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Aliases for GLYATL2 Gene

Aliases for GLYATL2 Gene

  • Glycine-N-Acyltransferase Like 2 2 3 5
  • Acyl-CoA:Glycine N-Acyltransferase-Like Protein 2 3 4
  • Glycine N-Acyltransferase-Like Protein 2 3
  • Glycine-N-Acyltransferase-Like 2 2
  • Glycine Acyltransferase Family-B 3
  • EC 2.3.1.13 4
  • BXMAS2-10 3
  • GATF-B 3

External Ids for GLYATL2 Gene

Previous GeneCards Identifiers for GLYATL2 Gene

  • GC11M058359
  • GC11M058601
  • GC11M054947

Summaries for GLYATL2 Gene

GeneCards Summary for GLYATL2 Gene

GLYATL2 (Glycine-N-Acyltransferase Like 2) is a Protein Coding gene. Among its related pathways are Metabolism and Cytochrome P450 - arranged by substrate type. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring acyl groups other than amino-acyl groups and glycine N-acyltransferase activity. An important paralog of this gene is GLYATL1B.

UniProtKB/Swiss-Prot for GLYATL2 Gene

  • Mitochondrial acyltransferase which transfers the acyl group to the N-terminus of glycine. Conjugates numerous substrates, such as arachidonoyl-CoA and saturated medium and long-chain acyl-CoAs ranging from chain-length C8:0-CoA to C18:0-CoA, to form a variety of N-acylglycines. Shows a preference for monounsaturated fatty acid oleoyl-CoA (C18:1-CoA) as an acyl donor. Does not exhibit any activity toward C22:6-CoA and chenodeoxycholoyl-CoA, nor toward serine or alanine.

Additional gene information for GLYATL2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GLYATL2 Gene

Genomics for GLYATL2 Gene

GeneHancer (GH) Regulatory Elements for GLYATL2 Gene

Promoters and enhancers for GLYATL2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I058904 Promoter/Enhancer 1.3 Ensembl ENCODE 556.4 -1.4 -1400 1.6 PKNOX1 ZNF76 SIN3A ZNF2 ZEB1 ZNF335 ZNF121 ZNF366 ZNF350 KLF7 GLYATL1 GLYATL2 GC11P058904 ENSG00000255523
GH11I058844 Promoter/Enhancer 0.7 EPDnew dbSUPER 550.2 +59.5 59494 0.1 GLYATL2 GC11P058813 GLYATL1P2
GH11I058770 Enhancer 1.4 Ensembl ENCODE dbSUPER 5.6 +131.7 131700 4.8 HDGF PKNOX1 SMAD1 ATF1 ARNT TCF12 POLR2B ZNF766 E2F8 ATF7 STX3 GLYATL2 LOC100420019 GC11M058796
GH11I058726 Enhancer 1.1 Ensembl ENCODE 6.3 +177.1 177125 1.5 HDAC1 PKNOX1 ATF1 TCF12 ZNF766 ZBTB11 CEBPB NCOA1 ZEB2 ELF1 GLYATL2 GLYAT GC11P058692
GH11I058788 Enhancer 0.9 Ensembl ENCODE 5.8 +115.6 115590 1 CTCF IRF2 RB1 RAD21 YY1 CHAMP1 FOSL1 CC2D1A ARID2 SMC3 GLYAT GLYATL2 GC11M058796 LOC100420019
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around GLYATL2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GLYATL2 gene promoter:

Genomic Locations for GLYATL2 Gene

Genomic Locations for GLYATL2 Gene
chr11:58,834,065-58,904,215
(GRCh38/hg38)
Size:
70,151 bases
Orientation:
Minus strand
chr11:58,601,538-58,671,688
(GRCh37/hg19)

Genomic View for GLYATL2 Gene

Genes around GLYATL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GLYATL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GLYATL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GLYATL2 Gene

Proteins for GLYATL2 Gene

  • Protein details for GLYATL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WU03-GLYL2_HUMAN
    Recommended name:
    Glycine N-acyltransferase-like protein 2
    Protein Accession:
    Q8WU03
    Secondary Accessions:
    • A5LGC7
    • Q86WC3
    • Q96AT2

    Protein attributes for GLYATL2 Gene

    Size:
    294 amino acids
    Molecular mass:
    34277 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GLYATL2 Gene

Post-translational modifications for GLYATL2 Gene

  • Acetylation at Lys-19 drastically decreases the production of N-oleoyl and N-arachidonoyl glycines.

Other Protein References for GLYATL2 Gene

No data available for DME Specific Peptides for GLYATL2 Gene

Domains & Families for GLYATL2 Gene

Gene Families for GLYATL2 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for GLYATL2 Gene

Graphical View of Domain Structure for InterPro Entry

Q8WU03

UniProtKB/Swiss-Prot:

GLYL2_HUMAN :
  • Belongs to the glycine N-acyltransferase family.
Family:
  • Belongs to the glycine N-acyltransferase family.
genes like me logo Genes that share domains with GLYATL2: view

Function for GLYATL2 Gene

Molecular function for GLYATL2 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=4.4 uM for oleoyl-CoA {ECO:0000269 PubMed:20305126}; Vmax=933 nmol/min/mg enzyme with oleoyl-CoA as substrate {ECO:0000269 PubMed:20305126};
UniProtKB/Swiss-Prot CatalyticActivity:
Acyl-CoA + glycine = CoA + N-acylglycine.
UniProtKB/Swiss-Prot Function:
Mitochondrial acyltransferase which transfers the acyl group to the N-terminus of glycine. Conjugates numerous substrates, such as arachidonoyl-CoA and saturated medium and long-chain acyl-CoAs ranging from chain-length C8:0-CoA to C18:0-CoA, to form a variety of N-acylglycines. Shows a preference for monounsaturated fatty acid oleoyl-CoA (C18:1-CoA) as an acyl donor. Does not exhibit any activity toward C22:6-CoA and chenodeoxycholoyl-CoA, nor toward serine or alanine.

Enzyme Numbers (IUBMB) for GLYATL2 Gene

Gene Ontology (GO) - Molecular Function for GLYATL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016740 transferase activity IEA --
GO:0016746 transferase activity, transferring acyl groups IEA --
GO:0047961 glycine N-acyltransferase activity IDA 20305126
genes like me logo Genes that share ontologies with GLYATL2: view
genes like me logo Genes that share phenotypes with GLYATL2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GLYATL2 Gene

Localization for GLYATL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GLYATL2 Gene

Endoplasmic reticulum.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GLYATL2 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 2
mitochondrion 2
nucleus 2
cytosol 2
extracellular 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for GLYATL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0005783 endoplasmic reticulum IDA,IEA 20305126
genes like me logo Genes that share ontologies with GLYATL2: view

Pathways & Interactions for GLYATL2 Gene

genes like me logo Genes that share pathways with GLYATL2: view

Interacting Proteins for GLYATL2 Gene

Gene Ontology (GO) - Biological Process for GLYATL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042758 long-chain fatty acid catabolic process IDA 20305126
GO:0051793 medium-chain fatty acid catabolic process IDA 20305126
GO:1903965 monounsaturated fatty acid catabolic process IDA 20305126
genes like me logo Genes that share ontologies with GLYATL2: view

No data available for SIGNOR curated interactions for GLYATL2 Gene

Drugs & Compounds for GLYATL2 Gene

(13) Drugs for GLYATL2 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Glycine Approved, Vet_approved Nutra Full agonist, Agonist, Target 254
Acetylcysteine Approved, Investigational Pharma Antioxidant;mucolytic agent 352
Aminohippuric acid Approved, Investigational Pharma 0
n-acetyltyrosine Approved Pharma 0
3-Hydroxyhippuric acid Experimental Pharma 0

(72) Additional Compounds for GLYATL2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(2E)-Decenoyl-CoA
  • (E)-S-2-decenoate
  • (E)-S-2-decenoate CoA
  • (E)-S-2-decenoate Coenzyme A
  • (E)-S-2-decenoic acid
  • 2-trans-Decenoyl-CoA
10018-95-8
(2E)-Dodecenoyl-CoA
  • (2E)-Dodec-2-enoyl-CoA
  • (2E)-Dodec-2-enoyl-Coenzyme A
  • 2-trans-Dodecenoyl-CoA
  • 2-trans-Dodecenoyl-Coenzyme A
1066-12-2
(2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-Coenzyme A
  • trans-2-Hexadecenoyl-CoA
  • trans-2-Hexadecenoyl-Coenzyme A
4460-95-1
(2E)-Octenoyl-CoA
  • (E)-S-2-octenoate
  • (E)-S-2-octenoate CoA
  • (E)-S-2-octenoate Coenzyme A
  • (E)-S-2-octenoic acid
  • 2,3-trans-Octenoyl coenzyme A
10018-94-7
(2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-Coenzyme A
  • Trans-tetra-dec-2-enoyl-CoA
  • Trans-tetra-dec-2-enoyl-CoA.
  • Trans-tetra-dec-2-enoyl-Coenzyme A
38795-33-4
genes like me logo Genes that share compounds with GLYATL2: view

Transcripts for GLYATL2 Gene

mRNA/cDNA for GLYATL2 Gene

(4) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(8) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GLYATL2 Gene

Glycine-N-acyltransferase-like 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for GLYATL2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7
SP1:
SP2: -

Relevant External Links for GLYATL2 Gene

GeneLoc Exon Structure for
GLYATL2
ECgene alternative splicing isoforms for
GLYATL2

Expression for GLYATL2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GLYATL2 Gene

mRNA differential expression in normal tissues according to GTEx for GLYATL2 Gene

This gene is overexpressed in Minor Salivary Gland (x35.4).

Protein differential expression in normal tissues from HIPED for GLYATL2 Gene

This gene is overexpressed in Skin (32.0) and Oral epithelium (29.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GLYATL2 Gene



Protein tissue co-expression partners for GLYATL2 Gene

NURSA nuclear receptor signaling pathways regulating expression of GLYATL2 Gene:

GLYATL2

SOURCE GeneReport for Unigene cluster for GLYATL2 Gene:

Hs.254271

mRNA Expression by UniProt/SwissProt for GLYATL2 Gene:

Q8WU03-GLYL2_HUMAN
Tissue specificity: Expressed at highest levels in salivary gland and trachea. Also detected in thyroid gland, spinal cord, prostate, lung and fetal brain.

Evidence on tissue expression from TISSUES for GLYATL2 Gene

  • Bone marrow(4)
  • Nervous system(3)
genes like me logo Genes that share expression patterns with GLYATL2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for GLYATL2 Gene

Orthologs for GLYATL2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GLYATL2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GLYATL2 33 34
  • 99.77 (n)
cow
(Bos Taurus)
Mammalia GLYATL2 33 34
  • 78.95 (n)
mouse
(Mus musculus)
Mammalia Keg1 34
  • 40 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia GLYATL2 34
  • 38 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii si:dkey-76k16.5 34
  • 24 (a)
ManyToMany
Species where no ortholog for GLYATL2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GLYATL2 Gene

ENSEMBL:
Gene Tree for GLYATL2 (if available)
TreeFam:
Gene Tree for GLYATL2 (if available)

Paralogs for GLYATL2 Gene

Paralogs for GLYATL2 Gene

(4) SIMAP similar genes for GLYATL2 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for GLYATL2 Gene

genes like me logo Genes that share paralogs with GLYATL2: view

Variants for GLYATL2 Gene

Sequence variations from dbSNP and Humsavar for GLYATL2 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000168154 -- 58,907,261(-) C/T upstream_transcript_variant
rs1000222601 -- 58,877,959(-) A/G genic_upstream_transcript_variant, intron_variant
rs1000313982 -- 58,871,027(-) A/G genic_upstream_transcript_variant, intron_variant
rs1000321676 -- 58,842,597(-) C/T intron_variant
rs1000405222 -- 58,870,717(-) C/T genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for GLYATL2 Gene

Variant ID Type Subtype PubMed ID
nsv1050013 CNV gain 25217958
esv3626525 CNV gain 21293372
esv3626524 CNV loss 21293372
esv3338733 CNV insertion 20981092
dgv71n21 CNV loss 19592680
dgv1207n100 CNV gain 25217958

Variation tolerance for GLYATL2 Gene

Residual Variation Intolerance Score: 96.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.52; 43.96% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GLYATL2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GLYATL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GLYATL2 Gene

Disorders for GLYATL2 Gene

Additional Disease Information for GLYATL2

No disorders were found for GLYATL2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GLYATL2 Gene

Publications for GLYATL2 Gene

  1. Identification of glycine N-acyltransferase-like 2 (GLYATL2) as a transferase that produces N-acyl glycines in humans. (PMID: 20305126) Waluk DP … Hunt MC (FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010) 2 3 4 58
  2. Reversible lysine acetylation regulates activity of human glycine N-acyltransferase-like 2 (hGLYATL2): implications for production of glycine-conjugated signaling molecules. (PMID: 22408254) Waluk DP … Hunt MC (The Journal of biological chemistry 2012) 3 4 58
  3. Designation of enzyme activity of glycine-N-acyltransferase family genes and depression of glycine-N-acyltransferase in human hepatocellular carcinoma. (PMID: 22475485) Matsuo M … Kishimoto T (Biochemical and biophysical research communications 2012) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P … Vidal M (Genomics 2007) 3 58

Products for GLYATL2 Gene

Sources for GLYATL2 Gene

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