This gene encodes a member of the ARHGAP family of Rho/Rac/Cdc42-like GTPase activating proteins. The encoded protein interacts with the Ras-related protein Gem through its N-terminal domain. Separately, it interacts with RhoA through a RhoGAP domain, and stimulates RhoA-dependent GTPase activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq... See more...

Aliases for GMIP Gene

Aliases for GMIP Gene

  • GEM Interacting Protein 2 3 5
  • GEM-Interacting Protein 3 4
  • ARHGAP46 2 3
  • GMIP 5

External Ids for GMIP Gene

Previous GeneCards Identifiers for GMIP Gene

  • GC19M020131
  • GC19M019585
  • GC19M019602
  • GC19M019603
  • GC19M019604
  • GC19M019740
  • GC19M019302

Summaries for GMIP Gene

Entrez Gene Summary for GMIP Gene

  • This gene encodes a member of the ARHGAP family of Rho/Rac/Cdc42-like GTPase activating proteins. The encoded protein interacts with the Ras-related protein Gem through its N-terminal domain. Separately, it interacts with RhoA through a RhoGAP domain, and stimulates RhoA-dependent GTPase activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

GeneCards Summary for GMIP Gene

GMIP (GEM Interacting Protein) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and p75 NTR receptor-mediated signalling. Gene Ontology (GO) annotations related to this gene include GTPase activator activity. An important paralog of this gene is ARHGAP45.

UniProtKB/Swiss-Prot Summary for GMIP Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GMIP Gene

Genomics for GMIP Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for GMIP Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GMIP on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GMIP

Top Transcription factor binding sites by QIAGEN in the GMIP gene promoter:
  • Lmo2
  • Olf-1
  • p53
  • Pax-5
  • PPAR-gamma1
  • PPAR-gamma2
  • Roaz
  • SEF-1 (1)
  • TGIF

Genomic Locations for GMIP Gene

Genomic Locations for GMIP Gene
chr19:19,629,476-19,643,657
(GRCh38/hg38)
Size:
14,182 bases
Orientation:
Minus strand
chr19:19,740,285-19,754,476
(GRCh37/hg19)
Size:
14,192 bases
Orientation:
Minus strand

Genomic View for GMIP Gene

Genes around GMIP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GMIP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GMIP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GMIP Gene

Proteins for GMIP Gene

  • Protein details for GMIP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P107-GMIP_HUMAN
    Recommended name:
    GEM-interacting protein
    Protein Accession:
    Q9P107
    Secondary Accessions:
    • A0AVN9
    • B7ZLZ0

    Protein attributes for GMIP Gene

    Size:
    970 amino acids
    Molecular mass:
    106683 Da
    Quaternary structure:
    • Interacts with GEM through its N-terminal.

    Three dimensional structures from OCA and Proteopedia for GMIP Gene

    Alternative splice isoforms for GMIP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GMIP Gene

Post-translational modifications for GMIP Gene

  • Ubiquitination at Lys624 and Lys672
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for GMIP Gene

Domains & Families for GMIP Gene

Gene Families for GMIP Gene

Protein Domains for GMIP Gene

InterPro:
Blocks:
  • RhoGAP domain
ProtoNet:

Suggested Antigen Peptide Sequences for GMIP Gene

GenScript: Design optimal peptide antigens:
  • GMIP protein (B7ZLZ0_HUMAN)
  • GEM-interacting protein (GMIP_HUMAN)
genes like me logo Genes that share domains with GMIP: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for GMIP Gene

Function for GMIP Gene

Molecular function for GMIP Gene

UniProtKB/Swiss-Prot Function:
Stimulates, in vitro and in vivo, the GTPase activity of RhoA.

Phenotypes From GWAS Catalog for GMIP Gene

Gene Ontology (GO) - Molecular Function for GMIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IDA 12093360
GO:0005515 protein binding IPI 12093360
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with GMIP: view
genes like me logo Genes that share phenotypes with GMIP: view

Animal Models for GMIP Gene

MGI Knock Outs for GMIP:
  • Gmip Gmip<tm1b(KOMP)Wtsi>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GMIP

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GMIP Gene

Localization for GMIP Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GMIP gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 4
extracellular 1
cytoskeleton 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (4)
  • Nucleoplasm (4)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GMIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with GMIP: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for GMIP Gene

Pathways & Interactions for GMIP Gene

genes like me logo Genes that share pathways with GMIP: view

Pathways by source for GMIP Gene

SIGNOR curated interactions for GMIP Gene

Inactivates:

Gene Ontology (GO) - Biological Process for GMIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0034260 negative regulation of GTPase activity IDA 12093360
GO:0035556 intracellular signal transduction IEA,IDA 12093360
GO:0043547 positive regulation of GTPase activity IEA --
GO:0051056 regulation of small GTPase mediated signal transduction TAS --
genes like me logo Genes that share ontologies with GMIP: view

Drugs & Compounds for GMIP Gene

(4) Additional Compounds for GMIP Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Diglycerides Group A
  • (2R)-2-Hydroxy-3-(pentadecanoyloxy)propyl (5Z,8Z,11Z)-icosa-5,8,11,14-tetraenoic acid
  • DG(15:0/0:0/20:4n6)
  • Diacylglycerol(15:0/0:0/20:4)
  • DG(35:4)
  • DAG(15:0/0:0/20:4)
Diglycerides Group B
  • 1-Myristoyl-2-eicosadienoyl-sn-glycerol
  • DAG(14:0/20:2)
  • DAG(14:0/20:2N6)
  • DAG(14:0/20:2W6)
  • DAG(34:2)
Diglycerides Group C
  • 1-(9Z-Octadecenoyl)-2-hexadecanoyl-sn-glycerol
  • 1-O-Oleoyl-2-O-palmitoyl-sn-glycerol
  • DG (18:1(9Z)/16:0/0:0)
  • DG(18:1/16:0)
  • Diglyceride
Diglycerides Group D
  • 1,2-Di-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol
  • 1,2-Didocosahexaenoyl-sn-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6N3/22:6N3)
  • DAG(22:6OMEGA3/22:6OMEGA3)
genes like me logo Genes that share compounds with GMIP: view

Transcripts for GMIP Gene

mRNA/cDNA for GMIP Gene

3 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GMIP

Alternative Splicing Database (ASD) splice patterns (SP) for GMIP Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22
SP1:
SP2:
SP3:
SP4: -
SP5:
SP6:

Relevant External Links for GMIP Gene

GeneLoc Exon Structure for
GMIP

Expression for GMIP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GMIP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GMIP Gene

This gene is overexpressed in Whole Blood (x25.5) and Spleen (x4.4).

Protein differential expression in normal tissues from HIPED for GMIP Gene

This gene is overexpressed in Peripheral blood mononuclear cells (18.5), Lavage (11.9), Lymph node (10.7), and Monocytes (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GMIP Gene



Protein tissue co-expression partners for GMIP Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GMIP

SOURCE GeneReport for Unigene cluster for GMIP Gene:

Hs.49427

Evidence on tissue expression from TISSUES for GMIP Gene

  • Nervous system(4.5)
  • Blood(4.4)
  • Liver(4.2)
genes like me logo Genes that share expression patterns with GMIP: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GMIP Gene

Orthologs for GMIP Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for GMIP Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia GMIP 30 31
  • 99.48 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia GMIP 30 31
  • 87.25 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia GMIP 30 31
  • 85.8 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Gmip 30 17 31
  • 82.88 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Gmip 30
  • 82.43 (n)
Oppossum
(Monodelphis domestica)
Mammalia GMIP 31
  • 63 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia GMIP 31
  • 54 (a)
OneToOne
Chicken
(Gallus gallus)
Aves GMIP 30 31
  • 58.81 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia GMIP 31
  • 52 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia gmip 30
  • 54.63 (n)
Zebrafish
(Danio rerio)
Actinopterygii LOC565801 30
  • 53.12 (n)
gmip 31
  • 42 (a)
OneToOne
Worm
(Caenorhabditis elegans)
Secernentea spv-1 31
  • 20 (a)
OneToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RGA2 31
  • 13 (a)
ManyToMany
RGA1 31
  • 13 (a)
ManyToMany
BAG7 33
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 34 (a)
OneToMany
Species where no ortholog for GMIP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for GMIP Gene

ENSEMBL:
Gene Tree for GMIP (if available)
TreeFam:
Gene Tree for GMIP (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GMIP: view image

Paralogs for GMIP Gene

Paralogs for GMIP Gene

(5) SIMAP similar genes for GMIP Gene using alignment to 6 proteins:

  • GMIP_HUMAN
  • B7ZLZ0_HUMAN
  • E7ERB7_HUMAN
  • K7EJC2_HUMAN
  • K7ELE8_HUMAN
  • K7EQR5_HUMAN
genes like me logo Genes that share paralogs with GMIP: view

Variants for GMIP Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GMIP Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs12003 - p.Asp641Asn

Additional dbSNP identifiers (rs#s) for GMIP Gene

Structural Variations from Database of Genomic Variants (DGV) for GMIP Gene

Variant ID Type Subtype PubMed ID
dgv1025e212 CNV loss 25503493
nsv1160593 CNV deletion 26073780
nsv509725 CNV insertion 20534489
nsv952427 CNV deletion 24416366

Variation tolerance for GMIP Gene

Residual Variation Intolerance Score: 35.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.23; 62.25% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GMIP Gene

Human Gene Mutation Database (HGMD)
GMIP
SNPedia medical, phenotypic, and genealogical associations of SNPs for
GMIP

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GMIP Gene

Disorders for GMIP Gene

Additional Disease Information for GMIP

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform

No disorders were found for GMIP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GMIP Gene

Publications for GMIP Gene

  1. The Gem interacting protein (GMIP) gene is associated with major depressive disorder. (PMID: 16086184) Tadokoro K … Kunugi H (Neurogenetics 2005) 2 3 23 41
  2. A novel Rho GTPase-activating-protein interacts with Gem, a member of the Ras superfamily of GTPases. (PMID: 12093360) Aresta S … de Gunzburg J (The Biochemical journal 2002) 2 3 4
  3. Gem GTPase acts upstream Gmip/RhoA to regulate cortical actin remodeling and spindle positioning during early mitosis. (PMID: 25173885) Andrieu G … Hatzoglou A (Carcinogenesis 2014) 2 3
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 41
  5. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3

Products for GMIP Gene

Sources for GMIP Gene