Free for academic non-profit institutions. Other users need a Commercial license
The glycine-N-acyltransferase protein conjugates glycine with acyl-CoA substrates in the mitochondria. The protein is thought to be important in the detoxification of endogenous and xenobiotic acyl-CoA's. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GLYAT (Glycine-N-Acyltransferase) is a Protein Coding gene. Diseases associated with GLYAT include Hairy Tongue and Contractural Arachnodactyly, Congenital. Among its related pathways are Tyrosine metabolism and Cytochrome P450 - arranged by substrate type. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring acyl groups and glycine N-benzoyltransferase activity. An important paralog of this gene is GLYATL2.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH11J058731 | Promoter | 0.7 | EPDnew | 600.7 | +0.0 | 11 | 0.1 | REST SP1 ATF3 YY1 JUND RAD21 HNF4A RXRA MAX HNF4G | GLYAT lnc-GLYATL2-6 CNTF | |
GH11J058787 | Enhancer | 0.9 | Ensembl ENCODE | 12 | -56.5 | -56472 | 1.3 | CTCF JUND ZNF143 REST RAD21 TRIM22 NFE2 E2F5 YY1 SMC3 | GLYAT GLYATL2 lnc-GLYATL2-3 HSALNG0084366 GLYATL1 | |
GH11J058762 | Enhancer | 0.8 | ENCODE | 11.7 | -31.1 | -31112 | 1.2 | GATAD2A SOX13 RCOR2 RBFOX2 RXRB IRF2 SP1 CEBPA TCF7 ZKSCAN8 | GLYAT GLYATL2 ENSG00000254926 HSALNG0084366 GLYATL1 | |
GH11J058675 | Enhancer | 0.6 | ENCODE | 11.6 | +56.2 | 56241 | 0.2 | CTCF ZNF143 REST RAD21 IRF2 TRIM22 ZNF600 RELA CTBP1 RUNX3 | GLYAT CNTF ENSG00000197254 lnc-CNTF-2 ENSG00000280010 | |
GH11J058674 | Enhancer | 0.2 | ENCODE | 11.6 | +57.2 | 57171 | 0.2 | GLYAT CNTF ENSG00000197254 lnc-CNTF-2 ENSG00000280010 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | 25416956 |
GO:0016410 | N-acyltransferase activity | IBA | 21873635 |
GO:0016740 | transferase activity | IEA | -- |
GO:0016746 | transferase activity, transferring acyl groups | TAS | 9202629 |
GO:0047961 | glycine N-acyltransferase activity | IDA | 22475485 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005739 | mitochondrion | TAS,ISS | -- |
GO:0005759 | mitochondrial matrix | TAS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Amino Acid conjugation | ||
2 | Cytochrome P450 - arranged by substrate type | ||
3 | Metabolism |
.40
|
|
4 | Tyrosine metabolism |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006544 | glycine metabolic process | ISS | -- |
GO:0006637 | acyl-CoA metabolic process | TAS | 7802672 |
GO:0006805 | xenobiotic metabolic process | TAS | -- |
GO:0009636 | response to toxic substance | TAS,IEA | -- |
GO:0032787 | monocarboxylic acid metabolic process | ISS | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Glycine | Approved, Vet_approved | Nutra | Agonist, Full agonist, Target, substrate | 196 | ||
Acetylcysteine | Approved, Investigational | Pharma | Antioxidant;mucolytic agent | 427 | ||
Aminohippuric acid | Approved, Investigational | Pharma | 0 | |||
Benzoic acid | Approved, Investigational | Pharma | 11 | |||
n-acetyltyrosine | Approved | Pharma | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
benzoyl-coa |
|
6756-74-7 | ||||
(2E)-Decenoyl-CoA |
|
10018-95-8 |
|
|||
(2E)-Dodecenoyl-CoA |
|
1066-12-2 |
|
|||
(2E)-Hexadecenoyl-CoA |
|
4460-95-1 |
|
|||
(2E)-Octenoyl-CoA |
|
10018-94-7 |
|
ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | |||||||||||||||||||
SP2: | - | - | |||||||||||||||||||
SP3: | - | ||||||||||||||||||||
SP4: | - |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | GLYAT 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | GLYAT 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Glyat 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Glyat 30 17 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | GLYAT 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | GLYAT 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | LOC100490041 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | si:ch73-106k19.2 31 |
|
ManyToMany |
SNP ID | Clinical significance and condition | Chr 11 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs10896818 | - | p.Ser17Thr | |||
rs675815 | - | p.Asn156Ser |
Disorder | Aliases | PubMed IDs |
---|---|---|
hairy tongue |
|
|
contractural arachnodactyly, congenital |
|
|
osteogenesis imperfecta, type i |
|
|
auditory agnosia |
|
|
isovaleric acidemia |
|
|