Aliases for GML Gene

Aliases for GML Gene

  • Glycosylphosphatidylinositol Anchored Molecule Like 2 3 5
  • LY6DL 2 3 4
  • Glycosyl-Phosphatidylinositol-Anchored Molecule-Like Protein 3 4
  • Glycosylphosphatidylinositol Anchored Molecule Like Protein 2 3
  • GPI Anchored Molecule Like Protein 2 3
  • Glycosylphosphatidylinositol-Anchored Molecule-Like Protein 3
  • GML 5

External Ids for GML Gene

Previous GeneCards Identifiers for GML Gene

  • GC08P142220
  • GC08P144256
  • GC08P143720
  • GC08P143979
  • GC08P143913
  • GC08P139168

Summaries for GML Gene

GeneCards Summary for GML Gene

GML (Glycosylphosphatidylinositol Anchored Molecule Like) is a Protein Coding gene. Diseases associated with GML include Ainhum and Yunis-Varon Syndrome. An important paralog of this gene is LY6K.

UniProtKB/Swiss-Prot Summary for GML Gene

  • May play a role in the apoptotic pathway or cell-cycle regulation induced by p53/TP53 after DNA damage.

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GML Gene

Genomics for GML Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for GML Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J142834 Promoter 0.3 EPDnew 607.3 +0.5 530 0.1 GML ENSG00000253728 CYP11B1
GH08J142841 Enhancer 0.8 FANTOM5 Ensembl ENCODE 11.9 +9.8 9754 5.6 FOSL1 CUX1 JUN JUND GML ENSG00000253715 LY6D LY6H SLURP1 LYNX1 ENSG00000253728 piR-32461-200 CYP11B1
GH08J142838 Enhancer 0.7 Ensembl ENCODE 12.2 +4.6 4553 0.8 CREB1 ZIC2 ZNF600 BATF HIC1 GLIS1 ZNF398 FOS IKZF1 IKZF2 GML ENSG00000253715 LY6D SLURP1 LYNX1 ENSG00000253728 piR-32461-200 CYP11B1
GH08J142869 Enhancer 0.4 Ensembl 20.2 +37.1 37054 2.2 PRDM1 EBF1 FOS lnc-CYP11B1-2 GML C8orf31 ENSG00000253728 LY6D ENSG00000253715 LYNX1 TOP1MT CYP11B1 ZNHIT1P1
GH08J143117 Enhancer 0.7 Ensembl ENCODE 10.1 +283.3 283253 1 PRDM10 TARDBP RFX1 CTBP1 ZNF444 USF1 ZNF592 PKNOX1 ZNF217 DPF2 ENSG00000243328 LY6H ZFP41 ENSG00000253728 GML piR-61945-496 piR-60519 LY6L RF00017-7363 RF00017-7364
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GML on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GML

Top Transcription factor binding sites by QIAGEN in the GML gene promoter:
  • ER-alpha
  • Nkx3-1
  • Nkx3-1 v1
  • Nkx3-1 v2
  • Nkx3-1 v3
  • Nkx3-1 v4
  • p53
  • Roaz

Genomic Locations for GML Gene

Genomic Locations for GML Gene
82,260 bases
Plus strand
82,260 bases
Plus strand

Genomic View for GML Gene

Genes around GML on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GML Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GML Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GML Gene

Proteins for GML Gene

  • Protein details for GML Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Glycosyl-phosphatidylinositol-anchored molecule-like protein
    Protein Accession:
    Secondary Accessions:
    • A0AVF6
    • O00686
    • O00731

    Protein attributes for GML Gene

    158 amino acids
    Molecular mass:
    17730 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GML Gene

Post-translational modifications for GML Gene

No Post-translational modifications

Other Protein References for GML Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GML Gene

Domains & Families for GML Gene

Gene Families for GML Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transporters

Protein Domains for GML Gene

  • CD59 antigen

Suggested Antigen Peptide Sequences for GML Gene

GenScript: Design optimal peptide antigens:
  • Glycosyl-phosphatidylinositol-anchored molecule-like protein (GML_HUMAN)
genes like me logo Genes that share domains with GML: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for GML Gene

Function for GML Gene

Molecular function for GML Gene

UniProtKB/Swiss-Prot Function:
May play a role in the apoptotic pathway or cell-cycle regulation induced by p53/TP53 after DNA damage.
UniProtKB/Swiss-Prot Induction:
By p53/TP53.
GENATLAS Biochemistry:
(glycosylphosphatidylinositol) GPI-anchored molecule-like protein,induced by p53,putatively involved in cell-cycle regulation

Phenotypes From GWAS Catalog for GML Gene

genes like me logo Genes that share phenotypes with GML: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GML

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GML Gene

Localization for GML Gene

Subcellular locations from UniProtKB/Swiss-Prot for GML Gene

Cell membrane. Lipid-anchor, GPI-anchor.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GML gene
Compartment Confidence
plasma membrane 5
extracellular 2
nucleus 2
cytoskeleton 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for GML Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS,IEA --
GO:0016020 membrane IEA --
GO:0019898 extrinsic component of membrane TAS 8934543
GO:0031225 anchored component of membrane IEA --
genes like me logo Genes that share ontologies with GML: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GML Gene

Pathways & Interactions for GML Gene

PathCards logo

SuperPathways for GML Gene

No Data Available

Interacting Proteins for GML Gene

Gene Ontology (GO) - Biological Process for GML Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process TAS 8934543
GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest TAS 8934543
GO:0008285 negative regulation of cell proliferation TAS 8934543
genes like me logo Genes that share ontologies with GML: view

No data available for Pathways by source and SIGNOR curated interactions for GML Gene

Drugs & Compounds for GML Gene

No Compound Related Data Available

Transcripts for GML Gene

mRNA/cDNA for GML Gene

4 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GML

Alternative Splicing Database (ASD) splice patterns (SP) for GML Gene

No ASD Table

Relevant External Links for GML Gene

GeneLoc Exon Structure for

Expression for GML Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GML Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GML Gene

This gene is overexpressed in Testis (x35.5) and Adrenal Gland (x9.7).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GML

SOURCE GeneReport for Unigene cluster for GML Gene:


Evidence on tissue expression from TISSUES for GML Gene

  • Skin(2.2)
  • Blood(2.1)
genes like me logo Genes that share expression patterns with GML: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GML Gene

Orthologs for GML Gene

This gene was present in the common ancestor of mammals.

Orthologs for GML Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GML 30 31
  • 98.73 (n)
(Canis familiaris)
Mammalia LOC100684332 30
  • 69.25 (n)
-- 31
  • 68 (a)
-- 31
  • 30 (a)
(Bos Taurus)
Mammalia GML 30 31
  • 68.43 (n)
(Mus musculus)
Mammalia Gml 30 17 31
  • 58.46 (n)
Hemt1 31
  • 42 (a)
Gml2 17
(Rattus norvegicus)
Mammalia Gml 30
  • 58.09 (n)
Species where no ortholog for GML was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for GML Gene

Gene Tree for GML (if available)
Gene Tree for GML (if available)
Evolutionary constrained regions (ECRs) for GML: view image

Paralogs for GML Gene

Paralogs for GML Gene Pseudogenes for GML Gene

genes like me logo Genes that share paralogs with GML: view

Variants for GML Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GML Gene

SNP ID Clinical significance and condition Chr 08 pos Variation AA Info Type
782280 Benign: not provided 142,840,503(+) C/T SYNONYMOUS_VARIANT
rs3764795 - p.Arg54Cys

Additional dbSNP identifiers (rs#s) for GML Gene

Structural Variations from Database of Genomic Variants (DGV) for GML Gene

Variant ID Type Subtype PubMed ID
esv2661137 CNV deletion 23128226
nsv1023021 CNV loss 25217958
nsv520940 CNV gain 19592680
nsv528545 CNV loss 19592680
nsv612714 CNV gain 21841781
nsv831486 CNV gain 17160897

Variation tolerance for GML Gene

Residual Variation Intolerance Score: 89.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.94; 87.24% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GML Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GML Gene

Disorders for GML Gene

MalaCards: The human disease database

(4) MalaCards diseases for GML Gene - From: DISEASES

Disorder Aliases PubMed IDs
  • dactylolysis spontanea
yunis-varon syndrome
  • yvs
cardiomyopathy, familial hypertrophic, 1
  • fhc
congenital myasthenic syndrome
  • congenital myasthenic syndromes
- elite association - COSMIC cancer census association via MalaCards
Search GML in MalaCards View complete list of genes associated with diseases

Additional Disease Information for GML

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with GML: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GML Gene

Publications for GML Gene

  1. Genomic structure and chromosomal localization of GML (GPI-anchored molecule-like protein), a gene induced by p53. (PMID: 9169150) Kimura Y … Tokino T (Genomics 1997) 2 3 4 23
  2. Isolation of a novel GPI-anchored gene specifically regulated by p53; correlation between its expression and anti-cancer drug sensitivity. (PMID: 8934543) Furuhata T … Nakamura Y (Oncogene 1996) 2 3 4 23
  3. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PMID: 20800603) Flachsbart F … Nebel A (Mutation research 2010) 3 41
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3

Products for GML Gene

Sources for GML Gene