Aliases for GLYATL3 Gene

Aliases for GLYATL3 Gene

  • Glycine-N-Acyltransferase Like 3 2 3 5
  • Acyl-CoA:Glycine-N-Acyltransferase-Like Protein 3 3 4
  • Glycine N-Acyltransferase-Like Protein 3 3 4
  • C6orf140 3 4
  • Chromosome 6 Open Reading Frame 140 2
  • Glycine-N-Acyltransferase-Like 3 2
  • EC 2.3.1.13 4
  • BA28H17.2 3

External Ids for GLYATL3 Gene

Previous HGNC Symbols for GLYATL3 Gene

  • C6orf140

Previous GeneCards Identifiers for GLYATL3 Gene

  • GC06U901652
  • GC06P049468
  • GC06P049197

Summaries for GLYATL3 Gene

GeneCards Summary for GLYATL3 Gene

GLYATL3 (Glycine-N-Acyltransferase Like 3) is a Protein Coding gene. Among its related pathways are Metabolism and Cytochrome P450 - arranged by substrate type. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring acyl groups other than amino-acyl groups and glycine N-acyltransferase activity. An important paralog of this gene is GLYAT.

UniProtKB/Swiss-Prot Summary for GLYATL3 Gene

  • Catalyzes the conjugation of long-chain fatty acyl-CoA thioester and glycine to produce long-chain N-(fatty acyl)glycine, an intermediate in the primary fatty acid amide biosynthetic pathway.

Additional gene information for GLYATL3 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GLYATL3 Gene

Genomics for GLYATL3 Gene

GeneHancer (GH) Regulatory Elements for GLYATL3 Gene

Promoters and enhancers for GLYATL3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J049523 Enhancer 0.9 ENCODE 11.9 +23.7 23716 1.3 EP300 FOXK2 POLR2G NCOR1 KDM6A TCF7 FOXA1 CUX1 ZBTB25 TGIF2 MMUT GLYATL3 ENSG00000235122 ENSG00000226707 CENPQ RF00017-5591 C6orf141
GH06J049532 Enhancer 0.8 ENCODE 12 +32.3 32340 0.2 ZNF217 CTCF ZNF639 TRIM28 REST RFX1 RAD21 TRIM22 TEAD1 SMC3 GLYATL3 C6orf141 RF00017-5591
GH06J049908 Enhancer 0.7 Ensembl ENCODE 10.6 +412.2 412192 7 EP300 USF1 ZNF316 GATA3 CTCF PBX2 SIN3A SMARCA4 MAFK TCF7L2 GLYATL3 DEFB112 CENPQ MMUT lnc-C6orf141-5 lnc-DEFB133-1
GH06J049526 Enhancer 0.6 Ensembl 11.9 +27.4 27378 1 FOXA2 JUND ZFP91 RAD21 RXRA MAX CEBPB HNF4A YY1 ZNF652 GLYATL3 CENPQ ENSG00000235122 ENSG00000226707 RF00017-5591 C6orf141
GH06J049528 Enhancer 0.5 Ensembl dbSUPER 11.9 +28.6 28578 0.2 FOSL1 ATF3 GLYATL3 ENSG00000235122 ENSG00000226707 CENPQ RF00017-5591 C6orf141
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GLYATL3 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GLYATL3

Genomic Locations for GLYATL3 Gene

Genomic Locations for GLYATL3 Gene
chr6:49,499,923-49,528,078
(GRCh38/hg38)
Size:
28,156 bases
Orientation:
Plus strand
chr6:49,467,671-49,495,777
(GRCh37/hg19)
Size:
28,107 bases
Orientation:
Plus strand

Genomic View for GLYATL3 Gene

Genes around GLYATL3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GLYATL3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GLYATL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GLYATL3 Gene

Proteins for GLYATL3 Gene

  • Protein details for GLYATL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5SZD4-GLYL3_HUMAN
    Recommended name:
    Glycine N-acyltransferase-like protein 3
    Protein Accession:
    Q5SZD4

    Protein attributes for GLYATL3 Gene

    Size:
    288 amino acids
    Molecular mass:
    32704 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GLYATL3 Gene

Post-translational modifications for GLYATL3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GLYATL3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GLYATL3 Gene

Domains & Families for GLYATL3 Gene

Gene Families for GLYATL3 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for GLYATL3 Gene

GenScript: Design optimal peptide antigens:
  • Glycine N-acyltransferase-like protein 3 (GLYL3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q5SZD4

UniProtKB/Swiss-Prot:

GLYL3_HUMAN :
  • Belongs to the glycine N-acyltransferase family.
Family:
  • Belongs to the glycine N-acyltransferase family.
genes like me logo Genes that share domains with GLYATL3: view

Function for GLYATL3 Gene

Molecular function for GLYATL3 Gene

UniProtKB/Swiss-Prot Function:
Catalyzes the conjugation of long-chain fatty acyl-CoA thioester and glycine to produce long-chain N-(fatty acyl)glycine, an intermediate in the primary fatty acid amide biosynthetic pathway.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=an acyl-CoA + glycine = an N-acylglycine + CoA + H(+); Xref=Rhea:RHEA:19869, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57305, ChEBI:CHEBI:57670, ChEBI:CHEBI:58342; EC=2.3.1.13; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(9Z)-octadecenoyl-CoA + glycine = CoA + H(+) + N-(9Z-octadecenoyl)glycine; Xref=Rhea:RHEA:51272, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57305, ChEBI:CHEBI:57387, ChEBI:CHEBI:133992; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=glycine + hexadecanoyl-CoA = CoA + H(+) + N-hexadecanoylglycine; Xref=Rhea:RHEA:58536, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57305, ChEBI:CHEBI:57379, ChEBI:CHEBI:142655; Evidence=. ;.

Enzyme Numbers (IUBMB) for GLYATL3 Gene

Phenotypes From GWAS Catalog for GLYATL3 Gene

Gene Ontology (GO) - Molecular Function for GLYATL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016740 transferase activity IEA --
GO:0016746 transferase activity, transferring acyl groups IEA --
GO:0047961 glycine N-acyltransferase activity ISS,IEA --
genes like me logo Genes that share ontologies with GLYATL3: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GLYATL3 Gene

Localization for GLYATL3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GLYATL3 gene
Compartment Confidence
mitochondrion 3
nucleus 1
cytosol 1
peroxisome 0

Gene Ontology (GO) - Cellular Components for GLYATL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with GLYATL3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for GLYATL3 Gene

Pathways & Interactions for GLYATL3 Gene

genes like me logo Genes that share pathways with GLYATL3: view

UniProtKB/Swiss-Prot Q5SZD4-GLYL3_HUMAN

  • Pathway: Lipid metabolism.

Interacting Proteins for GLYATL3 Gene

Selected Interacting proteins: Q5SZD4-GLYL3_HUMAN for GLYATL3 Gene via IID

Symbol External ID(s) Details
PPP4C
;

Gene Ontology (GO) - Biological Process for GLYATL3 Gene

None

No data available for SIGNOR curated interactions for GLYATL3 Gene

Drugs & Compounds for GLYATL3 Gene

(4) Drugs for GLYATL3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Aminohippuric acid Approved, Investigational Pharma 0
3-Hydroxyhippuric acid Experimental Pharma 0
Glycochenodeoxycholic Acid Experimental Pharma 0
Glycocholic acid Experimental, Investigational Pharma 1

(32) Additional Compounds for GLYATL3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
2-Furoylglycine
  • N-(2-Furoyl)glycine
  • Furfuroylglycine
  • Furoylglycine
  • N-(2-Furanylcarbonyl)glycine
  • N-(Carboxymethyl)-2-furancarboxamide
5657-19-2
2-Methylbutyrylglycine
  • alpha-Methylbutyrylglycine
  • a-Methylbutyrylglycine
  • α-methylbutyrylglycine
  • (2-Methyl-butyrylamino)-acetate
  • (2-Methyl-butyrylamino)-acetic acid
52320-67-9
3a,7b,12a-Trihydroxyoxocholanyl-Glycine
  • 3alpha,7beta,12alpha-Trihydroxyoxocholanyl-glycine
  • Glycocholic acid
  • N-Cholylglycine
68753-51-5
3-Methylcrotonylglycine
  • beta-Methylcrotonylglycine
  • b-Methylcrotonylglycine
  • β-methylcrotonylglycine
  • 3-Methylcrotonyl glycine
  • 3-Methylcrotonyl-glycine
33008-07-0
3-Phenylpropionylglycine
20989-69-9
genes like me logo Genes that share compounds with GLYATL3: view

Transcripts for GLYATL3 Gene

mRNA/cDNA for GLYATL3 Gene

1 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GLYATL3 Gene

No ASD Table

Relevant External Links for GLYATL3 Gene

GeneLoc Exon Structure for
GLYATL3

Expression for GLYATL3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GLYATL3 Gene

Protein differential expression in normal tissues from HIPED for GLYATL3 Gene

This gene is overexpressed in Uterus (47.8), Liver (11.7), and Rectum (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GLYATL3 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GLYATL3

SOURCE GeneReport for Unigene cluster for GLYATL3 Gene:

Hs.585172
genes like me logo Genes that share expression patterns with GLYATL3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for GLYATL3 Gene

Orthologs for GLYATL3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GLYATL3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GLYATL3 31 30
  • 99.07 (n)
OneToOne
dog
(Canis familiaris)
Mammalia GLYATL3 31 30
  • 89.08 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Glyatl3 17 31 30
  • 85.76 (n)
rat
(Rattus norvegicus)
Mammalia Glyatl3 30
  • 85.25 (n)
cow
(Bos Taurus)
Mammalia GLYATL3 31 30
  • 84.03 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GLYATL3 31
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-7407-1 31
  • 65 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 31
  • 44 (a)
OneToMany
-- 31
  • 38 (a)
OneToMany
-- 31
  • 37 (a)
OneToMany
-- 31
  • 36 (a)
OneToMany
-- 31
  • 36 (a)
OneToMany
-- 31
  • 36 (a)
OneToMany
-- 31
  • 35 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii si:dkey-76k16.5 31
  • 30 (a)
ManyToMany
Species where no ortholog for GLYATL3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GLYATL3 Gene

ENSEMBL:
Gene Tree for GLYATL3 (if available)
TreeFam:
Gene Tree for GLYATL3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GLYATL3: view image

Paralogs for GLYATL3 Gene

Paralogs for GLYATL3 Gene

(4) SIMAP similar genes for GLYATL3 Gene using alignment to 2 proteins:

  • GLYL3_HUMAN
  • F5GXQ5_HUMAN
genes like me logo Genes that share paralogs with GLYATL3: view

Variants for GLYATL3 Gene

Additional dbSNP identifiers (rs#s) for GLYATL3 Gene

Structural Variations from Database of Genomic Variants (DGV) for GLYATL3 Gene

Variant ID Type Subtype PubMed ID
dgv5960n100 CNV gain 25217958
nsv1019611 CNV gain 25217958

Variation tolerance for GLYATL3 Gene

Gene Damage Index Score: 20.87; 99.18% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GLYATL3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GLYATL3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GLYATL3 Gene

Disorders for GLYATL3 Gene

Additional Disease Information for GLYATL3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for GLYATL3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GLYATL3 Gene

Publications for GLYATL3 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41 54
  2. Voxelwise genome-wide association study (vGWAS). (PMID: 20171287) Stein JL … Alzheimer's Disease Neuroimaging Initiative (NeuroImage 2010) 3 41 54
  3. Identification of glycine N-acyltransferase-like 2 (GLYATL2) as a transferase that produces N-acyl glycines in humans. (PMID: 20305126) Waluk DP … Hunt MC (FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010) 2 3 54
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  5. An integrated workflow for charting the human interaction proteome: insights into the PP2A system. (PMID: 19156129) Glatter T … Gstaiger M (Molecular systems biology 2009) 3 54

Products for GLYATL3 Gene

Sources for GLYATL3 Gene