This gene encodes an enzyme that catalyzes the irreversible and NADPH-dependent reductive deamination of guanosine monophosphate (GMP) to inosine monophosphate (IMP). The protein also functions in the re-utilization of free intracellular bases and purine nucleosides. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2017] See more...

Aliases for GMPR2 Gene

Aliases for GMPR2 Gene

  • Guanosine Monophosphate Reductase 2 2 3 4 5
  • Guanosine 5'-Monophosphate Oxidoreductase 2 3 4
  • GMP Reductase 2 3 4
  • EC 1.7.1.7 4 51
  • GMPR 2 3 4
  • Guanosine Monophosphate Reductase Isolog 3
  • GMPR2 5

External Ids for GMPR2 Gene

Previous GeneCards Identifiers for GMPR2 Gene

  • GC00U990486
  • GC14P018488
  • GC14P022691
  • GC14P022692
  • GC14P023771
  • GC14P024701
  • GC14P004816

Summaries for GMPR2 Gene

Entrez Gene Summary for GMPR2 Gene

  • This gene encodes an enzyme that catalyzes the irreversible and NADPH-dependent reductive deamination of guanosine monophosphate (GMP) to inosine monophosphate (IMP). The protein also functions in the re-utilization of free intracellular bases and purine nucleosides. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2017]

GeneCards Summary for GMPR2 Gene

GMPR2 (Guanosine Monophosphate Reductase 2) is a Protein Coding gene. Diseases associated with GMPR2 include Urethra Cancer. Among its related pathways are Metabolism of nucleotides and Metabolism. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and GMP reductase activity. An important paralog of this gene is GMPR.

UniProtKB/Swiss-Prot Summary for GMPR2 Gene

  • Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (PubMed:12009299, PubMed:12669231, PubMed:16359702, PubMed:22037469). Plays a role in modulating cellular differentiation (PubMed:12669231).

Additional gene information for GMPR2 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GMPR2 Gene

Genomics for GMPR2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for GMPR2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GMPR2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GMPR2

Top Transcription factor binding sites by QIAGEN in the GMPR2 gene promoter:
  • POU2F1
  • POU2F1a
  • POU3F2
  • POU3F2 (N-Oct-5a)
  • POU3F2 (N-Oct-5b)

Genomic Locations for GMPR2 Gene

Genomic Locations for GMPR2 Gene
chr14:24,232,422-24,239,242
(GRCh38/hg38)
Size:
6,821 bases
Orientation:
Plus strand
chr14:24,701,628-24,708,448
(GRCh37/hg19)
Size:
6,821 bases
Orientation:
Plus strand

Genomic View for GMPR2 Gene

Genes around GMPR2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GMPR2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GMPR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GMPR2 Gene

Proteins for GMPR2 Gene

  • Protein details for GMPR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P2T1-GMPR2_HUMAN
    Recommended name:
    GMP reductase 2
    Protein Accession:
    Q9P2T1
    Secondary Accessions:
    • D3DS66
    • Q567T0
    • Q6IAJ8
    • Q86T14

    Protein attributes for GMPR2 Gene

    Size:
    348 amino acids
    Molecular mass:
    37874 Da
    Quaternary structure:
    • Homotetramer.

    Three dimensional structures from OCA and Proteopedia for GMPR2 Gene

    Alternative splice isoforms for GMPR2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GMPR2 Gene

Selected DME Specific Peptides for GMPR2 Gene

Q9P2T1:
  • IISDGGC
  • RPKRSTLKSRS
  • ECADAAHGL
  • AGNVVTG
  • KLDFKDVLLRPKRS
  • GSVCTTR
  • GYPQLSA
  • RTTFIRV
  • EELILSGAD
  • GADFVMLGGM
  • TAVHKHY
  • DVANGYSE
  • NMDTVGTF
  • RSTCTYVGA
  • GGVAEYRA
  • KLFYGMSS
  • FRNSKQTYSG
  • PGDVAKAFG

Post-translational modifications for GMPR2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for GMPR2 Gene

Gene Families for GMPR2 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for GMPR2 Gene

InterPro:
Blocks:
  • IMP dehydrogenase/GMP reductase
ProtoNet:

Suggested Antigen Peptide Sequences for GMPR2 Gene

GenScript: Design optimal peptide antigens:
  • Guanosine 5'-monophosphate oxidoreductase 2 (GMPR2_HUMAN)
  • GMP reductase (Q6PKC0_HUMAN)
  • Guanosine monophosphate reductase 2, isoform CRA_e (Q86SZ5_HUMAN)
  • GMP reductase (Q86T14_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9P2T1

UniProtKB/Swiss-Prot:

GMPR2_HUMAN :
  • Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily.
Family:
  • Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily.
genes like me logo Genes that share domains with GMPR2: view

Function for GMPR2 Gene

Molecular function for GMPR2 Gene

UniProtKB/Swiss-Prot Function:
Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (PubMed:12009299, PubMed:12669231, PubMed:16359702, PubMed:22037469). Plays a role in modulating cellular differentiation (PubMed:12669231).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=IMP + NADP(+) + NH4(+) = GMP + 2 H(+) + NADPH; Xref=Rhea:RHEA:17185, ChEBI:CHEBI:15378, ChEBI:CHEBI:28938, ChEBI:CHEBI:57783, ChEBI:CHEBI:58053, ChEBI:CHEBI:58115, ChEBI:CHEBI:58349; EC=1.7.1.7; Evidence={ECO:0000255|HAMAP-Rule:MF_03195, ECO:0000269|PubMed:12009299, ECO:0000269|PubMed:16359702, ECO:0000269|PubMed:22037469};.

Enzyme Numbers (IUBMB) for GMPR2 Gene

Phenotypes From GWAS Catalog for GMPR2 Gene

Gene Ontology (GO) - Molecular Function for GMPR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity IEA --
GO:0003920 GMP reductase activity IEA,IDA 22037469
GO:0003938 IMP dehydrogenase activity IEA --
GO:0005515 protein binding IPI 25416956
GO:0016491 oxidoreductase activity IEA --
genes like me logo Genes that share ontologies with GMPR2: view
genes like me logo Genes that share phenotypes with GMPR2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for GMPR2

CRISPR Products

miRNA for GMPR2 Gene

miRTarBase miRNAs that target GMPR2

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GMPR2

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GMPR2 Gene

Localization for GMPR2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GMPR2 gene
Compartment Confidence
mitochondrion 3
cytosol 3
peroxisome 1
plasma membrane 0
nucleus 0
golgi apparatus 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GMPR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:1902560 GMP reductase complex IEA --
genes like me logo Genes that share ontologies with GMPR2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for GMPR2 Gene

Pathways & Interactions for GMPR2 Gene

PathCards logo

SuperPathways for GMPR2 Gene

genes like me logo Genes that share pathways with GMPR2: view

Pathways by source for GMPR2 Gene

2 KEGG pathways for GMPR2 Gene

Gene Ontology (GO) - Biological Process for GMPR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006144 purine nucleobase metabolic process IEA --
GO:0006163 purine nucleotide metabolic process IEA --
GO:0006164 purine nucleotide biosynthetic process IEA --
GO:0009117 nucleotide metabolic process IEA --
GO:0015951 purine ribonucleotide interconversion IBA --
genes like me logo Genes that share ontologies with GMPR2: view

No data available for SIGNOR curated interactions for GMPR2 Gene

Drugs & Compounds for GMPR2 Gene

(5) Drugs for GMPR2 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Ammonia Approved Pharma 0
NADPH Experimental Pharma 0
Guanosine monophosphate Experimental Pharma 0
Inosinic acid Experimental Pharma 0
NADP Experimental Pharma 0

(2) Additional Compounds for GMPR2 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Hydrogen Ion
  • H+
  • H(+)
  • Hydrogen cation
  • Hydron
  • Proton
genes like me logo Genes that share compounds with GMPR2: view

Transcripts for GMPR2 Gene

mRNA/cDNA for GMPR2 Gene

12 REFSEQ mRNAs :
19 NCBI additional mRNA sequence :
31 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GMPR2

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GMPR2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9 ^ 10a ·
SP1: - - - - - - - - -
SP2: - - - - - - - -
SP3: - - - - -
SP4: - - - - -
SP5: - - - - -
SP6: - - - - - - -
SP7: - - - - - -
SP8: - - - -
SP9: - - - - - - -
SP10: - - - - - - -
SP11: - - - - - - - - -
SP12: - - - - - - - - - - - -
SP13: - - - - - - - - -
SP14: - - - -
SP15:
SP16: - - -
SP17: - - - -
SP18: - -
SP19:

ExUns: 10b ^ 11a · 11b · 11c · 11d ^ 12a · 12b · 12c
SP1: -
SP2: -
SP3: -
SP4: -
SP5: -
SP6: -
SP7: -
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:

Relevant External Links for GMPR2 Gene

GeneLoc Exon Structure for
GMPR2

Expression for GMPR2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GMPR2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for GMPR2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (10.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GMPR2 Gene



Protein tissue co-expression partners for GMPR2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GMPR2

SOURCE GeneReport for Unigene cluster for GMPR2 Gene:

Hs.368855

mRNA Expression by UniProt/SwissProt for GMPR2 Gene:

Q9P2T1-GMPR2_HUMAN
Tissue specificity: Highly expressed in heart, skeletal muscle, kidney, brain, liver, prostate, spleen, placenta, testis and ovary. Low expression in colon, thymus and peripheral blood leukocytes.

Evidence on tissue expression from TISSUES for GMPR2 Gene

  • Nervous system(4.7)
  • Blood(4.5)
  • Lung(4.3)
  • Liver(4.3)
  • Skin(2.1)
genes like me logo Genes that share expression patterns with GMPR2: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for GMPR2 Gene

Orthologs for GMPR2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for GMPR2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia GMPR2 30 31
  • 99.71 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia GMPR2 30 31
  • 92.58 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia GMPR2 30 31
  • 92.1 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Gmpr2 30
  • 91.14 (n)
Mouse
(Mus musculus)
Mammalia Gmpr2 30 17 31
  • 89.53 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia GMPR2 31
  • 81 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia GMPR2 31
  • 54 (a)
OneToOne
Chicken
(Gallus gallus)
Aves IMPDH2 31
  • 11 (a)
ManyToMany
Lizard
(Anolis carolinensis)
Reptilia GMPR2 31
  • 88 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia gmpr2 30
  • 74.18 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.12819 30
Zebrafish
(Danio rerio)
Actinopterygii gmpr2 30 31
  • 73.64 (n)
OneToOne
wufb63f02 30
Worm
(Caenorhabditis elegans)
Secernentea F32D1.5 30 31
  • 64.34 (n)
OneToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes IMD3 31
  • 20 (a)
ManyToMany
IMD2 31
  • 20 (a)
ManyToMany
IMD4 31
  • 19 (a)
ManyToMany
IMD1 31
  • 16 (a)
ManyToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.8181 31
  • 14 (a)
OneToMany
Species where no ortholog for GMPR2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for GMPR2 Gene

ENSEMBL:
Gene Tree for GMPR2 (if available)
TreeFam:
Gene Tree for GMPR2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GMPR2: view image

Paralogs for GMPR2 Gene

Paralogs for GMPR2 Gene

(4) SIMAP similar genes for GMPR2 Gene using alignment to 21 proteins:

  • GMPR2_HUMAN
  • H0YK13_HUMAN
  • H0YK71_HUMAN
  • H0YKE1_HUMAN
  • H0YKK3_HUMAN
  • H0YL68_HUMAN
  • H0YLB8_HUMAN
  • H0YLV5_HUMAN
  • H0YMB3_HUMAN
  • H0YMG3_HUMAN
  • H0YMR9_HUMAN
  • H0YMV5_HUMAN
  • H0YMW6_HUMAN
  • H0YN22_HUMAN
  • H0YN74_HUMAN
  • H0YNH0_HUMAN
  • H0YNJ6_HUMAN
  • H0YNS9_HUMAN
  • Q6PKC0_HUMAN
  • Q86SZ5_HUMAN
  • Q86T14_HUMAN
genes like me logo Genes that share paralogs with GMPR2: view

Variants for GMPR2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GMPR2 Gene

SNP ID Clinical significance and condition Chr 14 pos Variation AA Info Type
rs386352308 Uncertain Significance: not provided 24,238,360(+) C/T MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT
rs34354104 - p.Gly242Asp

Additional dbSNP identifiers (rs#s) for GMPR2 Gene

Variation tolerance for GMPR2 Gene

Residual Variation Intolerance Score: 71.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.53; 44.15% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GMPR2 Gene

Human Gene Mutation Database (HGMD)
GMPR2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
GMPR2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for GMPR2 Gene

Disorders for GMPR2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for GMPR2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
urethra cancer
  • cancer of urethra
- elite association - COSMIC cancer census association via MalaCards
Search GMPR2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for GMPR2

genes like me logo Genes that share disorders with GMPR2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GMPR2 Gene

Publications for GMPR2 Gene

  1. Cloning and functional characterization of GMPR2, a novel human guanosine monophosphate reductase, which promotes the monocytic differentiation of HL-60 leukemia cells. (PMID: 12669231) Zhang J … Cao X (Journal of cancer research and clinical oncology 2003) 3 4 23
  2. NADPH-dependent GMP reductase isoenzyme of human (GMPR2). Expression, purification, and kinetic properties. (PMID: 12009299) Deng Y … Mao Y (The international journal of biochemistry & cell biology 2002) 3 4 23
  3. Cofactor mobility determines reaction outcome in the IMPDH and GMPR (β-α)8 barrel enzymes. (PMID: 22037469) Patton GC … Hedstrom L (Nature chemical biology 2011) 3 4
  4. Crystal structure of human guanosine monophosphate reductase 2 (GMPR2) in complex with GMP. (PMID: 16359702) Li J … Mao Y (Journal of molecular biology 2006) 4 23
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4

Products for GMPR2 Gene

  • Signalway Proteins for GMPR2

Sources for GMPR2 Gene