Aliases for GMNC Gene

Aliases for GMNC Gene

  • Geminin Coiled-Coil Domain Containing 2 3 5
  • GEMC1 2 3 4
  • Geminin Coiled-Coil Domain-Containing Protein 1 3 4
  • GMNC 5

External Ids for GMNC Gene

Previous GeneCards Identifiers for GMNC Gene

  • GC03M190572

Summaries for GMNC Gene

GeneCards Summary for GMNC Gene

GMNC (Geminin Coiled-Coil Domain Containing) is a Protein Coding gene. Diseases associated with GMNC include Primary Ciliary Dyskinesia. Gene Ontology (GO) annotations related to this gene include chromatin binding. An important paralog of this gene is MCIDAS.

UniProtKB/Swiss-Prot Summary for GMNC Gene

  • Regulator of DNA replication. Promotes initiation of chromosomal DNA replication by mediating TOPBP1- and CDK2-dependent recruitment of CDC45L onto replication origins (By similarity).

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GMNC Gene

Genomics for GMNC Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for GMNC Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J190862 Promoter/Enhancer 1.1 Ensembl ENCODE 0.3 +29.5 29528 2.2 CREB1 PRDM10 ZNF629 RFX5 PRDM1 ZIC2 SP1 ZFX ZNF561 SP2 SNAR-I GMNC lnc-IL1RAP-2 LOC100131685 ENSG00000214147 IL1RAP
GH03J190911 Enhancer 0.8 Ensembl 0.4 -19.1 -19072 0.6 ZNF629 ZIC2 POLR2A PATZ1 ZNF600 ARNT ZNF639 ZEB1 TSHZ1 ZSCAN5C piR-48950-135 GMNC OSTN
GH03J190886 Enhancer 0.4 Ensembl 0.4 +5.3 5328 0.2 ZFHX2 SPI1 FEZF1 GMNC EU071077 IL1RAP
GH03J190853 Enhancer 0.5 Ensembl 0.3 +38.2 38228 1.6 SP1 CEBPB ATF3 ZBTB33 JUND SPI1 RAD21 HNF4A RXRA LOC100131685 ENSG00000214147 lnc-IL1RAP-2 SNAR-I GMNC IL1RAP
GH03J190972 Enhancer 0.9 Ensembl 0.2 -80.7 -80672 0.6 PRDM10 ZNF629 ZNF692 ZSCAN4 PATZ1 ZNF600 ZNF341 ZNF561 SCRT2 ZBTB44 CCDC50 piR-38423-040 piR-41245-185 GMNC OSTN
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GMNC on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GMNC

Genomic Locations for GMNC Gene

Genomic Locations for GMNC Gene
chr3:190,843,271-190,892,429
(GRCh38/hg38)
Size:
49,159 bases
Orientation:
Minus strand
chr3:190,570,526-190,610,218
(GRCh37/hg19)
Size:
39,693 bases
Orientation:
Minus strand

Genomic View for GMNC Gene

Genes around GMNC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GMNC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GMNC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GMNC Gene

Proteins for GMNC Gene

  • Protein details for GMNC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NCL1-GEMC1_HUMAN
    Recommended name:
    Geminin coiled-coil domain-containing protein 1
    Protein Accession:
    A6NCL1

    Protein attributes for GMNC Gene

    Size:
    334 amino acids
    Molecular mass:
    37887 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for GMNC Gene

neXtProt entry for GMNC Gene

Post-translational modifications for GMNC Gene

  • Highly phosphorylated by CDK2; stimulates initiation of DNA replication.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GMNC Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GMNC Gene

Domains & Families for GMNC Gene

Gene Families for GMNC Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for GMNC Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GMNC Gene

GenScript: Design optimal peptide antigens:
  • Geminin coiled-coil domain-containing protein 1 (GEMC1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

A6NCL1

UniProtKB/Swiss-Prot:

GEMC1_HUMAN :
  • Belongs to the GEMC1 family.
Family:
  • Belongs to the GEMC1 family.
genes like me logo Genes that share domains with GMNC: view

Function for GMNC Gene

Molecular function for GMNC Gene

UniProtKB/Swiss-Prot Function:
Regulator of DNA replication. Promotes initiation of chromosomal DNA replication by mediating TOPBP1- and CDK2-dependent recruitment of CDC45L onto replication origins (By similarity).

Phenotypes From GWAS Catalog for GMNC Gene

Gene Ontology (GO) - Molecular Function for GMNC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IEA,ISS --
genes like me logo Genes that share ontologies with GMNC: view
genes like me logo Genes that share phenotypes with GMNC: view

Animal Models for GMNC Gene

MGI Knock Outs for GMNC:
  • Gmnc Gmnc<tm1a(KOMP)Wtsi>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GMNC

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GMNC Gene

Localization for GMNC Gene

Subcellular locations from UniProtKB/Swiss-Prot for GMNC Gene

Nucleus. Note=Associates with chromatin during pre-replication complex (pre-RC) formation. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GMNC gene
Compartment Confidence
nucleus 4
cytosol 2
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for GMNC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,ISS --
genes like me logo Genes that share ontologies with GMNC: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GMNC Gene

Pathways & Interactions for GMNC Gene

PathCards logo

SuperPathways for GMNC Gene

No Data Available

Interacting Proteins for GMNC Gene

STRING Interaction Network Preview (showing top 1 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: A6NCL1-GEMC1_HUMAN ENSP00000406164 for GMNC Gene via UniProtKB STRING

Gene Ontology (GO) - Biological Process for GMNC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006260 DNA replication IEA --
GO:0006270 DNA replication initiation IEA --
GO:0007049 cell cycle IEA --
GO:0060271 cilium assembly IEA --
genes like me logo Genes that share ontologies with GMNC: view

No data available for Pathways by source and SIGNOR curated interactions for GMNC Gene

Drugs & Compounds for GMNC Gene

No Compound Related Data Available

Transcripts for GMNC Gene

mRNA/cDNA for GMNC Gene

1 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GMNC

Alternative Splicing Database (ASD) splice patterns (SP) for GMNC Gene

No ASD Table

Relevant External Links for GMNC Gene

GeneLoc Exon Structure for
GMNC

Expression for GMNC Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GMNC Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GMNC Gene

This gene is overexpressed in Liver (x12.0), Fallopian Tube (x8.9), Kidney - Cortex (x6.6), and Testis (x5.5).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GMNC

SOURCE GeneReport for Unigene cluster for GMNC Gene:

Hs.518490
genes like me logo Genes that share expression patterns with GMNC: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for GMNC Gene

Orthologs for GMNC Gene

This gene was present in the common ancestor of chordates.

Orthologs for GMNC Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia GMNC 30 31
  • 99.4 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia LOC608255 30
  • 90.79 (n)
GMNC 31
  • 86 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia GMNC 30 31
  • 89.09 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Gmnc 30 17 31
  • 83.23 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Gmnc 30
  • 82.38 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia GMNC 31
  • 65 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia GMNC 31
  • 63 (a)
OneToOne
Chicken
(Gallus gallus)
Aves GMNC 30 31
  • 61.74 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia GMNC 31
  • 45 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia gmnc 30
  • 62.43 (n)
Zebrafish
(Danio rerio)
Actinopterygii LOC100148564 30
  • 54.72 (n)
gmnc 31
  • 39 (a)
OneToOne
Species where no ortholog for GMNC was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for GMNC Gene

ENSEMBL:
Gene Tree for GMNC (if available)
TreeFam:
Gene Tree for GMNC (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GMNC: view image

Paralogs for GMNC Gene

Paralogs for GMNC Gene

genes like me logo Genes that share paralogs with GMNC: view

Variants for GMNC Gene

Additional dbSNP identifiers (rs#s) for GMNC Gene

Structural Variations from Database of Genomic Variants (DGV) for GMNC Gene

Variant ID Type Subtype PubMed ID
esv34194 CNV loss 18971310
esv3893843 CNV gain 25118596

Variation tolerance for GMNC Gene

Gene Damage Index Score: 13.03; 95.02% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GMNC Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GMNC

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GMNC Gene

Disorders for GMNC Gene

MalaCards: The human disease database

(1) MalaCards diseases for GMNC Gene - From: DISEASES

Disorder Aliases PubMed IDs
primary ciliary dyskinesia
  • pcd
- elite association - COSMIC cancer census association via MalaCards
Search GMNC in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with GMNC: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GMNC Gene

Publications for GMNC Gene

  1. GEMC1 is a TopBP1-interacting protein required for chromosomal DNA replication. (PMID: 20383140) Balestrini A … Costanzo V (Nature cell biology 2010) 2 3
  2. GEMC1 is a novel TopBP1-interacting protein involved in chromosomal DNA replication. (PMID: 20855966) Piergiovanni G … Costanzo V (Cell cycle (Georgetown, Tex.) 2010) 2 3
  3. The DNA sequence, annotation and analysis of human chromosome 3. (PMID: 16641997) Muzny DM … Gibbs RA (Nature 2006) 3 4
  4. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  5. Estrogen-regulated feedback loop limits the efficacy of estrogen receptor-targeted breast cancer therapy. (PMID: 29987050) Xiao T … Brown M (Proceedings of the National Academy of Sciences of the United States of America 2018) 3

Products for GMNC Gene

Sources for GMNC Gene