Free for academic non-profit institutions. Other users need a Commercial license

Aliases for GLT8D1 Gene

Aliases for GLT8D1 Gene

  • Glycosyltransferase 8 Domain Containing 1 2 3 5
  • Glycosyltransferase 8 Domain-Containing Protein 1 3
  • Glycosyltransferase AD-017 3
  • EC 2.4.1.- 4
  • EC 2.4.1 56
  • MSTP139 3
  • AD-017 3
  • GALA4A 4

External Ids for GLT8D1 Gene

Summaries for GLT8D1 Gene

Entrez Gene Summary for GLT8D1 Gene

  • This gene encodes a member of the glycosyltransferase family. The specific function of this protein has not been determined. Alternative splicing results in multiple transcript variants of this gene [provided by RefSeq, May 2013]

GeneCards Summary for GLT8D1 Gene

GLT8D1 (Glycosyltransferase 8 Domain Containing 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring glycosyl groups. An important paralog of this gene is GLT8D2.

Additional gene information for GLT8D1 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GLT8D1 Gene

Genomics for GLT8D1 Gene

GeneHancer (GH) Regulatory Elements for GLT8D1 Gene

Promoters and enhancers for GLT8D1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I052703 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 550.8 +0.3 346 4.6 HDGF PKNOX1 FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 GLT8D1 SPCS1 PBRM1 RFT1
GH03I053140 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 24.1 -435.0 -435018 1.4 HDGF ZSCAN26 ZSCAN4 ZNF133 MAX PAX8 SALL2 EBF1 ZFHX2 FOXK2 GLT8D1 RFT1 NISCH PRKCD ACTR8 NEK4 STIMATE ITIH4 DCP1A ITIH3
GH03I051955 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE dbSUPER 14.3 +749.9 749947 2 RING1 ZNF664 CTCF POLR2A MAX CTBP2 EZH2 GPR62 RPL29 NISCH GLT8D1 RAD54L2 NT5DC2 PARP3 GC03P051963
GH03I053517 Enhancer 1.1 Ensembl ENCODE dbSUPER 16.1 -813.1 -813073 2.8 ESRRA JUN ZNF140 SIN3A CEBPG RAD21 YY1 GATA3 RCOR1 FOSL2 GLT8D1 RFT1 CACNA1D SNORD38C PBRM1 NT5DC2 TKT GC03P053524 RPS25P4
GH03I052021 Enhancer 1.1 Ensembl ENCODE dbSUPER 16.1 +683.8 683763 1.4 SMAD1 NFIA ZNF140 EBF1 ZNF398 ZIC2 NFIC ZNF610 ZNF692 ZBTB48 RAD54L2 GLT8D1 NISCH RRP9 PBRM1 GPR62 GC03P052016 LOC105377088
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around GLT8D1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GLT8D1 gene promoter:

Genomic Locations for GLT8D1 Gene

Genomic Locations for GLT8D1 Gene
chr3:52,694,484-52,706,083
(GRCh38/hg38)
Size:
11,600 bases
Orientation:
Minus strand
chr3:52,728,504-52,740,048
(GRCh37/hg19)

Genomic View for GLT8D1 Gene

Genes around GLT8D1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GLT8D1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GLT8D1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GLT8D1 Gene

Proteins for GLT8D1 Gene

  • Protein details for GLT8D1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q68CQ7-GL8D1_HUMAN
    Recommended name:
    Glycosyltransferase 8 domain-containing protein 1
    Protein Accession:
    Q68CQ7
    Secondary Accessions:
    • Q7Z4D1
    • Q8N2J6
    • Q9P0I5

    Protein attributes for GLT8D1 Gene

    Size:
    371 amino acids
    Molecular mass:
    41935 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAQ13652.1; Type=Frameshift; Positions=26, 52, 66, 75, 85, 300, 309, 315, 317, 349; Evidence={ECO:0000305};

    Alternative splice isoforms for GLT8D1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GLT8D1 Gene

Selected DME Specific Peptides for GLT8D1 Gene

Q68CQ7:
  • KPLTFARFYLPILVP
  • GHAAAFS
  • PPLLIVFY
  • TADHLRSWL
  • TCSFNPGVFVANLTEW
  • KWYIPDPTGKF
  • FLLVLHHN
  • AKLLHWNG
  • IDPMWNVRHLG
  • NQYNYIG
  • DDDVIVQGDI
  • VRHLGSS
  • LDYKKERIR

Post-translational modifications for GLT8D1 Gene

  • Glycosylation at isoforms=2103, posLast=249249, isoforms=257, and posLast=365365

Domains & Families for GLT8D1 Gene

Gene Families for GLT8D1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for GLT8D1 Gene

Suggested Antigen Peptide Sequences for GLT8D1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q68CQ7

UniProtKB/Swiss-Prot:

GL8D1_HUMAN :
  • Belongs to the glycosyltransferase 8 family.
Family:
  • Belongs to the glycosyltransferase 8 family.
genes like me logo Genes that share domains with GLT8D1: view

Function for GLT8D1 Gene

Enzyme Numbers (IUBMB) for GLT8D1 Gene

Phenotypes From GWAS Catalog for GLT8D1 Gene

Gene Ontology (GO) - Molecular Function for GLT8D1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA,IBA --
genes like me logo Genes that share ontologies with GLT8D1: view
genes like me logo Genes that share phenotypes with GLT8D1: view

Animal Models for GLT8D1 Gene

MGI Knock Outs for GLT8D1:

Animal Model Products

miRNA for GLT8D1 Gene

miRTarBase miRNAs that target GLT8D1

Clone Products

No data available for Molecular function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GLT8D1 Gene

Localization for GLT8D1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GLT8D1 Gene

Membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GLT8D1 gene
Compartment Confidence
golgi apparatus 4
extracellular 2
mitochondrion 2
endoplasmic reticulum 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for GLT8D1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005794 Golgi apparatus IBA --
GO:0016020 membrane IEA,HDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GLT8D1: view

Pathways & Interactions for GLT8D1 Gene

SuperPathways for GLT8D1 Gene

No Data Available

Interacting Proteins for GLT8D1 Gene

Gene Ontology (GO) - Biological Process for GLT8D1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000271 polysaccharide biosynthetic process IBA --
genes like me logo Genes that share ontologies with GLT8D1: view

No data available for Pathways by source and SIGNOR curated interactions for GLT8D1 Gene

Drugs & Compounds for GLT8D1 Gene

No Compound Related Data Available

Transcripts for GLT8D1 Gene

Unigene Clusters for GLT8D1 Gene

Glycosyltransferase 8 domain containing 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GLT8D1 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c · 3d · 3e ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c ^ 12 ^ 13a ·
SP1: - - - - - - - - - - - - - -
SP2: -
SP3: - - - - - - - - -
SP4:
SP5: - - - - - - -
SP6:
SP7: - - - - - -
SP8: - - - - - -
SP9: - - - -
SP10: - - - - - - - - - - - - - - - - -
SP11: - - - - - - -
SP12: - - - - - - - - -
SP13: - -
SP14: -
SP15:
SP16:
SP17:
SP18: - - - - -

ExUns: 13b ^ 14a · 14b ^ 15a · 15b · 15c ^ 16a · 16b · 16c ^ 17 ^ 18a · 18b · 18c
SP1: -
SP2: -
SP3:
SP4: -
SP5:
SP6: - - -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14: - -
SP15:
SP16:
SP17:
SP18:

Relevant External Links for GLT8D1 Gene

GeneLoc Exon Structure for
GLT8D1
ECgene alternative splicing isoforms for
GLT8D1

Expression for GLT8D1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GLT8D1 Gene

Protein differential expression in normal tissues from HIPED for GLT8D1 Gene

This gene is overexpressed in Islet of Langerhans (18.2), Pancreatic juice (9.3), Placenta (7.9), and Testis (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GLT8D1 Gene



NURSA nuclear receptor signaling pathways regulating expression of GLT8D1 Gene:

GLT8D1

SOURCE GeneReport for Unigene cluster for GLT8D1 Gene:

Hs.297304

Evidence on tissue expression from TISSUES for GLT8D1 Gene

  • Adrenal gland(4.3)
  • Liver(4.3)
  • Nervous system(3.3)
genes like me logo Genes that share expression patterns with GLT8D1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GLT8D1 Gene

Orthologs for GLT8D1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GLT8D1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GLT8D1 33 34
  • 99.64 (n)
dog
(Canis familiaris)
Mammalia GLT8D1 33 34
  • 91.64 (n)
cow
(Bos Taurus)
Mammalia GLT8D1 33 34
  • 90.66 (n)
mouse
(Mus musculus)
Mammalia Glt8d1 33 16 34
  • 89.49 (n)
rat
(Rattus norvegicus)
Mammalia Glt8d1 33
  • 89.49 (n)
oppossum
(Monodelphis domestica)
Mammalia GLT8D1 34
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GLT8D1 34
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves GLT8D1 33 34
  • 74.32 (n)
lizard
(Anolis carolinensis)
Reptilia GLT8D1 34
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.9985 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.9402 33
zebrafish
(Danio rerio)
Actinopterygii glt8d1 33 34
  • 65.55 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons GATL6 33
  • 46.83 (n)
Species where no ortholog for GLT8D1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GLT8D1 Gene

ENSEMBL:
Gene Tree for GLT8D1 (if available)
TreeFam:
Gene Tree for GLT8D1 (if available)

Paralogs for GLT8D1 Gene

Paralogs for GLT8D1 Gene

(1) SIMAP similar genes for GLT8D1 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with GLT8D1: view

Variants for GLT8D1 Gene

Sequence variations from dbSNP and Humsavar for GLT8D1 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000322546 -- 52,697,456(-) T/C intron_variant
rs1000379708 -- 52,697,137(-) A/G intron_variant
rs1000525756 -- 52,697,230(-) A/G/T intron_variant
rs1000579401 -- 52,705,405(-) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000652330 -- 52,703,641(-) A/G 5_prime_UTR_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for GLT8D1 Gene

Variant ID Type Subtype PubMed ID
esv991877 CNV insertion 20482838
esv3336498 CNV insertion 20981092

Variation tolerance for GLT8D1 Gene

Residual Variation Intolerance Score: 25.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.35; 53.76% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GLT8D1 Gene

Human Gene Mutation Database (HGMD)
GLT8D1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
GLT8D1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GLT8D1 Gene

Disorders for GLT8D1 Gene

Additional Disease Information for GLT8D1

No disorders were found for GLT8D1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GLT8D1 Gene

Publications for GLT8D1 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 2 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. Defining the Protein-Protein Interaction Network of the Human Protein Tyrosine Phosphatase Family. (PMID: 27432908) Li X … Wang W (Molecular & cellular proteomics : MCP 2016) 3 58
  5. Investigation of association between hip osteoarthritis susceptibility loci and radiographic proximal femur shape. (PMID: 25939412) Lindner C … Wallis GA (Arthritis & rheumatology (Hoboken, N.J.) 2015) 3 58

Products for GLT8D1 Gene

Sources for GLT8D1 Gene

Content
Loading form....