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Aliases for GMEB2 Gene

Aliases for GMEB2 Gene

  • Glucocorticoid Modulatory Element Binding Protein 2 2 3 5
  • DNA-Binding Protein P79PIF 3 4
  • PIF P79 3 4
  • GMEB-2 3 4
  • Glucocorticoid Modulatory Element-Binding Protein 2 3
  • Parvovirus Initiation Factor, P79 3
  • Parvovirus Initiation Factor P79 4
  • KIAA1269 4
  • P79PIF 3
  • PIF79 3

External Ids for GMEB2 Gene

Previous GeneCards Identifiers for GMEB2 Gene

  • GC20M062096
  • GC20M062898
  • GC20M062945
  • GC20M061690
  • GC20M062218
  • GC20M058949

Summaries for GMEB2 Gene

Entrez Gene Summary for GMEB2 Gene

  • This gene is a member of KDWK gene family. The product of this gene associates with GMEB1 protein, and the complex is essential for parvovirus DNA replication. Study of rat homolog implicates the role of this gene in modulation of transactivation by the glucocorticoid receptor bound to glucocorticoid response elements. This gene appears to use multiple polyadenylation sites. [provided by RefSeq, Jul 2008]

GeneCards Summary for GMEB2 Gene

GMEB2 (Glucocorticoid Modulatory Element Binding Protein 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include obsolete signal transducer activity and transcription coactivator activity. An important paralog of this gene is GMEB1.

UniProtKB/Swiss-Prot for GMEB2 Gene

  • Trans-acting factor that binds to glucocorticoid modulatory elements (GME) present in the TAT (tyrosine aminotransferase) promoter and increases sensitivity to low concentrations of glucocorticoids. Binds also to the transferrin receptor promoter. Essential auxiliary factor for the replication of parvoviruses.

Gene Wiki entry for GMEB2 Gene

Additional gene information for GMEB2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GMEB2 Gene

Genomics for GMEB2 Gene

GeneHancer (GH) Regulatory Elements for GMEB2 Gene

Promoters and enhancers for GMEB2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20J063625 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 723.1 -0.8 -774 4.8 MLX ZFP64 DMAP1 IRF4 YY1 SLC30A9 E2F8 ZNF143 SP3 NFYC GMEB2 GC20P063629 MHENCR DIDO1 MRGBP CICP4 GID8 RTEL1 MIR647 UCKL1
GH20J063863 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 69.2 -237.8 -237831 3.6 MLX ZFP64 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF416 ZNF143 DNAJC5 ENSG00000268858 TPD52L2 DIDO1 GMEB2 PRPF6 CICP4 RTEL1 MIR647 ARFRP1
GH20J063657 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 50.7 -31.4 -31394 2.7 ZFP64 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC RTEL1 STMN3 RTEL1-TNFRSF6B DIDO1 MIR647 GMEB2 LINC00029 UCKL1 CICP4 LOC105372725
GH20J062935 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 41.4 +689.3 689288 4.7 MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 E2F8 ZNF143 SP3 DIDO1 GID8 LINC00029 GMEB2 LOC105372725 RPS21 ENSG00000226332 LINC01056 TAF4 SLC17A9
GH20J063519 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 32.5 +105.6 105585 4 HDGF PKNOX1 FOXA2 NEUROD1 SIN3A ZBTB7B YY1 POLR2B ZNF143 ZNF207 PPDPF GC20M063514 DIDO1 CICP4 GMEB2 PRPF6 RTEL1 MIR647 ARFRP1 UCKL1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GMEB2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GMEB2 gene promoter:
  • GR-alpha
  • GR
  • NF-kappaB1
  • Egr-2
  • Egr-4
  • Pax-2a
  • Pax-2
  • Arnt
  • Egr-3

Genomic Locations for GMEB2 Gene

Genomic Locations for GMEB2 Gene
chr20:63,587,602-63,627,041
(GRCh38/hg38)
Size:
39,440 bases
Orientation:
Minus strand
chr20:62,218,955-62,258,394
(GRCh37/hg19)
Size:
39,440 bases
Orientation:
Minus strand

Genomic View for GMEB2 Gene

Genes around GMEB2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GMEB2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GMEB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GMEB2 Gene

Proteins for GMEB2 Gene

  • Protein details for GMEB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UKD1-GMEB2_HUMAN
    Recommended name:
    Glucocorticoid modulatory element-binding protein 2
    Protein Accession:
    Q9UKD1
    Secondary Accessions:
    • E1P5J3
    • Q5TDS0
    • Q9H431
    • Q9H4X7
    • Q9H4X8
    • Q9UF78
    • Q9ULF1

    Protein attributes for GMEB2 Gene

    Size:
    530 amino acids
    Molecular mass:
    56421 Da
    Quaternary structure:
    • Homodimer, and heterodimer of GMEB1 and GMEB2. GMEB1 and GMEB2 form the parvovirus initiator complex (PIF). Interacts with the glucocorticoid receptor (NR3C1). May interact with CREB-binding protein (CBP).
    SequenceCaution:
    • Sequence=BAA86583.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for GMEB2 Gene

Post-translational modifications for GMEB2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GMEB2 Gene

No data available for DME Specific Peptides for GMEB2 Gene

Domains & Families for GMEB2 Gene

Gene Families for GMEB2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for GMEB2 Gene

Suggested Antigen Peptide Sequences for GMEB2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with GMEB2: view

No data available for UniProtKB/Swiss-Prot for GMEB2 Gene

Function for GMEB2 Gene

Molecular function for GMEB2 Gene

UniProtKB/Swiss-Prot Function:
Trans-acting factor that binds to glucocorticoid modulatory elements (GME) present in the TAT (tyrosine aminotransferase) promoter and increases sensitivity to low concentrations of glucocorticoids. Binds also to the transferrin receptor promoter. Essential auxiliary factor for the replication of parvoviruses.

Phenotypes From GWAS Catalog for GMEB2 Gene

Gene Ontology (GO) - Molecular Function for GMEB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IBA --
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS 19274049
GO:0003677 DNA binding IEA --
GO:0003713 transcription coactivator activity IEA --
GO:0005515 protein binding IPI 16713569
genes like me logo Genes that share ontologies with GMEB2: view
genes like me logo Genes that share phenotypes with GMEB2: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GMEB2 Gene

Localization for GMEB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GMEB2 Gene

Nucleus. Cytoplasm. Note=May be also cytoplasmic.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GMEB2 gene
Compartment Confidence
nucleus 5
cytosol 5

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for GMEB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 10523663
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with GMEB2: view

Pathways & Interactions for GMEB2 Gene

SuperPathways for GMEB2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for GMEB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IBA --
GO:0006366 transcription by RNA polymerase II TAS 10523663
GO:1903506 regulation of nucleic acid-templated transcription IEA --
genes like me logo Genes that share ontologies with GMEB2: view

No data available for Pathways by source and SIGNOR curated interactions for GMEB2 Gene

Drugs & Compounds for GMEB2 Gene

No Compound Related Data Available

Transcripts for GMEB2 Gene

mRNA/cDNA for GMEB2 Gene

Unigene Clusters for GMEB2 Gene

Glucocorticoid modulatory element binding protein 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GMEB2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b
SP1: - -
SP2: -
SP3: -

Relevant External Links for GMEB2 Gene

GeneLoc Exon Structure for
GMEB2
ECgene alternative splicing isoforms for
GMEB2

Expression for GMEB2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GMEB2 Gene

Protein differential expression in normal tissues from HIPED for GMEB2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (26.3), CD8 Tcells (11.2), Blymphocyte (8.8), and CD4 Tcells (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GMEB2 Gene



Protein tissue co-expression partners for GMEB2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GMEB2 Gene:

GMEB2

SOURCE GeneReport for Unigene cluster for GMEB2 Gene:

Hs.473286

mRNA Expression by UniProt/SwissProt for GMEB2 Gene:

Q9UKD1-GMEB2_HUMAN
Tissue specificity: Expressed in peripheral blood lymphocytes and fetal liver. Expressed preferentially in reproductive and/or developmentally important cells, such as testis, placenta, bone marrow and fetal tissues.

Evidence on tissue expression from TISSUES for GMEB2 Gene

  • Liver(4.1)
  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with GMEB2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for GMEB2 Gene

Orthologs for GMEB2 Gene

This gene was present in the common ancestor of animals.

Orthologs for GMEB2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GMEB2 34 33
  • 90.68 (n)
OneToOne
dog
(Canis familiaris)
Mammalia GMEB2 34 33
  • 88.18 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GMEB2 34
  • 87 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GMEB2 34 33
  • 86.92 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GMEB2 34
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gmeb2 33
  • 85 (n)
mouse
(Mus musculus)
Mammalia Gmeb2 16 34 33
  • 84.78 (n)
chicken
(Gallus gallus)
Aves GMEB2 34 33
  • 77.69 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GMEB2 34
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.19807 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.15678 33
zebrafish
(Danio rerio)
Actinopterygii si:ch73-302a13.2 33
  • 66.12 (n)
GMEB2 (2 of 2) 34
  • 58 (a)
OneToMany
GMEB2 (1 of 2) 34
  • 56 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea gmeb-1 34
  • 20 (a)
ManyToMany
gmeb-2 34
  • 17 (a)
ManyToMany
gmeb-3 34
  • 16 (a)
ManyToMany
spe-44 34
  • 14 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9551 34
  • 25 (a)
OneToMany
Species where no ortholog for GMEB2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GMEB2 Gene

ENSEMBL:
Gene Tree for GMEB2 (if available)
TreeFam:
Gene Tree for GMEB2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GMEB2: view image

Paralogs for GMEB2 Gene

Paralogs for GMEB2 Gene

(2) SIMAP similar genes for GMEB2 Gene using alignment to 3 proteins:

  • GMEB2_HUMAN
  • L8ECE2_HUMAN
  • Q5JTV1_HUMAN
genes like me logo Genes that share paralogs with GMEB2: view

Variants for GMEB2 Gene

Sequence variations from dbSNP and Humsavar for GMEB2 Gene

SNP ID Clin Chr 20 pos Variation AA Info Type
rs1000041142 -- 63,612,965(-) T/A genic_upstream_transcript_variant, intron_variant
rs1000060214 -- 63,623,892(-) A/C genic_upstream_transcript_variant, intron_variant
rs1000080615 -- 63,600,549(-) C/G intron_variant
rs1000099795 -- 63,617,707(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000136866 -- 63,600,858(-) G/A/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for GMEB2 Gene

Variant ID Type Subtype PubMed ID
dgv522n27 CNV loss 19166990
dgv7668n54 CNV loss 21841781
dgv7670n54 CNV gain 21841781
dgv7671n54 CNV loss 21841781
dgv7672n54 CNV gain+loss 21841781
dgv7673n54 CNV gain 21841781
dgv7674n54 CNV loss 21841781
dgv7675n54 CNV gain+loss 21841781
esv1026516 CNV deletion 17803354
esv1380934 CNV deletion 17803354
esv23497 CNV loss 19812545
esv2722947 CNV deletion 23290073
esv2722948 CNV deletion 23290073
esv2722949 CNV deletion 23290073
esv2758806 CNV gain+loss 17122850
esv3646320 CNV loss 21293372
nsv179147 CNV deletion 16902084
nsv428381 CNV gain+loss 18775914
nsv470563 CNV loss 18288195
nsv586571 CNV loss 21841781
nsv586582 CNV loss 21841781
nsv586591 CNV gain 21841781
nsv586602 CNV gain 21841781
nsv586604 CNV loss 21841781
nsv586605 CNV loss 21841781
nsv586610 CNV gain 21841781
nsv821165 CNV deletion 20802225
nsv834034 CNV loss 17160897
nsv9825 CNV gain 18304495
nsv9826 CNV gain+loss 18304495

Variation tolerance for GMEB2 Gene

Residual Variation Intolerance Score: 8.37% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.92; 19.06% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GMEB2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GMEB2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GMEB2 Gene

Disorders for GMEB2 Gene

Additional Disease Information for GMEB2

No disorders were found for GMEB2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GMEB2 Gene

Publications for GMEB2 Gene

  1. Two new members of the emerging KDWK family of combinatorial transcription modulators bind as a heterodimer to flexibly spaced PuCGPy half-sites. (PMID: 10523663) Christensen J … Tattersall P (Molecular and cellular biology 1999) 2 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. A consensus DNA recognition motif for two KDWK transcription factors identifies flexible-length, CpG-methylation sensitive cognate binding sites in the majority of human promoters. (PMID: 11743720) Burnett E … Tattersall P (Journal of molecular biology 2001) 2 3 58
  4. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P … Rogers J (Nature 2001) 3 4 58
  5. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10574462) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1999) 3 4 58

Products for GMEB2 Gene

Sources for GMEB2 Gene

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