Free for academic non-profit institutions. Other users need a Commercial license

GLYAT Gene(Protein Coding)

Glycine-N-Acyltransferase

GCID:
GC11M058727
GIFtS:
49
Genes Participants
UDN Logo

Aliases for GLYAT Gene

Aliases for GLYAT Gene

  • Glycine-N-Acyltransferase 2 3 5
  • Aralkyl Acyl-CoA:Amino Acid N-Acyltransferase 3 4
  • Benzoyl-Coenzyme A:Glycine N-Acyltransferase 3 4
  • Acyl-CoA:Glycine N-Acyltransferase 3 4
  • Aralkyl Acyl-CoA N-Acyltransferase 3 4
  • Glycine N-Benzoyltransferase 3 4
  • EC 2.3.1.13 4 56
  • HRP-1(CLP) 3 4
  • ACGNAT 3 4
  • CAT 3 4
  • AAc 3 4
  • GAT 3 4
  • Aralkyl-CoA N-Acyltransferase 3
  • Glycine N-Acyltransferase 3
  • EC 2.3.1.71 4

External Ids for GLYAT Gene

Previous GeneCards Identifiers for GLYAT Gene

  • GC11M060871
  • GC11M059990
  • GC11M058252
  • GC11M058251
  • GC11M058232
  • GC11M058476
  • GC11M054824

Summaries for GLYAT Gene

Entrez Gene Summary for GLYAT Gene

  • The glycine-N-acyltransferase protein conjugates glycine with acyl-CoA substrates in the mitochondria. The protein is thought to be important in the detoxification of endogenous and xenobiotic acyl-CoA's. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for GLYAT Gene

GLYAT (Glycine-N-Acyltransferase) is a Protein Coding gene. Diseases associated with GLYAT include Hairy Tongue and Substance-Induced Psychosis. Among its related pathways are Metabolism and Cytochrome P450 - arranged by substrate type. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring acyl groups and glycine N-benzoyltransferase activity. An important paralog of this gene is GLYATL2.

UniProtKB/Swiss-Prot for GLYAT Gene

  • Mitochondrial acyltransferase which transfers an acyl group to the N-terminus of glycine and glutamine, although much less efficiently. Can conjugate numerous substrates to form a variety of N-acylglycines, with a preference for benzoyl-CoA over phenylacetyl-CoA as acyl donors. Thereby detoxify xenobiotics, such as benzoic acid or salicylic acid, and endogenous organic acids, such as isovaleric acid.

Gene Wiki entry for GLYAT Gene

Additional gene information for GLYAT Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GLYAT Gene

Genomics for GLYAT Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for GLYAT Gene

Promoters and enhancers for GLYAT Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH11I058731 Promoter 0.9 EPDnew 550.8 +0.0 11 0.1 RXRA TAF1 MAX REST RAD21 YY1 JUND ATF3 HNF4G HNF4A GLYAT GC11P058692
GH11I058788 Enhancer 0.9 Ensembl ENCODE 12 -56.7 -56651 1 CTCF IRF2 RB1 RAD21 YY1 CHAMP1 FOSL1 CC2D1A ARID2 SMC3 GLYAT GLYATL2 GC11M058796 LOC100420019
GH11I058762 Enhancer 0.8 ENCODE 11.7 -31.1 -31112 1.2 FOXA2 ARID4B DMAP1 THRB ZSCAN9 RAD21 RARA YY1 CREM THAP11 GLYAT GLYATL2 LOC100420019 GC11M058796
GH11I058675 Enhancer 0.6 ENCODE 11.6 +56.2 56241 0.2 CTCF ZNF654 TRIM22 REST IRF4 RAD21 RELA TGIF2 CTBP1 ZNF143 GLYAT CNTF ENSG00000197254 ENSG00000280010 GC11P058595
GH11I058787 Enhancer 0.5 ENCODE 12 -56.1 -56069 0.2 ZNF148 FOSL1 ZNF639 TRIM24 EMSY ZNF395 GLYAT GC11M058796 LOC100420019
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around GLYAT on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GLYAT gene promoter:

Genomic Locations for GLYAT Gene

Genomic Locations for GLYAT Gene
chr11:58,640,426-58,731,974
(GRCh38/hg38)
Size:
91,549 bases
Orientation:
Minus strand
chr11:58,407,899-58,499,447
(GRCh37/hg19)

Genomic View for GLYAT Gene

Genes around GLYAT on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GLYAT Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GLYAT Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for GLYAT Gene

Proteins for GLYAT Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for GLYAT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6IB77-GLYAT_HUMAN
    Recommended name:
    Glycine N-acyltransferase
    Protein Accession:
    Q6IB77
    Secondary Accessions:
    • H1AE11
    • O14833
    • Q96QK7

    Protein attributes for GLYAT Gene

    Size:
    296 amino acids
    Molecular mass:
    33924 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAB81453.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAL43174.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for GLYAT Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GLYAT Gene

Protein Expression for GLYAT Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for GLYAT Gene

Q6IB77:
  • CLLGPEGTP
  • WHFGGNE
  • INWKQHLQIQSSQ
  • QMLQMLE

Post-translational modifications for GLYAT Gene

No Post-translational modifications

Other Protein References for GLYAT Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for GLYAT Gene

Gene Families for GLYAT Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for GLYAT Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GLYAT Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6IB77

UniProtKB/Swiss-Prot:

GLYAT_HUMAN :
  • Belongs to the glycine N-acyltransferase family.
Family:
  • Belongs to the glycine N-acyltransferase family.
genes like me logo Genes that share domains with GLYAT: view

Function for GLYAT Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for GLYAT Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=57.9 mM for benzoyl-CoA {ECO:0000269 PubMed:7802672}; KM=83.7 mM for salicyl-CoA {ECO:0000269 PubMed:7802672}; KM=124 mM for isovaleryl-CoA {ECO:0000269 PubMed:7802672}; KM=198 mM for octanoyl-CoA {ECO:0000269 PubMed:7802672}; Vmax=17.1 umol/min/mg enzyme with benzoyl-CoA as substrate {ECO:0000269 PubMed:7802672}; Vmax=10.1 umol/min/mg enzyme with salicyl-CoA as substrate {ECO:0000269 PubMed:7802672}; Vmax=7.64 umol/min/mg enzyme with isovaleryl-CoA as substrate {ECO:0000269 PubMed:7802672}; Vmax=3.3 umol/min/mg enzyme with octanoyl-CoA as substrate {ECO:0000269 PubMed:7802672};
UniProtKB/Swiss-Prot CatalyticActivity:
Acyl-CoA + glycine = CoA + N-acylglycine.
UniProtKB/Swiss-Prot CatalyticActivity:
Benzoyl-CoA + glycine = CoA + hippurate.
UniProtKB/Swiss-Prot Function:
Mitochondrial acyltransferase which transfers an acyl group to the N-terminus of glycine and glutamine, although much less efficiently. Can conjugate numerous substrates to form a variety of N-acylglycines, with a preference for benzoyl-CoA over phenylacetyl-CoA as acyl donors. Thereby detoxify xenobiotics, such as benzoic acid or salicylic acid, and endogenous organic acids, such as isovaleric acid.

Enzyme Numbers (IUBMB) for GLYAT Gene

Phenotypes From GWAS Catalog for GLYAT Gene

Gene Ontology (GO) - Molecular Function for GLYAT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0016740 transferase activity IEA --
GO:0016746 transferase activity, transferring acyl groups TAS 9202629
GO:0047961 glycine N-acyltransferase activity IDA 22475485
GO:0047962 glycine N-benzoyltransferase activity TAS --
genes like me logo Genes that share ontologies with GLYAT: view
genes like me logo Genes that share phenotypes with GLYAT: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GLYAT Gene

Localization for GLYAT Gene

Subcellular locations from UniProtKB/Swiss-Prot for GLYAT Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GLYAT gene
Compartment Confidence
extracellular 5
mitochondrion 5
nucleus 2
cytosol 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for GLYAT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion ISS,TAS --
GO:0005759 mitochondrial matrix TAS --
GO:0070062 extracellular exosome HDA,IDA 23376485
genes like me logo Genes that share ontologies with GLYAT: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GLYAT Gene

Pathways & Interactions for GLYAT Gene

genes like me logo Genes that share pathways with GLYAT: view

Gene Ontology (GO) - Biological Process for GLYAT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006544 glycine metabolic process ISS --
GO:0006637 acyl-CoA metabolic process TAS 7802672
GO:0006805 xenobiotic metabolic process TAS --
GO:0009636 response to toxic substance IEA,TAS --
GO:0032787 monocarboxylic acid metabolic process ISS --
genes like me logo Genes that share ontologies with GLYAT: view

No data available for SIGNOR curated interactions for GLYAT Gene

Drugs & Compounds for GLYAT Gene

Products:

  1. Drug

(14) Drugs for GLYAT Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Glycine Approved, Vet_approved Nutra Full agonist, Agonist, Target 254
Acetylcysteine Approved, Investigational Pharma Antioxidant;mucolytic agent 352
Aminohippuric acid Approved, Investigational Pharma 0
n-acetyltyrosine Approved Pharma 0
3-Hydroxyhippuric acid Experimental Pharma 0

(76) Additional Compounds for GLYAT Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
benzoyl-coa
  • Benzoyl CoA
  • Benzoyl Coenzyme A
  • Benzoyl-S-CoA
  • Benzoyl-S-Coenzyme A
  • S-Benzoate
 6756-74-7
(2E)-Decenoyl-CoA
  • (E)-S-2-decenoate
  • (E)-S-2-decenoate CoA
  • (E)-S-2-decenoate Coenzyme A
  • (E)-S-2-decenoic acid
  • 2-trans-Decenoyl-CoA
 10018-95-8
(2E)-Dodecenoyl-CoA
  • (2E)-Dodec-2-enoyl-CoA
  • (2E)-Dodec-2-enoyl-Coenzyme A
  • 2-trans-Dodecenoyl-CoA
  • 2-trans-Dodecenoyl-Coenzyme A
 1066-12-2
(2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-Coenzyme A
  • trans-2-Hexadecenoyl-CoA
  • trans-2-Hexadecenoyl-Coenzyme A
 4460-95-1
(2E)-Octenoyl-CoA
  • (E)-S-2-octenoate
  • (E)-S-2-octenoate CoA
  • (E)-S-2-octenoate Coenzyme A
  • (E)-S-2-octenoic acid
  • 2,3-trans-Octenoyl coenzyme A
 10018-94-7
genes like me logo Genes that share compounds with GLYAT: view

Transcripts for GLYAT Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for GLYAT Gene

(3) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(87) Selected AceView cDNA sequences:
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GLYAT Gene

Glycine-N-acyltransferase:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for GLYAT Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b
SP1: - -
SP2: - -
SP3: -
SP4: -

Relevant External Links for GLYAT Gene

GeneLoc Exon Structure for
GLYAT
ECgene alternative splicing isoforms for
GLYAT

Expression for GLYAT Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GLYAT Gene

mRNA expression in normal human tissues for GLYAT Gene
mRNA expression by BioGPS for GLYAT GenemRNA expression by GTEx for GLYAT Gene

mRNA differential expression in normal tissues according to GTEx for GLYAT Gene

This gene is overexpressed in Liver (x28.3) and Kidney - Cortex (x21.4).

Protein differential expression in normal tissues from HIPED for GLYAT Gene

This gene is overexpressed in Liver (25.1), Liver, secretome (20.3), and Kidney (16.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GLYAT Gene



Protein tissue co-expression partners for GLYAT Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GLYAT Gene:

GLYAT

SOURCE GeneReport for Unigene cluster for GLYAT Gene:

Hs.145384

mRNA Expression by UniProt/SwissProt for GLYAT Gene:

Q6IB77-GLYAT_HUMAN
Tissue specificity: Predominantly expressed in liver (at protein level) and kidney. Down-regulated in hepatocellular carcinoma and other liver cancers.

Evidence on tissue expression from TISSUES for GLYAT Gene

  • Kidney(4.6)
  • Liver(4.6)
genes like me logo Genes that share expression patterns with GLYAT: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for GLYAT Gene

Orthologs for GLYAT Gene

This gene was present in the common ancestor of chordates.

Orthologs for GLYAT Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia GLYAT 33 34
  • 99.55 (n)
dog
(Canis familiaris)
 Mammalia GLYAT 33 34
  • 80.71 (n)
rat
(Rattus norvegicus)
 Mammalia Glyat 33
  • 80.07 (n)
mouse
(Mus musculus)
 Mammalia Glyat 33 16 34
  • 79.62 (n)
cow
(Bos Taurus)
 Mammalia GLYAT 33 34
  • 78.87 (n)
oppossum
(Monodelphis domestica)
 Mammalia GLYAT 34
  • 58 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia -- 34
  • 56 (a)
 OneToMany
-- 34
  • 54 (a)
 OneToMany
-- 34
  • 52 (a)
 OneToMany
tropical clawed frog
(Silurana tropicalis)
 Amphibia LOC100490041 33
  • 48.43 (n)
zebrafish
(Danio rerio)
 Actinopterygii si:ch73-106k19.2 34
  • 26 (a)
 ManyToMany
Species where no ortholog for GLYAT was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GLYAT Gene

ENSEMBL:
Gene Tree for GLYAT (if available)
TreeFam:
Gene Tree for GLYAT (if available)

Paralogs for GLYAT Gene

Paralogs for GLYAT Gene

(4) SIMAP similar genes for GLYAT Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for GLYAT Gene

genes like me logo Genes that share paralogs with GLYAT: view

Variants for GLYAT Gene

Sequence variations from dbSNP and Humsavar for GLYAT Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000030467 -- 58,718,282(-) C/A intron_variant
rs1000098982 -- 58,724,603(-) T/G genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000113181 -- 58,730,202(-) T/A genic_upstream_transcript_variant, intron_variant
rs1000186089 -- 58,726,021(-) C/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000229688 -- 58,729,936(-) T/C genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for GLYAT Gene

Variant ID Type Subtype PubMed ID
nsv832168 CNV gain 17160897
nsv507592 OTHER sequence alteration 20534489
nsv330 CNV insertion 18451855
nsv329 CNV deletion 18451855
nsv1050013 CNV gain 25217958

Variation tolerance for GLYAT Gene

Residual Variation Intolerance Score: 88.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.71; 46.43% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GLYAT Gene

Human Gene Mutation Database (HGMD)
GLYAT
SNPedia medical, phenotypic, and genealogical associations of SNPs for
GLYAT

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GLYAT Gene

Disorders for GLYAT Gene

MalaCards: The human disease database

(5) MalaCards diseases for GLYAT Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
hairy tongue
  • overgrowth of filiform papillae
substance-induced psychosis
osteogenesis imperfecta, type i
  • oi1
isovaleric acidemia
  • iva
fissured tongue
  • congenital fissure of tongue
- elite association - COSMIC cancer census association via MalaCards
Search GLYAT in MalaCards View complete list of genes associated with diseases

Additional Disease Information for GLYAT

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with GLYAT: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GLYAT Gene

Publications for GLYAT Gene

  1. Genetic polymorphisms of glycine N-acyltransferase in Japanese individuals. (PMID: 19252341) Yamamoto A … Azuma J (Drug metabolism and pharmacokinetics 2009) 3 22 44 58
  2. The utilization of alanine, glutamic acid, and serine as amino acid substrates for glycine N-acyltransferase. (PMID: 10630424) van der Westhuizen FH … Erasmus E (Journal of biochemical and molecular toxicology 2000) 3 4 22 58
  3. Purification to homogeneity of mitochondrial acyl coa:glycine n-acyltransferase from human liver. (PMID: 7802672) Mawal YR … Qureshi IA (Biochemical and biophysical research communications 1994) 3 4 22 58
  4. Designation of enzyme activity of glycine-N-acyltransferase family genes and depression of glycine-N-acyltransferase in human hepatocellular carcinoma. (PMID: 22475485) Matsuo M … Kishimoto T (Biochemical and biophysical research communications 2012) 3 4 58
  5. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 44 58

Products for GLYAT Gene

Sources for GLYAT Gene

Content
Loading form....