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Aliases for GLTP Gene

Aliases for GLTP Gene

  • Glycolipid Transfer Protein 2 3 3 5
  • Truncated Glycolipid Transfer Protein 3

External Ids for GLTP Gene

Previous GeneCards Identifiers for GLTP Gene

  • GC12M109355
  • GC12M110128
  • GC12M108752
  • GC12M110288
  • GC12M107304

Summaries for GLTP Gene

Entrez Gene Summary for GLTP Gene

  • The protein encoded by this gene is similar to bovine and porcine proteins which accelerate transfer of certain glycosphingolipids and glyceroglycolipids between membranes. It is thought to be a cytoplasmic protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for GLTP Gene

GLTP (Glycolipid Transfer Protein) is a Protein Coding gene. Among its related pathways are Metabolism and Sphingolipid metabolism. Gene Ontology (GO) annotations related to this gene include lipid binding and glycolipid transporter activity.

UniProtKB/Swiss-Prot for GLTP Gene

  • Accelerates the intermembrane transfer of various glycolipids. Catalyzes the transfer of various glycosphingolipids between membranes but does not catalyze the transfer of phospholipids. May be involved in the intracellular translocation of glucosylceramides.

Gene Wiki entry for GLTP Gene

Additional gene information for GLTP Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GLTP Gene

Genomics for GLTP Gene

GeneHancer (GH) Regulatory Elements for GLTP Gene

Promoters and enhancers for GLTP Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J109878 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 665 0.0 -41 3.4 HDGF ARNT SIN3A ZNF2 ZBTB7B ZNF213 ZNF143 FOS NFYC ZHX2 GLTP ENSG00000249094 TCHP LINC01486 ENSG00000257268 RNU4-32P KCTD10 IFT81 ANKRD13A PPP1CC
GH12J109863 Enhancer 1.3 Ensembl ENCODE dbSUPER 33 +15.8 15828 2.7 FOXA2 MLX ZFP64 ARID4B DMAP1 ZNF48 NFKBIZ RXRA SP5 PPARG RN7SL441P GLTP ENSG00000256351
GH12J109899 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 20.3 -20.1 -20128 2.2 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 CBX5 ZNF213 TCHP IFT81 GLTP UBE3B RNU4-32P GPN3 TRPV4 PIR43904
GH12J109860 Enhancer 1.1 ENCODE dbSUPER 27.4 +18.7 18680 1.8 PKNOX1 MLX ARID4B ZNF48 ETS1 GLIS2 ATF7 ZHX2 ZNF488 PPARG ENSG00000256351 GLTP GIT2 RN7SL441P
GH12J109844 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 15.2 +34.6 34613 2 HDGF FOXA2 ARNT ARID4B SIN3A ZNF2 ZNF48 ZNF121 GLIS2 ZNF213 GLTP GIT2 LOC105369975 PIR37961
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GLTP on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GLTP gene promoter:
  • Pax-4a
  • RFX1
  • GATA-1
  • YY1
  • Sox5
  • c-Myc
  • Max
  • Sox9
  • Arnt

Genomic Locations for GLTP Gene

Genomic Locations for GLTP Gene
chr12:109,850,943-109,880,488
(GRCh38/hg38)
Size:
29,546 bases
Orientation:
Minus strand
chr12:110,288,748-110,318,293
(GRCh37/hg19)
Size:
29,546 bases
Orientation:
Minus strand

Genomic View for GLTP Gene

Genes around GLTP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GLTP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GLTP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GLTP Gene

Proteins for GLTP Gene

  • Protein details for GLTP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NZD2-GLTP_HUMAN
    Recommended name:
    Glycolipid transfer protein
    Protein Accession:
    Q9NZD2
    Secondary Accessions:
    • Q53Z13
    • Q96J68

    Protein attributes for GLTP Gene

    Size:
    209 amino acids
    Molecular mass:
    23850 Da
    Quaternary structure:
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for GLTP Gene

neXtProt entry for GLTP Gene

Post-translational modifications for GLTP Gene

  • Ubiquitination at Lys66
  • Modification sites at PhosphoSitePlus

Other Protein References for GLTP Gene

No data available for DME Specific Peptides for GLTP Gene

Domains & Families for GLTP Gene

Gene Families for GLTP Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for GLTP Gene

Suggested Antigen Peptide Sequences for GLTP Gene

Graphical View of Domain Structure for InterPro Entry

Q9NZD2

UniProtKB/Swiss-Prot:

GLTP_HUMAN :
  • Belongs to the GLTP family.
Family:
  • Belongs to the GLTP family.
genes like me logo Genes that share domains with GLTP: view

Function for GLTP Gene

Molecular function for GLTP Gene

UniProtKB/Swiss-Prot Function:
Accelerates the intermembrane transfer of various glycolipids. Catalyzes the transfer of various glycosphingolipids between membranes but does not catalyze the transfer of phospholipids. May be involved in the intracellular translocation of glucosylceramides.

Phenotypes From GWAS Catalog for GLTP Gene

Gene Ontology (GO) - Molecular Function for GLTP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0008289 lipid binding IDA 15901739
GO:0017089 glycolipid transporter activity TAS --
GO:0042802 identical protein binding IPI 22078563
GO:0051861 glycolipid binding IDA 15287756
genes like me logo Genes that share ontologies with GLTP: view

Phenotypes for GLTP Gene

genes like me logo Genes that share phenotypes with GLTP: view

Animal Model Products

  • Taconic Biosciences Mouse Models for GLTP

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GLTP Gene

Localization for GLTP Gene

Subcellular locations from UniProtKB/Swiss-Prot for GLTP Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GLTP gene
Compartment Confidence
extracellular 5
cytosol 5
plasma membrane 1
endoplasmic reticulum 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for GLTP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS,IDA --
GO:0016020 membrane IDA 15901739
GO:0070062 extracellular exosome HDA --
genes like me logo Genes that share ontologies with GLTP: view

Pathways & Interactions for GLTP Gene

genes like me logo Genes that share pathways with GLTP: view

Pathways by source for GLTP Gene

Interacting Proteins for GLTP Gene

Gene Ontology (GO) - Biological Process for GLTP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006687 glycosphingolipid metabolic process TAS --
GO:0006869 lipid transport IEA --
GO:0046836 glycolipid transport IEA --
GO:0120009 intermembrane lipid transfer IDA,IEA 15901739
genes like me logo Genes that share ontologies with GLTP: view

No data available for SIGNOR curated interactions for GLTP Gene

Drugs & Compounds for GLTP Gene

(9) Drugs for GLTP Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
lactose Approved, Investigational Pharma Target 0
lauric acid Approved, Experimental Pharma Agonist, Target 0
oleic acid Approved, Investigational, Vet_approved Pharma Full agonist, Agonist, Activation, Activator, Target 0
Capric acid Experimental Pharma Target 0
Sphingosine Experimental Pharma Target 0

(521) Additional Compounds for GLTP Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
3-Dehydrosphinganine
  • 3-dehydro-D-Sphinganine
  • 3-Ketodihydrosphingosine
  • 3-Ketosphinganine
  • (2S)-2-amino-1-Hydroxyoctadecan-3-one
  • 1-Hydroxy-2-amino-3-oxo-octadecane
16105-69-4
3-O-Sulfogalactosylceramide (d18:1/12:0)
  • 3'-O-Sulphogalactosylceramide
  • 3-O-SulfO-beta-D-galactosylceramide
  • 3-O-SulfO-beta-delta-galactosylceramide
  • 3-O-Sulfogalactosylceramide
  • Cerebroside 3-sulfate
852100-88-0
3-O-Sulfogalactosylceramide (d18:1/14:0)
  • 3'-O-Sulphogalactosylceramide
  • 3-O-SulfO-beta-D-galactosylceramide
  • 3-O-SulfO-beta-delta-galactosylceramide
  • 3-O-Sulfogalactosylceramide
  • Cerebroside 3-sulfate
3-O-Sulfogalactosylceramide (d18:1/16:0)
  • 3'-O-Sulphogalactosylceramide
  • 3-O-SulfO-beta-D-galactosylceramide
  • 3-O-SulfO-beta-delta-galactosylceramide
  • 3-O-Sulfogalactosylceramide
  • Cerebroside 3-sulfate
862509-48-6
3-O-Sulfogalactosylceramide (d18:1/18:0)
  • 3'-O-Sulphogalactosylceramide
  • 3-O-SulfO-beta-D-galactosylceramide
  • 3-O-SulfO-beta-delta-galactosylceramide
  • 3-O-Sulfogalactosylceramide
  • Cerebroside 3-sulfate
244215-65-4
genes like me logo Genes that share compounds with GLTP: view

Transcripts for GLTP Gene

mRNA/cDNA for GLTP Gene

Unigene Clusters for GLTP Gene

Glycolipid transfer protein:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GLTP Gene

No ASD Table

Relevant External Links for GLTP Gene

GeneLoc Exon Structure for
GLTP
ECgene alternative splicing isoforms for
GLTP

Expression for GLTP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GLTP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GLTP Gene

This gene is overexpressed in Esophagus - Mucosa (x6.6), Skin - Sun Exposed (Lower leg) (x5.3), and Skin - Not Sun Exposed (Suprapubic) (x4.8).

Protein differential expression in normal tissues from HIPED for GLTP Gene

This gene is overexpressed in Frontal cortex (11.6), Spinal cord (8.0), and Oral epithelium (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GLTP Gene



Protein tissue co-expression partners for GLTP Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GLTP Gene:

GLTP

SOURCE GeneReport for Unigene cluster for GLTP Gene:

Hs.381256

mRNA Expression by UniProt/SwissProt for GLTP Gene:

Q9NZD2-GLTP_HUMAN
Tissue specificity: Detected in fibroblasts (at protein level). Detected in fibroblasts and in various cancer cell lines.

Evidence on tissue expression from TISSUES for GLTP Gene

  • Nervous system(4.6)
  • Skin(4.4)
genes like me logo Genes that share expression patterns with GLTP: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for GLTP Gene

Orthologs for GLTP Gene

This gene was present in the common ancestor of animals.

Orthologs for GLTP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GLTP 34 33
  • 99.52 (n)
OneToOne
dog
(Canis familiaris)
Mammalia TRPV4 34
  • 99 (a)
OneToOne
GLTP 33
  • 94.58 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia GLTP 34
  • 93 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GLTP 34 33
  • 90.27 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GLTP 34
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gltp 16 34 33
  • 88.84 (n)
rat
(Rattus norvegicus)
Mammalia Gltp 33
  • 88.68 (n)
chicken
(Gallus gallus)
Aves GLTP 34 33
  • 75.96 (n)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gltp 33
  • 70.83 (n)
Str.3312 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.33566 33
zebrafish
(Danio rerio)
Actinopterygii gltpa 34 33
  • 72.09 (n)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10792 33
fruit fly
(Drosophila melanogaster)
Insecta CG6299 34
  • 25 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea Y82E9BR.14 34 33
  • 44.68 (n)
OneToOne
Species where no ortholog for GLTP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GLTP Gene

ENSEMBL:
Gene Tree for GLTP (if available)
TreeFam:
Gene Tree for GLTP (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GLTP: view image

Paralogs for GLTP Gene

Pseudogenes.org Pseudogenes for GLTP Gene

genes like me logo Genes that share paralogs with GLTP: view

No data available for Paralogs for GLTP Gene

Variants for GLTP Gene

Sequence variations from dbSNP and Humsavar for GLTP Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000163398 -- 109,865,887(-) T/C intron_variant
rs1000181545 -- 109,873,887(-) T/G intron_variant
rs1000249621 -- 109,865,913(-) G/T intron_variant
rs1000363546 -- 109,855,342(-) C/T intron_variant
rs1000394898 -- 109,855,621(-) G/A coding_sequence_variant, stop_gained

Structural Variations from Database of Genomic Variants (DGV) for GLTP Gene

Variant ID Type Subtype PubMed ID
esv1367232 CNV insertion 17803354
esv2588131 CNV insertion 19546169
esv2676313 CNV deletion 23128226
esv3302754 CNV tandem duplication 20981092
esv3549768 CNV deletion 23714750
nsv1142814 CNV tandem duplication 24896259

Variation tolerance for GLTP Gene

Residual Variation Intolerance Score: 33.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.76; 15.98% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GLTP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GLTP

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GLTP Gene

Disorders for GLTP Gene

Additional Disease Information for GLTP

No disorders were found for GLTP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GLTP Gene

Publications for GLTP Gene

  1. Human glycolipid transfer protein: probing conformation using fluorescence spectroscopy. (PMID: 15287756) Li XM … Brown RE (Biochemistry 2004) 2 3 4 22 58
  2. Human glycolipid transfer protein (GLTP) genes: organization, transcriptional status and evolution. (PMID: 18261224) Zou X … Brown RE (BMC genomics 2008) 3 4 22 58
  3. Human glycolipid transfer protein--intracellular localization and effects on the sphingolipid synthesis. (PMID: 17980653) Tuuf J … Mattjus P (Biochimica et biophysica acta 2007) 3 4 22 58
  4. The liganding of glycolipid transfer protein is controlled by glycolipid acyl structure. (PMID: 17105344) Malinina L … Patel DJ (PLoS biology 2006) 3 4 22 58
  5. Point mutational analysis of the liganding site in human glycolipid transfer protein. Functionality of the complex. (PMID: 15901739) Malakhova ML … Brown RE (The Journal of biological chemistry 2005) 2 3 22 58

Products for GLTP Gene

Sources for GLTP Gene

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