This gene encodes a member of KDWK gene family which associates with GMEB2 protein. The GMEB1-GMEB2 complex is essential for parvovirus DNA replication. Studies in rat for a similar gene suggest that this gene's role is to modulate the transactivation of the glucocorticoid receptor when it is bound to glucocorticoid response elements. Three alternative spliced transcript varian... See more...

Aliases for GMEB1 Gene

Aliases for GMEB1 Gene

  • Glucocorticoid Modulatory Element Binding Protein 1 2 3 5
  • Glucocorticoid Modulatory Element-Binding Protein 1 3 4
  • Parvovirus Initiation Factor P96 3 4
  • DNA-Binding Protein P96PIF 3 4
  • PIF P96 3 4
  • P96PIF 2 3
  • PIF96 2 3
  • GMEB-1 4
  • GMEB1 5

External Ids for GMEB1 Gene

Previous GeneCards Identifiers for GMEB1 Gene

  • GC01P029001
  • GC01P028160
  • GC01P028500
  • GC01P028815
  • GC01P028867
  • GC01P027247

Summaries for GMEB1 Gene

Entrez Gene Summary for GMEB1 Gene

  • This gene encodes a member of KDWK gene family which associates with GMEB2 protein. The GMEB1-GMEB2 complex is essential for parvovirus DNA replication. Studies in rat for a similar gene suggest that this gene's role is to modulate the transactivation of the glucocorticoid receptor when it is bound to glucocorticoid response elements. Three alternative spliced transcript variants encoding different isoforms exist. [provided by RefSeq, Feb 2016]

GeneCards Summary for GMEB1 Gene

GMEB1 (Glucocorticoid Modulatory Element Binding Protein 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and transcription coactivator activity. An important paralog of this gene is GMEB2.

UniProtKB/Swiss-Prot Summary for GMEB1 Gene

  • Trans-acting factor that binds to glucocorticoid modulatory elements (GME) present in the TAT (tyrosine aminotransferase) promoter and increases sensitivity to low concentrations of glucocorticoids. Binds also to the transferrin receptor promoter. Essential auxiliary factor for the replication of parvoviruses.

Gene Wiki entry for GMEB1 Gene

Additional gene information for GMEB1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GMEB1 Gene

Genomics for GMEB1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for GMEB1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GMEB1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GMEB1

Top Transcription factor binding sites by QIAGEN in the GMEB1 gene promoter:
  • GR
  • GR-alpha
  • TBP

Genomic Locations for GMEB1 Gene

Genomic Locations for GMEB1 Gene
chr1:28,668,732-28,719,353
(GRCh38/hg38)
Size:
50,622 bases
Orientation:
Plus strand
chr1:28,995,240-29,045,865
(GRCh37/hg19)
Size:
50,626 bases
Orientation:
Plus strand

Genomic View for GMEB1 Gene

Genes around GMEB1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GMEB1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GMEB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GMEB1 Gene

Proteins for GMEB1 Gene

  • Protein details for GMEB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y692-GMEB1_HUMAN
    Recommended name:
    Glucocorticoid modulatory element-binding protein 1
    Protein Accession:
    Q9Y692
    Secondary Accessions:
    • B1AT48
    • Q9NWH1
    • Q9UKD0

    Protein attributes for GMEB1 Gene

    Size:
    573 amino acids
    Molecular mass:
    62591 Da
    Quaternary structure:
    • Homodimer, and heterodimer of GMEB1 and GMEB2. GMEB1 and GMEB2 form the parvovirus initiator complex (PIF). Interacts with the glucocorticoid receptor (NR3C1) and NCOA2/TIF2 (By similarity). May interact with HSP27 and CREB-binding protein (CBP).

    Three dimensional structures from OCA and Proteopedia for GMEB1 Gene

    Alternative splice isoforms for GMEB1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GMEB1 Gene

Post-translational modifications for GMEB1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for GMEB1 Gene

Domains & Families for GMEB1 Gene

Gene Families for GMEB1 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for GMEB1 Gene

InterPro:
Blocks:
  • SAND domain
  • SAND-like
ProtoNet:

Suggested Antigen Peptide Sequences for GMEB1 Gene

GenScript: Design optimal peptide antigens:
  • cDNA, FLJ96492, Homo sapiens glucocorticoid modulatory element binding protein 1(GMEB1), transcript variant 2, mRNA (B1AT47_HUMAN)
  • Parvovirus initiation factor p96 (GMEB1_HUMAN)
genes like me logo Genes that share domains with GMEB1: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for GMEB1 Gene

Function for GMEB1 Gene

Molecular function for GMEB1 Gene

UniProtKB/Swiss-Prot Function:
Trans-acting factor that binds to glucocorticoid modulatory elements (GME) present in the TAT (tyrosine aminotransferase) promoter and increases sensitivity to low concentrations of glucocorticoids. Binds also to the transferrin receptor promoter. Essential auxiliary factor for the replication of parvoviruses.

Phenotypes From GWAS Catalog for GMEB1 Gene

Gene Ontology (GO) - Molecular Function for GMEB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA,IBA 21873635
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISM 19274049
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific IEA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity IEA --
genes like me logo Genes that share ontologies with GMEB1: view
genes like me logo Genes that share phenotypes with GMEB1: view

Animal Model Products

CRISPR Products

miRNA for GMEB1 Gene

miRTarBase miRNAs that target GMEB1

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GMEB1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GMEB1 Gene

Localization for GMEB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GMEB1 Gene

Nucleus. Cytoplasm. Note=May be also cytoplasmic.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GMEB1 gene
Compartment Confidence
nucleus 5
plasma membrane 1
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for GMEB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin ISA --
GO:0005634 nucleus TAS,IBA 21873635
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with GMEB1: view

Pathways & Interactions for GMEB1 Gene

PathCards logo

SuperPathways for GMEB1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for GMEB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006357 regulation of transcription by RNA polymerase II IBA 21873635
GO:0045944 positive regulation of transcription by RNA polymerase II IEA --
GO:1903508 positive regulation of nucleic acid-templated transcription IEA --
genes like me logo Genes that share ontologies with GMEB1: view

No data available for Pathways by source and SIGNOR curated interactions for GMEB1 Gene

Drugs & Compounds for GMEB1 Gene

No Compound Related Data Available

Transcripts for GMEB1 Gene

mRNA/cDNA for GMEB1 Gene

3 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GMEB1

Alternative Splicing Database (ASD) splice patterns (SP) for GMEB1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
SP1: -
SP2: -
SP3:

Relevant External Links for GMEB1 Gene

GeneLoc Exon Structure for
GMEB1

Expression for GMEB1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GMEB1 Gene

Protein differential expression in normal tissues from HIPED for GMEB1 Gene

This gene is overexpressed in Pancreas (23.0), Peripheral blood mononuclear cells (10.1), NK cells (7.6), CD8 Tcells (7.2), and Monocytes (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GMEB1 Gene



Protein tissue co-expression partners for GMEB1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GMEB1

SOURCE GeneReport for Unigene cluster for GMEB1 Gene:

Hs.632373

Evidence on tissue expression from TISSUES for GMEB1 Gene

  • Heart(4.3)
  • Muscle(2)
genes like me logo Genes that share expression patterns with GMEB1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GMEB1 Gene

Orthologs for GMEB1 Gene

This gene was present in the common ancestor of animals.

Orthologs for GMEB1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia GMEB1 30 31
  • 99.83 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia GMEB1 30 31
  • 95.15 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia GMEB1 30 31
  • 95.09 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 93 (a)
OneToMany
-- 31
  • 75 (a)
OneToMany
Mouse
(Mus musculus)
Mammalia Gmeb1 30 17 31
  • 89.38 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Gmeb1 30
  • 88.79 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia GMEB1 31
  • 79 (a)
OneToOne
Chicken
(Gallus gallus)
Aves GMEB1 30 31
  • 80.15 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia GMEB1 31
  • 84 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia gmeb1 30
  • 66.33 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.23484 30
Zebrafish
(Danio rerio)
Actinopterygii gmeb1 30 31
  • 60.44 (n)
OneToOne
Worm
(Caenorhabditis elegans)
Secernentea gmeb-1 31
  • 23 (a)
ManyToMany
gmeb-3 31
  • 19 (a)
ManyToMany
gmeb-2 31
  • 16 (a)
ManyToMany
spe-44 31
  • 16 (a)
ManyToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.9551 31
  • 24 (a)
OneToMany
Species where no ortholog for GMEB1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for GMEB1 Gene

ENSEMBL:
Gene Tree for GMEB1 (if available)
TreeFam:
Gene Tree for GMEB1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GMEB1: view image

Paralogs for GMEB1 Gene

Paralogs for GMEB1 Gene

(1) SIMAP similar genes for GMEB1 Gene using alignment to 3 proteins:

  • GMEB1_HUMAN
  • B1AT46_HUMAN
  • B1AT47_HUMAN
genes like me logo Genes that share paralogs with GMEB1: view

Variants for GMEB1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GMEB1 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs11557120 - p.Val14Ala

Additional dbSNP identifiers (rs#s) for GMEB1 Gene

Structural Variations from Database of Genomic Variants (DGV) for GMEB1 Gene

Variant ID Type Subtype PubMed ID
esv27154 CNV loss 19812545
nsv1113096 CNV deletion 24896259
nsv545920 CNV loss 21841781

Variation tolerance for GMEB1 Gene

Residual Variation Intolerance Score: 12.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.93; 19.26% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GMEB1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GMEB1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GMEB1 Gene

Disorders for GMEB1 Gene

No disorders were found for GMEB1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GMEB1 Gene

Publications for GMEB1 Gene

  1. Cloning and characterization of hGMEB1, a novel glucocorticoid modulatory element binding protein. (PMID: 10386584) Thériault JR … Landry J (FEBS letters 1999) 2 3 4 23
  2. Crystal structure and nuclear magnetic resonance analyses of the SAND domain from glucocorticoid modulatory element binding protein-1 reveals deoxyribonucleic acid and zinc binding regions. (PMID: 12702733) Surdo PL … Scheffzek K (Molecular endocrinology (Baltimore, Md.) 2003) 3 4 23
  3. Properties of the glucocorticoid modulatory element binding proteins GMEB-1 and -2: potential new modifiers of glucocorticoid receptor transactivation and members of the family of KDWK proteins. (PMID: 10894151) Kaul S … Simons SS (Molecular endocrinology (Baltimore, Md.) 2000) 3 4 23
  4. Two new members of the emerging KDWK family of combinatorial transcription modulators bind as a heterodimer to flexibly spaced PuCGPy half-sites. (PMID: 10523663) Christensen J … Tattersall P (Molecular and cellular biology 1999) 2 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4

Products for GMEB1 Gene

Sources for GMEB1 Gene