Aliases for GMPPB Gene
External Ids for GMPPB Gene
Previous GeneCards Identifiers for GMPPB Gene
This gene is thought to encode a GDP-mannose pyrophosphorylase. The encoded protein catalyzes the conversion of mannose-1-phosphate and GTP to GDP-mannose, a reaction involved in the production of N-linked oligosaccharides. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jan 2009]
GeneCards Summary for GMPPB Gene
GMPPB (GDP-Mannose Pyrophosphorylase B) is a Protein Coding gene. Diseases associated with GMPPB include Muscular Dystrophy-Dystroglycanopathy , Type C, 14 and Muscular Dystrophy-Dystroglycanopathy , Type A, 14. Among its related pathways are Fructose and mannose metabolism and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include GTP binding and mannose-1-phosphate guanylyltransferase activity. An important paralog of this gene is GMPPA.
UniProtKB/Swiss-Prot for GMPPB Gene
Catalyzes the formation of GDP-mannose, an essential precursor of glycan moieties of glycoproteins and glycolipids.