Aliases for GMDS Gene
External Ids for GMDS Gene
Previous GeneCards Identifiers for GMDS Gene
GDP-mannose 4,6-dehydratase (GMD; EC 22.214.171.124) catalyzes the conversion of GDP-mannose to GDP-4-keto-6-deoxymannose, the first step in the synthesis of GDP-fucose from GDP-mannose, using NADP+ as a cofactor. The second and third steps of the pathway are catalyzed by a single enzyme, GDP-keto-6-deoxymannose 3,5-epimerase, 4-reductase, designated FX in humans (MIM 137020).[supplied by OMIM, Aug 2009]
GeneCards Summary for GMDS Gene
GMDS (GDP-Mannose 4,6-Dehydratase) is a Protein Coding gene. Diseases associated with GMDS include Anterior Segment Dysgenesis 3 and Axenfeld-Rieger Syndrome. Among its related pathways are Metabolism of proteins and Transport to the Golgi and subsequent modification. Gene Ontology (GO) annotations related to this gene include coenzyme binding and NADP+ binding. An important paralog of this gene is GFUS.
UniProtKB/Swiss-Prot Summary for GMDS Gene
Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose.