Aliases for GLRX5 Gene
External Ids for GLRX5 Gene
Previous HGNC Symbols for GLRX5 Gene
Previous GeneCards Identifiers for GLRX5 Gene
This gene encodes a mitochondrial protein, which is evolutionarily conserved. It is involved in the biogenesis of iron-sulfur clusters, which are required for normal iron homeostasis. Mutations in this gene are associated with autosomal recessive pyridoxine-refractory sideroblastic anemia. [provided by RefSeq, May 2010]
GeneCards Summary for GLRX5 Gene
GLRX5 (Glutaredoxin 5) is a Protein Coding gene. Diseases associated with GLRX5 include Anemia, Sideroblastic, 3, Pyridoxine-Refractory and Spasticity, Childhood-Onset, With Hyperglycinemia. Among its related pathways are PAK Pathway. Gene Ontology (GO) annotations related to this gene include electron transfer activity and 2 iron, 2 sulfur cluster binding. An important paralog of this gene is GLRX3.
UniProtKB/Swiss-Prot Summary for GLRX5 Gene
Monothiol glutaredoxin involved in mitochondrial iron-sulfur (Fe/S) cluster transfer (PubMed:20364084, PubMed:23615440). Receives 2Fe/2S clusters from scaffold protein ISCU and mediates their transfer to apoproteins, to the 4Fe/FS cluster biosynthesis machinery, or export from mitochondrion (PubMed:20364084, PubMed:23615440, PubMed:24334290). Required for normal regulation of hemoglobin synthesis by the iron-sulfur protein ACO1 (PubMed:20364084).