Aliases for GLYAT Gene
External Ids for GLYAT Gene
Previous GeneCards Identifiers for GLYAT Gene
The glycine-N-acyltransferase protein conjugates glycine with acyl-CoA substrates in the mitochondria. The protein is thought to be important in the detoxification of endogenous and xenobiotic acyl-CoA's. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for GLYAT Gene
GLYAT (Glycine-N-Acyltransferase) is a Protein Coding gene. Diseases associated with GLYAT include Hairy Tongue and Osteogenesis Imperfecta, Type I. Among its related pathways are Amino Acid conjugation and Metabolism. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring acyl groups and glycine N-benzoyltransferase activity. An important paralog of this gene is GLYATL2.
UniProtKB/Swiss-Prot Summary for GLYAT Gene
Mitochondrial acyltransferase which transfers an acyl group to the N-terminus of glycine and glutamine, although much less efficiently. Can conjugate numerous substrates to form a variety of N-acylglycines, with a preference for benzoyl-CoA over phenylacetyl-CoA as acyl donors. Thereby detoxify xenobiotics, such as benzoic acid or salicylic acid, and endogenous organic acids, such as isovaleric acid.