Aliases for GMPPA Gene
External Ids for GMPPA Gene
Previous GeneCards Identifiers for GMPPA Gene
This gene is thought to encode a GDP-mannose pyrophosphorylase. This enzyme catalyzes the reaction which converts mannose-1-phosphate and GTP to GDP-mannose which is involved in the production of N-linked oligosaccharides. [provided by RefSeq, Jul 2008]
GeneCards Summary for GMPPA Gene
GMPPA (GDP-Mannose Pyrophosphorylase A) is a Protein Coding gene. Diseases associated with GMPPA include Alacrima, Achalasia, And Mental Retardation Syndrome and Achalasia-Addisonianism-Alacrima Syndrome. Among its related pathways are Transport to the Golgi and subsequent modification and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include nucleotidyltransferase activity. An important paralog of this gene is GMPPB.
UniProtKB/Swiss-Prot Summary for GMPPA Gene
May serve as a regulatory subunit and allow allosteric feedback inhibition of GMPPB by GDP-mannose.