Aliases for GLYAT Gene
External Ids for GLYAT Gene
Previous GeneCards Identifiers for GLYAT Gene
The glycine-N-acyltransferase protein conjugates glycine with acyl-CoA substrates in the mitochondria. The protein is thought to be important in the detoxification of endogenous and xenobiotic acyl-CoA's. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for GLYAT Gene
GLYAT (Glycine-N-Acyltransferase) is a Protein Coding gene. Diseases associated with GLYAT include Hairy Tongue and Contractural Arachnodactyly, Congenital. Among its related pathways are Tyrosine metabolism and Cytochrome P450 - arranged by substrate type. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring acyl groups and glycine N-benzoyltransferase activity. An important paralog of this gene is GLYATL2.
UniProtKB/Swiss-Prot Summary for GLYAT Gene
Mitochondrial acyltransferase which transfers an acyl group to the N-terminus of glycine and glutamine, although much less efficiently. Can conjugate numerous substrates to form a variety of N-acylglycines, with a preference for benzoyl-CoA over phenylacetyl-CoA as acyl donors. Thereby detoxify xenobiotics, such as benzoic acid or salicylic acid, and endogenous organic acids, such as isovaleric acid.