Aliases for GLYR1 Gene
External Ids for GLYR1 Gene
Previous GeneCards Identifiers for GLYR1 Gene
GeneCards Summary for GLYR1 Gene
GLYR1 (Glyoxylate Reductase 1 Homolog) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include methylated histone binding and phosphogluconate dehydrogenase (decarboxylating) activity. An important paralog of this gene is HIBADH.
UniProtKB/Swiss-Prot for GLYR1 Gene
Putative oxidoreductase that is recruited on chromatin and promotes KDM1B demethylase activity (PubMed:23260659). Recognizes and binds trimethylated 'Lys-36' of histone H3 (H3K36me3) (PubMed:20850016). Regulates p38 MAP kinase activity by mediating stress activation of p38alpha/MAPK14 and specifically regulating MAPK14 signaling (PubMed:16352664). Indirectly promotes phosphorylation of MAPK14 and activation of ATF2 (PubMed:16352664). The phosphorylation of MAPK14 requires upstream activity of MAP2K4 and MAP2K6 (PubMed:16352664).