Aliases for GMFG Gene

Aliases for GMFG Gene

  • Glia Maturation Factor Gamma 2 3 4 5
  • GMF-Gamma 4
  • GMFG 5

External Ids for GMFG Gene

Previous GeneCards Identifiers for GMFG Gene

  • GC19M040434
  • GC19M040210
  • GC19M044495
  • GC19M044510
  • GC19M039821
  • GC19M036265

Summaries for GMFG Gene

GeneCards Summary for GMFG Gene

GMFG (Glia Maturation Factor Gamma) is a Protein Coding gene. Among its related pathways are Nanog in Mammalian ESC Pluripotency and Apoptotic Pathways in Synovial Fibroblasts. Gene Ontology (GO) annotations related to this gene include actin binding and enzyme activator activity. An important paralog of this gene is GMFB.

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GMFG Gene

Genomics for GMFG Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for GMFG Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GMFG on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GMFG

Top Transcription factor binding sites by QIAGEN in the GMFG gene promoter:
  • C/EBPalpha
  • HNF-4alpha1
  • HNF-4alpha2
  • HSF1 (long)
  • HSF1short
  • Pax-4a
  • STAT1
  • STAT1alpha
  • STAT1beta

Genomic Locations for GMFG Gene

Latest Assembly
14,020 bases
Minus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
7,685 bases
Minus strand

(GRCh37/hg19 by Ensembl)
14,020 bases
Minus strand

Genomic View for GMFG Gene

Genes around GMFG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GMFG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GMFG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GMFG Gene

Proteins for GMFG Gene

  • Protein details for GMFG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Glia maturation factor gamma
    Protein Accession:
    Secondary Accessions:
    • Q6IB37

    Protein attributes for GMFG Gene

    142 amino acids
    Molecular mass:
    16801 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for GMFG Gene

neXtProt entry for GMFG Gene

Post-translational modifications for GMFG Gene

  • Ubiquitination at Lys17, Lys25, Lys35, Lys74, Lys108, and Lys137
  • Modification sites at PhosphoSitePlus

Antibodies for research

  • Abcam antibodies for GMFG

No data available for DME Specific Peptides for GMFG Gene

Domains & Families for GMFG Gene

Gene Families for GMFG Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for GMFG Gene

  • Actin-binding, cofilin/tropomyosin type

Suggested Antigen Peptide Sequences for GMFG Gene

GenScript: Design optimal peptide antigens:
  • Glia maturation factor gamma (GMFG_HUMAN)
  • Glia maturation factor, gamma (Q6IB37_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the actin-binding proteins ADF family. GMF subfamily.
  • Belongs to the actin-binding proteins ADF family. GMF subfamily.
genes like me logo Genes that share domains with GMFG: view

Function for GMFG Gene

Phenotypes From GWAS Catalog for GMFG Gene

Gene Ontology (GO) - Molecular Function for GMFG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
GO:0004860 protein kinase inhibitor activity TAS 8639570
GO:0008047 enzyme activator activity TAS 8798479
GO:0008083 growth factor activity IEA --
GO:0071933 Arp2/3 complex binding IEA,IBA 21873635
genes like me logo Genes that share ontologies with GMFG: view
genes like me logo Genes that share phenotypes with GMFG: view

Animal Models for research

  • Taconic Biosciences Mouse Models for GMFG

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GMFG

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GMFG Gene

Localization for GMFG Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GMFG gene
Compartment Confidence
extracellular 4
cytosol 3
nucleus 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nuclear bodies (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GMFG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0034774 secretory granule lumen TAS --
GO:1904813 ficolin-1-rich granule lumen TAS --
genes like me logo Genes that share ontologies with GMFG: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for GMFG Gene

Pathways & Interactions for GMFG Gene

PathCards logo

SuperPathways for GMFG Gene

SuperPathway Contained pathways
1 Apoptotic Pathways in Synovial Fibroblasts
2 GPCR Pathway
3 ERK Signaling
4 Nanog in Mammalian ESC Pluripotency
5 CREB Pathway
genes like me logo Genes that share pathways with GMFG: view

Pathways by source for GMFG Gene

3 Reactome pathways for GMFG Gene
54 Qiagen pathways for GMFG Gene
  • 14-3-3 Induced Intracellular Signaling
  • Actin-Based Motility by Rho Family GTPases
  • Activation of cAMP-Dependent PKA
  • Activation of PKA through GPCR
  • Activation of PKC through GPCR

Gene Ontology (GO) - Biological Process for GMFG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation TAS 7598724
GO:0006469 negative regulation of protein kinase activity IEA --
GO:0007165 signal transduction IEA --
GO:0034316 negative regulation of Arp2/3 complex-mediated actin nucleation IEA,IBA 21873635
GO:0043312 neutrophil degranulation TAS --
genes like me logo Genes that share ontologies with GMFG: view

No data available for SIGNOR curated interactions for GMFG Gene

Drugs & Compounds for GMFG Gene

No Compound Related Data Available

Transcripts for GMFG Gene

mRNA/cDNA for GMFG Gene

17 NCBI additional mRNA sequence :
12 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GMFG

Alternative Splicing Database (ASD) splice patterns (SP) for GMFG Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7
SP1: -
SP2: - -
SP3: - -
SP5: - - -
SP6: - - - -
SP7: - - - -

Relevant External Links for GMFG Gene

GeneLoc Exon Structure for

Expression for GMFG Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GMFG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GMFG Gene

This gene is overexpressed in Whole Blood (x26.5) and Spleen (x5.4).

Protein differential expression in normal tissues from HIPED for GMFG Gene

This gene is overexpressed in Peripheral blood mononuclear cells (23.0), Neutrophil (8.9), and CD8 Tcells (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GMFG Gene

Protein tissue co-expression partners for GMFG Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GMFG

SOURCE GeneReport for Unigene cluster for GMFG Gene:


mRNA Expression by UniProt/SwissProt for GMFG Gene:

Tissue specificity: Expressed predominantly in lung, heart and placenta.

Evidence on tissue expression from TISSUES for GMFG Gene

  • Blood(4.5)
  • Nervous system(4.4)
  • Lung(4.4)
  • Spleen(2.7)
  • Bone marrow(2.5)
  • Intestine(2.4)
  • Lymph node(2.1)
  • Heart(2)
genes like me logo Genes that share expression patterns with GMFG: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for GMFG Gene

Orthologs for GMFG Gene

This gene was present in the common ancestor of animals.

Orthologs for GMFG Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GMFG 29 30
  • 99.53 (n)
(Bos Taurus)
Mammalia GMFG 29 30
  • 94.37 (n)
(Canis familiaris)
Mammalia GMFG 29 30
  • 90.38 (n)
(Monodelphis domestica)
Mammalia GMFG 30
  • 89 (a)
(Rattus norvegicus)
Mammalia Gmfg 29
  • 88.26 (n)
(Mus musculus)
Mammalia Gmfg 29 16 30
  • 87.56 (n)
Gmfg-ps 16
(Ornithorhynchus anatinus)
Mammalia GMFG 30
  • 41 (a)
(Anolis carolinensis)
Reptilia GMFG 30
  • 82 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia gmfg 29
  • 73.94 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.24513 29
(Danio rerio)
Actinopterygii gmfg 29
  • 71.13 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta CG5869 30
  • 52 (a)
BG:DS02740.9 31
  • 52 (a)
(Caenorhabditis elegans)
Secernentea Y50D7A.10 29 30
  • 47.93 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 43 (a)
-- 30
  • 39 (a)
-- 30
  • 38 (a)
Species where no ortholog for GMFG was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for GMFG Gene

Gene Tree for GMFG (if available)
Gene Tree for GMFG (if available)
Evolutionary constrained regions (ECRs) for GMFG: view image
Alliance of Genome Resources:
Additional Orthologs for GMFG

Paralogs for GMFG Gene

Paralogs for GMFG Gene

(1) SIMAP similar genes for GMFG Gene using alignment to 11 proteins:

  • M0QX47_HUMAN
  • M0R0C1_HUMAN
  • M0R1D2_HUMAN
  • M0R2P2_HUMAN
  • Q6IB37_HUMAN
genes like me logo Genes that share paralogs with GMFG: view

Variants for GMFG Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GMFG Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs34035414 -- p.Glu136Lys
rs36110047 -- p.Glu122Lys

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for GMFG Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for GMFG Gene

Variant ID Type Subtype PubMed ID
esv25791 CNV gain 19812545
nsv833830 CNV loss 17160897
nsv953572 CNV deletion 24416366

Variation tolerance for GMFG Gene

Residual Variation Intolerance Score: 56.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.15; 39.03% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GMFG Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
Leiden Open Variation Database (LOVD)

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GMFG Gene

Disorders for GMFG Gene

Additional Disease Information for GMFG

No disorders were found for GMFG Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GMFG Gene

Publications for GMFG Gene

  1. Glia maturation factor gamma (GMFG): a cytokine-responsive protein during hematopoietic lineage development and its functional genomics analysis. (PMID: 17127212) Shi Y … Rodgers GP (Genomics, proteomics & bioinformatics 2006) 2 3 22
  2. Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning. (PMID: 9653160) Mao M … Chen Z (Proceedings of the National Academy of Sciences of the United States of America 1998) 2 3 4
  3. Isolation of novel human cDNA (hGMF-gamma) homologous to Glia Maturation Factor-beta gene. (PMID: 9545571) Asai K … Kato T (Biochimica et biophysica acta 1998) 2 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. The human glia maturation factor-gamma gene: genomic structure and mutation analysis in gliomas with chromosome 19q loss. (PMID: 10541589) Peters N … Jenkins RB (Neurogenetics 1999) 3 4

Products for GMFG Gene

Sources for GMFG Gene