Aliases for GMPR2 Gene
External Ids for GMPR2 Gene
Previous GeneCards Identifiers for GMPR2 Gene
This gene encodes an enzyme that catalyzes the irreversible and NADPH-dependent reductive deamination of guanosine monophosphate (GMP) to inosine monophosphate (IMP). The protein also functions in the re-utilization of free intracellular bases and purine nucleosides. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2017]
GeneCards Summary for GMPR2 Gene
GMPR2 (Guanosine Monophosphate Reductase 2) is a Protein Coding gene. Among its related pathways are Metabolism and Pyrimidine metabolism (KEGG). Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and GMP reductase activity. An important paralog of this gene is GMPR.
UniProtKB/Swiss-Prot for GMPR2 Gene
Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (PubMed:12009299, PubMed:12669231, PubMed:16359702, PubMed:22037469). Plays a role in modulating cellular differentiation (PubMed:12669231).