Aliases for GMPPA Gene
External Ids for GMPPA Gene
Previous GeneCards Identifiers for GMPPA Gene
This gene is thought to encode a GDP-mannose pyrophosphorylase. This enzyme catalyzes the reaction which converts mannose-1-phosphate and GTP to GDP-mannose which is involved in the production of N-linked oligosaccharides. [provided by RefSeq, Jul 2008]
GeneCards Summary for GMPPA Gene
GMPPA (GDP-Mannose Pyrophosphorylase A) is a Protein Coding gene. Diseases associated with GMPPA include Alacrima, Achalasia, And Mental Retardation Syndrome and Achalasia. Among its related pathways are Synthesis of substrates in N-glycan biosythesis and Fructose and mannose metabolism. Gene Ontology (GO) annotations related to this gene include nucleotidyltransferase activity. An important paralog of this gene is GMPPB.
UniProtKB/Swiss-Prot for GMPPA Gene
May serve as a regulatory subunit and allow allosteric feedback inhibition of GMPPB by GDP-mannose.