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Aliases for GMPS Gene

Aliases for GMPS Gene

  • Guanine Monophosphate Synthase 2 3 5
  • Guanine Monophosphate Synthetase 2 3
  • Glutamine Amidotransferase 3 4
  • GMP Synthetase 3 4
  • GMP Synthase 2 3
  • GMP Synthase [Glutamine-Hydrolyzing] 3
  • Guanosine 5-Monophosphate Synthase 3
  • Testicular Tissue Protein Li 82 3
  • MLL/GMPS Fusion Protein 3
  • EC 4
  • GATD7 3

External Ids for GMPS Gene

Previous GeneCards Identifiers for GMPS Gene

  • GC03P152441
  • GC03P156575
  • GC03P156869
  • GC03P156909
  • GC03P157071
  • GC03P155588
  • GC03P152982

Summaries for GMPS Gene

Entrez Gene Summary for GMPS Gene

  • In the de novo synthesis of purine nucleotides, IMP is the branch point metabolite at which point the pathway diverges to the synthesis of either guanine or adenine nucleotides. In the guanine nucleotide pathway, there are 2 enzymes involved in converting IMP to GMP, namely IMP dehydrogenase (IMPD1), which catalyzes the oxidation of IMP to XMP, and GMP synthetase, which catalyzes the amination of XMP to GMP. [provided by RefSeq, Jul 2008]

GeneCards Summary for GMPS Gene

GMPS (Guanine Monophosphate Synthase) is a Protein Coding gene. Diseases associated with GMPS include Pallister-Killian Syndrome and Chronic Laryngitis. Among its related pathways are Pyrimidine metabolism (KEGG) and Metabolism. Gene Ontology (GO) annotations related to this gene include enzyme binding and transferase activity.

UniProtKB/Swiss-Prot for GMPS Gene

  • Involved in the de novo synthesis of guanine nucleotides which are not only essential for DNA and RNA synthesis, but also provide GTP, which is involved in a number of cellular processes important for cell division.

Gene Wiki entry for GMPS Gene

Additional gene information for GMPS Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GMPS Gene

Genomics for GMPS Gene

GeneHancer (GH) Regulatory Elements for GMPS Gene

Promoters and enhancers for GMPS Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J155851 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 669.2 -15.8 -15821 4 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 GMPS SLC33A1 ENSG00000284952 LOC105374174 C3orf33
GH03J155869 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 656 +1.9 1855 3.8 CLOCK ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 POLR2B ZNF766 E2F8 GMPS C3orf33 PLCH1 SETP14
GH03J156549 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 16 +683.5 683512 6.4 HDGF PKNOX1 CLOCK SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SSR3 GMPS CCNL1 ENSG00000272990 KCNAB1 GC03P156555 GC03M156535
GH03J156814 Promoter/Enhancer 2 FANTOM5 Ensembl ENCODE dbSUPER 15.2 +948.3 948274 6.8 CLOCK SMAD1 ARNT SIN3A FEZF1 ZNF2 IRF4 YY1 ZNF207 ZNF143 LINC00886 GC03M156815 GMPS CCNL1 LEKR1 TIPARP
GH03J155862 Enhancer 1.1 Ensembl ENCODE 14.3 -6.7 -6678 1.3 HDGF HDAC1 PKNOX1 TAF9B ZBTB40 POLR2B ZNF766 EGR1 SCRT2 FOS GMPS SLC33A1 PLCH1 LOC105374174
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GMPS on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GMPS gene promoter:
  • C/EBPalpha
  • p53
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5

Genomic Locations for GMPS Gene

Genomic Locations for GMPS Gene
74,597 bases
Plus strand
73,491 bases
Plus strand

Genomic View for GMPS Gene

Genes around GMPS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GMPS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GMPS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GMPS Gene

Proteins for GMPS Gene

  • Protein details for GMPS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    GMP synthase [glutamine-hydrolyzing]
    Protein Accession:
    Secondary Accessions:
    • A8K639
    • B4DXV7
    • F8W720

    Protein attributes for GMPS Gene

    693 amino acids
    Molecular mass:
    76715 Da
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for GMPS Gene

    Alternative splice isoforms for GMPS Gene


neXtProt entry for GMPS Gene

Post-translational modifications for GMPS Gene

  • Ubiquitination at isoforms=2535, isoforms=2457, isoforms=2412, isoforms=2389, isoforms=2204, isoforms=2183, isoforms=2182, and isoforms=65
  • Modification sites at PhosphoSitePlus

Other Protein References for GMPS Gene

No data available for DME Specific Peptides for GMPS Gene

Domains & Families for GMPS Gene

Gene Families for GMPS Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Enzymes
  • Plasma proteins
  • Potential drug targets
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with GMPS: view

No data available for UniProtKB/Swiss-Prot for GMPS Gene

Function for GMPS Gene

Molecular function for GMPS Gene

UniProtKB/Swiss-Prot Function:
Involved in the de novo synthesis of guanine nucleotides which are not only essential for DNA and RNA synthesis, but also provide GTP, which is involved in a number of cellular processes important for cell division.
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + XMP + L-glutamine + H(2)O = AMP + diphosphate + GMP + L-glutamate.
GENATLAS Biochemistry:
guanosine 5-monophosphate synthetase

Enzyme Numbers (IUBMB) for GMPS Gene

Phenotypes From GWAS Catalog for GMPS Gene

Gene Ontology (GO) - Molecular Function for GMPS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity IBA --
GO:0003921 GMP synthase activity TAS,IBA --
GO:0003922 GMP synthase (glutamine-hydrolyzing) activity IBA --
GO:0005524 ATP binding IEA --
GO:0016462 pyrophosphatase activity IEA --
genes like me logo Genes that share ontologies with GMPS: view
genes like me logo Genes that share phenotypes with GMPS: view

Animal Model Products

miRNA for GMPS Gene

miRTarBase miRNAs that target GMPS

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GMPS Gene

Localization for GMPS Gene

Subcellular locations from UniProtKB/Swiss-Prot for GMPS Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GMPS gene
Compartment Confidence
cytosol 5
mitochondrion 2
nucleus 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for GMPS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with GMPS: view

Pathways & Interactions for GMPS Gene

genes like me logo Genes that share pathways with GMPS: view

UniProtKB/Swiss-Prot P49915-GUAA_HUMAN

  • Pathway: Purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route): step 1/1.

SIGNOR curated interactions for GMPS Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for GMPS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006164 purine nucleotide biosynthetic process IEA --
GO:0006177 GMP biosynthetic process IEA,IBA --
GO:0006541 glutamine metabolic process IEA --
GO:0009113 purine nucleobase biosynthetic process TAS 8089153
GO:0009168 purine ribonucleoside monophosphate biosynthetic process TAS --
genes like me logo Genes that share ontologies with GMPS: view

Drugs & Compounds for GMPS Gene

(14) Drugs for GMPS Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Glutamic Acid Approved Nutra Full agonist, Agonist, Target 251
L-Glutamine Approved, Investigational Nutra Full agonist, Agonist, Enzyme, substrate 0
Azathioprine Approved Pharma 190
Ammonia Approved Pharma 0
Water Approved Pharma 0

(18) Additional Compounds for GMPS Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
6-Thioguanosine monophosphate
  • 6-TG Nucleotide
  • 6-Thioguanine nucleotide
  • 6-Thioguanosine-5'-phosphate
6-Thioxanthine 5'-monophosphate
  • TXMP
  • [(ho)2P(O)OP(O)(OH)2]
  • Acide diphosphorique
  • Diphosphorsaeure
  • H4P2O7
  • PYROphosphATE
Xanthylic acid
  • (9-D-Ribosylxanthine)-5'-phosphate
  • Xanthosine 5'-phosphate
  • Xanthosine monophosphate
  • XMP
  • (9-D-Ribosylxanthine)-5'-phosphoric acid
genes like me logo Genes that share compounds with GMPS: view

Transcripts for GMPS Gene

mRNA/cDNA for GMPS Gene

Unigene Clusters for GMPS Gene

Guanine monphosphate synthetase:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GMPS Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
SP1: -

Relevant External Links for GMPS Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GMPS Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GMPS Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for GMPS Gene

This gene is overexpressed in Lymph node (19.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GMPS Gene

Protein tissue co-expression partners for GMPS Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GMPS Gene:


SOURCE GeneReport for Unigene cluster for GMPS Gene:


Evidence on tissue expression from TISSUES for GMPS Gene

  • Nervous system(2.8)
  • Blood(2.6)
  • Bone marrow(2.6)
  • Spleen(2.5)
  • Heart(2.3)
  • Liver(2.3)
  • Muscle(2.1)
genes like me logo Genes that share expression patterns with GMPS: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GMPS Gene

Orthologs for GMPS Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for GMPS Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GMPS 34 33
  • 99.66 (n)
(Monodelphis domestica)
Mammalia GMPS 34
  • 96 (a)
(Ornithorhynchus anatinus)
Mammalia GMPS 34
  • 96 (a)
(Bos Taurus)
Mammalia GMPS 34 33
  • 95.23 (n)
(Canis familiaris)
Mammalia GMPS 34 33
  • 94.57 (n)
(Rattus norvegicus)
Mammalia Gmps 33
  • 92.02 (n)
(Mus musculus)
Mammalia Gmps 16 34 33
  • 91.58 (n)
(Gallus gallus)
Aves GMPS 34 33
  • 82.83 (n)
(Anolis carolinensis)
Reptilia GMPS 34
  • 94 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia gmps 33
  • 80.23 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.11147 33
(Danio rerio)
Actinopterygii gmps 34 33
  • 74.18 (n)
zgc66002 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6472 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010139 33
  • 58.63 (n)
fruit fly
(Drosophila melanogaster)
Insecta bur 34 35 33
  • 58.23 (n)
(Caenorhabditis elegans)
Secernentea M106.4 35 33
  • 56.05 (n)
gmps-1 34
  • 46 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GUA1 36 34
  • 42 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3703 34
  • 59 (a)
Cin.4241 33
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4241 33
Species where no ortholog for GMPS was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GMPS Gene

Gene Tree for GMPS (if available)
Gene Tree for GMPS (if available)
Evolutionary constrained regions (ECRs) for GMPS: view image

Paralogs for GMPS Gene Pseudogenes for GMPS Gene

genes like me logo Genes that share paralogs with GMPS: view

No data available for Paralogs for GMPS Gene

Variants for GMPS Gene

Sequence variations from dbSNP and Humsavar for GMPS Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000007607 -- 155,905,090(+) C/A intron_variant
rs1000225992 -- 155,930,969(+) C/T intron_variant
rs1000253567 -- 155,878,690(+) T/C intron_variant
rs1000296175 -- 155,927,732(+) T/C intron_variant
rs1000340093 -- 155,937,311(+) G/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for GMPS Gene

Variant ID Type Subtype PubMed ID
esv3598287 CNV loss 21293372
esv3598288 CNV loss 21293372
esv3598289 CNV loss 21293372

Variation tolerance for GMPS Gene

Residual Variation Intolerance Score: 15% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.61; 30.94% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GMPS Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GMPS Gene

Disorders for GMPS Gene

MalaCards: The human disease database

(2) MalaCards diseases for GMPS Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
pallister-killian syndrome
  • pks
chronic laryngitis
- elite association - COSMIC cancer census association via MalaCards
Search GMPS in MalaCards View complete list of genes associated with diseases


  • Note=A chromosomal aberration involving GMPS is found in acute myeloid leukemias. Translocation t(3,11)(q25,q23) with KMT2A/MLL1.

Additional Disease Information for GMPS

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with GMPS: view

No data available for Genatlas for GMPS Gene

Publications for GMPS Gene

  1. Human GMP synthetase. Protein purification, cloning, and functional expression of cDNA. (PMID: 8089153) Hirst M … Lou L (The Journal of biological chemistry 1994) 2 3 4 22 58
  2. Human variation in alcohol response is influenced by variation in neuronal signaling genes. (PMID: 20201926) Joslyn G … White RL (Alcoholism, clinical and experimental research 2010) 3 44 58
  3. Common variants conferring risk of schizophrenia: a pathway analysis of GWAS data. (PMID: 20659789) Jia P … Zhao Z (Schizophrenia research 2010) 3 44 58
  4. EBNA1-mediated recruitment of a histone H2B deubiquitylating complex to the Epstein-Barr virus latent origin of DNA replication. (PMID: 19834552) Sarkari F … Frappier L (PLoS pathogens 2009) 3 22 58
  5. Genetic variations in the HGPRT, ITPA, IMPDH1, IMPDH2, and GMPS genes in Japanese individuals. (PMID: 20045992) Kudo M … Hiratsuka M (Drug metabolism and pharmacokinetics 2009) 3 44 58

Products for GMPS Gene

Sources for GMPS Gene

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