Aliases for GMCL1 Gene
External Ids for GMCL1 Gene
Previous GeneCards Identifiers for GMCL1 Gene
This gene encodes a nuclear envelope protein that appears to be involved in spermatogenesis, either directly or by influencing genes that play a more direct role in the process. This multi-exon locus is the homolog of the mouse and drosophila germ cell-less gene but the human genome also contains a single-exon locus on chromosome 5 that contains an open reading frame capable of encoding a highly-related protein. [provided by RefSeq, Jul 2008]
GeneCards Summary for GMCL1 Gene
GMCL1 (Germ Cell-Less 1, Spermatogenesis Associated) is a Protein Coding gene. Diseases associated with GMCL1 include Lipodystrophy, Congenital Generalized, Type 4 and Aggressive Systemic Mastocytosis. An important paralog of this gene is GMCL2.
UniProtKB/Swiss-Prot Summary for GMCL1 Gene
Possible function in spermatogenesis. Enhances the degradation of MDM2 and increases the amount of p53 probably by modulating the nucleocytoplasmic transport (By similarity).