miR-335-3p (MIRT616790)
- hsa-miR-1305 (MIRT616791)
- hsa-miR-4309 (MIRT616792)
- hsa-miR-3198 (MIRT616793)
- hsa-miR-4653-3p (MIRT616794)
- hsa-miR-4424 (MIRT616795)
- hsa-miR-432-5p (MIRT616796)
- hsa-miR-335-5p (MIRT616797)
- hsa-miR-1266-5p (MIRT736703)
- hsa-miR-211-3p (MIRT738927)
- hsa-miR-3664-3p (MIRT742022)
- hsa-miR-4270 (MIRT743565)
- hsa-miR-4441 (MIRT744532)
- hsa-miR-4518 (MIRT745776)
- hsa-miR-6754-5p (MIRT754707)
- hsa-miR-7-5p (MIRT759430)
- hsa-miR-8087 (MIRT760261)
- hsa-miR-9500 (MIRT760883)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for GNA12
- Browse OriGene Inhibitory RNA Products For GNA12
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GNA12
Clone products for research
- Applied Biological Materials (abm): Clones for GNA12 - Starting at $45 >
- * GNA12 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for GNA12
- Addgene plasmids for GNA12
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for GNA12
Cell Lines for research
-
Horizon Cell Lines for GNA12
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GNA12 Gene
Localization for GNA12 Gene
Subcellular locations from UniProtKB/Swiss-Prot for GNA12 Gene
- Cell membrane. Lipid-anchor. Lateral cell membrane. Lipid-anchor. Cytoplasm. Note=CDH1 enhances cell membrane localization. {ECO:0000269 PubMed:15240885}.
| Compartment | Confidence |
|---|---|
| plasma membrane | 4 |
| mitochondrion | 3 |
| cytosol | 3 |
| extracellular | 1 |
| cytoskeleton | 1 |
| peroxisome | 1 |
| nucleus | 1 |
| endoplasmic reticulum | 1 |
- Cytosol (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005834 | heterotrimeric G-protein complex | IBA | 21873635 |
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0005925 | focal adhesion | HDA | 21423176 |
| GO:0016020 | membrane | IEA | -- |
Pathways & Interactions for GNA12 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | fMLP Pathway |
CCR3 Pathway in Eosinophils
.44
VEGF and S-1P Signaling
.44
fMLP Pathway
.43
|
CXCR4 Pathway
.39
Huntington's Disease Pathway
.30
|
| 2 | G-Beta Gamma Signaling |
G-Beta Gamma Signaling
.46
GHRH Signaling
.46
CRHR Pathway
.44
|
Relaxin Pathway
.37
Hedgehog Signaling in Mammals
.32
|
| 3 | S1P3 pathway |
.44
.44
|
.36
.01
|
| 4 | Actin Nucleation by ARP-WASP Complex |
Actin Nucleation and Branching
.66
Actin Nucleation by ARP-WASP Complex
.66
|
CDC42 Pathway
.41
RhoA Pathway
.35
|
| 5 | Activation of cAMP-Dependent PKA |
Activation of cAMP-Dependent PKA
.77
cAMP Pathway
.77
|
Activation of PKA through GPCR
.71
PKA Signaling
.56
|
Pathways by source for GNA12 Gene
11 BioSystems pathways for GNA12 Gene
7 Reactome pathways for GNA12 Gene
1 PharmGKB pathway for GNA12 Gene
11 KEGG pathways for GNA12 Gene
8 GeneGo (Thomson Reuters) pathways for GNA12 Gene
- Cell adhesion Integrin inside-out signaling
- Development G-Proteins mediated regulation MARK-ERK signaling
- G-protein signaling G-Protein alpha-12 signaling pathway
- G-protein signaling M-RAS regulation pathway
- G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins
66 Qiagen pathways for GNA12 Gene
- Actin Nucleation and Branching
- Actin Nucleation by ARP-WASP Complex
- Actin-Based Motility by Rho Family GTPases
- Activation of cAMP-Dependent PKA
- Activation of PKA through GPCR
Interacting Proteins for GNA12 Gene
Selected Interacting proteins:
Q03113-GNA12_HUMAN
ENSP00000275364
for GNA12 Gene via
MINT
STRING
IID
GPS-Prot Interaction Network for GNA12
SIGNOR curated interactions for GNA12 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007165 | signal transduction | IEA | -- |
| GO:0007186 | G protein-coupled receptor signaling pathway | IEA,TAS | -- |
| GO:0007188 | adenylate cyclase-modulating G protein-coupled receptor signaling pathway | IBA | 21873635 |
| GO:0007266 | Rho protein signal transduction | IBA | 21873635 |
| GO:0007596 | blood coagulation | TAS | 8290554 |
Drugs & Compounds for GNA12 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| [D-Trp7,9,10]-Substance P |
|
89430-38-6 |
|
|
||
| G-Protein antagonist peptide |
|
143675-79-0 |
|
|
||
| Gue 1654 |
|
397290-30-1 |
|
|
||
| mastoparan |
|
72093-21-1 |
|
|
||
| SCH 202676 hydrobromide |
|
265980-25-4 |
|
|
(5) Tocris Compounds for GNA12 Gene
| Compound | Action | Cas Number |
|---|---|---|
| [D-Trp7,9,10]-Substance P | Inhibits M1 ACh receptor activation of Gq/11 | 89430-38-6 |
| G-Protein antagonist peptide | Inhibits G protein activation by GPCRs | 143675-79-0 |
| Gue 1654 | Selective inhibitor of OXE-R Gbetagamma signaling | 397290-30-1 |
| Mastoparan | Activates Gi and Go | 72093-21-1 |
| SCH 202676 hydrobromide | Inhibitor of ligand binding to G-protein-coupled receptors | 265980-25-4 |
Transcripts for GNA12 Gene
mRNA/cDNA for GNA12 Gene
- 4 REFSEQ mRNAs :
- 20 NCBI additional mRNA sequence :
- 8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000275364 4369 nts (view in UCSC)
- ENST00000407653 3785 nts (view in UCSC)
- ENST00000407904 3918 nts (view in UCSC)
- ENST00000447791 559 nts (view in UCSC)
- ENST00000471281 1205 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for GNA12 - Starting at $85 >
- * GNA12 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for GNA12
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for GNA12
-
Santa Cruz Biotechnology (SCBT) CRISPR for GNA12
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for GNA12
- Browse OriGene Inhibitory RNA Products For GNA12
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GNA12
Clone products for research
- Applied Biological Materials (abm): Clones for GNA12 - Starting at $45 >
- * GNA12 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for GNA12
- Addgene plasmids for GNA12
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for GNA12
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | · | 6c | · | 6d | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | · | 10c | · | 10d | · | 10e |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||
| SP5: | - | - | - | ||||||||||||||||||||||||||||||||||
| SP6: | - | - | |||||||||||||||||||||||||||||||||||
| SP7: | |||||||||||||||||||||||||||||||||||||
| SP8: | - |
Relevant External Links for GNA12 Gene
- GeneLoc Exon Structure for
- GNA12
Expression for GNA12 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Brain (Nervous System)
- Myelinating Oligodendrocyte Cells Forebrain White Matter
-
Glial Cells
- Myelinating Oligodendrocyte Cells Forebrain White Matter
- Blood (Hematopoietic System)
-
Placenta (Extraembryonic Tissues)
-
Ovary (Reproductive System)
This gene is overexpressed in Brain (28.8), Pancreas (12.9), and Bone (9.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GNA12 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GNA12
SOURCE GeneReport for Unigene cluster for GNA12 Gene:
Hs.487341Evidence on tissue expression from TISSUES for GNA12 Gene
- Nervous system(4.9)
- Pancreas(4.2)
- Lung(2.4)
- Intestine(2.1)
- Blood(2.1)
- Heart(2)
- Skin(2)
Primer products for research
-
OriGene qPCR primer pairs for GNA12
-
OriGene qPCR primer pairs and template standards for GNA12
Gene Expression Assays for research
No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GNA12 Gene
Orthologs for GNA12 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | GNA12 29 30 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | GNA12 30 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | GNA12 30 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | GNA12 29 30 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | GNA12 29 30 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Gna12 29 16 30 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Gna12 29 |
|
||
| Chicken (Gallus gallus) |
Aves | GNA12 29 30 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | GNA12 30 |
|
OneToOne | |
| Zebrafish (Danio rerio) |
Actinopterygii | gna12a 29 30 |
|
OneToOne | |
| Fruit Fly (Drosophila melanogaster) |
Insecta | CG40005 30 |
|
ManyToMany | |
| cta 30 31 |
|
ManyToMany | |||
| Worm (Caenorhabditis elegans) |
Secernentea | gpa-12 29 30 31 |
|
OneToMany | |
| gpa-14 31 |
|
|
|||
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | GPA2 30 |
|
OneToMany | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 30 |
|
OneToMany | |
| Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.3611 29 |
|
- Species where no ortholog for GNA12 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
Evolution for GNA12 Gene
- ENSEMBL:
- Gene Tree for GNA12 (if available)
- TreeFam:
- Gene Tree for GNA12 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for GNA12: view image
- Alliance of Genome Resources:
- Additional Orthologs for GNA12
Paralogs for GNA12 Gene
Paralogs for GNA12 Gene
(19) SIMAP similar genes for GNA12 Gene using alignment to 7 proteins:
- GNA12_HUMAN
- B3KXS2_HUMAN
- B7Z3F7_HUMAN
- C9J2Y7_HUMAN
- E7EUG4_HUMAN
- E9PC54_HUMAN
- Q5PPR5_HUMAN
Variants for GNA12 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GNA12 Gene
| SNP ID | Clinical significance and condition | Chr 07 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs61758983 | Benign: not provided | 2,731,349(-) |
G/A NM_007353.3(GNA12):c.978C>T (p.Asp326=) |
SYNONYMOUS_VARIANT,INTRON | |
| rs11552939 | -- |
p.Ser68Gly |
|||
| rs45583847 | -- |
p.Tyr330His |
|||
| rs45606633 | -- |
p.Phe242Leu |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2761071 | CNV | loss | 21179565 |
| esv3541054 | CNV | deletion | 23714750 |
| esv3611852 | CNV | loss | 21293372 |
| esv3611853 | CNV | loss | 21293372 |
| esv3611854 | CNV | loss | 21293372 |
| esv3891011 | CNV | gain | 25118596 |
| nsv1074476 | CNV | deletion | 25765185 |
| nsv471227 | CNV | loss | 18288195 |
| nsv605872 | CNV | loss | 21841781 |
| nsv966746 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
54.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.52;
11.24% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for GNA12 Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GNA12 Gene
Disorders for GNA12 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| familial hyperaldosteronism |
|
|
Search GNA12 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for GNA12
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for GNA12 Gene
Publications for GNA12 Gene
- Identification of 20 novel SNPs in the guanine nucleotide binding protein alpha 12 gene locus. (PMID: 15221642) Iida A … Nakamura Y (Journal of human genetics 2004) 3 22 40
- Expression cDNA cloning of a transforming gene encoding the wild-type G alpha 12 gene product. (PMID: 8423800) Chan AM … Aaronson SA (Molecular and cellular biology 1993) 2 3 4
- Gα₁₂ drives invasion of oral squamous cell carcinoma through up-regulation of proinflammatory cytokines. (PMID: 23762476) Jian SL … Juang JL (PloS one 2013) 3 4
- PRR5L degradation promotes mTORC2-mediated PKC-δ phosphorylation and cell migration downstream of Gα12. (PMID: 22609986) Gan X … Wu D (Nature cell biology 2012) 3 4
- Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. (PMID: 21297633) Anderson CA … Rioux JD (Nature genetics 2011) 3 40
ExternalLinks
Products for GNA12 Gene
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- antibodies-online: Show 17 available GNA12 Antibodies ranked by validation data
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- Boster Bio Antibodies for GNA12
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Sources for GNA12 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Apr-2021)
- (7) GeneLoc
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