Aliases for GLS2 Gene
External Ids for GLS2 Gene
Previous GeneCards Identifiers for GLS2 Gene
The protein encoded by this gene is a mitochondrial phosphate-activated glutaminase that catalyzes the hydrolysis of glutamine to stoichiometric amounts of glutamate and ammonia. Originally thought to be liver-specific, this protein has been found in other tissues as well. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Jul 2013]
GeneCards Summary for GLS2 Gene
GLS2 (Glutaminase 2) is a Protein Coding gene. Diseases associated with GLS2 include Juvenile Dermatitis Herpetiformis and Metabolic Acidosis. Among its related pathways are Proximal tubule bicarbonate reclamation and D-Glutamine and D-glutamate metabolism. Gene Ontology (GO) annotations related to this gene include glutaminase activity. An important paralog of this gene is GLS.
UniProtKB/Swiss-Prot Summary for GLS2 Gene
Plays an important role in the regulation of glutamine catabolism. Promotes mitochondrial respiration and increases ATP generation in cells by catalyzing the synthesis of glutamate and alpha-ketoglutarate. Increases cellular anti-oxidant function via NADH and glutathione production. May play a role in preventing tumor proliferation.