Aliases for GMPS Gene
External Ids for GMPS Gene
Previous GeneCards Identifiers for GMPS Gene
In the de novo synthesis of purine nucleotides, IMP is the branch point metabolite at which point the pathway diverges to the synthesis of either guanine or adenine nucleotides. In the guanine nucleotide pathway, there are 2 enzymes involved in converting IMP to GMP, namely IMP dehydrogenase (IMPD1), which catalyzes the oxidation of IMP to XMP, and GMP synthetase, which catalyzes the amination of XMP to GMP. [provided by RefSeq, Jul 2008]
GeneCards Summary for GMPS Gene
GMPS (Guanine Monophosphate Synthase) is a Protein Coding gene. Diseases associated with GMPS include Pallister-Killian Syndrome and Chronic Laryngitis. Among its related pathways are purine nucleotides de novo biosynthesis and Thiopurine Pathway, Pharmacokinetics/Pharmacodynamics. Gene Ontology (GO) annotations related to this gene include enzyme binding and transferase activity.
UniProtKB/Swiss-Prot Summary for GMPS Gene
Involved in the de novo synthesis of guanine nucleotides which are not only essential for DNA and RNA synthesis, but also provide GTP, which is involved in a number of cellular processes important for cell division.