Free for academic non-profit institutions. Other users need a Commercial license
The protein encoded by this gene is a mitochondrial phosphate-activated glutaminase that catalyzes the hydrolysis of glutamine to stoichiometric amounts of glutamate and ammonia. Originally thought to be liver-specific, this protein has been found in other tissues as well. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Jul 2013]
GLS2 (Glutaminase 2) is a Protein Coding gene. Diseases associated with GLS2 include Metabolic Acidosis and Juvenile Dermatitis Herpetiformis. Among its related pathways are D-Glutamine and D-glutamate metabolism and Neurotransmitter Release Cycle. Gene Ontology (GO) annotations related to this gene include glutaminase activity. An important paralog of this gene is GLS.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004359 | glutaminase activity | IEA,IBA | 21873635 |
GO:0005515 | protein binding | IEA,IPI | 11163757 |
GO:0016787 | hydrolase activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005739 | mitochondrion | TAS,IDA | 20351271 |
GO:0005759 | mitochondrial matrix | TAS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | D-Glutamine and D-glutamate metabolism | ||
2 | Metabolism |
.40
|
|
3 | Gene Expression |
.48
|
|
4 | Neurotransmitter Release Cycle | ||
5 | Transmission across Chemical Synapses |
.62
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006520 | cellular amino acid metabolic process | TAS | 10620514 |
GO:0006537 | glutamate biosynthetic process | IBA | 21873635 |
GO:0006541 | glutamine metabolic process | IEA | -- |
GO:0006543 | glutamine catabolic process | IBA | 21873635 |
GO:0008652 | cellular amino acid biosynthetic process | TAS | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Ammonia | Approved | Pharma | Enzyme, substrate | 0 | ||
Glutamic acid | Approved | Nutra | Agonist, Full agonist, Target | 304 | ||
L-Glutamine | Approved, Investigational | Nutra | Agonist, Full agonist, Enzyme, substrate | 0 | ||
Famotidine | Approved | Pharma | Histamine H2-receptor antagonist | 82 | ||
Water | Approved | Pharma | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c | · | 7d | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12a | · | 12b | ^ |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP2: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP3: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
SP4: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
SP5: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP6: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||
SP7: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
SP8: | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
SP9: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP10: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
SP11: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
SP12: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP13: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP14: |
ExUns: | 13 | ^ | 14 | ^ | 15 | ^ | 16a | · | 16b | ^ | 17a | · | 17b | ^ | 18 | ^ | 19a | · | 19b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | |||||||||||||||||||
SP2: | |||||||||||||||||||
SP3: | |||||||||||||||||||
SP4: | |||||||||||||||||||
SP5: | |||||||||||||||||||
SP6: | |||||||||||||||||||
SP7: | |||||||||||||||||||
SP8: | |||||||||||||||||||
SP9: | - | ||||||||||||||||||
SP10: | |||||||||||||||||||
SP11: | |||||||||||||||||||
SP12: | |||||||||||||||||||
SP13: | |||||||||||||||||||
SP14: |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | GLS2 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | GLS2 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | GLS2 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Gls2 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Gls2 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | GLS2 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
Lizard (Anolis carolinensis) |
Reptilia | GLS2 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | gls2 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | si:dkey-102c8.6 30 |
|
||
gls2 31 |
|
OneToMany | |||
GLS2 (1 of 3) 31 |
|
OneToMany | |||
GLS2 (2 of 3) 31 |
|
OneToMany | |||
Fruit Fly (Drosophila melanogaster) |
Insecta | CG42708 31 |
|
OneToMany | |
Worm (Caenorhabditis elegans) |
Secernentea | glna-2 31 |
|
ManyToMany | |
glna-3 31 |
|
ManyToMany | |||
glna-1 31 |
|
ManyToMany | |||
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToOne |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2677984 | CNV | deletion | 23128226 |
esv2745928 | CNV | deletion | 23290073 |
esv3629598 | CNV | loss | 21293372 |
nsv1052713 | CNV | gain | 25217958 |
nsv482992 | CNV | gain+loss | 15286789 |
Disorder | Aliases | PubMed IDs |
---|---|---|
metabolic acidosis |
|
|
juvenile dermatitis herpetiformis |
|
|
myasthenic syndrome, congenital, 10 |
|
|
gillespie syndrome |
|
|
sclerosing keratitis |
|
|