Aliases for GLYATL3 Gene

Aliases for GLYATL3 Gene

  • Glycine-N-Acyltransferase Like 3 2 3 5
  • Acyl-CoA:Glycine-N-Acyltransferase-Like Protein 3 3 4
  • Glycine N-Acyltransferase-Like Protein 3 3 4
  • BA28H17.2 2 3
  • C6orf140 3 4
  • Chromosome 6 Open Reading Frame 140 2
  • Glycine-N-Acyltransferase-Like 3 2
  • EC 4
  • GLYATL3 5

External Ids for GLYATL3 Gene

Previous HGNC Symbols for GLYATL3 Gene

  • C6orf140

Previous GeneCards Identifiers for GLYATL3 Gene

  • GC06U901652
  • GC06P049468
  • GC06P049197

Summaries for GLYATL3 Gene

GeneCards Summary for GLYATL3 Gene

GLYATL3 (Glycine-N-Acyltransferase Like 3) is a Protein Coding gene. Among its related pathways are Conjugation of carboxylic acids and Cytochrome P450 - arranged by substrate type. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring acyl groups other than amino-acyl groups and glycine N-acyltransferase activity. An important paralog of this gene is GLYATL2.

UniProtKB/Swiss-Prot Summary for GLYATL3 Gene

  • Catalyzes the conjugation of long-chain fatty acyl-CoA thioester and glycine to produce long-chain N-(fatty acyl)glycine, an intermediate in the primary fatty acid amide biosynthetic pathway.

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GLYATL3 Gene

Genomics for GLYATL3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for GLYATL3 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J049499 Enhancer 0.2 Ensembl 250.7 -0.6 -622 0.2 GLYATL3 MMUT RF00994-901 CENPQ
GH06J049523 Enhancer 0.9 ENCODE 11.9 +23.7 23716 1.3 ZMYM3 KLF9 CEBPA ATF3 CHD4 YY1 MXD4 FOXA1 ZFP64 HOMEZ MMUT GLYATL3 ENSG00000235122 ENSG00000226707 CENPQ RF00017-5096 C6orf141
GH06J049532 Enhancer 0.8 ENCODE 12 +32.3 32340 0.2 ZNF654 ZNF592 CEBPA NFIC CEBPB REST TRIM22 ZNF639 CTCF ZNF217 GLYATL3 C6orf141 RF00017-5096
GH06J049526 Enhancer 0.6 Ensembl 11.9 +27.3 27278 1.2 CEBPA YY1 FOXA2 RXRA ZFP91 JUND HNF4A RAD21 ZNF652 MAX GLYATL3 CENPQ ENSG00000235122 ENSG00000226707 RF00017-5096 C6orf141
GH06J049529 Enhancer 0.6 Ensembl dbSUPER 11.9 +28.8 28778 0.2 JUND ATF3 FOS GLYATL3 ENSG00000235122 ENSG00000226707 RF00017-5096 C6orf141
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GLYATL3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GLYATL3

Genomic Locations for GLYATL3 Gene

Latest Assembly
28,156 bases
Plus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
28,156 bases
Plus strand

(GRCh37/hg19 by Ensembl)
27,090 bases
Plus strand

Genomic View for GLYATL3 Gene

Genes around GLYATL3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GLYATL3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GLYATL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GLYATL3 Gene

Proteins for GLYATL3 Gene

  • Protein details for GLYATL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Glycine N-acyltransferase-like protein 3
    Protein Accession:

    Protein attributes for GLYATL3 Gene

    288 amino acids
    Molecular mass:
    32704 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GLYATL3 Gene

Post-translational modifications for GLYATL3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GLYATL3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GLYATL3 Gene

Domains & Families for GLYATL3 Gene

Gene Families for GLYATL3 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for GLYATL3 Gene

GenScript: Design optimal peptide antigens:
  • Glycine N-acyltransferase-like protein 3 (GLYL3_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the glycine N-acyltransferase family.
  • Belongs to the glycine N-acyltransferase family.
genes like me logo Genes that share domains with GLYATL3: view

Function for GLYATL3 Gene

Molecular function for GLYATL3 Gene

UniProtKB/Swiss-Prot Function:
Catalyzes the conjugation of long-chain fatty acyl-CoA thioester and glycine to produce long-chain N-(fatty acyl)glycine, an intermediate in the primary fatty acid amide biosynthetic pathway.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=an acyl-CoA + glycine = an N-acylglycine + CoA + H(+); Xref=Rhea:RHEA:19869, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57305, ChEBI:CHEBI:57670, ChEBI:CHEBI:58342; EC=; Evidence={ECO:0000250|UniProtKB:E9Q5L8};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(9Z)-octadecenoyl-CoA + glycine = CoA + H(+) + N-(9Z-octadecenoyl)glycine; Xref=Rhea:RHEA:51272, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57305, ChEBI:CHEBI:57387, ChEBI:CHEBI:133992; Evidence={ECO:0000250|UniProtKB:E9Q5L8};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=glycine + hexadecanoyl-CoA = CoA + H(+) + N-hexadecanoylglycine; Xref=Rhea:RHEA:58536, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57305, ChEBI:CHEBI:57379, ChEBI:CHEBI:142655; Evidence={ECO:0000250|UniProtKB:E9Q5L8};.

Enzyme Numbers (IUBMB) for GLYATL3 Gene

Phenotypes From GWAS Catalog for GLYATL3 Gene

Gene Ontology (GO) - Molecular Function for GLYATL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016410 N-acyltransferase activity IBA 21873635
GO:0016740 transferase activity IEA --
GO:0016746 transferase activity, transferring acyl groups IEA --
GO:0047961 glycine N-acyltransferase activity IEA,ISS --
genes like me logo Genes that share ontologies with GLYATL3: view

Phenotypes for GLYATL3 Gene

MGI mutant phenotypes for GLYATL3:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with GLYATL3: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GLYATL3

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GLYATL3 Gene

Localization for GLYATL3 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GLYATL3 gene
Compartment Confidence
mitochondrion 3
cytoskeleton 1
nucleus 1
cytosol 1
peroxisome 0

Gene Ontology (GO) - Cellular Components for GLYATL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with GLYATL3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for GLYATL3 Gene

Pathways & Interactions for GLYATL3 Gene

genes like me logo Genes that share pathways with GLYATL3: view

UniProtKB/Swiss-Prot Q5SZD4-GLYL3_HUMAN

  • Pathway: Lipid metabolism.

Interacting Proteins for GLYATL3 Gene

Selected Interacting proteins: Q5SZD4-GLYL3_HUMAN for GLYATL3 Gene via IID

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for GLYATL3 Gene


No data available for SIGNOR curated interactions for GLYATL3 Gene

Drugs & Compounds for GLYATL3 Gene

(3) Drugs for GLYATL3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Aminohippuric acid Approved, Investigational Pharma 0
3-Hydroxyhippuric acid Experimental Pharma 0
Glycocholic acid Experimental, Investigational Pharma 1

(33) Additional Compounds for GLYATL3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • N-(2-Furoyl)glycine
  • Furfuroylglycine
  • Furoylglycine
  • N-(2-Furanylcarbonyl)glycine
  • N-(Carboxymethyl)-2-furancarboxamide
  • alpha-Methylbutyrylglycine
  • a-Methylbutyrylglycine
  • Α-methylbutyrylglycine
  • (2-Methyl-butyrylamino)-acetate
  • (2-Methyl-butyrylamino)-acetic acid
  • 3alpha,7beta,12alpha-Trihydroxyoxocholanyl-glycine
  • Glycocholic acid
  • N-Cholylglycine
  • beta-Methylcrotonylglycine
  • b-Methylcrotonylglycine
  • Β-methylcrotonylglycine
  • 3-Methylcrotonyl glycine
  • 3-Methylcrotonyl-glycine
  • 2-[(3-oxo-3-Phenylpropyl)amino]acetate
genes like me logo Genes that share compounds with GLYATL3: view

Transcripts for GLYATL3 Gene

mRNA/cDNA for GLYATL3 Gene

2 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GLYATL3

Alternative Splicing Database (ASD) splice patterns (SP) for GLYATL3 Gene

No ASD Table

Relevant External Links for GLYATL3 Gene

GeneLoc Exon Structure for

Expression for GLYATL3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GLYATL3 Gene

Protein differential expression in normal tissues from HIPED for GLYATL3 Gene

This gene is overexpressed in Uterus (47.8), Liver (11.7), and Rectum (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GLYATL3 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GLYATL3

SOURCE GeneReport for Unigene cluster for GLYATL3 Gene:

genes like me logo Genes that share expression patterns with GLYATL3: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for GLYATL3 Gene

Orthologs for GLYATL3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GLYATL3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GLYATL3 29 30
  • 99.07 (n)
(Canis familiaris)
Mammalia GLYATL3 29 30
  • 89.08 (n)
(Mus musculus)
Mammalia Glyatl3 29 16 30
  • 85.76 (n)
(Rattus norvegicus)
Mammalia Glyatl3 29
  • 85.25 (n)
(Bos Taurus)
Mammalia GLYATL3 29 30
  • 84.03 (n)
(Monodelphis domestica)
Mammalia GLYATL3 30
  • 77 (a)
(Ornithorhynchus anatinus)
Mammalia oan-mir-7407-1 30
  • 65 (a)
(Anolis carolinensis)
Reptilia -- 30
  • 44 (a)
-- 30
  • 38 (a)
-- 30
  • 37 (a)
-- 30
  • 36 (a)
-- 30
  • 36 (a)
-- 30
  • 36 (a)
-- 30
  • 35 (a)
(Danio rerio)
Actinopterygii si:dkey-76k16.5 30
  • 30 (a)
Species where no ortholog for GLYATL3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for GLYATL3 Gene

Gene Tree for GLYATL3 (if available)
Gene Tree for GLYATL3 (if available)
Evolutionary constrained regions (ECRs) for GLYATL3: view image
Alliance of Genome Resources:
Additional Orthologs for GLYATL3

Paralogs for GLYATL3 Gene

Paralogs for GLYATL3 Gene

(4) SIMAP similar genes for GLYATL3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with GLYATL3: view

Variants for GLYATL3 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for GLYATL3 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for GLYATL3 Gene

Variant ID Type Subtype PubMed ID
dgv5960n100 CNV gain 25217958
nsv1019611 CNV gain 25217958

Variation tolerance for GLYATL3 Gene

Gene Damage Index Score: 20.87; 99.18% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GLYATL3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
Leiden Open Variation Database (LOVD)

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GLYATL3 Gene

Disorders for GLYATL3 Gene

Additional Disease Information for GLYATL3

Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform

No disorders were found for GLYATL3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GLYATL3 Gene

Publications for GLYATL3 Gene

  1. Identification of glycine N-acyltransferase-like 2 (GLYATL2) as a transferase that produces N-acyl glycines in humans. (PMID: 20305126) Waluk DP … Hunt MC (FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010) 2 3
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 40
  3. Voxelwise genome-wide association study (vGWAS). (PMID: 20171287) Stein JL … Alzheimer's Disease Neuroimaging Initiative (NeuroImage 2010) 3 40
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for GLYATL3 Gene

Sources for GLYATL3 Gene